Patents Examined by Nathan Bowers
  • Patent number: 10047334
    Abstract: A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: August 14, 2018
    Assignee: 3M Innovative Properties Company
    Inventors: Sailaja Chandrapati, Heather M. Webb, Jeffrey C. Pederson, Jeffrey D. Smith, RuthAnn R. Duda, Brian J. Engel
  • Patent number: 10046326
    Abstract: A supporting device for a multiplicity of parallel, highly elongate bioreactor elements having an at least partially transparent wall of plastic, through which a microorganism-inoculated nutrient solution is conducted for producing biomass by photosynthesis, includes a plurality of stationary support pylons disposed along the bioreactor elements and horizontally spaced apart from one another. The expenditure on production and assembly is decreased by providing at least one carrying element running between at least two support pylons above the respective bioreactor elements to be carried. The carrying element is supported on the corresponding support pylons and the bioreactor elements to be carried are connected to at least one carrying element by at least one holding element at least at one support point situated between the two support pylons.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: August 14, 2018
    Assignee: PatEffect Schutzrechtsmanagement GbR
    Inventor: Hans Vaeth
  • Patent number: 10047331
    Abstract: A tray (100; 400; 500; 600) for accommodating a cell culture (101), such as an embryo, for use during culturing thereof and for optical monitoring of the cell culture, e.g. during in vitro fertilization comprises a carrier structure (104;404;504;604) defining at least one accommodating zone (102; 402; 502; 602) for accommodating the cell culture. At least one focal lens (110; 410; 510; 610), notably a numerical aperture increasing lens is integrally formed with the carrier structure to facilitate monitoring of the cell culture through the carrier structure. A diameter of the focal lens may exceed a diameter of the at least one accommodating zone. The focal lens may be integrally molded with the carrier structure from a thermoplastic material.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 14, 2018
    Assignee: UNISENSE FERTILITECH A/S
    Inventors: Jonas Lerche Hansen, Niels B. Ramsing, Søren Porsgaard, Holger Søe Plougsgaard, Mai Faurschou Isaksen
  • Patent number: 10041062
    Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: August 7, 2018
    Assignee: NeuMoDx Molecular, Inc.
    Inventors: Jeffrey Williams, Sundaresh Brahmasandra, Michael T. Kusner
  • Patent number: 10035734
    Abstract: The present disclosure suggests a food waste treatment apparatus. A food waste treatment apparatus in accordance with an exemplary embodiment of the present disclosure includes: a housing including a food inlet opening at its top surface; an inner chamber where food introduced through the food inlet opening is collected; a stirring unit provided within the inner chamber and configured to stir food waste; an outer chamber positioned outside the inner chamber; and a rotation driving unit configured to rotate the stirring unit and the inner chamber, and the inner chamber and the stirring unit are rotated by the rotation driving unit in opposite directions.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: July 31, 2018
    Inventor: James Chun Koh
  • Patent number: 10030220
    Abstract: A single-use bioreactor, suitable in particular for use in a parallel bioreactor system for applications in cell culture and/or microbiology, a head plate for such a single-use bioreactor and a process for manufacturing the single-use bioreactor and the head plate. The single-use bioreactor comprises a head plate, a dimensionally stable container and a mixer, the head plate and the container enclosing a reaction chamber, and the mixer having a mixer shaft and a stirring member, said mixer shaft being mounted rotatably about a rotational axis in a bearing and the stirring member being fastened torsionally rigidly to the mixer shaft. The mixer and the bearing are arranged entirely within the reaction chamber and the mixer shaft has a magnetic portion which is arranged and adapted in such a way that it can be coupled magnetically in an axial direction to a rotary drive.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: July 24, 2018
    Assignee: EPPENDORF AG
    Inventors: Matthias Arnold, Heinz Gerhard Kohn, Nico Gulzow, Sven Eikelmann, Sebastian Selzer, Jochen Beese, Christopher Gunther, Eckart Kopowski
  • Patent number: 10023833
    Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: July 17, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Patrik Akerstrom, Hakan Wahlnas
  • Patent number: 10022717
    Abstract: A method of manufacturing a micro-chamber plate with a built-in sample, including: settling a micro-chamber plate for sample injection at a micro-chamber plate receiving part formed with an upper opening; disposing a cover for micro-chamber plate receiving part to cover the upper opening, the cover for micro-chamber plate receiving part having a provisional storing part and an auxiliary covering part connected with the provisional storing part and formed with a through-hole for auxiliary covering part; and manufacturing a micro-chamber plate with a built-in sample by putting the micro-chamber plate receiving part, on which the cover is disposed, into a centrifugal separator which can apply vacuum, applying centrifugal force and injecting a sample solution provisionally stored in the provisional storing part into the micro-chamber plate through a vessel communication part which is formed at the provisional storing part to be communicated with the micro-chamber plate receiving part.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: July 17, 2018
    Assignee: BIONEER CORPORATION
    Inventors: Han Oh Park, Gu Young Song, Jung A Bae
  • Patent number: 10018620
    Abstract: The present disclosure describes systems and methods for mimicking body tissue and the function thereof. The mimicked body tissue can include kidney tissue, the blood brain barrier, and other tissues. In some implementations, the systems described herein are used to test the impact of controlled factors on the tissue. The controlled factors can include flow rates, shear rates, and test chemicals (e.g., therapeutics and toxins). In some implementations, the system and methods are used to test pharmaceutical and biological therapies, characterize healthy or diseased tissue, and observe phenomena of the tissue in vitro.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: July 10, 2018
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Joseph L. Charest, Else Frohlich, Christopher DiBiasio, Kenneth Vandevoordt
  • Patent number: 10018581
    Abstract: A method for assaying target molecules in a sample liquid, the method comprising: providing an impedance monitoring device operably connected to an impedance analyzer; adding a sample liquid suspected of having target molecules to the well thereby permitting binding of target molecules to the capture molecules; monitoring impedance of the well; and determining the presence, amount or concentration of target molecules in the liquid sample from the monitored impedance. The device includes a nonconducting substrate having a well, at least two electrodes fabricated on a bottom of the well and on a same plane, wherein the surfaces of the at least two electrodes are modified with capture molecules configured to bind target molecules in a liquid sample, and at least two connection pads electrically connected to the at least two electrodes.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: July 10, 2018
    Assignee: ACEA Biosciences, Inc.
    Inventors: Xiaobo Wang, Xiao Xu
  • Patent number: 10018568
    Abstract: The present invention relates to a device for monitoring a biofilm, which can monitor a formation state of the biofilm by using a biofilm shadow image. According to one embodiment of the present invention, the device for monitoring a biofilm can comprise: a water tank for storing water; a monitoring substrate arranged inside the water tank and surface-treated so as to accelerate the biofilm formation; a light-emitting module located at an upper portion of the monitoring substrate so as to emit light in a monitoring substrate direction; and an image sensor unit arranged below the monitoring substrate so as to capture a shadow image of the biofilm, which is formed on the monitoring substrate.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: July 10, 2018
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS
    Inventors: Sung-Kyu Seo, Un-Hwan Ha
  • Patent number: 10012640
    Abstract: A cell culture assay device can include: a substrate having a plurality of discrete microfluidic networks and a plurality of wells over the discrete microfluidic networks, each discrete microfluidic network having one or more wells fluidly coupled thereto, the wells extending upward from the discrete microfluidic networks; and a manifold body coupled with the substrate and having at least one fluid conduit pair for each microfluidic network and/or each well, each fluid conduit pair including a fluid inlet conduit and a fluid outlet conduit fluidly coupled to a corresponding microfluidic network and/or well. The substrate can be formed from a substrate base having the microfluidic networks coupled to a well plate having the wells associated with the microfluidic networks.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: July 3, 2018
    Assignee: CFD RESEARCH CORPORATION
    Inventors: Kapil Pant, Balabhaskar Prabhakarpandian
  • Patent number: 10010887
    Abstract: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: July 3, 2018
    Assignee: Applied Biosystems, LLC
    Inventors: Hon Siu Shin, Jew Kwee Ngui, Chee Kiong Lim, Ching Ong Lau, Lim Hi Tan, Yang Hooi Kee
  • Patent number: 10012664
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: July 3, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: James Wasson, John Kent Frankovich, Elizabeth A. Holmes, Timothy Smith, Michael Chen, Daniel Young
  • Patent number: 10010888
    Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: July 3, 2018
    Assignee: NeuMoDx Molecular, Inc.
    Inventors: Jeffrey Williams, Sundaresh Brahmasandra, Michael T. Kusner
  • Patent number: 10006861
    Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: June 26, 2018
    Assignee: Streck, Inc.
    Inventors: Matthew R. Kreifels, Scott E. Whitney, Gregg Wilder, John Flanagan, James Dowling, Philip Hills, Michael Tilleman, Jeremie Jackson
  • Patent number: 10006867
    Abstract: There is provided a device (1) for carrying out an assay to detect a target nucleic acid in a sample, the device (1) comprising a body in which is formed: •a) a sample entry well location comprising a sample entry well (22) or means for engaging with a sample entry well (22), the sample entry well (22) having a first volume; •b) an amplification well location comprising an amplification well (56) or means for engaging with an amplification well (56), the well (56) having a second volume less than or the same as the first volume and in which a nucleic acid amplification reaction of the target nucleic acid may be effected; •c) a first channel (60) linking the sample entry well (22) with the amplification well (56); •d) a diluent well location comprising a diluent well (35) or means for engaging with a diluent well (35), the well (35) being sealed, having a third volume greater than the second volume and being openable to an unsealed configuration; •e) a second channel (65) linking the diluent well (35), when in
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: June 26, 2018
    Assignee: The Secretary of State of Environment, Food and Rural Affairs, acting through the Animal and Plant Health Agency.
    Inventors: Graham Gutsell, Philip Wakeley
  • Patent number: 10006862
    Abstract: A continuous process for performing multiple nucleic acid amplification assays, where at least a portion of a second subset of reaction mixtures are transferred to a heater while a first subset of reaction mixtures are being subjected to conditions for performing a nucleic acid amplification assay. During the process, a plurality of reaction mixtures from the first and second subsets of reaction mixtures are simultaneously subjected to conditions sufficient to perform multiple nucleic acid amplification assays in the reaction mixtures. The presence or absence of a target nucleic acid in the first subset of reaction mixtures is determined while the reaction mixtures are in the heater.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: June 26, 2018
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Gary D. Lair, Thanh N. Nguyen, Haitao Li, Florence Li, Byron J. Knight, Robert E. Heinz, Jerzy A. Macioszek, Christopher B. Davis, Robert F. Scalese
  • Patent number: 10004185
    Abstract: A closed loop compost tea brewing system with a hydroponic reservoir and a compost tea brewing assembly configured to brew compost tea. The compost tea brewer assembly includes a tea brewing reservoir. The system includes has a closed loop arrangement fluidly connecting the tea brewing reservoir and the hydroponic reservoir. The closed loop arrangement is configured to provide continuous fluid flow from the tea brewing reservoir to the hydroponic reservoir, which is recirculated back from the hydroponic reservoir to the tea brewing reservoir.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: June 26, 2018
    Inventor: Matthew Fingerle
  • Patent number: 10000429
    Abstract: A method and apparatus for operating a composter device includes a compost container, a condensate reservoir, a first fluid pathway fluidly coupling the composting chamber and the condensate reservoir, and a fan moving air from the composting chamber to the condensate reservoir along the first fluid pathway to define a first airflow.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: June 19, 2018
    Assignee: Whirlpool Corporation
    Inventors: Rachel Maghas, Thomas Alan Latack