Abstract: A resealable assembly for a container such as a bottle or vial featuring a membrane for selectively opening or sealing a fluid path between the bottle and a medical delivery device introduced into the assembly. The assembly includes a body disposed on said bottle, and a luer connector hub which may be separately provided with the body or formed integrally therewith. The luer connector hub features a connector end open for access by the medical delivery device, and an opposed end which is disposed for fluid communication with the open top of the bottle. A membrane, preferably formed from an elastomeric material, is secured across both the opposed end of the luer connector hub and the open top of the bottle, and may be retained between the top surface of the bottle and the body. The membrane preferably includes a central area sealing the opposed end of the luer connector hub from the open top of the bottle, with one or more fluid openings defined on a portion of the membrane outside of the central area.