Patents Examined by Monika Sheinberg
  • Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification an bioelectronic chip technology
    Patent number: 6864071
    Abstract: This invention relates to devices, methods, and compositions of matter for the multiplex amplification and analysis of nucleic acid sequences in a sample using ligation-dependent strand displacement amplification technologies in combination with bioelectronic microchip technology.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: March 8, 2005
    Assignee: Nanogen/Becton Dickinson Partnership
    Inventors: John J. Carrino, Louis O. Gerrue, Jonathan M. Diver
  • Prediction of molecular polar surface area and bioabsorption
    Patent number: 6522975
    Abstract: The polar surface area of molecules is computed without reference to three dimensional molecular structures using a linear equation incorporating counts of nitrogens, oxygens, and related atom clusters. Methods and systems for predicting intestinal absorption of candidate compounds use the polar surface area and the octanol/water partition coefficient as descriptors.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: February 18, 2003
    Assignee: Pharmacopeia, Inc.
    Inventors: William J. Egan, Giorgio Lauri
  • Rational selection of putative peptides from identified nucleotide, or peptide sequences, of unknown function
    Patent number: 6507788
    Abstract: A method for identifying putative peptides of a given function from among nucleotide or peptide sequences of unknown function comprising the steps of: (i) obtaining a polynucleotide or polypeptide database; (ii) screening the database for the presence of a combination of nucleotides or amino acids indicative of the peptide of given function; (ii) identifying the polynucleotide or polypeptide sequences which comprise the combination of nucleotides or amino acids indicative of the peptide of given function.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: January 14, 2003
    Assignees: Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.), Centre National de la Recherche Scientifique (C.N.R.S)
    Inventors: Jose Antonio Camara y Ferrer, Christophe Alain Thurieau, Jean Martinez, Gilbert Bergé, Catherine Gozé
  • Mathematical analysis for the estimation of changes in the level of gene expression
    Patent number: 6502039
    Abstract: The present invention relates to a highly accurate and reproducible mathematically-based methodology for quantifying the levels of differential gene expression from microassay protocols. Specifically, the present invention provides a simple deductive approach, grounded in a Bayesian framework, to circumvent the heuristic-based limitation of previous methodologies. Rather than seeking a point-estimate of the fold-change of the level of gene expression, the present invention utilizes the derivation of mathematical formula to determine the a posteriori distribution of all the fold-changes of differential gene expression which may be inferred from the given measurements. From this a posteriori distribution the following information may be obtained: (i) an estimator for the fold-change of the level of gene expression; (ii) confidence limits for the fold-change, at any given confidence level; and (iii) a P-value for assessing the statistical significance of change.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: December 31, 2002
    Assignee: Aventis Pharmaceuticals
    Inventors: Joachim Theilhaber, Steven Bushnell, Rainer Fuchs