Abstract: Pressure-sintered polycrystalline mixed materials, with a base of boron nitride, oxides and carbides, are provided in which the hexagonal boron nitride fraction is about 30 to about 85% by weight, the oxide fraction (ZrO.sub.2, MgO) is about 10 to about 50% by weight, and the carbide fraction (SiC, TiC, ZrC) is about 5 to about 20% by weight. These mixed materials have a density of at least 94% of the theoretical density and can be produced by hot-pressing powder mixtures composed of hexagonal boron nitride, the selected oxides and carbides at temperatures in the range of from 1500.degree. C. to 1800.degree. C. under a die pressure of 7 to 20 MPa or by isostatically hot-pressing, in a vacuum tight closed case, at temperatures in the range from about 1400.degree. C. to about 1700.degree. C. under a pressure of about 100 to about 300 MPa in a high-pressure autoclave using an inert gas as the pressure transfer medium.

Abstract: A K-252 compound represented by the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently H or OH; X represents COOH, COOR or CH.sub.2 OH; Y represents H, R or COR; and Z represents OH, OR or SR, wherein R represents lower alkyl has C-kinase inhibitory activity and is expected to be useful as an active ingredient of anti-tumor agents, etc.

Abstract: A reaction medium of ethanol condensed with 1-20, most preferably 4-6 moles, of ethylene or propylene oxide per mole of ethanol greatly improves the practicality of the preparation of azacycloalkane-2,2-diphosphonic acids of the general formula I: ##STR1## where R means a hydrogen or a lower alkyl radical with from 1 to 3 carbon atoms, and n means an integer between 3 and 11, by phosphonylating the corresponding lactams with phosphonic acid and phosphorous trihalides in the presence of water.

Abstract: A compound of formula (I): ##STR1## in which R is optionally substituted phenyl; C.sub.3-8 cycloalkyl; C.sub.5-8 cycloalkenyl; C.sub.1-8 alkyl which may be straight or branched; C.sub.2-8 alkenyl which may be straight or branched; 5- or 6-membered heterocyclyl; or optionally substituted phenyl C.sub.1-4 alkyl, each of Y and Z, which may be the same or different, is oxygen or sulphur; and X is --CH.sub.2 -- or oxygen, a process for the preparation of such compounds and their use in human and veterinary medicine.

Abstract: The present invention refers to an improved method for the preparation of 6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one in which the condensation between 2-chloronicotinic acid and o-phenylenediamine is carried out by refluxing in the presence of a solvent consisting of a cycloalkanol. The end product is in pure state and it may be utilized as such.

Abstract: This disclosure relates to a novel class of 2-alkyl-3-haloisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of novel and known antibacterial and antifungal compounds.

Abstract: Novel ethanobenzazepines, processes for the preparation thereof, and a method of alleviating pain utilizing compounds or compositions thereof are disclosed.

Abstract: An indene compound of the general formula (I): ##STR1## in which R.sub.1 represents a lower alkyl group, R.sub.2 represents a hydrogen atom, an aryl group or lower alkyl group, R.sub.3 represents an alkyl group, and n indicates an integer of 2 or 3; or a salt thereof. The compound has very strong ameliorating or improving effects on cerebral circulation and metabolism, and thus is very useful for ameliorating, or suppressing the progress of, disturbances of brain tissues and functions.

Abstract: The muscle relaxant (E)-3-(9-chloro-5,6-dihydro-11H-pyrrolo[2,1-b][3]benzazepin-11-ylidene-N,N -dimethyl-1-propanamine is prepared by the geometric stereoselective dehydration of the intermediate carbinol with acidic agents and organic bases and low temperatures.