Abstract: A system and method for fluorescence imaging of tissue in vivo and in situ, e.g., for minimally invasive diagnosis of patients. A fluorescent imaging system is provided that has a dye carrier coupled to the distal end of a probe containing a fiber optics bundle, which allows for the introduction of at least one fluorescent dye therein the dye carrier into a portion of the tissue of interest of a subject or patient when the dye carrier is selectively brought into contact with the portion of the tissue of interest. The resulting fluorescence images permit the acquisition of diagnostic information on the progression of diseases at cellular/tissue level in patients.

Abstract: A method and medical system for estimating the deformation of an anatomic structure that comprises generating a first model of at least one anatomical passageway from anatomical data describing a patient anatomy and determining a shape of a device positioned within the branched anatomical passageways. The method and medical system also comprise generating a second model of the plurality of branched anatomical passageways by adjusting the first model relative to the determined shape of the device.

Abstract: An ultrasonic diagnostic apparatus according to an embodiment include a transmitter/receiver, a signal processor, and an image generator. The transmitter/receiver causes an ultrasonic probe to transmit on each scanning line at least three ultrasonic pulses, the three ultrasonic pulses being: a first ultrasonic pulse including at least one frequency component and being transmitted with a first phase; a second ultrasonic pulse including the frequency component and being transmitted with a second phase different from the first phase by 180 degrees; and a third ultrasonic pulse including the frequency component and being transmitted with a third phase different from the first phase and the second phase by 90 degrees and generates a plurality of reception signals corresponding to the respective ultrasonic pulses. The signal processor combines the plurality of the reception signals and generates a composite signal. The image generator generates ultrasonic image data.

Abstract: An ultrasound diagnostic apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain the position of the boundary of a region of interest that is set in first ultrasound image data of a subject. The processing circuitry is configured to generate second ultrasound image data by assigning a pixel value to each of pixels of which a change of the brightness value between before and after a contrast enhancement is equal to or larger than a threshold value with regard to pre-contrast-enhanced image data and post-contrast-enhanced image data of the subject both of which were acquired after a treatment using a puncture needle has been performed, the assigned pixel value corresponding to the distance between the pixel and the boundary of the region of interest. The processing circuitry is configured to cause a display unit to display the second ultrasound image data.

Abstract: Devices and methods for enhancing observability under ultrasound imaging of medical devices include temporal markers which are dynamic, producing a variable ultrasound image over time. Included are rotating markers which produce a Doppler shift visible through ultrasound imaging in a Doppler mode and which enhance visibility of the marker. Other devices and methods include alternating streams of fluid contrast agents and saline as well as destroying a fluid contrast agent stream with a high intensity ultrasound pulse.

Abstract: The present invention presents an applicator having a non-reusable static pointing device reversibly attachable to a face of an ultrasound transducer to attach the non-reusable static pointing device to the face of the ultrasound transducer in a consistent and accurate way. The static pointing device attached to the face of the ultrasound transducer is coupled with an ultrasound positioning apparatus and is to produce a linear shadow line in a visualized ultrasonographic field.

Abstract: In a special mode for imaging an oxygen saturation level of blood, an internal body portion is imaged under irradiation with special illumination light. A light amount evaluation section judges based on an obtained image whether or not a reflected light amount of the special illumination light is adequate for calculating the oxygen saturation level. When the reflected light amount is judged to be adequate, a normal image sensor captures an image under irradiation with the special illumination light. When the reflected light amount is judged to be low, a high-sensitivity image sensor is used. In using the high-sensitivity image sensor, a binning process is applied to an image signal in accordance with the reflected light amount of the special illumination light, in order to further sensitize the image signal.

Abstract: A method for high spatial and temporal resolution dynamic contrast enhanced magnetic resonance imaging using a random subsampled Cartesian k-space using a Poisson-disk random pattern acquisition strategy and a compressed sensing reconstruction algorithm incorporating magnitude image subtraction is presented. One reconstruction uses a split-Bregman minimization of the sum of the L1 norm of the pixel-wise magnitude difference between two successive temporal frames, a fidelity term and a total variation (TV) sparsity term.

Abstract: A magnetic resonance imaging sequence is defined by an imaging protocol and parameter values for a set of parameters of the imaging protocol. A contrast signal score is computed for the magnetic resonance imaging sequence respective to a contrast type to be scored using a scoring equation. A contrast type is determined for the magnetic resonance imaging sequence based on the computed contrast signal score. In one approach, the computing is repeated for a plurality of different contrast types to be scored, and the determining is based on the computed contrast signal scores.

Abstract: Systems and methods for assisting the placement of a catheter within the body of a patient through the use of an ultrasound imaging system are disclosed. In particular, the systems and methods described herein enable a clinician to determine, prior to insertion of the medical device, how much of the device will be disposed within the vessel, thus enabling the clinician to choose a catheter with suitable length. In one embodiment, an ultrasound imaging system for assisting with placement of the medical device comprises a console, a probe for producing an image of a target location, and a processor. The processor provides to a user proximity information relating to the anticipated proximity of the medical device to the target location prior to insertion of the medical device. A display is included for depicting the image, target location depth, and the proximity information of the medical device to the target location.

Abstract: A backing block for an ultrasonic transducer array stack of an ultrasound probe is formed as a composite structure of graphite foam impregnated with an epoxy resin. The epoxy resin penetrates the porous foam structure at least part-way into the depth of the graphite foam block and, when cured, provides the backing block with good structural stability. The composite graphite foam backing block is bonded to the integrated circuit of a transducer to provide high thermal conductivity away from the transducer and good acoustic attenuation or scattering of rearward acoustic reverberations.

Abstract: A needle access assembly and method for obtaining percutaneous needle access with little or no fluoroscopy. The method can include selecting a target for percutaneous access, directing a laser guide at a desired needle-insertion angle and in line with the selected target, aligning the needle access assembly with the laser, and inserting the needle into the target.

Abstract: The invention comprises a virtual window system that creates a visual coherency between the image of the patient and his or her anatomy and the patient by aligning the image of the patient anatomy on the display to the patient and presenting the image to the user that feels as if the user is looking directly into the patient through the display. The invention is designed to also display medical devices, such as a minimally invasive tool. The system substantially unifies the coordinate systems of the patient, the medical device, the display, and the physician's hands. The invention creates a visual coherency between the motion of the medical device in the image and the motion of the physician's hands manipulating the device. This invention also creates a visual coherency between the motion of the image in the display and of that display.

Abstract: Described herein is an optical coherence tomograph (OCT) angiography technique based on the decorrelation of OCT signal amplitude to provide flow information. The full OCT spectrum can be split into several narrower spectral bands, resulting in the OCT resolution cell in each band being isotropic and less susceptible to axial motion nose. Inter-B-scan decorrelation can be determined using the individual spectral bands separately and then averaged. Recombining the decorrelation images from the spectral bands yields angiograms that use the full information in the entire OCT spectral range. Such images provide significant improvement of signal-to-noise ratio (SNR) for both flow detection and connectivity of microvascular networks compared to other techniques. Further, creation of isotropic resolution cells can be useful for quantifying flow having equal sensitivity to axial and transverse flow.

Abstract: An imaging capsule with a fail-safe radiation mechanism includes a first rotatable disk with a radiation source mounted thereon and having a collimator structure allowing emission of radiation from radiation source from a few locations on the first disk. A second rotatable disk surrounds the first disk, is rotatable relative to first disk, and includes areas that block radiation and areas that are transparent to emission of radiation. In a rest position, second disk is situated relative to first disk such that areas that block radiation are blocking the emission of radiation from the locations on the circumference of the disk that allow the emission of radiation. A motor is activated to rotate one of the disks and allow emission of radiation. A connector is configured to automatically return first disk and second disk to the rest position when the motor is deactivated.

Abstract: Cross-calibration is provided for functional imaging. In PET or SPECT, the inaccuracies from the dose and detector sensitivity may be reduced or removed in both activity concentration and uptake. By using measures from both the radiotracer for the patient and factory calibrated sources, the variability due to dose may be removed. In SPECT, a measurement of system specific sensitivity to a factory calibrated point source is used to improve the accuracy of uptake values, not just activity concentration.

Abstract: An aspect of an embodiment of the invention, relates to an imaging capsule for scanning inside a living body with a fail-safe radiation mechanism that prevents the emission of radiation from the imaging capsule until the imaging capsule is instructed to emit radiation and power is available to activate a motor to unblock the emission of radiation. Optionally, when power is not available the imaging capsule automatically, blocks the emission of radiation.

Abstract: A method is disclosed for generating at least one x-ray image of a patient having incorporated contrast medium, using x-rays having an energy spectrum and an x-ray detector. The energy spectrum is modified by at least one first filter arranged in the beam path in front of the patient, the patient absorbing a dose in order to generate detector data for the x-ray image and the x-ray image having a CNR value which represents the ratio of the maximum contrast in the image to the noise. The energy spectrum and contrast medium are matched to each other, taking into account the thickness of the patient to be x-rayed, in such a way that an optimization criterion which is taken from an x-ray image that is generated or simulated by way of trials is maximized. Furthermore, an x-ray system is also disclosed.

Abstract: The present invention provides a radiotherapy system that can monitor a target location in real time. The radiotherapy system includes a remote control system operable to actuate a real-time image capturing device to acquire images in real time for monitoring the target location. The system also includes an image registration system that can register the acquired image with an image previously captured for the treatment plan, whereby it can be determined whether the patient's tumor is in the beam's eye view of the treatment plan. By confirming that the tumor is in the range of the beam's eye view, the accuracy of the treatment can be improved, and the irradiated area can be reduced, which makes the radiation treatment safer.

Abstract: An apparatus and a method are disclosed for obtaining ultrasound images of a patient's breast that is chestwardly compressed with a template that is essentially planar and rotates relative to the breast while one or more ultrasound transducers moving with the template take 2D images of the breast through one or more respective radially oriented slots in the template, preferably through a membrane that is porous to a gel. The 2D images are processed into slice images representing breast slices of desired thicknesses and orientation that are displayed alone or with some of the 2D images, preferably pairs of orthogonally disposed 2D images.