Abstract: Embodiments of the present disclosure are directed to medical devices, methods, and systems for delivering a medical device to a target site. In one embodiment, a medical device includes a proximal lobe and a distal lobe, at least one of the proximal lobe or the distal lobe configured to receive a delivery device therethrough. The medical device also includes a central engagement member disposed between the proximal lobe and the distal lobe, the central engagement member configured to be engaged by a delivery device for facilitating deployment of the proximal and distal lobes at the target site.

Abstract: A positioning and retrieval device manipulated by carrying element coupled to an handle and driven by an actuator that allows for axial movement and rotational movement of a capturing portion on the carrying element.

Abstract: Configurations are described for assisting in the execution of a percutaneous procedure while protecting the vascular pathway to the operational theater, which may comprise diseased tissue. A railed sheath may be controllably expandable and collapsible, and may comprise two or more elongate rail structures configured to assist in the distribution of loads to associated diseased tissue structures, while also contributing to the deployment of percutaneous tools by maintaining alignment of such tools with the railed catheter and associated anatomy.

Abstract: Venous endoluminal devices, in particular for the treatment of defects of the veins, are provided with a substantially tubular body which defines an inner lumen and support modules oriented longitudinally and joined, in a distal direction, by distal bridges and in a proximal direction, by proximal bridges. Each support module includes a distal section, extending in a distal direction beyond the distal bridges, wherein the distal section is at least partially projecting in a radial direction, internally in relation to the inner lumen of the body. Methods of treatment using such devices are also provided.

Abstract: Devices and methods for preventing reperfusion injuries when an occlusion balloon is deflated. A catheter having an infusion lumen exiting the catheter distal of a stent balloon and/or occlusion balloon allows a therapeutic agent to be introduced to a target location to establish desired temperatures and pressures prior to deflation of the balloon such that negative effects of reperfusion are minimized.

Abstract: A catheter system with a proximal end and a distal end means at the proximal end to actuate a device at the distal end of the system, and an actuator element that runs the length of the system, from the actuator means to the device and actuates the device by transmitting a physical force from the proximal end to the distal end and characterized by a pre-tensioner near the distal end of the system, that can be set in a pre-tensioning disposition prior to actuation of the device, the pre-tensioner thereby reducing the magnitude of the said physical force that must be transmitted from the proximal end when actuation of the device is required.

Abstract: Intravascular devices and systems useful for blocking the opening of an aneurysm or a vessel branch are disclosed. In some aspects, the disclosure provides arrangements that align a covering material of a stent graft with an opening in the vessel wall before, during, and/or after expansion of the stent graft within the vasculature of a patient. In some instances, systems and devices include a sheath with a side aperture arranged to align a portion of the sheath and/or a portion of a stent graft contained within the sheath with the mouth of an aneurysm. Similarly, the present disclosure also provides embodiments in which the stent graft comprises an aligning member arranged to align the stent graft and/or a sheath with the mouth of an aneurysm. Other embodiments are disclosed.

Abstract: Assemblies and methods for modifying an intraocular pressure of a patient's one or both eyes are disclosed. The assemblies and methods can be used to treat, inhibit, or prevent ocular conditions such as glaucoma, high intraocular pressure, optic disc edema, idiopathic intracranial hypertension, zero-gravity induced papilledema, and other optic pressure related conditions. An assembly can include a goggle including at least one cavity, a pump in fluid communication with the at least one cavity, and a control mechanism. The control mechanism can be operatively coupled to the pump and can maintain a target pressure or target pressure range in the at least one cavity, which, when the assembly is worn by a patient, is the area between a patient's eye(s) and wall surfaces of the goggle. Controlling the pressure over the outer surfaces of the patient's eye(s) can drive a desired change in the intraocular pressure of the eye(s).

Abstract: A method may include accessing an artery in communication with an ophthalmic artery of a subject, and advancing a microcatheter along the accessed artery so as to align a distal end of the microcatheter with an ostium of the ophthalmic artery, wherein the microcatheter includes a lumen having a guidewire positioned therein. In addition, the method includes proximally withdrawing the guidewire relative to the microcatheter so as to enable a distal portion of the microcatheter to assume a curved relaxed configuration, and cannulating the ostium with the distal portion of the microcatheter when the distal portion is in the curved relaxed configuration.

Abstract: Provided is technology which can prevent the circumferential section of the end surface of a tip end opening from being damaged when an intraocular lens is extruded from an insertion apparatus, even when an insertion tube of the intraocular lens insertion apparatus has been further reduced in size.

Abstract: A suturing system including apparatus and methods for disposing stitches in a substrate comprising a thread carrier which inserts a thread in the substrate at a first location and withdraws the thread from the substrate at a second location.

Abstract: Devices, systems, and methods can be used for the closure of surgical wounds. For example, surgical wounds can be closed using magnetic closure devices rather than the conventional methods of using sutures, clips, or staples. Additionally, in some implementations the magnetic closure devices provided herein are delivered laparoscopically or endoscopically via a vacuum catheter.

Abstract: A catheter for positioning a valve during a transcatheter aortic valve replacement is formed from a resilient hollow body conformable to a guide wire when a guide wire is passed in through an upper opening in the hollow body and through the hollow body. When the guide wire is retracted, the catheter deploys to form a substantially straight upper shaft portion that extends downwardly from the upper opening and a distal ring perpendicular to the upper shaft portion. The distal ring approximates the size and shape of the patient's aortic valve annulus. A lower loop connects the upper shaft portion of the catheter to the distal ring. An outer surface of the distal ring is radiopaque, and the distal ring comprises openings for dispersing radio opaque medium used in imaging of the patient's aortic valve annulus.

Abstract: A method for deploying a medical device such as a heart valve to a desired location in a blood vessel comprising first deploying a tubular filter adjacent to at least one tributary vessel location with a filter deployment member, disengaging said deployment member and removing it, inserting an expandable sheath into the blood vessel, passing a medical device through said sheath to deploy its removing said sheath and removing said filter.

Abstract: Disclosed are devices and methods suitable for application of a curable fluid composition to a bodily organ, such as to a lower portion of a bodily organ. The device comprises a monolithic piece of material having a lower surface, two spaced-apart sides, and two spaced-apart walls connecting the two spaced-apart sides. A receptacle for containing the curable fluid composition is defined by the lower surface, the two sides, and the two walls. At least a portion of the height of the two walls is less than the height of at least a portion of the two sides. The device is deployable underneath the bodily organ such that a lower portion of the bodily organ is supported by at least a portion of each of the two walls.

Abstract: A soft tissue fixation assembly includes a plurality of deformable bone anchors and a suture that is configured to fixedly attach to each of the bone anchors. One or more of the bone anchors can be inserted into a bone, and one or more of the bone anchors can be inserted through soft tissue and into the bone. The suture can be inserted through the bone anchors, and energy can be applied to the anchors, thereby causing a deformable material of the bone anchors to deform, thereby capturing the strand of suture in the bone anchor. The strand of suture can be placed in tension, and can extend over the soft tissue so as to retain the soft tissue in contact with the bone.

Abstract: Ultrasonic surgical instruments having angularly and/or linearly off-set blades are described. The angularly and/or linearly off-set blades may facilitate increased surgical site access, visibility, and manipulability.

Abstract: A tattoo needle tip (10) with a capillary ink reservoir (13) and combined device thereof are provided. The tattoo needle tip (10) includes a needle tip body (11). A needle passage (100) is defined inside the needle tip body (11) for placing a tattoo needle (20). The needle opening (12) is communicated with the needle passage (100). A capillary disposed ink reservoir (13) directly connected to the needle opening (12) whereby can directly feed ink to the sharp end of the tattoo needle (20).

Abstract: A detachment system for delivering an implantable medical device to a target location of a body vessel has a generally hollow distal tube. The distal tube includes a proximal end, a distal end, and a compressible portion of the tube itself, between the proximal and distal ends which is axially movable from a compressed to an elongated condition. A generally hollow proximal tube has a proximal end and a distal end. A coupling joins the proximal and distal tubes. An engagement system engages and deploys the implantable medical device engaged at the distal end of the distal tube. The engagement system moves the compressible portion to the compressed condition when engaging the implantable medical device, and deploys the implantable medical device and releases the compressible portion to the elongated condition.

Abstract: A method may include accessing an artery in communication with an ophthalmic artery of a subject, and advancing a microcatheter along the accessed artery so as to align a distal end of the microcatheter with an ostium of the ophthalmic artery, wherein the microcatheter includes a lumen having a guidewire positioned therein. In addition, the method includes proximally withdrawing the guidewire relative to the microcatheter so as to enable a distal portion of the microcatheter to assume a curved relaxed configuration, and cannulating the ostium with the distal portion of the microcatheter when the distal portion is in the curved relaxed configuration.