Patents Examined by Mitchell E Alter
  • Patent number: 10433757
    Abstract: A method and a device for diagnosing brain injury (e.g. concussion) based on analysis of electromyogram (EMG) signals and presence of neurological modulation impairment of motor activity are described. The method consists of recording specific EMG signals under defined conditions, processing the acquired EMG signals, extracting the relevant information, and making diagnosis of brain injury and disorders that are associated with brain pathology. Specifically, the steps and device involved in the method include placing an EMG electrode set on the subject's body area, acquiring EMG signals from a subject's muscle(s) undergoing contraction, processing the acquired EMG signals using a signal processing algorithm that includes Fourier transformation. The resulting EMG data with a frequency domain (frequency power spectra) are then analyzed in comparison with databases stored in the device and used to determine anomaly of diagnostic value in the EMG power spectra from subjects.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: October 8, 2019
    Inventor: Jian Chen
  • Patent number: 10426395
    Abstract: The present system is directed in various embodiments to devices, systems and methods for detection, evaluation and/or monitoring olfactory dysfunction by measuring and determining the patient's olfactory detection threshold for the left and the right nostril. More specifically, the present invention relates to devices, systems and methods for detecting an asymmetric differential in a patient's olfactory detection threshold (left vs right nostril) which, when present, may be used as a tool to screen, detect, diagnose and/or monitor relative olfactory deterioration resulting from Alzheimer's disease. A preferred embodiment comprises cascading aromas by serially administering more than one pure odorant to the patient's nostrils, left vs right, with measurement of the time, or numbers of breaths, required to cognitively notice the pure odorants' presence.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: October 1, 2019
    Assignee: Inspired Technologies, Inc.
    Inventor: Gregory B. Mills
  • Patent number: 10413201
    Abstract: The invention relates to a pressure sensor catheter and method for measuring pressure on a distal side of a flow constriction, such as a stenosis, in a body lumen or measuring a pressure difference over the flow constriction. The catheter includes a pressure transfer tube for passing through the constriction, the tube being connected to and extending from a pressure sensor for transferring the pressure at the distal side of the constriction via the tube to the sensor, and a catheter body for introduction of the catheter into the body lumen, wherein the catheter body comprises the sensor at a sensor position, such that the sensor in use is positioned in the body lumen, and wherein a distal end region of the catheter including the distal end region of the pressure transfer tube has a smaller maximum outer diameter than the outer diameter of the catheter at the sensor position.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: September 17, 2019
    Assignee: Wellinq Medical B.V.
    Inventor: Bas Ludoph
  • Patent number: 10413195
    Abstract: A method for determining an arteriovascular condition of a subject having an arterial blood flow is shown. The method involves determining a temporal progression of an instantaneous blood flow condition of the arterial blood flow as well as deriving a slew rate of the temporal progression during an increase of the temporal progression. In addition, an arteriovascular condition indicator device is shown, which comprises: an input for receiving an input signal representing an instantaneous arterial blood flow condition of a subject and a slew rate monitor connected to the input. A corresponding control device for providing an activation signal is also shown. The control device comprises a maximum detector connected to the slew rate monitor. A method for stimulation of arteriogenesis is also shown, wherein a temporal progression of an instantaneous blood flow condition is monitored, a slew rate of the temporal progression is derived, and the maximum of the slew rate is determined.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: September 17, 2019
    Inventors: Ivo Buschmann, Axel Pries, Ferdinand Lenoble
  • Patent number: 10398322
    Abstract: A biological information measuring apparatus includes a blood pressure pulse wave measuring unit configured to measure a blood pressure pulse wave of a subject, a unit pulse wave producing unit configured to produce unit pulse waves of a certain unit from the blood pressure pulse wave based on an analysis of heart beats of the subject, a unit pulse wave extracting unit configured to analyze the unit pulse waves produced by the unit pulse wave producing unit and to extract only necessary unit pulse waves in accordance with the analysis, and an output unit configured to perform an output based on the unit pulse waves extracted by the unit pulse wave extracting unit.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: September 3, 2019
    Assignee: NIHON KOHDEN CORPORATION
    Inventor: Yukio Koyama
  • Patent number: 10390731
    Abstract: The invention provides a system for measuring respiratory rate (RR) from a patient. The system includes an impedance pneumography (IP) sensor, connected to at least two electrodes, and a processing system that receives and processes signals from the electrodes to measure an IP signal. A motion sensor (e.g. an accelerometer) measures at least one motion signal (e.g. an ACC waveform) describing movement of a portion of the patient's body to which it is attached. The processing system receives the IP and motion signals, and processes them to determine, respectfully, frequency-domain IP and motion spectra. Both spectra are then collectively processed to remove motion components from the IP spectrum and determine RR. For example, during the processing, an algorithm determines motion frequency components from the frequency-domain motion spectrum, and then using a digital filter removes these, or parameters calculated therefrom, from the IP spectrum.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: August 27, 2019
    Assignee: SOTERA WIRELESS, INC.
    Inventors: Matt Banet, Marshal Dhillon, Devin McCombie
  • Patent number: 10390743
    Abstract: Electrode systems are disclosed for measuring the concentration of an analyte under in-vivo conditions, where such systems include a counter electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: August 27, 2019
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Ewald Rieger, Reinhold Mischler, Ortrud Quarder, Arnulf Staib, Ulrike Kamecke, Ralph Gillen
  • Patent number: 10390734
    Abstract: An oral procedural apparatus includes a main body, a bite block attached to the main body, and a sampling return line at least partially disposed within the main body. The sampling return line is configured to connect to a systemic biomarker sampling device that samples exhaled breath of a patient.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: August 27, 2019
    Assignee: Bohnas Innovations LLC
    Inventors: Casey Johnson, Greg Bauer, Doran Thomas
  • Patent number: 10314527
    Abstract: Disclosed herein is a sensor comprising a conduit; the conduit comprising an organic polymer; a working electrode; the working electrode being etched and decorated with a nanostructured material; a reference electrode; and a counter electrode; the working electrode, the reference electrode and the counter electrode being disposed in the conduit; the working electrode, the reference electrode and the counter electrode being separated from each other by an electrically insulating material; and wherein a cross-sectional area of the conduit that comprises a section of the working electrode, a section of the reference electrode and a section of the counter electrode is exposed to detect analytes.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: June 11, 2019
    Assignee: THE UNIVERSITY OF CONNECTICUT
    Inventors: Liangliang Qiang, Santhisagar Vaddiraju, Fotios Papadimitrakopoulos
  • Patent number: 10285597
    Abstract: A process is provided for monitoring a patient being anesthetized, as well as a process for determining a combined effect of different anesthetics used. Devices for carrying out the processes are also provided.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: May 14, 2019
    Assignees: DRÄGERWERK AG & CO. KGAA, INSELSPITAL BERN, DIREKTION LEHRE UND FORSCHUNG
    Inventors: Frank Franz, Maral Haar, Jürgen Manigel, Kai Kück, Susanne Stahlkopf, Marcel Voigt, Thomas Bouillon, Martin Luginbühl, Peter Schumacher
  • Patent number: 10281452
    Abstract: There is provided a blood coagulation system analyzer, including a measurement section and an analysis section. The measurement section measures a time change of impedance of a blood sample, which is obtainable by applying an alternating electric field to the blood sample. The analysis section extracts a parameter indicating the characteristics of the impedance from the measured data of the time change of the impedance. Furthermore, the analysis section analyzes a degree of enhancement of blood coagulation on the basis of a comparison of the extracted parameter with at least one reference value which defines the criteria of the enhancement of blood coagulation.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: May 7, 2019
    Assignee: Sony Corporation
    Inventors: Yoshihito Hayashi, Marc-Aurele Brun, Isao Uchimura
  • Patent number: 10271739
    Abstract: This invention is directed to devices and methods for assessing a patient. The devices have at least one impedance measuring element functionally connected to a programmable element, programmed to analyze an impedance measurement, and to provide an assessment of at least one respiratory parameter of the patient. Preferably the device includes electronics which aid in calibration, signal acquisition, conditioning, and filtering.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: April 30, 2019
    Assignee: Respiratory Motion, Inc.
    Inventors: Jenny E Freeman, Michael Lalli, Alex Mattfolk, Alexander Panasyuk, Charles Jahnke, Nathaniel Steiger, Svetlana V Panasyuk, Arvil Nagpal, James F Toy, IV, Roman Bokhenik, Anita Karcz
  • Patent number: 10251588
    Abstract: Disclosed are methods, apparatuses, etc. for glucose sensor signal reliability analysis.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: April 9, 2019
    Assignee: Medtronic Minimed, Inc.
    Inventors: Bradley Liang, Kenneth W. Cooper, Raghavendhar Gautham, Rajiv Shah
  • Patent number: 10238302
    Abstract: Intravascular devices, systems, and methods are disclosed. In some embodiments, the intravascular devices include at least one pressure sensing component within a distal portion of the device. In that regard, one or more electrical, electronic, optical, and/or electro-optical pressure-sensing components is secured to an elongated substrate such that the pressure-sensing component is mounted perpendicular to a central longitudinal axis of the device. In some implementations, the elongated substrate has a cylindrical profile. Methods of making, assembling, and/or using such intravascular devices and associated systems are also provided.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: March 26, 2019
    Assignee: VOLCANO CORPORATION
    Inventors: Bret C. Millett, David H. Burkett, Paul Douglas Corl
  • Patent number: 10235756
    Abstract: According to some aspects, a method of identifying a boundary of a portion of a vasculature is provided, the vasculature comprising a geometric representation of a plurality of vessels. The method comprises logically dividing the geometric representation into a plurality of regions, determining at least one feature within each of the plurality of regions, and defining the boundary of the portion of the vasculature based, at least in part, on the at least one feature determined within each of the plurality of regions, wherein the boundary forms a volume defining a separation between inside and outside of the portion of the vasculature. According to some aspects, a method of performing vascular analysis using a geometric representation of a plurality of vessels of the vasculature is provided.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: March 19, 2019
    Assignee: Bio-Tree Systems, Inc.
    Inventors: Raul A. Brauner, Kongbin Kang, Yanchun Wu, Joao Cruz
  • Patent number: 10213116
    Abstract: The application relates to an apparatus and a method for estimating a central systolic blood pressure (cSBP) of a subject, in which a peripheral blood pressure waveform of the subject's pulse and at least two peripheral blood pressure measurements within the cardiac cycle of the subject are determined and the peripheral blood pressure waveform is manipulated with a transfer function to provide an estimate of the central blood pressure waveform of the subject's pulse. The at least two peripheral blood pressure measurements within the cardiac cycle of the subject and the peripheral blood pressure waveform of the subject's pulse are determined at substantially the same point on a peripheral artery of the subject. The estimate of the central blood pressure waveform of the subject's pulse provides an estimate of the central systolic blood pressure of the subject.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: February 26, 2019
    Assignee: SunTech Medical, Inc.
    Inventors: Philip Jan Chowienczyk, Sally Emma Brett, Antoine Yves Marie Guilcher
  • Patent number: 10188352
    Abstract: There is provided a acne-affected skin determination method including: setting an upper region and a lower region so as to vertically divide the face of a subject into two regions; acquiring a measurement value of the amount of moisture in the lower region; acquiring a measurement value of the amount of moisture in the upper region; calculating a target moisture value indicating the level of the amounts of moisture distributed in one of the upper region or the lower region and a reference moisture value indicating the level of the amounts of moisture distributed in a reference region including the other of the upper region and the lower region, based on the measurement values of the amounts of moisture in the upper region and the lower region; obtaining the degree of change in moisture of the target moisture value with respect to the reference moisture value; and determining the ease of generation of acne in the face of the subject based on the obtained degree of change in moisture.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: January 29, 2019
    Assignee: FUJIFILM Corporation
    Inventors: Naoko Yoshida, Noriko Ohira
  • Patent number: 10175247
    Abstract: The invention provides a physical change evaluation device, method, and program capable of easily evaluating physical change from the past to the present, and from the present into the future. A physical change evaluation device 10 acquires a ketone concentration measurement measuring ketone excreted from a user, acquires physical data relating to the body of the user, evaluates physical change in the user based on the acquired ketone concentration measurement and the physical data, and outputs an evaluation result.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: January 8, 2019
    Assignee: Tanita Corporation
    Inventors: Miyuki Kodama, Ayumi Sano, Yasuhiro Kasahara, Naotaka Minagawa, Moe Watabe
  • Patent number: 10165966
    Abstract: Methods for non-invasively and accurately estimating and monitoring resistance and work of breathing parameters from airway pressure and flow sensors attached to the ventilator-dependent patient using an adaptive mathematical model are provided. These methods are based on calculations using multiple parameters derived from the above-mentioned sensors. The resistance and work of breathing parameters are important for: assessing patient status and diagnosis, appropriately selecting treatment, assessing efficacy of treatment, and properly adjusting ventilatory support.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: January 1, 2019
    Assignees: University of Florida Research Foundation, Incorporated, Convergent Engineering, Inc.
    Inventors: Michael J. Banner, Neil Russell Euliano, Andrea Gabrielli, Nawar Nazar Yousif Al-Rawas
  • Patent number: 10137265
    Abstract: Systems and methods regarding ventilation of a patient, such as a victim at the scene of an emergency are described herein.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: November 27, 2018
    Assignee: ZOLL MEDICAL CORPORATION
    Inventors: Gary A. Freeman, Annemarie Silver, Ulrich Herken, Jon P. Cloutier