Patents Examined by Minh-Tam B. Davis
  • Sertoli cells as transplantation facilitator for cell transplantation
    Patent number: 5830460
    Abstract: A method of producing a sustained localized brain immunosuppressive effect in localized tissues is achieved by transplanting Sertoli cells proximate to the brain tissue.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: November 3, 1998
    Assignee: University of South Florida
    Inventors: Paul R. Sanberg, Don F. Cameron, Cesario V. Borlongan, Richard Heller
  • Melanoma and prostate cancer specific antibodies for immunodetection and immunotherapy
    Patent number: 5719032
    Abstract: Methods and compositions are provided for detecting antigens having a specific epitope associated with melanoma and prostatic carcinoma. The epitope is present in melanoma cells and prostatic cancer cells but is essentially absent from melanocytes and normal prostatic tissue. The antibody can be used in diagnostic methods for histochemical detection of human melanoma and prostate carcinoma, of various progression stages and in treatment of melanoma and prostate carcinoma.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: February 17, 1998
    Assignee: University of British Columbia
    Inventor: Juergen R. Vielkind
  • Method for treating tumors with a toxin
    Patent number: 5667786
    Abstract: A method for treating a tumor is provided, which comprises the steps of preliminarily immunizing a patient in need of antitumor treatment with a toxin or toxin surrogate vaccine in an amount which is effective to generate an immune response to the toxin in the patient, thereby providing systemic protection from the toxin to the patient, and subsequently administering the toxin to the patient in an amount which is effective to kill tumor cells. The toxin may be any suitable toxin, for example ricin, abrin, gelonin or diphtheria.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 16, 1997
    Assignee: Novavax, Inc.
    Inventors: Paul V. Lemley, Jr., Arthur E. Frankel
  • Specific immune system modulation
    Patent number: 5651993
    Abstract: Methods and pharmaceutical compositions for modifying the immune response of a mammal to a specific antigen are provided. The methods include treating an antigen presenting cell to enhance expression of a major histocompatibility complex molecule and reacting the treated antigen presenting cell with the antigen extracorporeally to form an antigen-associated antigen presenting cell.
    Type: Grant
    Filed: November 18, 1992
    Date of Patent: July 29, 1997
    Assignee: Yale University
    Inventors: Richard L. Edelson, Francis P. Gasparro, Robert E. Tigelaar
  • Monoclonal antibodies differentially reactive with native and reductively modified Bowman-Birk protease inhibitor
    Patent number: 5616492
    Abstract: Monoclonal antibodies and a method capable of detecting BBI metabolites in a sample of body fluid or tissue are provided.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: April 1, 1997
    Assignees: Trustees of the University of Pennsylvania, University of Rochester
    Inventors: Ann R. Kennedy, Cameron J. Koch, Edith M. Lord, Xingsheng Wan