Patents Examined by Nathan Bowers
  • Patent number: 9862918
    Abstract: A well plate is formed with a well for holding a subject to be sucked by a suction nozzle on an inner bottom part and storing liquid and, a clearance forming member for forming a clearance to allow the liquid to flow in a state where a tip part of the suction nozzle is inserted into and held in contact with the well is provided in the well. According to the present invention, the clearance enabling the liquid to flow is formed even in the state where the tip part of the suction nozzle is inserted into and held in contact with the well in sucking the subject held in the well by the suction nozzle. The suction nozzle can suck the liquid around through the clearance and the subject held in the well is efficiently sucked through the suction port along the flow of the sucked liquid.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: January 9, 2018
    Inventor: Saburo Ito
  • Patent number: 9855558
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: January 2, 2018
    Inventors: Hon Siu Shin, Hock Lai Khoo
  • Patent number: 9856503
    Abstract: A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: January 2, 2018
    Assignee: bioMerieux, Inc.
    Inventors: Ronnie J. Robinson, Mark S. Wilson, Christopher S. Ronsick, John D. Walsh, Jones M. Hyman, Thurman C. Thorpe, Bradford G. Clay
  • Patent number: 9845453
    Abstract: A cell culture apparatus is provided which can continuously and accurately measure turbidity of a cell culture solution and culture a cell, without inserting a turbidity sensor from outside into a sterile bag. The cell culture apparatus includes: a flexible and transparent sterile bag that is installed at a prescribed position in the cell culture apparatus and in which a cell contained in a cell culture solution is cultured; and a turbidity sensor that includes a light emitter which emits light to the cell culture solution in the sterile bag via a portion of the sterile bag, a light receiver which receives the light transmitted through the cell culture solution via another portion of the sterile bag, and that is configured to place the light emitter, the portion of the sterile bag, another portion of the sterile bag, and the light receiver, optically on a same straight line.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: December 19, 2017
    Assignee: HITACHI, LTD.
    Inventors: Masaru Nanba, Ryouichi Haga, Sei Murakami, Haruo Suzuki
  • Patent number: 9840688
    Abstract: A bioreactor system includes a sample chamber capable of receiving a specimen and a cover which can be placed on the chamber to enclose the specimen within the chamber. A first member is movable between (i) a closed position in which the member restricts the cover from being moved away from the chamber in a first direction, and (ii) an open position in which the member does not restrict the cover from being moved away from the chamber. When the first member is in the closed position there is a substantially liquid proof seal between the cover and the chamber.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: December 12, 2017
    Inventors: Aaron M. Owens, Stefanie Vawn Biechler, David Louis Dingmann, Charles W. Groepper, Tomas M. Hays, Chrysanthi Williams
  • Patent number: 9828579
    Abstract: A cell culture apparatus comprises at least one storage space, at least one barrier, a working space, a sterilization space, and a control space. The at least one storage space comprises a container shelf, an upright track, a rotatable holder, and a light tube. The working space comprises a filling station and an inspecting station. The filling station comprises a first delivering device, an open-close device, and a filling mechanism. The inspecting station comprises a first inspecting mechanism and a second delivering device. Also provided is a method of using the cell culture apparatus including steps of filling, inspecting, or collecting cell cultures, therefore, the cell culture apparatus performs multiple cell culture processes automatically.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: November 28, 2017
    Assignee: DrSignal BioTechnology co., Ltd
    Inventors: Hsin-Wu Mi, Ming-Cheng Lee
  • Patent number: 9822337
    Abstract: A device for performing micro-operations on a vesicular target, comprising an injection pipette (27); a barrel assembly (9); and an outer assembly (1). The injection pipette, barrel assembly, and outer assembly being designed and situated in relation to each other such that an axial vacuum passage is created between the injection pipette and the barrel assembly, and a radial vacuum passage is created between the barrel assembly and outer assembly, and such vacuum passages are isolated from each other and from atmospheric pressure (FIG. 8). The device also comprises a means of advancing and withdrawing the distal end of the barrel assembly in relation to the distal end of the outer assembly so as to create a holding well (31) and a means of advancing the pipette into, and withdrawing the pipette from, a vesicular object.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: November 21, 2017
    Inventor: Paul J. Taylor
  • Patent number: 9823195
    Abstract: An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: November 21, 2017
    Inventors: Mark F. Oldham, Eugene F. Young
  • Patent number: 9815038
    Abstract: A clotting serum production device including a main chamber, an inlet housing, and an outlet port. The main chamber is defined by a first end wall, a second end wall opposite to the first end wall, and a side wall extending between the first end wall and the second end wall. The inlet housing extends from the first end wall. The inlet housing includes a first inlet port, a second inlet port, and a first conduit extending between the first inlet port and a second conduit. The second conduit extends between the second inlet port and the main chamber. The inlet housing is configured to provide one-way fluid flow from the first inlet port to the second inlet port and to provide one-way fluid flow from the second inlet port to the main chamber. An outlet port is in fluid communication with the main chamber and provides fluid communication with an exterior of the clotting serum production device.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: November 14, 2017
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Jennifer E. Woodell-May, Hillary Overholser, Joel C. Higgins, Jason Chavarria, Ned M. Hamman
  • Patent number: 9816131
    Abstract: Methods and apparatus for use in connection with the performance of the polymerase chain reaction are provided. An exemplary sample processing module is described that includes a sample assembly and a PCR assembly, the sample processing module being configured to hold the sample therein at a pressure higher than ambient pressure. A sample is added to the sample assembly at the time of use, which is then connected to the PCR assembly. Embodiments of the cartridge include a flow restriction device that enables or aids in creating a higher pressure within the reaction vial. The sample is introduced into a PCR reaction vial, which contains all of the constituents of a PCR reaction mixture that are necessary to process the sample and provide amplified DNA of interest, if that DNA was present in the sample.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: November 14, 2017
    Assignee: DXNA LLC
    Inventors: Brent L. Weight, William D. Bickmore, Darryl K. Zitting
  • Patent number: 9802199
    Abstract: The present technology provides for a fluorescent detector that is configured to detect light emitted for a probe characteristic of a polynucleotide. The polynucleotide is undergoing amplification in a microfluidic channel with which the detector is in optical communication. The detector is configured to detect minute quantities of polynucleotide, such as would be contained in a microfluidic volume. The detector can also be multiplexed to permit multiple concurrent measurements on multiple polynucleotides concurrently.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: October 31, 2017
    Assignee: HandyLab, Inc.
    Inventors: Kalyan Handique, Sundaresh N. Brahmasandra
  • Patent number: 9803168
    Abstract: An incubator 1 includes a cultivating chamber 4 for cultivating culture in a plurality of containers 3 and a supply device 5 provided outside the cultivating chamber 4 and supplying steam into the cultivating chamber 4 for humidification. The supply device 5 includes a supply chamber 5A in which a tray 42 for reserving water is accommodated and an ultrasonic atomizing device 43 for atomizing water. The water in the tray 42 is easily made into steam by the ultrasonic atomizing device 43, passes through an HEPA filter 45 provided in an opening portion 5B and is supplied into the circulation passage 37 of the cultivating chamber 4.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: October 31, 2017
    Inventors: Tetsuya Nishimura, Masaomi Shioya, Katsuki Hashimoto
  • Patent number: 9795968
    Abstract: A nucleic acid amplification and detection device includes an amplification cartridge with a plurality of reaction chambers for containing an amplification reagent and a visual detection reagent, and a plurality of optically transparent view ports for viewing inside the reaction chambers. The cartridge also includes a sample receiving port which is adapted to receive a fluid sample and fluidically connected to distribute the fluid sample to the reaction chamber, and in one embodiment, a plunger is carried by the cartridge for occluding fluidic communication to the reaction chambers. The device also includes a heating apparatus having a heating element which is activated by controller to generate heat when a trigger event is detected. The heating apparatus includes a cartridge-mounting section which positioned a cartridge in thermal communication with the heating element so that visual changes to the contents of the reaction chambers are viewable through the view ports.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: October 24, 2017
    Assignee: Lawrence Livermore National Security, LLCq
    Inventor: Lawrence Dugan
  • Patent number: 9791433
    Abstract: The present invention is directed to a multi-organ-chip device comprising a base layer; an organ layer arranged on the base layer; an antra layer arranged on the organ layer; and an actuator layer; wherein the base layer is configured to provide a solid support for the further layers; the organ layer is configured to comprise a multiplicity of individual organ equivalents, each organ equivalent comprising one or more organ growth sections, each of the organ growth sections being configured to comprise an organoid cavity for housing at least one organoid of an organ and to comprise a micro-inlet and a micro-outlet for fluid communication between the organoid cavity of the organ growth section and a self-contained circulation system, wherein the organ layer comprises at least one organ equivalent configured to represent the organs lung, small intestine, spleen, pancreas, liver, kidney and bone marrow, respectively, and a self-contained circulation system configured to be in direct fluid communication with the o
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: October 17, 2017
    Assignee: TISSUSE GMBH
    Inventor: Uwe Marx
  • Patent number: 9789459
    Abstract: A nucleic acid amplification reaction vessel includes a first inner wall, and a second inner wall that is arranged opposite to the first inner wall, in which a distance between the first inner wall and the second inner wall is a length in which a nucleic acid amplification reaction solution comes into contact with both the first inner wall and the second inner wall when the nucleic acid amplification reaction solution is poured.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: October 17, 2017
    Assignee: Seiko Epson Corporation
    Inventor: Toshiro Murayama
  • Patent number: 9784653
    Abstract: A first apparatus for processing a liquid sample is disclosed. The apparatus includes a sample-receiving, a filtrate-receiving component, and an analyte-capture element. The apparatus forms a liquid flow path through which the sample passes, thereby causing the analyte-capture element to capture an analyte, if present. A method is disclosed whereby a liquid sample is passed through the first apparatus and the analyte-capture element is easily separated from the apparatus for further processing and detection of the analyte. A structurally-related second apparatus for processing a plurality of liquid samples, and a corresponding method of use, also is disclosed.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: October 10, 2017
    Inventors: Wensheng Xia, Jon A. Kirschhoffer, Andrew W. Rabins
  • Patent number: 9783773
    Abstract: A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of the sterile space and an outside of the sterile space communicate with each other, the delivery flow path configured to limit a flow in the delivery flow path to a direction that is directed from the inside of the sterile space toward the outside of the sterile space; and a culture solution delivering section configured to deliver the sampled culture solution to the outside of the sterile space via the delivery flow path.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: October 10, 2017
    Inventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda
  • Patent number: 9783768
    Abstract: The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: October 10, 2017
    Assignee: Octane Biotech, Inc.
    Inventors: Yves Larcher, Rupert Hagg
  • Patent number: 9778255
    Abstract: An assembly for selectively performing a clinical chemical test or an ELISA assay including a reagent cartridge with a housing 11 having at least one cavity 12, 13, 14 that contains a reaction or diluting component and having a recess 15 in which a solid phase 20 to which an antigen or antibody can be coupled is inserted into the recess 15 of the housing 11. The assembly also includes at least one measuring cell, wherein a measuring cell is assigned to each reagent cartridge and wherein the reagent cartridge and the measuring cell assigned to it are in a linear assembly in an analytical device.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: October 3, 2017
    Assignee: DRG Instruments GMBH
    Inventors: Alfred Janetzko, Wilhelm Sänger, Cyril E. Geacintov
  • Patent number: 9776771
    Abstract: A screw cap lidded container for laboratory use includes a container body defining a chamber, a tubular section of the container body that is connected at the rear to the chamber and has a container opening in the front and an external thread on the outer periphery of the tubular section. There is a circumferential first sealing surface on the tubular section and at least one first projection, which projects from the container body at a peripheral position of the tubular section, and a screw cap having an internal thread on the inner periphery that can be screwed onto the external thread with thread play, a second sealing surface on the screw cap can be brought into sealing contact with the first sealing surface, and at least one second projection, which projects at a peripheral position of the screw cap.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: October 3, 2017
    Assignee: Eppendorf AG
    Inventor: Martin Seippel