Patents Examined by Minna Moezie
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Patent number: 6541483Abstract: The present invention relates to several novel acridone-derived compounds of of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as Human Immunodeficiency Virus. In addition, these compounds are anti-neoplastic agents useful in the treatment of various forms of cancer. wherein R1 and R2 are independently —H, —OH, amino, alkylamino, dialkylamino, alkoxy, alkyl, haloalkyl or halogen; n is 2 to 6, X and X′ are independently —N or —NO2; Y and Y′ are independently —N or —CH, or —H; and the double-slash represents a double bond or no bond.Type: GrantFiled: January 15, 2001Date of Patent: April 1, 2003Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Christopher J. Michejda, Marek W. Cholody, William G. Rice, James A. Turpin
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Patent number: 6512002Abstract: This invention relates to methods and pharmaceutical compositions useful in the treatment of conditions that are responsive to the elevation of testosterone levels in the body and the use of estrogen agonists/antagonists for the manufacture of medicaments for the treatment of conditions that are responsive to the elevation of testosterone levels in the body. The compositions are comprised of an estrogen agonist/antagonist and a pharmaceutically acceptable vehicle, carrier or diluent. These compositions are effective in treating male subject sexual dysfunction and timidity in female subjects including post-menopausal women and are effective in increasing libido in female subjects including post-menopausal women. In the case of male subject sexual dysfunction, the compositions may also include a compound which is an elevator of cyclic guanosine 3′,5′-monophosphate (cGMP).Type: GrantFiled: January 10, 2001Date of Patent: January 28, 2003Assignee: Pfizer Inc.Inventors: Andrew G. Lee, Wesley W. Day, David D. Thompson
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Patent number: 6482826Abstract: Method of treating individuals with alopecia or having inferior quality hair, by administering to the scalp of said individuals an effective amount of ketoconazole. Novel compositions comprising as an active ingredient ketoconazole and an inert carrier.Type: GrantFiled: May 9, 1995Date of Patent: November 19, 2002Assignee: Janssen Pharmaceutica N.v.Inventor: GĂ©rald E. Pierard
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Patent number: 6455574Abstract: This invention relates to pharmaceutical combinations of amlodipine or a pharmaceutically acceptable acid addition salt thereof and atorvastatin or a pharmaceutically acceptable salt thereof, kits containing such combinations and methods of using such combinations to treat subjects suffering from angina pectoris, atherosclerosis, combined hypertension and hyperlipidemia and to treat subjects presenting with symptoms of cardiac risk, including humans. This invention also relates to additive and synergistic combinations of amlodipine and atorvastatin whereby those synergistic combinations are useful in treating subjects suffering from angina pectoris, atherosclerosis, combined hypertension and hyperlipidemia and those subjects presenting with symptoms of cardiac risk, including humans.Type: GrantFiled: February 25, 2000Date of Patent: September 24, 2002Assignee: Pfizer Inc.Inventor: Jan Buch
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Patent number: 6447749Abstract: This invention describes galenical formulations that contain perfluoroalkyl-containing dye molecules and other perfluoroalkyl-containing substances. The new formulations are suitable as, i.a., contrast media for near-infrared diagnosis.Type: GrantFiled: September 29, 2000Date of Patent: September 10, 2002Assignees: Schering Aktiengesellschaft, Institut fuer DiagnostikforschungInventors: Kai Licha, Andreas Becker, Bjoern Riefke, Johannes Platzek
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Patent number: 6440985Abstract: Methods are provided for the treatment and prophylaxis of viral infection and disease associated with such infection.Type: GrantFiled: September 3, 1999Date of Patent: August 27, 2002Assignee: ViroPharma IncorporatedInventors: Thomas R. Bailey, Dorothy C. Young
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Patent number: 6436988Abstract: The present application relates to the use of 3-(2,4,6-trimethylphenyl) -4-neopentylcarbonyloxy-5,5-tetramethylene-&Dgr;3-dihydrofuran-2-one for controlling insects of the family Aleurodidae (white fly).Type: GrantFiled: July 17, 2001Date of Patent: August 20, 2002Assignee: Bayer AktiengesellschaftInventor: Ulrike Wachendorff-Neumann
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Patent number: 6432424Abstract: The present invention relates to a cosmetic composition comprising (i) a compound selected from the group consisting of creatine, carnitine, and pyruvic acid, and a cosmetically acceptable salt or ester thereof, (ii) a nutrient, and (iii) a skin-conditioning agent selected from the group consisting of an emollient and a humectant.Type: GrantFiled: June 29, 2000Date of Patent: August 13, 2002Assignee: Johnson & Johnson Consumer Companies, Inc.Inventors: Stanley S. Shapiro, Katharine M. Martin, Steven A. Shaya, Claudia K. Kaminski
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Patent number: 6429217Abstract: Controlled cessation of heart beat during coronary bypass surgery and other cardiac surgeries on a beating heart improves surgical technique, and is achieved typically by electrical stimulation of the vagus nerve and administration of a combination of drugs.Type: GrantFiled: November 20, 2000Date of Patent: August 6, 2002Assignee: Emory UniversityInventor: John D. Puskas
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Patent number: 6426092Abstract: A novel powder composition comprised of a skin irritation reducing agent comprising 1-Carboxy-N,N,N-trimethylmethanaminium hydroxide inner salt, scutellaria baicalensis extract, bisabolol, or mixtures thereof. Also provided is a method for treating prickly heat comprised of topically applying an effective amount of the powder to a desired area.Type: GrantFiled: February 24, 2000Date of Patent: July 30, 2002Assignee: Johnson & Johnson Consumer Companies, Inc.Inventors: Attaya Nitikhunkasem, Alain V. Khaiat, John Hopkins
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Patent number: 6423699Abstract: This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: wherein: A is O, S, or NR4; B is a bond between A and C═Q, or the moiety CR5R6; R4, R5, R6 are independently selected from H or optionally substituted C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, or heterocyclic groups, or cyclic alkyl constructed by fusing R4 and R5 to from a 5 to 7 membered ring; R1 is selected from H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, substituted alkynyl, —COH, or optionally substituted —CO(C1 to C3 alkyl), —CO(aryl), —CO(C1 to C3 alkoxy), or —CO(C1 to C3 aminoalkyl) groups; R2 is selected from H, halogen, CN, NO2, or optionally substituted C1 to C6 alkyl C1 to C6 alkoxy, or C1 to C6 aminoalkyl groType: GrantFiled: April 19, 2000Date of Patent: July 23, 2002Assignees: American Home Products Corporation, Ligand Pharmaceutical, Inc.Inventors: Gary S. Grubb, Puwen Zhang, Reinhold R. W. Bender, Jay E. Wrobel, James P. Edwards, Todd K. Jones, Christopher M. Tegley, Lin Zhi
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Patent number: 6403631Abstract: Enhancement of pregnancy success in an animal is achieved by a method of treatment which includes administration of a single dose of melatonin during follicular development. An additional dose of melatonin can be administered during pregnancy to modulate accessory follicle formation. Novel compositions, which include a mixture of melatonin isomers or analogs, are also useful for enhancing pregnancy success.Type: GrantFiled: January 14, 2000Date of Patent: June 11, 2002Assignee: Equitech Laboratories, Inc.Inventors: Dan Sharp, Brian D. Cleaver
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Patent number: 6403640Abstract: The use of a COX-2 selective inhibitor for the treatment of chronic prostatitis or chronic pelvic pain syndrome is disclosed.Type: GrantFiled: August 24, 2000Date of Patent: June 11, 2002Assignees: Merck & Co., Inc., Temple University of the Commonwealth of Higher Ed.Inventors: Elizabeth Stoner, Joanne Waldstreicher, Curtis J. Nickel, Michel A. Pontari
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Patent number: 6399593Abstract: This invention concerns cyclic combination therapies using progestational agents and indoline derivatives which are progesterone receptor antagonists of the general structure: wherein: A, B and D are N or CH, though not all can be CH; R1 and R2 are H, CORA, NRBCORA, or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, or aryl groups; or R1 and R2 form a spirocyclic ring; RA is H or optionally substituted alkyl aryl, alkoxy, or aminoalkyl; RB is H, alkyl alkyl; R3 is H, OH, NH2, alkyl, alkenyl, or CORC; RC is H, alkyl, aryl, alkoxy, or aminoalkyl; R4 is benzene or a 5 or 6 membered heteroaromatic ring; RF is H, alkyl, aryl, alkoxy, or aminoalkyl; RG is H or alkyl; R5 is H or alkyl; W is O or a chemical bond; or a pharmaceutically acceptable salt thereof. These methods may be used for contraception.Type: GrantFiled: April 19, 2000Date of Patent: June 4, 2002Assignees: Wyeth, Ligand Pharmaceuticals, Inc.Inventors: Gary S. Grubb, Puwen Zhang, Arthur A. Santilli, Andrew Fensome, Eugene A. Terefenko, Andrew Q. Viet, Jay E. Wrobel, James P. Edwards, Todd K. Jones, Christopher M. Tegley, Lin Zhi
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Patent number: 6387959Abstract: The invention relates to the field of antiviral agents, and more specifically to antiviral therapy. The invention provides use of at least one compound or mixture of compounds of the general formula or a functional equivalent or pharmaceutically acceptable salt, ester or hydrate thereof for the treatment of a viral infection.Type: GrantFiled: June 30, 2000Date of Patent: May 14, 2002Assignees: Universiteit Utrecht, Universitair Medisch Centrum UtrechtInventor: Johannes Servatius Leonardus Maria Nottet
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Patent number: 6387889Abstract: Medicinal compositions for treating eye diseases which contain as the active ingredient 2-alkynyladenosine derivatives having an acetylene union at the 2-position of adenine base. Having a long-lasting and remarkable effect of lowering ocular tension, these compositions are useful as remedies for eye diseases accompanying increased ocular tension or optic nerve failures, such as glaucoma and hypertonia oculi.Type: GrantFiled: March 1, 2001Date of Patent: May 14, 2002Assignees: Yamasa Corporation, Toa Eiyo Ltd.Inventors: Kazuki Endo, Toichi Abiru, Tomokazu Hosokawa, Miwa Misawa, Takashi Konno
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Patent number: 6380255Abstract: The present invention is directed to a method for treating dermal atrophy of the skin. The method of the invention includes applying a composition to the skin of a mammal suffering from dermal atrophy of the skin, and comprising at least one thyroid hormone compound or thyroid hormone-like compound together with a pharmacologically acceptable base suitable for topical application, wherein the thyroid hormone compound or the thyroid hormone-like compound binds to TR-&agr; or TR-&bgr; with an equilibrium dissociation constant, Kd, of at least 10−5 M. The invention is also directed to an article of manufacture comprising packaging material and a pharmaceutical agent contained within the packaging material, wherein the pharmaceutical agent is therapeutically effective for treating dermal atrophy of the skin.Type: GrantFiled: July 14, 2000Date of Patent: April 30, 2002Assignee: Karo Bio ABInventor: Thomas N. Lavin
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Patent number: 6380178Abstract: This invention relates to cyclic combination therapies and regimens utilizing, in combination with progestins, substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: where A and B are independent substituents selected from S, CH or N; provided that when A is S, B is CH or N; and when B is S, A is CH or N; and A and B cannot both be CH; and when A and B both equal N, one N may be optionally substituted with an C1 to C6 alkyl group; R1 and R2 are independent substituents selected from the group of H, C1 to C6 alkyl, substituted C1 to C6 alkyl, C2 to C6 alkenyl, substituted C2 to C6 alkenyl, C2 to C6 alkynyl, substituted C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, substituted aryl, heterocyclic, substituted heterocyclic, CORA, or NRBCORA; or R1 and R2 are fused to form optionally substituted 3 to 8 membered spirocyclic alkyl, alkenyl or heterocyclic ring, the heterocyclic ring containing one toType: GrantFiled: April 19, 2000Date of Patent: April 30, 2002Assignees: American Home Products Corporation, Ligand Pharmaceuticals, Inc.Inventors: Gary S. Grubb, Arthur A. Santilli, Andrew Q. Viet, Puwen Zhang, Andrew Fensome, Jay E. Wrobel, James P. Edwards, Todd K. Jones, Christopher M. Tegley, Lin Zhi
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Patent number: 6352724Abstract: A method for the topical treatment of skin affected with acne, rosacea, or a combination thereof. Sodium chloride in a substantially pure form is topically applied to the affected skin by gently gliding the sodium chloride over the affected skin in a manner insufficient to cause abrasion and debridement of the affected skin. A solid block of about 98% to about 100% by weight sodium chloride free of a carrier and/or free of other topical acne-treatment medicaments and/or free of other topical rosacea-treatment medicaments should be used. The applied sodium chloride is left on the skin. Preferably, the affected skin is pre-moistened with water from shaving, bathing, splashing water on the skin, and the like prior to gliding the sodium chloride thereon.Type: GrantFiled: March 11, 1996Date of Patent: March 5, 2002Inventors: Lesli A. Taylor, Ralph L. Bass
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Patent number: 6353004Abstract: Anti-pruritic compositions and methods of using the compositions for the prevention or treatment of pruritus comprising: wherein: R, R2, R3, R4, R7, Ar1 and Ar2 are as defined in the specification in a pharmaceutically acceptable carrier.Type: GrantFiled: October 9, 1998Date of Patent: March 5, 2002Assignee: Adolor CoporationInventors: John J. Farrar, Alan Cowan