Abstract: The present disclosures are directed to personal care compositions comprising crosslinked silicone elastomer; personal care compositions comprising a crosslinked silicone elastomer powder that is free of surfactant; and personal care compositions that are free of a polyether compound. The present disclosures are further directed to personal care compositions comprising one or more of oils, an aqueous phase, sunscreens, film formers, waxes, emulsifiers, particulates, pigments, dyes, and preservatives.

Abstract: The compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl)octadecanamide is a useful drug compound for enhancing immune response and can be used, for example, as a retrovirus vaccine adjuvant.

Abstract: According to the present invention, provided is a carbonate- and magnesium-substituted hydroxyapatite having a particle size of 5 nm or more and 60 nm or less, wherein a portion of the calcium atoms in the hydroxyapatite are substituted with magnesium atoms and a portion of phosphate groups are substituted with carbonate groups.

Abstract: The present invention relates to an extrudable photocrosslinkable hydrogel comprising a biochemically modified extracellular matrix (ECM) with an electroconductive nanomaterial embedded; a photoinitiator and a solvent, the method for its preparation starting from decellularized extracellular matrices (dECMs) and its applications for preparing electroconductive scaffolds, electroconductive extrudable hydrogels for in situ defect-filling, conductive grafts, in situ or in vitro printed tissues or organs, adhesives for different tissues, or bone adhesives.

Abstract: A method and composition for promoting hair growth comprises an oil solution created with predetermined quantities of certain oils such as sesame oil, avocado oil, sweet almond oil, coconut oil, and ricinus oil. A blended final product is created by adding predetermined quantities of certain plants to the oil solution, such as parsley and aloe vera. The final product is heated and applied to a surface for hair growth. After a certain amount of time it is washed off the surface for hair growth. These steps are repeated daily for a full course of treatment, which comprises a few weeks. The course may be repeated about every other month.

Abstract: Zinc di-(dibutyryl lysinate) s, topical compositions comprising the same, and their use in skin lightening/brightening/even toning applications.

Abstract: Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and/or NTM culture conversion to negative during or after the administration period.

Abstract: Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and/or NTM culture conversion to negative during or after the administration period.

Abstract: A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

Abstract: The present invention relates to a topical pharmaceutical composition comprising pregabalin and a reduced micellar phospholipid as an active ingredient, which results in a prolonged analgesic effect of pregabalin. The product can reduce neuropathic pain by at least 5 hours.

Abstract: A composition comprising a liposome comprising a first phospholipid comprising a C14-C19:0 fatty acid and a C3-C15:0 fatty acid with a c-terminal carboxyl or a carboxaldehyde group; a second phospholipid comprising a C14-C19:0 fatty acid and a C14-C19:0 fatty acid and a sterol. The first phospholipid is preferably a phosphatidylcholine. The second phospholipid is preferably HSPC and the sterol is preferably cholesterol. In some embodiments, the molar ratio of the respective ingredients is 2-3:5-6:2-3; preferably 2:6:2; or 3:5:2, respectively. The invention also relates to the use of this composition in the targeting of M2 macrophages.

Abstract: A polyethylene glycol-functionalized triglyceride polyol polymer comprising a glycerol component and three fatty acid components bonded to the glycerol component, wherein at least one of the fatty acid components comprises: a fatty acid chain; a hydroxyl functional group bound to a carbon atom of the fatty acid chain; and a polyethylene glycol-based functional group bound to an adjacent carbon atom of the fatty acid chain; according to Structure I wherein: n is from 10 to 40; and R is selected from the group consisting of H, alkyl, and silyl.

Abstract: Resorbable implants, coverings and receptacles comprising poly(butylene succinate) and copolymers thereof have been developed. The implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing molding, pultrusion or other melt or solvent processing method. The implants, or the fibers preset therein, may be oriented. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings, receptacles and implants described herein, may be made from meshes, webs, lattices, non-wovens, films, fibers, foams, molded, pultruded, machined and 3D printed forms.

Abstract: A new superfine powder of selenium disulfide with a particle size in the range of 1-50 ?m and the particle size distribution with D90 of (1.0˜15.0) ?m, and its application in lotion products, are provided in the present invention. Compared with the prior art, the superfine powder of selenium disulfide in the present invention is beneficial to the preparation of the selenium disulfide lotion product and the improvement of the quality of the selenium disulfide lotion product.

Abstract: A broad spectrum sun protection transfer device includes a backing paper; a release coating affixed to the backing paper; and a sun protection transfer film deposited on the release coating. The transfer film is adhesive to skin and opaque to ultraviolet radiation. The transfer film significantly reduces UV radiation penetrating high risk areas of the skin for a long duration of protection.

Abstract: Cleansing compositions are provided. The mask cleansing composition includes a) A polyvinyl alcohol; b) At least one sugar alcohol; c) At least one surfactant; d) At least one or more hydrophobically-modified polymers; e) At least one silicone oil; and wherein the composition provides the self-bubbling action. The cleansing composition is free of perfluoro compound.

Abstract: Provided herein is a method of reducing or preventing sunburn caused from visible and ultraviolet radiation in a subject, the method comprising topically applying to the subject a sunscreen composition comprising inorganic UV filtering agents, antioxidants, and at least one inorganic pigment, wherein the at least one inorganic pigments and antioxidants are present in an amount effective to reduce or prevent sunburn caused from visible light. Also provided herein are sunscreen compositions and methods of increasing the SPF of a sunscreen composition that comprises at least one inorganic UV filtering agent.

Abstract: The present invention relates to avobenzone-dendrimer conjugates comprising: a polyamide dendrimer conjugated with 1 to 18 units of avobenzone. Also disclosed are sunscreen formulations comprising an avobenzone-dendrimer conjugate and a dermatologically acceptable vehicle.

Abstract: Matrix compositions comprising structurally diverse matrix particles (1) formed from at least five different types of primary particles distinguishable from one another due to different characteristics, shape characteristics, or both, (2) that constitute 15-50% of the matrix composition by weight, (3) that comprise or more types of particle agglomerates, (4) where at least 33% of the weight concentration of the matrix particle mixture being composed of UV-protectant metal oxide particles having a minimum particle size of over 100 nm, (5) where scanning electron microscope analysis of the composition fails to identify any significant number of discrete matrix particles of having a size of 100 nm or less, and (6) the composition exhibits one or more of sun protection factor (SPF) of at least 30, a critical wavelength of at least 370 nm, UVA/UVB ratio of at least 0.333, and a UVA1 to UV ratio of at least 0.7.

Abstract: Described herein are transdermal solvent systems comprising at least one active agent in solution in a base solution, the base solution comprising at least one fatty acid ester compound, at least one monoterpene compound and a co-solvent in the form of DMSO or DMI and at least one plant oil. The base solution was found to be highly versatile and provide superior or at least comparable skin penetration efficacy and active agent compatibility. Methods of treatment, uses of the solvent system and methods of manufacture are also described.