Patents Examined by Minna Moezie
  • Patent number: 6541483
    Abstract: The present invention relates to several novel acridone-derived compounds of of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as Human Immunodeficiency Virus. In addition, these compounds are anti-neoplastic agents useful in the treatment of various forms of cancer. wherein R1 and R2 are independently —H, —OH, amino, alkylamino, dialkylamino, alkoxy, alkyl, haloalkyl or halogen; n is 2 to 6, X and X′ are independently —N or —NO2; Y and Y′ are independently —N or —CH, or —H; and the double-slash represents a double bond or no bond.
    Type: Grant
    Filed: January 15, 2001
    Date of Patent: April 1, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Christopher J. Michejda, Marek W. Cholody, William G. Rice, James A. Turpin
  • Patent number: 6512002
    Abstract: This invention relates to methods and pharmaceutical compositions useful in the treatment of conditions that are responsive to the elevation of testosterone levels in the body and the use of estrogen agonists/antagonists for the manufacture of medicaments for the treatment of conditions that are responsive to the elevation of testosterone levels in the body. The compositions are comprised of an estrogen agonist/antagonist and a pharmaceutically acceptable vehicle, carrier or diluent. These compositions are effective in treating male subject sexual dysfunction and timidity in female subjects including post-menopausal women and are effective in increasing libido in female subjects including post-menopausal women. In the case of male subject sexual dysfunction, the compositions may also include a compound which is an elevator of cyclic guanosine 3′,5′-monophosphate (cGMP).
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: January 28, 2003
    Assignee: Pfizer Inc.
    Inventors: Andrew G. Lee, Wesley W. Day, David D. Thompson
  • Patent number: 6482826
    Abstract: Method of treating individuals with alopecia or having inferior quality hair, by administering to the scalp of said individuals an effective amount of ketoconazole. Novel compositions comprising as an active ingredient ketoconazole and an inert carrier.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: November 19, 2002
    Assignee: Janssen Pharmaceutica N.v.
    Inventor: GĂ©rald E. Pierard
  • Patent number: 6455574
    Abstract: This invention relates to pharmaceutical combinations of amlodipine or a pharmaceutically acceptable acid addition salt thereof and atorvastatin or a pharmaceutically acceptable salt thereof, kits containing such combinations and methods of using such combinations to treat subjects suffering from angina pectoris, atherosclerosis, combined hypertension and hyperlipidemia and to treat subjects presenting with symptoms of cardiac risk, including humans. This invention also relates to additive and synergistic combinations of amlodipine and atorvastatin whereby those synergistic combinations are useful in treating subjects suffering from angina pectoris, atherosclerosis, combined hypertension and hyperlipidemia and those subjects presenting with symptoms of cardiac risk, including humans.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: September 24, 2002
    Assignee: Pfizer Inc.
    Inventor: Jan Buch
  • Patent number: 6447749
    Abstract: This invention describes galenical formulations that contain perfluoroalkyl-containing dye molecules and other perfluoroalkyl-containing substances. The new formulations are suitable as, i.a., contrast media for near-infrared diagnosis.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: September 10, 2002
    Assignees: Schering Aktiengesellschaft, Institut fuer Diagnostikforschung
    Inventors: Kai Licha, Andreas Becker, Bjoern Riefke, Johannes Platzek
  • Patent number: 6440985
    Abstract: Methods are provided for the treatment and prophylaxis of viral infection and disease associated with such infection.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: August 27, 2002
    Assignee: ViroPharma Incorporated
    Inventors: Thomas R. Bailey, Dorothy C. Young
  • Patent number: 6436988
    Abstract: The present application relates to the use of 3-(2,4,6-trimethylphenyl) -4-neopentylcarbonyloxy-5,5-tetramethylene-&Dgr;3-dihydrofuran-2-one for controlling insects of the family Aleurodidae (white fly).
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: August 20, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventor: Ulrike Wachendorff-Neumann
  • Patent number: 6432424
    Abstract: The present invention relates to a cosmetic composition comprising (i) a compound selected from the group consisting of creatine, carnitine, and pyruvic acid, and a cosmetically acceptable salt or ester thereof, (ii) a nutrient, and (iii) a skin-conditioning agent selected from the group consisting of an emollient and a humectant.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: August 13, 2002
    Assignee: Johnson & Johnson Consumer Companies, Inc.
    Inventors: Stanley S. Shapiro, Katharine M. Martin, Steven A. Shaya, Claudia K. Kaminski
  • Patent number: 6429217
    Abstract: Controlled cessation of heart beat during coronary bypass surgery and other cardiac surgeries on a beating heart improves surgical technique, and is achieved typically by electrical stimulation of the vagus nerve and administration of a combination of drugs.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: August 6, 2002
    Assignee: Emory University
    Inventor: John D. Puskas
  • Patent number: 6426092
    Abstract: A novel powder composition comprised of a skin irritation reducing agent comprising 1-Carboxy-N,N,N-trimethylmethanaminium hydroxide inner salt, scutellaria baicalensis extract, bisabolol, or mixtures thereof. Also provided is a method for treating prickly heat comprised of topically applying an effective amount of the powder to a desired area.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: July 30, 2002
    Assignee: Johnson & Johnson Consumer Companies, Inc.
    Inventors: Attaya Nitikhunkasem, Alain V. Khaiat, John Hopkins
  • Patent number: 6423699
    Abstract: This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: wherein: A is O, S, or NR4; B is a bond between A and C═Q, or the moiety CR5R6; R4, R5, R6 are independently selected from H or optionally substituted C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, or heterocyclic groups, or cyclic alkyl constructed by fusing R4 and R5 to from a 5 to 7 membered ring; R1 is selected from H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, substituted alkynyl, —COH, or optionally substituted —CO(C1 to C3 alkyl), —CO(aryl), —CO(C1 to C3 alkoxy), or —CO(C1 to C3 aminoalkyl) groups; R2 is selected from H, halogen, CN, NO2, or optionally substituted C1 to C6 alkyl C1 to C6 alkoxy, or C1 to C6 aminoalkyl gro
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: July 23, 2002
    Assignees: American Home Products Corporation, Ligand Pharmaceutical, Inc.
    Inventors: Gary S. Grubb, Puwen Zhang, Reinhold R. W. Bender, Jay E. Wrobel, James P. Edwards, Todd K. Jones, Christopher M. Tegley, Lin Zhi
  • Patent number: 6403640
    Abstract: The use of a COX-2 selective inhibitor for the treatment of chronic prostatitis or chronic pelvic pain syndrome is disclosed.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: June 11, 2002
    Assignees: Merck & Co., Inc., Temple University of the Commonwealth of Higher Ed.
    Inventors: Elizabeth Stoner, Joanne Waldstreicher, Curtis J. Nickel, Michel A. Pontari
  • Patent number: 6403631
    Abstract: Enhancement of pregnancy success in an animal is achieved by a method of treatment which includes administration of a single dose of melatonin during follicular development. An additional dose of melatonin can be administered during pregnancy to modulate accessory follicle formation. Novel compositions, which include a mixture of melatonin isomers or analogs, are also useful for enhancing pregnancy success.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: June 11, 2002
    Assignee: Equitech Laboratories, Inc.
    Inventors: Dan Sharp, Brian D. Cleaver
  • Patent number: 6399593
    Abstract: This invention concerns cyclic combination therapies using progestational agents and indoline derivatives which are progesterone receptor antagonists of the general structure: wherein: A, B and D are N or CH, though not all can be CH; R1 and R2 are H, CORA, NRBCORA, or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, or aryl groups; or R1 and R2 form a spirocyclic ring; RA is H or optionally substituted alkyl aryl, alkoxy, or aminoalkyl; RB is H, alkyl alkyl; R3 is H, OH, NH2, alkyl, alkenyl, or CORC; RC is H, alkyl, aryl, alkoxy, or aminoalkyl; R4 is benzene or a 5 or 6 membered heteroaromatic ring; RF is H, alkyl, aryl, alkoxy, or aminoalkyl; RG is H or alkyl; R5 is H or alkyl; W is O or a chemical bond; or a pharmaceutically acceptable salt thereof. These methods may be used for contraception.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: June 4, 2002
    Assignees: Wyeth, Ligand Pharmaceuticals, Inc.
    Inventors: Gary S. Grubb, Puwen Zhang, Arthur A. Santilli, Andrew Fensome, Eugene A. Terefenko, Andrew Q. Viet, Jay E. Wrobel, James P. Edwards, Todd K. Jones, Christopher M. Tegley, Lin Zhi
  • Patent number: 6387959
    Abstract: The invention relates to the field of antiviral agents, and more specifically to antiviral therapy. The invention provides use of at least one compound or mixture of compounds of the general formula or a functional equivalent or pharmaceutically acceptable salt, ester or hydrate thereof for the treatment of a viral infection.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: May 14, 2002
    Assignees: Universiteit Utrecht, Universitair Medisch Centrum Utrecht
    Inventor: Johannes Servatius Leonardus Maria Nottet
  • Patent number: 6387889
    Abstract: Medicinal compositions for treating eye diseases which contain as the active ingredient 2-alkynyladenosine derivatives having an acetylene union at the 2-position of adenine base. Having a long-lasting and remarkable effect of lowering ocular tension, these compositions are useful as remedies for eye diseases accompanying increased ocular tension or optic nerve failures, such as glaucoma and hypertonia oculi.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: May 14, 2002
    Assignees: Yamasa Corporation, Toa Eiyo Ltd.
    Inventors: Kazuki Endo, Toichi Abiru, Tomokazu Hosokawa, Miwa Misawa, Takashi Konno
  • Patent number: 6380178
    Abstract: This invention relates to cyclic combination therapies and regimens utilizing, in combination with progestins, substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: where A and B are independent substituents selected from S, CH or N; provided that when A is S, B is CH or N; and when B is S, A is CH or N; and A and B cannot both be CH; and when A and B both equal N, one N may be optionally substituted with an C1 to C6 alkyl group; R1 and R2 are independent substituents selected from the group of H, C1 to C6 alkyl, substituted C1 to C6 alkyl, C2 to C6 alkenyl, substituted C2 to C6 alkenyl, C2 to C6 alkynyl, substituted C2 to C6 alkynyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, substituted aryl, heterocyclic, substituted heterocyclic, CORA, or NRBCORA; or R1 and R2 are fused to form optionally substituted 3 to 8 membered spirocyclic alkyl, alkenyl or heterocyclic ring, the heterocyclic ring containing one to
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: April 30, 2002
    Assignees: American Home Products Corporation, Ligand Pharmaceuticals, Inc.
    Inventors: Gary S. Grubb, Arthur A. Santilli, Andrew Q. Viet, Puwen Zhang, Andrew Fensome, Jay E. Wrobel, James P. Edwards, Todd K. Jones, Christopher M. Tegley, Lin Zhi
  • Patent number: 6380255
    Abstract: The present invention is directed to a method for treating dermal atrophy of the skin. The method of the invention includes applying a composition to the skin of a mammal suffering from dermal atrophy of the skin, and comprising at least one thyroid hormone compound or thyroid hormone-like compound together with a pharmacologically acceptable base suitable for topical application, wherein the thyroid hormone compound or the thyroid hormone-like compound binds to TR-&agr; or TR-&bgr; with an equilibrium dissociation constant, Kd, of at least 10−5 M. The invention is also directed to an article of manufacture comprising packaging material and a pharmaceutical agent contained within the packaging material, wherein the pharmaceutical agent is therapeutically effective for treating dermal atrophy of the skin.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: April 30, 2002
    Assignee: Karo Bio AB
    Inventor: Thomas N. Lavin
  • Patent number: 6352724
    Abstract: A method for the topical treatment of skin affected with acne, rosacea, or a combination thereof. Sodium chloride in a substantially pure form is topically applied to the affected skin by gently gliding the sodium chloride over the affected skin in a manner insufficient to cause abrasion and debridement of the affected skin. A solid block of about 98% to about 100% by weight sodium chloride free of a carrier and/or free of other topical acne-treatment medicaments and/or free of other topical rosacea-treatment medicaments should be used. The applied sodium chloride is left on the skin. Preferably, the affected skin is pre-moistened with water from shaving, bathing, splashing water on the skin, and the like prior to gliding the sodium chloride thereon.
    Type: Grant
    Filed: March 11, 1996
    Date of Patent: March 5, 2002
    Inventors: Lesli A. Taylor, Ralph L. Bass
  • Patent number: 6353004
    Abstract: Anti-pruritic compositions and methods of using the compositions for the prevention or treatment of pruritus comprising: wherein: R, R2, R3, R4, R7, Ar1 and Ar2 are as defined in the specification in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: March 5, 2002
    Assignee: Adolor Coporation
    Inventors: John J. Farrar, Alan Cowan