Patents Examined by Nathan Bowers
  • Patent number: 9943848
    Abstract: An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: April 17, 2018
    Assignee: Cepheid
    Inventors: Michael T. Taylor, Phillip Belgrader, Farzad Pourahmadi, William A. McMillan, Ronald Chang, Stanley H. Sakai, Jesus Ching
  • Patent number: 9938494
    Abstract: A cell detachment device includes: a base; a vessel holder, to which a culture vessel is to be fitted; a guide mechanism configured to guide reciprocating movement of the vessel holder; a collided member configured to collide with the vessel holder when the vessel holder is moving; an urging member configured to urge the culture vessel toward the collided member; and a power imparting mechanism configured to impart, to the vessel holder, power for causing the vessel holder to move.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: April 10, 2018
    Inventors: Keizo Watakabe, Junji Iizaka, Hitoshi Hasunuma, Katsumi Nakashima
  • Patent number: 9932555
    Abstract: The present invention includes a conveyor body which partitions a plurality of storage chambers, a connection opening connected to an external device, and a conveying chamber that connects the plurality of storage chambers to the connection opening, a plurality of incubators detachably stored in the plurality of incubators, a conveyor device that conveys one of the plurality of incubators from the storage chamber to the connection opening, and an environment control device that individually controls an interior environment of the plurality of incubators by supplying and discharging gas to and from each incubator.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: April 3, 2018
    Inventors: Tomoyoshi Tokumaru, Akira Higuchi
  • Patent number: 9926525
    Abstract: The present invention relates to systems and methods for optimising the usage of laboratory and cell culturing space for cell culture and biomanufacturing. The invention provides a system and method that can be used to provide a plurality of workstations and/or storage bays for bioreactors in cell culturing and/or biomanufacturing facilities.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 27, 2018
    Assignee: GE Healthcare UK Limited
    Inventors: Christopher George Norey, Michelle Louise Janas, Anthony Patterson, Adrian Crawley
  • Patent number: 9926521
    Abstract: The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: March 27, 2018
    Assignee: Fluidigm Corporation
    Inventor: Antoine Daridon
  • Patent number: 9927421
    Abstract: The invention relates to a sample chamber for testing samples, comprising a bottom plate and a cover plate connected thereto, a sample reservoir for receiving a liquid and/or a sample to be tested, and a contact electrode which is arranged entirely in the bottom plate, in the cover plate or between the bottom plate and the cover plate and which is electrically conductively connected to a conductor element or semiconductor element disposed in and/or on the sample chamber, wherein the bottom plate and/or the cover plate are designed in such a way that an electrical contact with the contact electrode can be established from the outside in such a way that an electrically conductive connection to the conductor element or to the semiconductor element can be established from the outside through the bottom plate or through the cover plate via the contact electrode.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: March 27, 2018
    Assignee: IBIDI GMBH
    Inventors: Roman Zantl, Valentin Kahl
  • Patent number: 9920290
    Abstract: The present disclosure relates to a continuous fermentation apparatus and a multi-step continuous fermentation process using the same.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: March 20, 2018
    Assignees: Biol Systems Co., Ltd., Daewoo Shipbuilding & Marine Engineering Co., Ltd.
    Inventors: Myung Kyo Shin, Jin Hyuk Shin, In Sik Kim, Dongjoong Im
  • Patent number: 9918464
    Abstract: The straw comprises a tube (11) having a swelling plug (15) provided with a fibrous support agent and a swelling agent combined with the support agent and configured, at least close to a second end (18) of the swelling plug, after a liquid-based substance has come up against its second end, to be in a state of swelling constrained by said tube such that if a first part (26) of the swelling plug of length comprised between 2 mm and 3 mm starting from its second end has come out of the tube via a second end (14) of the tube, whereas a second part of the swelling plug remains in the tube, the first part of the swelling plug becomes decompacted and expands with the second end of the swelling plug which assumes a diameter (d) at least equal to one and a half times the inner diameter of the tube.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: March 20, 2018
    Inventors: Eric Schmitt, Jean-Charles Gorges
  • Patent number: 9918463
    Abstract: The invention relates to a bioreactor for charging the outside and the interior of a hollow element (1) or hollow element framework with a liquid, having a housing (2) accommodating the liquid, forming a liquid surface, and a rotation device (3) arranged within the housing (2) and receiving the hollow element (1), which rotation device (3) is for rotating the hollow element (1) about the longitudinal axis (4) thereof in the region of the liquid surface. In known bioreactors of this type, the interior of the hollow element must be flushed with a special device, and so here also a liquid exchange takes place.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: March 20, 2018
    Assignee: BIOSTAGE, INC.
    Inventors: Roger Zink, Hermann Rees, Ottmar Heiny
  • Patent number: 9914920
    Abstract: Provided herein are a culture apparatus, culture systems and an alternating ionic magnetic resonance electromagnetic chamber for culturing cells, tissues or organoid bodies or for delivering a pulsating alternating ionic magnetic resonance field to an object of interest including the above or to an animal, human or plant. The culture apparatus comprises a culture unit having growth and nutrient modules and a randomizing adapter to continually randomize the gravity vector in the growth module. The culture systems further comprise the alternating ionic magnetic resonance electromagnetic chamber.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: March 13, 2018
    Inventors: Thomas J Goodwin, Moses J Kushman
  • Patent number: 9915601
    Abstract: An examination apparatus 1 for microorganisms for measuring an amount of microorganisms in a sample solution, the apparatus including stirring and mixing means 7 for stirring and mixing the sample solution into which a sample and a fluorescent staining reagent are added, in a sample container 5 formed of a material allowing light to pass through, an excitation light source 10 including a light source that irradiates an irradiation target surface of the sample container 5 with excitation light while the sample solution is being stirred by the stirring and mixing means 7, light receiving means 14 for detecting light and converting the light resulting from a fluorescent emission caused by excitation light from the excitation light source 10, into an electric signal, and control means 23 for detecting the number of emissions based on the electric signal from the light receiving means 14 and calculating the amount of the microorganisms contained in the sample in the sample container 5 based on the number of emissi
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: March 13, 2018
    Inventors: Akiko Nakata, Shinya Fushida, Akira Eto, Masanori Matsuda, Yukio Hosaka
  • Patent number: 9915813
    Abstract: The invention relates to a system and a method for determination of a value for at least one parameter describing microbial activity of individual biological organisms in a liquid sample. Images, wherein individual biological organisms may be identified, are combined to provide optical sectionings of the biological organisms and the optical sectionings are analyzed to determine the value for said at least one parameter describing microbial activity of said individual biological organisms in each sample container.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: March 13, 2018
    Inventors: Tom Olesen, Martin Christian Valvik, Niels Agersnap Larsen
  • Patent number: 9910030
    Abstract: Small and extremely small molecules and ions or atoms may be detected with the novel device with exceptional sensitivity. The detection is implemented in a simple manner by the known acoustic resonator FBAR or by means of other technologies that measure the physical properties of the filled layer. The permeability of substances (e.g. active ingredients) through membranes such as cell membranes, lipid bilayers, and cell walls can be examined by combining a sensor with the reservoir and the membrane.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: March 6, 2018
    Inventors: Martin Nirschl, Kaori Sugihara, Janos Vörös, Tomaso Zambelli
  • Patent number: 9909093
    Abstract: The present disclosure relates to a funnel apparatus for channeling cells onto a plurality of distinct, closely spaced regions of a seeding surface. The funnel apparatus has a body portion having an upper surface and a lower surface. The body portion forms a plurality of flow paths, at least one of which is shaped to have a decreasing cross-sectional area from the upper surface to the lower surface. The flow paths are formed at the lower surface to enable cells deposited into the flow paths at the upper surface of the funnel apparatus to be channeled into a plurality of distinct, closely spaced regions on the seeding surface positioned adjacent the lower surface.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: March 6, 2018
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: David Soscia, William J. Benett, Erik V. Mukerjee
  • Patent number: 9908119
    Abstract: A thermal cycling apparatus having a sample interfacing wall extending from a mounting wall. The sample interfacing wall can accept and apply thermal cycles to samples. An air source can direct an air stream to cool the sample. Another source can direct heated air away from the sample.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: March 6, 2018
    Assignee: Cepheid
    Inventor: Doug Dority
  • Patent number: 9909090
    Abstract: A cell culture kit for cultivating cells in a closed system includes at least one or more of each of: a culture container for cultivating cells; a culture medium storage container for storing a culture medium or the like; a cell injection container for injecting cells; and a cell collecting container for collecting a suspension of cells after cultivation; wherein the culture medium storage container is also used as a waste liquid container for collecting a culture medium after cultivation, and the culture container, the culture medium storage container, the cell injection container and the cell collecting container are linked to one another through a conduit.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: March 6, 2018
    Inventors: Satoshi Tanaka, Takahiko Totani, Yoichi Ishizaki
  • Patent number: 9902930
    Abstract: The present invention relates to a laboratory incubator, more particularly, a gassing incubator, comprising an outer housing incorporating a door and an inner housing surrounding an internal chamber, which comprises a floor, a ceiling, three side walls and a lateral surface that is capable of being closed by said door or by an additional, inner door, and in which a flow channel is present, which comprises at least one air inlet opening in an end region and at least one air outlet opening in a different end region, wherein said at least one air outlet opening is formed such that effluent air is guided along at least one of the side walls and/or the lateral surface in the peripheral region of the internal chamber, and wherein a water reservoir capable of being heated is disposed within the flow channel such that air flowing in the flow channel is passed across or through said water reservoir.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: February 27, 2018
    Assignee: Thermo Electron LED GmbH
    Inventors: Waldemar Pieczarek, Juergen Andreas Schneider, Hermann Stahl
  • Patent number: 9890343
    Abstract: The invention relates to a process and a biofilter system (10) for removing H2S from a H2S contaminated energy production gas stream containing methane. The aqueous biofilter system comprises a biofilter (6) having biofilter support material constituting a biofilter bed supporting a humidified biofilm having microorganisms that are capable of oxidizing H2S. The process comprises the steps of contacting the H2S contaminated energy production gas stream with the microorganisms of the humidified biofilm, and oxidation of at least part of the H2S in the H2S contaminated energy production gas stream by the microorganisms, resulting in a H2S depleted energy production gas stream, wherein the process further comprises the step of adding an aqueous nitrate solution to the H2S contaminated energy production gas stream prior to being contacted with the microorganisms, enabling the microorganisms to oxidize the H2S under anoxic conditions.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: February 13, 2018
    Inventors: Marina Ettl, Wolfram Franke, Werner Van Borm
  • Patent number: 9885059
    Abstract: Many applications in cell biology, genetic engineering, cell-based therapeutics, and drug discovery require precise and safe methods for introducing membrane-impermeable molecules into cells. This can be implemented satisfactorily by microinjection. However, disadvantages of traditional manual microinjection include high degree of operator skill, low throughput and labor-intensiveness. Many studies have focused on developing automated and high-throughput systems for microinjection to address these limitations. However, none have provided sufficient throughput for applications such as ex vivo cell therapy, where manipulation of many cells is helpful.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: February 6, 2018
    Assignees: Indiana University Research and Technology Corporation, The Regents of the University of California
    Inventors: Chris Ballas, Masa Rao, Yanyan Zhang
  • Patent number: 9885012
    Abstract: Devices, systems, and methods for facilitating placement of cells and materials in culture plates configured for high-throughput applications are provided. A culture system is provided with a culture plate having a lid for guiding placement of cells and materials in each individual culture well of a culture plate. The lid may provide for coupling to an electrophysiology culture plate comprising a biosensor plate and a biologic culture plate, where the biosensor plate underlies and is coupled to the culture well plate such that each biosensor is operatively coupled to one culture well of the plurality of culture wells. A containment device that physically influences the positioning of fluid received in the culture plate is also provided herein.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: February 6, 2018
    Inventors: Robert Dixon Grier, Jr., Anthony Michael Nicolini, Colin Michael Arrowood, Swaminathan Rajaraman