Patents Examined by Nathan Bowers
  • Patent number: 10155699
    Abstract: An apparatus for treating organic mass. The apparatus comprises a treatment chamber and agitation means provided in the chamber to agitate the organic mass. The agitation means comprises a rotatable shaft extending through the chamber, a plurality of agitator arms extending from the shaft, and a paddle connected to each agitator arm. The paddle is arranged to make a first angle with respect to the longitudinal axis of the agitator arm and a second angle with respect to the longitudinal axis of the shaft. There is also provided a system for recycling ammonia generated from the treated organic mass by the apparatus.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: December 18, 2018
    Assignee: Biomax Holdings Pte Ltd
    Inventors: Eng Tong Sim, Siok Lui Chua, Chum Mok Puah
  • Patent number: 10155924
    Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom, a top, a tubular neck, and, one or more shelves. The first shelf adjoins the top with the first shelf being located intermediate the bottom and the top. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: December 18, 2018
    Assignee: Corning Incorporated
    Inventors: Amy W Cai, William J Lacey, Michael S Shanler
  • Patent number: 10144910
    Abstract: A multilayered cell culture apparatus for the co-culturing of at least two cell types is disclosed. The cell co-culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between some cell culture chambers and the external environment. In addition, some cell culture chambers may have limited access to air creating relatively lower oxygen content cell culture chambers. The size of the apparatus, and location of an optional neck section, allows for its manipulation by standard automated assay equipment, further making the apparatus amenable to high throughput applications.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: December 4, 2018
    Assignee: Corning Incorporated
    Inventors: Allison Jean Tanner, Gregory Roger Martin
  • Patent number: 10138450
    Abstract: An automatic culture device which employs closed-system culture vessels and in which, when a passage part (2) and a rotational valve mechanism (3) are configured, the multiple culture vessels in a culture vessel part (1) can be rendered equal in liquid-feeding conditions by, for example, regulating the length of each passage. As a result, the evenness in quality of cells incubated in the multiple culture vessels is rendered possible. Furthermore, by providing a mechanism which enables a user to normally set passages in the device, the evenness in quality of the cells is rendered possible likewise.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 27, 2018
    Assignee: Hitachi, Ltd.
    Inventors: Takayuki Nozaki, Guangbin Zhou, Masaharu Kiyama, Ryota Nakajima, Shizu Matsuoka, Taku Nakamura, Masakazu Sugaya, Koichi Terada
  • Patent number: 10138456
    Abstract: A device which automatically performs a step in which expanded and cultured cells are diluted to a desired cell concentration and re-inoculated using a cell-concentration adjustment device having an inlet for taking in a cell suspension; an outlet for discharging a diluted cell suspension; and a flow path which is provided between the inlet and the outlet and is capable of holding a cell suspension, the flow path being provided with: a liquid delivery pump for causing a cell suspension inside to flow; a cell-concentration measurement instrument for collecting data related to a cell concentration per unit amount of the cell suspension; and a dilution-liquid container for holding a dilution liquid which is supplied to the flow path to dilute the cell suspension.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: November 27, 2018
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Akihiro Shimase, Kazumichi Imai, Sadamitsu Aso, Eiichiro Takada, Masako Kawarai, Toshinari Sakurai
  • Patent number: 10138451
    Abstract: The present invention relates to a novel culturing apparatus (assembly) which can be termed a cell culture dish. More particularly, the present invention is a “combined cell culture dish” or “dish-in-dish” apparatus comprising at least one smaller cell culture dish fixedly positioned within a larger cell culture dish, and the number of such fixated cell culture dishes can include a multiple number of fixated cell culture dishes within one another, either concentric or eccentric, in any number of geometric shapes, and without limitation to the number of petri dishes included. An alternate embodiment of this invention can include a plurality of cell culture dishes juxtaposed side-by-side having common interior well walls, and the well walls may or may not be different in height depending on the application.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: November 27, 2018
    Inventors: Christopher B. Reid, Keith Norris, Taehoon Cho, Victor Chaban
  • Patent number: 10130922
    Abstract: A receptacle has a wall defining a receptacle interior and a shaft housing for guiding a shaft through the wall into the receptacle interior. The shaft housing defines an annular cap with spaced apart inner and outer walls connected by an inner end face facing the receptacle interior. A shaft guide part has an end facing the receptacle interior and an outer surface that defines a gap relative to the inner wall of the shaft housing. The shaft guide part has an annular wall spaced apart from and parallel to its outer surface. The annular wall extends over the free end of the inner wall of the shaft housing and is sealed to the inner and outer walls of the shaft housing by at least one seal each. The shaft guide part is mounted in the shaft housing by a radial ball bearing and by an axial ball bearing.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: November 20, 2018
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Reiner Seitz, Rainer Salzmann, Thomas Regen, Matthias Hielscher, Bernward Husemann, Stefan Zeuch, Ute Husemann, Gerhard Greller
  • Patent number: 10119970
    Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: November 6, 2018
    Assignee: MILTENYI BIOTEC GMBH
    Inventors: Stefan Miltenyi, Winfried Schimmelpfennig, Holger Lantow, Niklas Elmar Neuschaefer, Martin Biehl, Eiad Kabaha, Juergen Schulz
  • Patent number: 10101274
    Abstract: An interrogation device for detecting luminescent light produced by analytes in a sample excited by multiple excitation light beams each having individual spectral contents, comprising a plurality of light sources each generating an excitation light beam; at least one detector for detecting the luminescent light produced by the sample; and an optical assembly defining distinct and fixed excitation light paths for each of the excitation light beams from the light sources to a common excitation site on the sample and defining a shared luminescence light path for the luminescent light from the excitation site on sample to the at least one detector, the excitation light paths and the luminescence light path being on a same side of the sample, the optical assembly including sample-side optics projecting the excitation light towards the sample and collecting luminescent light from the sample.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: October 16, 2018
    Assignees: GenePOC INC., Universite Laval
    Inventors: Hugo Lemieux, Sébastien Chapdelaine, David Béliveau-Viel, Jean-François Gravel
  • Patent number: 10094762
    Abstract: A patterned capillary device comprising a pattern on an inner surface is described herein. More specifically, the patterned capillary device comprises a wall having an outer surface and an inner surface, the wall defining a fluidic channel. A substantially opaque film covers the inner surface of the wall, the opaque film comprising a plurality of substantially transparent segments defining a pattern. A process for fabricating a pattern formed of opaque and transparent portions on an inner surface of a capillary device is also described herein.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: October 9, 2018
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Denis Boudreau, Felix-Antoine Lavoie, Olivier Ratelle
  • Patent number: 10091986
    Abstract: An organ perfusion device includes an inlet for connection to the organ, and an outlet for connection to the organ. The device also includes a perfusion circuit including: a reservoir configured to hold a perfusion fluid; a waste receptacle, and a plurality of fluid conduits. The fluid conduits define: a delivery fluid path connecting the reservoir with the inlet; a return fluid path, independent of the delivery fluid path, connecting the reservoir with the outlet; and a waste fluid path connecting the reservoir with the waste receptacle. The device also includes a first flow control device configured to selectively prevent or allow fluid flow from the reservoir to the organ via the delivery fluid path; and a second flow control device configured to selectively prevent or allow fluid flow from the reservoir to the waste receptacle via the waste fluid path.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: October 9, 2018
    Assignee: XOR-LABS TORONTO INC.
    Inventors: Lahav Gil, Siew Hong Tan, Martin Leandro Par, Philipp Stücklin, Shafique Keshavjee, Mingyao Liu, Marcelo Cypel, David Christopher Lynch, Thomas Kenneth Waddell, Geoffrey Samuel Frost, Grzegorz Piotr Burdyszek
  • Patent number: 10094783
    Abstract: A system for use in rapid sample analysis that includes a biosensor reagent, wherein the biosensor reagent includes living biological cells; a reservoir card, wherein the reservoir card stores the biosensor reagent; and a test cartridge base, wherein the test cartridge base is configured to accept the reservoir card, and wherein the test cartridge base further includes a reaction chamber having a central axis, wherein the reaction chamber has the shape of a revolved half ellipse; and an inlet channel connected to the reaction chamber, wherein the inlet channel is positioned above the reaction chamber at an angle of 15-60 degrees above the horizontal, and wherein the inlet channel is offset from the central axis of the reaction chamber.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: October 9, 2018
    Assignee: Fundamental Solutions Corporation
    Inventors: Marvin R. Williams, Charles McBrairty, Daniel W. Pfautz, Thomas J. Zupancic, Lingchun Zeng, Andrew Weiman, Richard S. Brody, Joseph D. Kittle, Anthony Truscott, Robert Baranowski
  • Patent number: 10093963
    Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: October 9, 2018
    Assignee: NeuMoDx Molecular, Inc.
    Inventors: Michael T. Kusner, Jeffrey Williams
  • Patent number: 10087409
    Abstract: Provided is a cell culturing vessel for holding and culturing cells. It has a first vessel that stores a culture medium and cells or only a culture medium, a second vessel that is placed above the first vessel and stores a culture medium and cells or only a culture medium, a main vessel that holds the first vessel and houses the second vessel, and a lid member that engages with the main vessel. The main vessel has a pressing member that fixes and holds the first vessel in the main vessel and the second vessel is eccentrically held in the first vessel by the pressing member.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 2, 2018
    Assignee: Hitachi, Ltd.
    Inventors: Masaharu Kiyama, Guangbin Zhou, Ryota Nakajima, Takayuki Nozaki, Naoko Senda, Shizu Matsuoka
  • Patent number: 10086375
    Abstract: Disclosed is a multi-stage thermal convection apparatus such as a two-stage thermal convection apparatus and uses thereof. In one embodiment, the two-stage thermal convection apparatus includes a temperature shaping element that assists a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying nucleic acid without cumbersome and expensive hardware associated with many prior devices. In a typical embodiment, the apparatus can fit in the palm of a user's hand for use as a portable, simple to operate, and low cost PCR amplification device.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: October 2, 2018
    Assignee: Ahram Biosystems, Inc.
    Inventor: Hyun Jin Hwang
  • Patent number: 10086374
    Abstract: Disclosed is a multi-stage thermal convection apparatus and uses thereof. In one embodiment, the invention features a three-stage thermal convection apparatus that includes a temperature shaping element for assisting a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying nucleic acid without cumbersome and expensive hardware associated with many prior devices. In a typical embodiment, the apparatus can fit in the palm of a user's hand for use as a portable, simple to operate, and low cost PCR amplification device.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: October 2, 2018
    Assignee: Ahram Biosystems, Inc.
    Inventor: Hyun Jin Hwang
  • Patent number: 10081788
    Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: September 25, 2018
    Assignee: Repligen Corporation
    Inventor: Jerry Shevitz
  • Patent number: 10076112
    Abstract: The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: September 18, 2018
    Assignee: TRANSMEDIC, INC.
    Inventors: Waleed H. Hassanein, Tamer I. Khayal, Ahmed Elbetanony, Jeff Barnes, Greg Ritchie, Richard Bringham, Mark Anderson, John Sullivan
  • Patent number: 10077422
    Abstract: A harvesting device and methods of harvesting (i.e., dewatering) algae are described. The harvesting device and methods involve the use of stimuli-sensitive hydrogels.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: September 18, 2018
    Assignee: The University of Toledo
    Inventors: Agasteswar Vadlamani, Xiaofei Zhao, Sridhar Viamajala, Sasidhar Varanasi
  • Patent number: 10072240
    Abstract: Present invention relates to a modular system for fabrication of a biocolumn for generating fuel stocks. The biocolumn of independent units called modules and which function as independent units and can be assembled together to fabricate a biocolumn. These modules can be assembled together to form various zones of biocolumn. Fuel stocks can be prepared by inputting a nutrient, a renewable energy source, photon energy and a carbon source into said zones and outputting fuel stock and by products from zones. The zones are interconnected so that byproducts from each zone can be recycled as input or transformed into product.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: September 11, 2018
    Assignees: SINGAPORE TECHNOLOGIES DYNAMICS PTE LTD, GIBBS ENERGY, LLC
    Inventor: Joseph P Maceda