Patents Examined by Nathan Bowers
  • Patent number: 10101274
    Abstract: An interrogation device for detecting luminescent light produced by analytes in a sample excited by multiple excitation light beams each having individual spectral contents, comprising a plurality of light sources each generating an excitation light beam; at least one detector for detecting the luminescent light produced by the sample; and an optical assembly defining distinct and fixed excitation light paths for each of the excitation light beams from the light sources to a common excitation site on the sample and defining a shared luminescence light path for the luminescent light from the excitation site on sample to the at least one detector, the excitation light paths and the luminescence light path being on a same side of the sample, the optical assembly including sample-side optics projecting the excitation light towards the sample and collecting luminescent light from the sample.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: October 16, 2018
    Assignees: GenePOC INC., Universite Laval
    Inventors: Hugo Lemieux, Sébastien Chapdelaine, David Béliveau-Viel, Jean-François Gravel
  • Patent number: 10094762
    Abstract: A patterned capillary device comprising a pattern on an inner surface is described herein. More specifically, the patterned capillary device comprises a wall having an outer surface and an inner surface, the wall defining a fluidic channel. A substantially opaque film covers the inner surface of the wall, the opaque film comprising a plurality of substantially transparent segments defining a pattern. A process for fabricating a pattern formed of opaque and transparent portions on an inner surface of a capillary device is also described herein.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: October 9, 2018
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Denis Boudreau, Felix-Antoine Lavoie, Olivier Ratelle
  • Patent number: 10093963
    Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: October 9, 2018
    Assignee: NeuMoDx Molecular, Inc.
    Inventors: Michael T. Kusner, Jeffrey Williams
  • Patent number: 10091986
    Abstract: An organ perfusion device includes an inlet for connection to the organ, and an outlet for connection to the organ. The device also includes a perfusion circuit including: a reservoir configured to hold a perfusion fluid; a waste receptacle, and a plurality of fluid conduits. The fluid conduits define: a delivery fluid path connecting the reservoir with the inlet; a return fluid path, independent of the delivery fluid path, connecting the reservoir with the outlet; and a waste fluid path connecting the reservoir with the waste receptacle. The device also includes a first flow control device configured to selectively prevent or allow fluid flow from the reservoir to the organ via the delivery fluid path; and a second flow control device configured to selectively prevent or allow fluid flow from the reservoir to the waste receptacle via the waste fluid path.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: October 9, 2018
    Assignee: XOR-LABS TORONTO INC.
    Inventors: Lahav Gil, Siew Hong Tan, Martin Leandro Par, Philipp Stücklin, Shafique Keshavjee, Mingyao Liu, Marcelo Cypel, David Christopher Lynch, Thomas Kenneth Waddell, Geoffrey Samuel Frost, Grzegorz Piotr Burdyszek
  • Patent number: 10094783
    Abstract: A system for use in rapid sample analysis that includes a biosensor reagent, wherein the biosensor reagent includes living biological cells; a reservoir card, wherein the reservoir card stores the biosensor reagent; and a test cartridge base, wherein the test cartridge base is configured to accept the reservoir card, and wherein the test cartridge base further includes a reaction chamber having a central axis, wherein the reaction chamber has the shape of a revolved half ellipse; and an inlet channel connected to the reaction chamber, wherein the inlet channel is positioned above the reaction chamber at an angle of 15-60 degrees above the horizontal, and wherein the inlet channel is offset from the central axis of the reaction chamber.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: October 9, 2018
    Assignee: Fundamental Solutions Corporation
    Inventors: Marvin R. Williams, Charles McBrairty, Daniel W. Pfautz, Thomas J. Zupancic, Lingchun Zeng, Andrew Weiman, Richard S. Brody, Joseph D. Kittle, Anthony Truscott, Robert Baranowski
  • Patent number: 10086375
    Abstract: Disclosed is a multi-stage thermal convection apparatus such as a two-stage thermal convection apparatus and uses thereof. In one embodiment, the two-stage thermal convection apparatus includes a temperature shaping element that assists a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying nucleic acid without cumbersome and expensive hardware associated with many prior devices. In a typical embodiment, the apparatus can fit in the palm of a user's hand for use as a portable, simple to operate, and low cost PCR amplification device.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: October 2, 2018
    Assignee: Ahram Biosystems, Inc.
    Inventor: Hyun Jin Hwang
  • Patent number: 10086374
    Abstract: Disclosed is a multi-stage thermal convection apparatus and uses thereof. In one embodiment, the invention features a three-stage thermal convection apparatus that includes a temperature shaping element for assisting a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying nucleic acid without cumbersome and expensive hardware associated with many prior devices. In a typical embodiment, the apparatus can fit in the palm of a user's hand for use as a portable, simple to operate, and low cost PCR amplification device.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: October 2, 2018
    Assignee: Ahram Biosystems, Inc.
    Inventor: Hyun Jin Hwang
  • Patent number: 10087409
    Abstract: Provided is a cell culturing vessel for holding and culturing cells. It has a first vessel that stores a culture medium and cells or only a culture medium, a second vessel that is placed above the first vessel and stores a culture medium and cells or only a culture medium, a main vessel that holds the first vessel and houses the second vessel, and a lid member that engages with the main vessel. The main vessel has a pressing member that fixes and holds the first vessel in the main vessel and the second vessel is eccentrically held in the first vessel by the pressing member.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 2, 2018
    Assignee: Hitachi, Ltd.
    Inventors: Masaharu Kiyama, Guangbin Zhou, Ryota Nakajima, Takayuki Nozaki, Naoko Senda, Shizu Matsuoka
  • Patent number: 10081788
    Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: September 25, 2018
    Assignee: Repligen Corporation
    Inventor: Jerry Shevitz
  • Patent number: 10077422
    Abstract: A harvesting device and methods of harvesting (i.e., dewatering) algae are described. The harvesting device and methods involve the use of stimuli-sensitive hydrogels.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: September 18, 2018
    Assignee: The University of Toledo
    Inventors: Agasteswar Vadlamani, Xiaofei Zhao, Sridhar Viamajala, Sasidhar Varanasi
  • Patent number: 10076112
    Abstract: The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: September 18, 2018
    Assignee: TRANSMEDIC, INC.
    Inventors: Waleed H. Hassanein, Tamer I. Khayal, Ahmed Elbetanony, Jeff Barnes, Greg Ritchie, Richard Bringham, Mark Anderson, John Sullivan
  • Patent number: 10071403
    Abstract: A system and method for decomposing municipal solid waste (MSW) under anaerobic conditions. The system includes a bioreactor landfill with the MSW, a leachate recirculation unit in connection with the bioreactor landfill, a multilevel thermocouple unit, placed inside the bioreactor landfill for monitoring temperature in the bioreactor landfill. Further, the system includes a sensor for monitoring moisture level within the bioreactor landfill. Furthermore, the system includes the leachate recirculation unit configured to initiate recirculation of a leachate, collected from the bioreactor landfill, when temperature in the bioreactor reaches a determined temperature and a determined moisture level.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: September 11, 2018
    Assignee: Indian Institute of Technology Bombay
    Inventors: Devendra Narain Singh, Bhagawan Shamrao Patil
  • Patent number: 10072240
    Abstract: Present invention relates to a modular system for fabrication of a biocolumn for generating fuel stocks. The biocolumn of independent units called modules and which function as independent units and can be assembled together to fabricate a biocolumn. These modules can be assembled together to form various zones of biocolumn. Fuel stocks can be prepared by inputting a nutrient, a renewable energy source, photon energy and a carbon source into said zones and outputting fuel stock and by products from zones. The zones are interconnected so that byproducts from each zone can be recycled as input or transformed into product.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: September 11, 2018
    Assignees: SINGAPORE TECHNOLOGIES DYNAMICS PTE LTD, GIBBS ENERGY, LLC
    Inventor: Joseph P Maceda
  • Patent number: 10058869
    Abstract: A micro-fluidic device includes a plurality of heating elements on a substrate for heating the substrate. They define a plurality of temperature regions having distinct temperatures on the substrate. A flow feature layer is formed above the substrate to define a channel extending across the substrate through each temperature region. As fluid is repeatedly pumped within the channel, it flows from one temperature region to a next temperature region to undergo thermal cycling. Fluid wells reside in the flow feature layer under a cover and connect to the channel whereby fluid can dwell for diagnostic applications.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: August 28, 2018
    Assignee: Microfluidic MEMS Solution, LLC
    Inventors: Steven Wayne Bergstedt, Stephen Jacob DeMoor, Yimin Guan
  • Patent number: 10053661
    Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom, a top, a tubular neck, and, one or more shelves. The first shelf adjoins the top with the first shelf being located intermediate the bottom and the top. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: August 21, 2018
    Assignee: Corning Incorporated
    Inventors: William J. Lacey, Michael S. Shanler, Amy W. Cai
  • Patent number: 10053663
    Abstract: The invention is directed to a centrifuge chamber comprising a cylinder having a base plate and a cover plate, a rotational axis with at least one port for input and/or output of liquids, at least one port for input of gases and at least one layer for cell culturing, wherein the layer for cell culturing comprises a gas-permeable membrane on which cells can be cultured and wherein the at least one port for input and/or output of gases is connected to the gas-permeable membrane.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: August 21, 2018
    Assignee: Miltenyi Biotec, GmbH
    Inventors: Eiad Kabaha, Stefan Miltenyi, Ralf-Peter Peters
  • Patent number: 10046326
    Abstract: A supporting device for a multiplicity of parallel, highly elongate bioreactor elements having an at least partially transparent wall of plastic, through which a microorganism-inoculated nutrient solution is conducted for producing biomass by photosynthesis, includes a plurality of stationary support pylons disposed along the bioreactor elements and horizontally spaced apart from one another. The expenditure on production and assembly is decreased by providing at least one carrying element running between at least two support pylons above the respective bioreactor elements to be carried. The carrying element is supported on the corresponding support pylons and the bioreactor elements to be carried are connected to at least one carrying element by at least one holding element at least at one support point situated between the two support pylons.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: August 14, 2018
    Assignee: PatEffect Schutzrechtsmanagement GbR
    Inventor: Hans Vaeth
  • Patent number: 10047331
    Abstract: A tray (100; 400; 500; 600) for accommodating a cell culture (101), such as an embryo, for use during culturing thereof and for optical monitoring of the cell culture, e.g. during in vitro fertilization comprises a carrier structure (104;404;504;604) defining at least one accommodating zone (102; 402; 502; 602) for accommodating the cell culture. At least one focal lens (110; 410; 510; 610), notably a numerical aperture increasing lens is integrally formed with the carrier structure to facilitate monitoring of the cell culture through the carrier structure. A diameter of the focal lens may exceed a diameter of the at least one accommodating zone. The focal lens may be integrally molded with the carrier structure from a thermoplastic material.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 14, 2018
    Assignee: UNISENSE FERTILITECH A/S
    Inventors: Jonas Lerche Hansen, Niels B. Ramsing, Søren Porsgaard, Holger Søe Plougsgaard, Mai Faurschou Isaksen
  • Patent number: 10047334
    Abstract: A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: August 14, 2018
    Assignee: 3M Innovative Properties Company
    Inventors: Sailaja Chandrapati, Heather M. Webb, Jeffrey C. Pederson, Jeffrey D. Smith, RuthAnn R. Duda, Brian J. Engel
  • Patent number: 10041062
    Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: August 7, 2018
    Assignee: NeuMoDx Molecular, Inc.
    Inventors: Jeffrey Williams, Sundaresh Brahmasandra, Michael T. Kusner