Patents Examined by Myron G. Hill
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Patent number: 11780906Abstract: The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).Type: GrantFiled: May 23, 2022Date of Patent: October 10, 2023Assignee: ADMA BIOMANUFACTURING, LLCInventors: Adam S. Grossman, James Mond, Jerrold B. Grossman, Dov A. Goldstein
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Patent number: 11723967Abstract: The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of an infection with Zika virus or a disorder related to such an infection. In particular, the present invention concerns a Zika virus vaccine. The present invention is directed to an artificial nucleic acid, polypeptides, compositions and vaccines comprising the artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptides, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial nucleic acid, polypeptides, compositions and vaccines.Type: GrantFiled: February 17, 2017Date of Patent: August 15, 2023Assignees: CureVac SE, Sanofi PasteurInventors: Benjamin Petsch, Edith Jasny, Yves Girerd-Chambaz
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Patent number: 11707517Abstract: The present disclosure provides recombinantly manufactured fusion proteins comprising a SARS-CoV-2 Receptor Binding Domain (SARS-CoV-2-RBD) fragment or an analog thereof linked to a human Fc fragment for use in relation to the 2019 Novel Coronavirus (COVID-19). Embodiments include the administration of the fusion proteins to patients that have recovered from COVID-19 as a booster vaccination, to antibody naïve patients to produce antibodies to the SARS-CoV-2 virus to enable the patients to become convalescent plasma donors, to patients who have been infected by the SARS-CoV-2 virus and have contracted COVID-19 in order to limit the scope of the infection and ameliorate the disease, and as a prophylactic COVID-19 vaccine. Exemplary Fc fusion proteins and pharmaceutical formulations of exemplary Fc fusion proteins are provided, in addition to methods of use and preparation.Type: GrantFiled: December 7, 2021Date of Patent: July 25, 2023Assignee: Akston Biosciences CorporationInventors: Todd C. Zion, Thomas M. Lancaster, Thillainayagam Sathiyaseelan, Kexin Huang
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Patent number: 11702464Abstract: Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositions comprising anti-neuraminidase agents (e.g., antibodies) that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith.Type: GrantFiled: March 1, 2019Date of Patent: July 18, 2023Assignee: The University of ChicagoInventors: Patrick Wilson, Yaoqing Chen, Haley L. Dugan
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Patent number: 11661449Abstract: This application provides antibodies and functional equivalents thereof which are capable of specifically binding RSV, as well as means and methods for producing them.Type: GrantFiled: October 22, 2021Date of Patent: May 30, 2023Assignee: MedImmune LimitedInventors: Nancy Ulbrandt, Nicole Kallewaard-Lelay, Andy Q. Yuan, Bettina Richter
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Patent number: 11655284Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.Type: GrantFiled: June 23, 2022Date of Patent: May 23, 2023Assignee: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Kurt Swanson, Philip R. Dormitzer
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Patent number: 11643641Abstract: A method and composition for inactivating both naked genetic material such as RNA and DNA and inactivating mechanical delivery vectors in a treatment space external of the human body. To practice the method, apply a mist of lipid molecule degrading agent effective against viral membranes with lipid molecules. Then apply an inactivator of spike proteins and other viral residues. Next, reduce the threat of transmitting genetic material by applying inactivators of mechanical transport vectors such as mold, yeast, and bacteria. Further, pretreat the treating space to receive enzymatic agents by applying a surface detoxifying agent in quantity sufficient to inactivate substances detrimental to enzymes that break the naked viral genetic material. Then, apply preparatory enzymes that degrade microorganisms and their cellular components. Finally, apply enzymes for breaking the naked viral genetic material, as present.Type: GrantFiled: February 25, 2022Date of Patent: May 9, 2023Inventor: Malireddy S. Reddy
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Patent number: 11629181Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.Type: GrantFiled: June 23, 2022Date of Patent: April 18, 2023Assignee: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Kurt Swanson, Philip R. Dormitzer
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Patent number: 11629172Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least one introduced amino acid mutation relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.Type: GrantFiled: December 19, 2019Date of Patent: April 18, 2023Assignee: Pfizer Inc.Inventors: Philip Ralph Dormitzer, Ye Che, Xiaoyuan Sherry Chi, Seungil Han, Kyle Paul Heim, Thomas Richard Jones, Yuhang Liu, Xiayang Qiu, Xinzhen Yang, Xiaojie Yao, Matthew Curtis Griffor, Jennifer Anne Nicki
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Patent number: 11623004Abstract: Disclosed herein are compositions for vaccination against respiratory syncytial virus (RSV) comprising a RSV F polypeptide stabilized in a prefusion conformation and an inulin adjuvant. Also disclosed herein are methods of vaccinating a subject against a respiratory syncytial virus (RSV) infection comprising administering to the subject an RSV F polypeptide stabilized in a prefusion conformation and an inulin adjuvant. In some embodiments, the subject is a female, and the method can reduce RSV infection in the subject and/or in the offspring of the subject. In some embodiments, the method decreases vaccine-enhanced respiratory disease (VERD) and/or eosinophilia in the subject or offspring of the subject.Type: GrantFiled: March 15, 2019Date of Patent: April 11, 2023Assignees: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, CALDER BIOSCIENCES INC., VAXINE PTY LTDInventors: Kerry McGarr Empey, Nikolai Petrovsky, Christopher Marshall
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Patent number: 11571472Abstract: Immunogenic combinations that include a) an immunogenic component containing a peptide or polypeptide antigen of a respiratory pathogen; and b) an immunogenic component containing a nucleic acid encoding an antigen of the same respiratory pathogen, wherein the immunogenic components are formulated for concurrent administration are provided, as well as methods for making and for administering such immunogenic combinations to elicit an immune response specific for the respiratory pathogen.Type: GrantFiled: June 12, 2015Date of Patent: February 7, 2023Assignee: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Ann-Muriel Steff, Jean-Francois Toussaint, Alessandra Vitelli
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Patent number: 11564993Abstract: The present invention provides a nanogel nasal vaccine that induces cell-mediated immunity. The present invention relates to a vaccine preparation comprising a complex of a nanogel, a vaccine antigen, and an adjuvant, wherein the vaccine preparation can efficiently induce the cell-mediated immunity, and can also induce a systemic and mucosal immune response.Type: GrantFiled: August 2, 2019Date of Patent: January 31, 2023Assignees: THE UNIVERSITY OF TOKYO, HANAVAX INC.Inventors: Yoshikazu Yuki, Rika Nakahashi, Hiroshi Kiyono
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Patent number: 11566051Abstract: The disclosure relates to stable RSV F proteins and immunogenic compositions containing the same, as well as methods of using the immunogenic compositions and compositions comprising the RSV F proteins.Type: GrantFiled: January 24, 2019Date of Patent: January 31, 2023Assignee: Merck Sharp & Dohme LLCInventors: Lan Zhang, Arthur Fridman, Eberhard Durr, Andrew Bett
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Patent number: 11549101Abstract: This invention provides highly attenuated influenza viruses and vaccines. The attenuated viruses and vaccines proliferate well and have high safety factors. The attenuated viruses providing protective immunity from challenge by virus of the same subtype, as well as cross protection against heterologous viruses.Type: GrantFiled: June 10, 2019Date of Patent: January 10, 2023Assignee: The Research Foundation for State University of New YorkInventors: Steffen Mueller, Eckard Wimmer, Bruce Futcher, Steven Skiena, Chen Yang
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Patent number: 11535865Abstract: The subject matter disclosed herein is generally directed to methods and compositions for stable transduction of target cells with libraries of genetic elements. The invention reduces intermolecular recombination between library elements and integration of multiple genetic elements.Type: GrantFiled: February 6, 2019Date of Patent: December 27, 2022Assignees: The Broad Institute, Inc., Massachusetts Institute of TechnologyInventors: David Feldman, Avtar Singh, Paul Blainey
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Patent number: 11530457Abstract: A saliva-based testing method that bypasses the need for RNA isolation/purification is described herein. In experiments with inactivated SARS-CoV-2 virus spiked into saliva, this method has a limit of detection of 500-1000 viral particles per mL, rivalling the standard NP swab method. Initial studies showed excellent performance with 100 clinical samples. This saliva-based process is operationally simple, utilizes readily available materials, and can be easily implemented by existing testing sites thus allowing for high-throughput, rapid, and repeat testing of large populations.Type: GrantFiled: June 17, 2021Date of Patent: December 20, 2022Assignee: The Board of Trustees of the University of IllinoisInventors: Diana Rose Ranoa, Robin L. Holland, Fadi G. Alnaji, Kelsie J. Green, Leyi Wang, Christopher B. Brooke, Martin D. Burke, Timothy M. Fan, Paul J. Hergenrother
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Patent number: 11525830Abstract: A biosensor for detecting an influenza A virus in a sample is disclosed, which includes: an influenza A virus antibody immobilized on a surface of Au—Fe3O4 composite; where the antibody binds with the influenza A virus in the sample, which converts 4-methylumbelliferyl-N-acetyl-?-D-neuraminic acid (MUNANA) to 4-methylumbelliferone (4-MU), where the 4-MU emits green light at pH of 5.5-6.5; and wherein the 4-MU emits blue light at pH of 9.3-11.3. In the biosensor, 1,1?-oxalyldiimidazole chemiluminescence (ODI-CL) reagent may be utilized to emit the blue and green lights.Type: GrantFiled: October 15, 2018Date of Patent: December 13, 2022Inventor: Ji Hoon Lee
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Patent number: 11504424Abstract: The present invention relates to an attenuated virus strain derived from a human metapneumovirus strain comprising the genome sequence represented by sequence SEQ ID NO. 1, said attenuated strain comprising one or more genetic modifications of said sequence SEQ ID NO. 1 attenuating the virulence of said strain.Type: GrantFiled: July 12, 2019Date of Patent: November 22, 2022Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE LAVALInventors: Manuel Rosa-Calatrava, Guy Boivin, Julia Dubois, Mario Andres Pizzorno, Olivier Terrier, Marie-Eve Hamelin, Marie-Helene Cavanagh
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Patent number: 11492379Abstract: This invention relates to SARS-CoV-2 viruses adapted with nanoluciferase reporter molecules and mouse-adapted SARS-CoV-2 viruses, compositions including the same and methods of use thereof.Type: GrantFiled: December 20, 2021Date of Patent: November 8, 2022Assignee: The University of North Carolina at Chapel HillInventors: Ralph Baric, Harold Kenneth Dinnon, III, Sarah Rebecca Leist, Yixuan Hou
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Patent number: 11479600Abstract: Anti-RSV antibodies with neutralizing potency against RSV subtype A and RSV subtype B are provided, as well as nucleic acid sequences encoding such antibodies, methods for their identification, isolation, generation, and methods for their preparation and use are provided.Type: GrantFiled: October 20, 2017Date of Patent: October 25, 2022Assignee: Adimab, LLCInventor: Laura M. Walker