Abstract: A suture clip applier for applying a suture around a tubular tissue adjacent to an open lumen. The suture clip applier includes an elongated body having a tissue clinching mechanism at one end of the body. The tissue clinching mechanism comprises two arms that are movable between open and clinched positions. The suture clip applier includes a plurality of deformable suture clips mounted along a longitudinal length of the elongated body, wherein each suture clip is configured to be detachably positioned within an interior of the two arms and to be deformed between open and clinched positions in response to the two arms being moved between the open and clinched positions. The suture clip applier further includes a length of suture comprising a pre-formed adjustable fastening and a loop extending from the pre-formed adjustable fastening, the loop extending between the two arms.

Abstract: Disclosed is an occluder for occluding a defect in a vasculature. The occluder includes: two occluding disks and a tightening element. The two occluding disks is configured for covering different openings of the defect; wherein the tightening element includes a tightening thread, the tightening thread passing through the defect and being connected to the two occluding disks, the tightening thread has a length between the two occluding disks and the length is adjustable by means of a free end of the tightening thread. Further provided are an occluding system provided with the occluder, a knotting method for the tightening element of the occluder and a method for occluding an oval foramen with the occluder.

Abstract: Various embodiments include a vessel clamping pressure device that is configured to receive suture threads extending from the closure of a vascular vessel of a patient, and maintaining tension on suture threads between the patient and the vessel clamping pressure device to apply pressure to the patient so as to apply a clamping pressure to the vascular vessel to facilitate clotting.

Abstract: Devices and methods establish and facilitate retrograde or reverse flow blood circulation in the region of the carotid artery bifurcation in order to limit or prevent the release of emboli into the cerebral vasculature. Devices and methods are configured for procedures performed through a transcarotid approach for performing transcarotid procedures, including carotid angioplasty, stent deployment, and post stent deployment procedures.

Abstract: A device for applying rubber bands in the human body and in other living beings includes: an axial element having a first handle; a trigger movably mounted on the axial element having one or more handles for moving the trigger along the axial element wherein the trigger serves to pull a wire; and an assembly that has a spool for winding up the wire. The spool is tightly connected with the trigger by a gear mechanism formed in such a way that, when the trigger is pulled, the spool is not rotationally driven and the wire is pulled along by way of the pulling movement of the trigger, whereby one or more rubber bands can be applied to a part of a living being to be treated, and that when the trigger moves back into a starting position, the wire is wound onto the spool.

Abstract: The present disclosure provides a tissue-removing catheter that includes an elongate body with proximal and distal end portions, a tissue-removing element, an inner liner, and a coupling assembly. The tissue-removing element removes tissue by rotation from the elongate body. The inner liner defines a guidewire lumen received within the elongate body and is coupled to the tissue-removing element at its distal end portion. The coupling assembly includes a bushing attached to the distal end portion of the inner liner and a bearing disposed around the bushing with an exterior surface of the bushing contacting an interior surface of the bearing along less than 50% of an internal surface area of the interior surface of the bearing. At least one of the exterior surface of the bushing and the interior surface of the bearing may define a non-uniform dimension extending along a length of one of the bushing and bearing.

Abstract: A balloon embolization apparatus, system and method include a detachable balloon device mounted to the distal end of a catheter or microcatheter. The balloon device includes an elongated cannula having first and second axial lumens defined in the cannula, one lumen which allows for travel over a wire, an inflatable balloon disposed on the cannula, and a valve sleeve disposed between the balloon and the cannula. An inflation port on the cannula allows fluid to be introduced to the balloon via a channel in the catheter. The valve sleeve includes a vent offset from the inflation port in the cannula. The valve sleeve allows the introduced fluid to inflate the balloon, but prevents the fluid from escaping, thereby forming a check valve. Once inflated, the catheter is detached from the balloon apparatus. When the catheter is withdrawn, the balloon remains in place to allow for embolization.

Abstract: A balloon embolization apparatus, system and method include a detachable balloon device mounted to the distal end of a catheter or microcatheter. The balloon device includes an elongated cannula having first and second axial lumens defined in the cannula, one lumen which allows for travel over a wire, an inflatable balloon disposed on the cannula, and a valve sleeve disposed between the balloon and the cannula. An inflation port on the cannula allows fluid to be introduced to the balloon via a channel in the catheter. The valve sleeve includes a vent offset from the inflation port in the cannula. The valve sleeve allows the introduced fluid to inflate the balloon, but prevents the fluid from escaping, thereby forming a check valve. Once inflated, the catheter is detached from the balloon apparatus. When the catheter is withdrawn, the balloon remains in place to allow for embolization.

Abstract: A tool for treating hematoma in the brain, and other tissue in the body, especially suited for use through a cannula. The tool may include a cautery probe for sealing blood vessels in the brain, and a macerating structure for disrupting a hematoma, and aspiration features for removing macerated hematoma debris from the body.

Abstract: Disclosed herein are minimally invasive systems and methods for performing an edge to edge repair of a heart valve on a beating heart of a patient. One or more sutures are inserted into a plurality of leaflets of the heart valve while the heart is beating through a minimally invasive access. The sutures can be threaded through a suture crimp that is advanced to the leaflets. A movable gate on the suture crimp can be actuated to secure the sutures at an appropriate tension to maintain the leaflets in a coapted position.

Abstract: Minimally invasive, multi-functional robotic surgical tool devices for use as lavaging, material aspiration or delivery surgical forceps, scissors or clamp or other device, consisting of a monolithic work element and open central lumen with various functional tips. Such devices may in use follow a central lumen of another device or over a wire in a longitudinal direction upon introduction to a body. Flush and vacuum transport mechanisms, imaging mechanisms or energy source mechanisms may be incorporated. Inner and outer sheaths which may be co-axially disposed relative to a work element may be configured to actuate a beak or beaks and provisions for simultaneous beak closing under rotation may be incorporated.

Abstract: Devices and methods for resecting tissue from the interior of a patient's body with a motor-driven rotating tubular cutter and multiple cutting windows located at a working end of the resecting device.

Abstract: An anchor guide includes an elongate shaft, an atraumatic tip, a channel defined at least in part by the elongate shaft and configured to retain a suture associated with an anchor, and a spacing feature configured to provide a spacing distance between the channel and a device disposed in physical contact with the spacing feature.

Abstract: A balloon guide catheter having a sleeved inflation lumen secured with a wire wrap for improved inflation lumen kink protection and a welded balloon construction provides a robust and flexible catheter with an exceptionally large inner lumen relative to its outer profile and enables rapid and reliable balloon inflation and deflation in a highly deliverable and kink resistant catheter. Balloon guide catheters having multiple sleeved inflation lumens and proximal luers for utilizing the multiple inflation lumens are also provided.

Abstract: Disclosed is a delivery device, kit, system, method, etc. for localized fusion of leaflets of a tissue valve, for example, a native heart valve, using an adhesive. The delivery device can have one or more capture features for capturing separate leaflets, for example, the anterior and posterior mitral leaflets. An applicator can be configured to apply a biocompatible adhesive between the captured leaflets, and one or more curing elements can be configured to cure the applied biocompatible adhesive. The kit can have the aforementioned delivery device, and the biocompatible adhesive used therewith. The method can include positioning the aforementioned delivery device adjacent the anterior and posterior mitral leaflets, capturing the mitral leaflets between the paddles of the delivery device, applying a biocompatible adhesive between the captured mitral leaflets via the applicator, and curing the applied biocompatible adhesive via the energy elements to locally fuse the mitral leaflets.

Abstract: A releasable elongated assembly includes a release member having a length and an opening that extends along the length. The releasable elongated assembly includes a first elongated element having a first coupling member disposed in the opening and a second elongated element having a second coupling member disposed in the opening opposite the first coupling member along the length. The first and second elongated elements are interlaced with each other in the opening at a location between the first coupling member and the second coupling member such that the first and second elongated elements are attached to each other. The release member is moveable from a first position where the first and second coupling members are captured in the opening to a second position where the first and second coupling members are released from the opening so as to detach the first and second elongated elements from each other.

Abstract: A tourniquet for occluding blood flow to a limb is improved by the addition of proximal and distal strain gauges. The proximal strain gauge may be monitored under conditions of total blood flow occlusion for time-varying signals indicative of volumetric limb changes arising from the subject's blood flow in the proximal section of the limb. Upon a change in limb occlusion pressure, the signals from the proximal strain gauge can be observed to change also, and the working pressure in the tourniquet can be adjusted safely in response. Automated control systems may further use inputs from a distal strain gauge and/or from a sensor that detects induced pressure changes within the tourniquet to improve the control of the tourniquet working pressure during operation to avoid unwanted blood flow past the tourniquet.

Abstract: The presently disclosed subject matter relates generally to a device for cutting soft tissue, such as transverse carpal ligaments and annular ligaments of the finger, and methods of using the soft tissue cutting device. A soft tissue cutting device includes an inner tubular member extending between a distal end and a proximal end of the inner tube, an outer tubular member disposed over at least a portion of the inner tubular member and movable between an initial position and an extended position, an outer tubular member movement controller that controls movement of the outer tubular member between the initial position and the extended position, and an attachment mechanism for removably coupling the proximal end of the inner tubular member to a dispensing member. A distal end of the outer tubular member includes a cutting member.

Abstract: A medical device system configured to dynamically control a shaver window opening via controlling positioning of an opening in an inner drive shaft relative to an opening in an outer housing based on continuously tracking the motor is disclosed. The medical device system may include a shaver at a distal end and an aspiration system configured to aspirate material through the inner drive shaft. A processor of the medical device system may control rotational motion of the inner drive shaft based on continuously sensing the position of the opening in the inner drive shaft to reduce clogs and increase cutting effectiveness of the system. By continuously monitoring the medical device system, the processor can correct out of phase conditions in oscillation mode to prevent poor cutting conditions. The processor can also dynamically determine a reversal position on the opening in the inner drive shaft to create a desired cutting action.

Abstract: A catheter system for pressure wave and inertial impulse generation for intravascular lesion disruption at a treatment site includes a catheter including an elongate shaft and balloon coupled to the elongate shaft. The catheter system includes a light guide disposed along the elongate shaft and at least partially within the balloon, where the light guide is in optical communication with a light source and a balloon fluid. The catheter can include a first focusing element located at a distal portion of the light guide and in optical communication with the light source. The first focusing element can direct light from within the light guide to a first location at a first distance away from the distal portion of the light guide to initiate plasma formation in the balloon fluid away from the distal portion and to cause rapid bubble formation, thereby imparting pressure waves at the treatment site.