Abstract: A process for preparing cimetidine by sulfur extrusion from N-cyano-N'-methyl-N"-[2-(5-methyl-4-imidazolylmethyldithio)ethyl]guanidine .

Abstract: Two compounds represented by the formula ##STR1## wherein R is hydrogen or a 2-hydroxyethyl radical are reported to have minimum penetration into the brain and nerve tissues combined with maximum penetration into hypoxic tumor cells. This combination of properties makes these compounds the optimal radiosensitizers among electron-affinic 1-substituted 2-nitroinidazoles.

Abstract: The invention concerns novel 2-aryl-1,2-benzisothiazolinone-1,1-dioxide compounds; methods for their preparation; pharmaceutical compositions containing them as an active ingredient; and methods of selectively inhibiting proteases, especially elastase, and of treating emphysema, rheumatoid arthritis, and various inflammatory diseases, for example, bronchial inflammation.

Abstract: 2-benzimidazolinone compounds of the formula ##STR1## wherein R is lower alkyl,R.sub.1 and R.sub.2, which can be the same or different, are lower straight-chained or branched alkyl and one of R.sub.1 and R.sub.2 can also be hydrogen orR.sub.1 and R.sub.2 together represent an alkylene radical and R.sub.3 is hydrogen or acyl, i.e., alkanoyl or aromatic carboxylic acid moieties;and the pharmacologically acceptable salts thereof; have marked .beta.-receptor blocking action and are outstandingly useful in the treatment or prophylaxis of cardiac and circulatory diseases.

Abstract: Novel benzofuranyl benzimidazoles of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkenyloxy or cycloalkyloxy radical, an unsubstituted or substituted alkoxy, phenylalkoxy or phenoxy radical,each ofR.sub.2 and R.sub.3 independently represents a hydrogen atom, an alkyl or alkoxy radical, a halogen atom, or, if R.sub.1 represents hydrogen, together in the ortho-position to each other they represent a radical of the formula --CH.dbd.CH--CH.dbd.CH--, --O--CH.sub.2 --O-- or --O--CH.sub.2 --CH.sub.2 --O--,R.sub.4 represents a hydrogen atom, an alkyl, alkoxy or phenyl radical,R.sub.5 represents a sulpho or carboxyl group or the functional derivatives thereof including the cyano group or the trifluoromethyl group,R.sub.6 represents a hydrogen or halogen atom, an alkyl or alkoxy radical,R.sub.7 represents a cycloalkyl, alkenyl, or unsubstituted or substituted alkyl, phenyl or phenylalkyl radical, or, if n is 0, also represents a hydrogen atom,R.sub.

Abstract: A method of treating pain, meliorating inflammation in warm-blooded animals as well as a method for treating fungal and bacterial infections in such animals using certain 3-amino-1-phenyl-2-pyrazolines and 3-amino-1-substituted phenyl-2-pyrazolines and their C4 and C5 analogs, as well as compounds used in the above are disclosed.

Abstract: 4-Nitro-1,2-hydrocarbyl pyrazolidines are prepared by a novel route from 1,2-disubstituted hydrazines and 1,3-di-(secondary amino)-2-nitropropanes and reduced to the corresponding 4-amino-1,2-hydrocarbyl pyrazolidines, which latter compounds are intermediates in the preparation of certain pharmaceutical benzamides.The novel 4-nitro-1,2-hydrocarbyl pyrazolidines have the formula: ##STR1## wherein R.sup.1 and R.sup.2 are selected from loweralkyl, lowercycloalkyl or phenyl-loweralkyl and may be the same or different.

Abstract: 1,5-Dimethyl-6,7-dioxabicyclo[3.2.1]-octane and 1,5-dimethyl-6,7-diazabicyclo[3.2.1]-oct-6-ene are synthesized. They are analogs of the western and southern pine beetle natural-pheromone, frontalin. They are useful for controlling the multiplication of these harmful insects and for limiting infestation of wooded areas by them.

Abstract: Derivatives of certain pyridyliminomethylbenzenes, useful as fungicides.

Abstract: New and valuable pyrazole derivatives having a good herbicidal action, herbicides containing these compounds as active ingredients, and processes for controlling the growth of unwanted plants with these compounds.

Abstract: Novel 1,2-disubstituted imidazol(in)es are described herein. The compounds are generally produced by reacting a haloacylanilide with an excess of 2-substituted-imidazol(in)e. The compounds are antiarrhythmic agents.

Abstract: A new salt of [(1-benzyl-1H-indazol-3-yl)oxy] acetic acid (or bendazac) with L. lysine.Following oral administrations of this compound in man, the concentrations of bendazac found in the blood are higher than those obtained after administration of bendazac as such.This discovery extends the therapeutic use of bendazac. In fact, whereas up to now bendazac could only be used topically, the L. lysine salt of bendazac makes it possible to perform therapeutic treatments with the oral route of administration as an agent with a normalizing effect on blood lipids.

Abstract: 1-Hydroxypyrazole and a process for its preparation by conversion of isoxazolineazoxy compounds at 140.degree.-600.degree. C.The end products obtainable by the process of the invention are valuable starting materials for the preparation of dyes, crop protection agents and drugs.

Abstract: The invention relates to imidazolyl-indenothiophene compounds of Formula (I) and a process for their production. Also included in the invention are antimycotic compositions containing said imidazolyl-indenothiophene compounds and methods for the use of said compounds and compositions.

Abstract: This disclosure describes novel 3-substituted amino-1-phenyl-2-pyrazolines and 3-substituted amino-1-mono and disubstituted phenyl-2-pyrazolines and their C.sub.4 and C.sub.5 analogs, effective as anti-inflammatory and analgesic agents, and as antibacterial agents and/or antifungal agents.

Abstract: The invention relates to the preparation of 1-phenyl-3-carbamoyl-5-pyrazolones of the formula: ##STR1## in which the two symbols R and R' may be the same or different and each represents a hydrogen atom, an alkyl radical or a substituted alkyl radical containing 1 to 4 carbon atoms.An aqueous paste of diethyl oxalacetate phenylhydrazone is heated at a temperature not greater than 85.degree. C. until the hydrazone is completely melted, and the aqueous phase is then removed and the remaining hydrazone is treated with 2 to 12 molar equivalents of a compound of the formula HNRR' at a temperature between 20.degree. and 100.degree. C. The formation of 1-phenyl-3-carboxy-5-pyrazolone is thus avoided.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen; alkyl of 1 to 5 carbon atoms; or optionally substituted aralkyl of 7 to 14 carbon atoms;R.sub.5 is heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.

Abstract: A derivative of benzimidazole of the general formula I: ##STR1## wherein: R.sub.1 represents a linear or ramified alkyl radical C.sub.1,C.sub.2,C.sub.3,C.sub.4,C.sub.5,C.sub.6,C.sub.7,C.sub.8,C.sub.9,C. sub.10,C.sub.11,C.sub.12,C.sub.13,C.sub.14,C.sub.15, C.sub.16,C.sub.17 or C.sub.18, a cycloalkyl radical C.sub.3,C.sub.4,C.sub.5,C.sub.6,C.sub.7 or C.sub.8, a linear or ramified alkyl radical C.sub.1,C.sub.2,C.sub.3,C.sub.4 or C.sub.5 substituted by one or more radicals selected from the group comprising:phenyl, phenoxy, phenylthio, phenylsufinyl radicals;phenyl, phenoxy, phenylthio, phenylsulfinyl radicals substituted by one or more linear or ramified alkyl radicals C.sub.1,C.sub.2, C.sub.3 or C.sub.4, by one or more linear or ramified alkoxy radicals C.sub.1,C.sub.2, C.sub.3 or C.sub.4, by a methylenedioxy radical, for one or more halogen atoms, such as fluorine, chlorine or bromine;linear or ramified alkylcarboxamido groups C.sub.1,C.sub.2,C.sub.3,C.sub.4,C.sub.5 or C.sub.

Abstract: 1-Aryl-4-.gamma.-arylsulphonyl-3-aminopropoxy-1H-pyrazoles of the formula: ##STR1## and their acid addition salts. Application of these compounds as medicaments useful in particular as hypolipemiant or hypocholesterolemiant agents.

Abstract: Novel phosphate quaternary compound of the formula ##STR1## wherein R is a tertiary amine radical of from 6 to 40 carbon atoms; andX is an anion.