Patents Examined by Nathan Bowers
  • Patent number: 10000429
    Abstract: A method and apparatus for operating a composter device includes a compost container, a condensate reservoir, a first fluid pathway fluidly coupling the composting chamber and the condensate reservoir, and a fan moving air from the composting chamber to the condensate reservoir along the first fluid pathway to define a first airflow.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: June 19, 2018
    Assignee: Whirlpool Corporation
    Inventors: Rachel Maghas, Thomas Alan Latack
  • Patent number: 9994806
    Abstract: A transport device for a container has a base, a vertical member extending up from the base and a complementary handling unit extending from an end of the vertical member spaced from the base. The complementary handling unit is configured for releasably engaging a container, such as a bioreactor container, so that the container can be transported to a holding device.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: June 12, 2018
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Bernward Husemann, Wolfgang Kahlert, Sebastien Chaussin, Reiner Seitz
  • Patent number: 9993782
    Abstract: A bioreactor has a stirrer shaft that is driveable by a drive and on which a stirrer element is positioned. The position of the stirrer element is determined by a stirrer installation aid. The stirrer installation aid has a free end with an abutment surface on which the free end of the stirrer element abuts. The stirrer installation aid is designed as a sleeve that comprises a slot extending between the axial ends of the sleeve. The slot is delimited by opposite flanks of a wall, and the sleeve is placed on the stirrer shaft. The stirrer installation aid can be pulled off laterally from the stirrer shaft. A method for installing the stirrer element on the stirrer shaft arranged in the bioreactor also is provided.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: June 12, 2018
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Thomas Dreher, Oliver Scheibe, Gerhard Greller, Ute Husemann, Oscar-Werner Reif
  • Patent number: 9994807
    Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: June 12, 2018
    Inventors: Patrik Akerstrom, Hakan Wahlnas
  • Patent number: 9983197
    Abstract: Low-cost and portable microfluidic systems are needed for cell migration research and Point of Care (POC) testing. This study introduces a low-cost and portable USB Microscope Microfluidic Chemotaxis Analysis System (UMCAS) for rapid analysis of cell chemotaxis studies. A standalone microfluidic gradient generator is also developed for rapid generation of chemical gradient in microfluidic device without need of any peripheral perfusion apparatus. A smart phone based application program was developed for the real-time remote monitoring of the migration data. This system is validated by observing the neutrophil migration in three different conditions: 1) medium control, 2) uniform IL-8 control, and 3) IL-8 gradient. The results show that neutrophils exhibit random migration in both medium and uniform IL-8 control experiments, while they show strong directional migration to the IL-8 gradient. These results successfully validated the developed UMCAS system.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: May 29, 2018
    Inventors: Francis Lin, Jiandong Wu
  • Patent number: 9977009
    Abstract: A planar patch clamp device comprising: an electrical insulating substrate (2) having a first surface having a cell arrangement region and a second surface of the opposite surface and having a through hole (3) in the cell arrangement region which does not pass cells, but pass liquid; a first reservoir (6) provided at the first surface side (2S) of the electrical insulating substrate (2) to be able to communicate with the through hole (3) and hold a first conductive liquid; a first electrode part (7) arranged to be able to be electrically conductive with the first reservoir (6) through the first conductive liquid; a second reservoir (6?) provided at the second surface side (2S?) of the electrical insulating substrate to be able to communicate with the through hole (3) and hold a second conductive liquid; a second electrode part (7?) arranged to be able to be electrically conductive with the second reservoir (6?) through the second conductive liquid; a supply path (8) connected to the second reservoir (6?) and
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: May 22, 2018
    Inventors: Tsuneo Urisu, Zhi-hong Wang, Hidetaka Uno, Yasutaka Nagaoka, Kei Kobayashi
  • Patent number: 9976114
    Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom, a top, a tubular neck, and, one or more shelves. The first shelf adjoins the top with the first shelf being located intermediate the bottom and the top. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: May 22, 2018
    Assignee: Corning Incorporated
    Inventors: Amy W Cai, William J Lacey, Michael S Shanler
  • Patent number: 9976161
    Abstract: A reactor for continuous saccharification of biomass having a high solid content comprises perforated plates and stirring means, in which the perforated plates includes nozzles for feeding additives, including a saccharification enzyme, and a sensor, which communicate with the holes of the perforated plates.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: May 22, 2018
    Assignees: SK Innovation Co., Ltd., SK Energy Co., Ltd.
    Inventors: Taewan Kim, Minsu Koo, Younghwan Chu, Donghyun Kim, Taeseung Kim, Bonwook Koo, Minji Sung
  • Patent number: 9970922
    Abstract: With the object of preventing deterioration of or damage to a photodetector caused by excessive light by more reliably preventing the excessive light from entering the photodetector, a microscope of the present invention is provided with a high-sensitivity detector, such as an HPD, a GaAsP, an EM-CCD or the like, that detects observation light coming from a specimen, a box-shaped casing that has an opening that allows contained items to be placed therein and removed therefrom and that covers the high-sensitivity detector, a door that can close off the opening of the casing, a switch that restricts light detection by the high-sensitivity detector by turning on and off a drive voltage to be applied to the high-sensitivity detector, and an opening restricting mechanism that allows the opening of the casing in the closed state imposed by the door to be opened only when the light detection by the high-sensitivity detector is restricted by the switch.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: May 15, 2018
    Inventors: Atsuhiro Tsuchiya, Hiroyuki Okahira, Koichiro Izumi
  • Patent number: 9969964
    Abstract: The invention generally relates to a cell culture system for coculturing non-neoplastic and neoplastic cells on a planar member which more faithfully mimics the in vivo geometry of a lumen or a cavity.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: May 15, 2018
    Inventors: Sophie Andree Lelievre, Pierre-Alexandre Vidi, James Francis Leary, Teimour Maleki-Jafarabadi
  • Patent number: 9963668
    Abstract: The invention relates to a device for culturing cells in a bioreactor, the waste-air line of which leading out of the reactor interior comprises a waste-air filter having a sterile-filtration microfilter membrane, wherein at least one prefilter having a hydrophobic filter material is placed upstream of the waste-air filter toward the reactor interior.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: May 8, 2018
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Oscar-Werner Reif, Gerhard Greller, Paschalis Nikoloudis, Ralf Lausch, Ute Husemann, Thomas Loewe, Thomas Friese, Thomas Dreher
  • Patent number: 9963665
    Abstract: The present invention relates to a biogas plant and to a process for the production of biogas from ligneous renewable resources, in particular straw. Means are provided for pre-treating the ligneous renewable resource in order to bring about chemical, thermal and/or mechanical digestion of said resource before it is introduced into a fermenter in which anaerobic bacterial fermentation takes place.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: May 8, 2018
    Inventor: Michael Feldmann
  • Patent number: 9943848
    Abstract: An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: April 17, 2018
    Assignee: Cepheid
    Inventors: Michael T. Taylor, Phillip Belgrader, Farzad Pourahmadi, William A. McMillan, Ronald Chang, Stanley H. Sakai, Jesus Ching
  • Patent number: 9938494
    Abstract: A cell detachment device includes: a base; a vessel holder, to which a culture vessel is to be fitted; a guide mechanism configured to guide reciprocating movement of the vessel holder; a collided member configured to collide with the vessel holder when the vessel holder is moving; an urging member configured to urge the culture vessel toward the collided member; and a power imparting mechanism configured to impart, to the vessel holder, power for causing the vessel holder to move.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: April 10, 2018
    Inventors: Keizo Watakabe, Junji Iizaka, Hitoshi Hasunuma, Katsumi Nakashima
  • Patent number: 9932555
    Abstract: The present invention includes a conveyor body which partitions a plurality of storage chambers, a connection opening connected to an external device, and a conveying chamber that connects the plurality of storage chambers to the connection opening, a plurality of incubators detachably stored in the plurality of incubators, a conveyor device that conveys one of the plurality of incubators from the storage chamber to the connection opening, and an environment control device that individually controls an interior environment of the plurality of incubators by supplying and discharging gas to and from each incubator.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: April 3, 2018
    Inventors: Tomoyoshi Tokumaru, Akira Higuchi
  • Patent number: 9926525
    Abstract: The present invention relates to systems and methods for optimising the usage of laboratory and cell culturing space for cell culture and biomanufacturing. The invention provides a system and method that can be used to provide a plurality of workstations and/or storage bays for bioreactors in cell culturing and/or biomanufacturing facilities.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 27, 2018
    Assignee: GE Healthcare UK Limited
    Inventors: Christopher George Norey, Michelle Louise Janas, Anthony Patterson, Adrian Crawley
  • Patent number: 9926521
    Abstract: The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: March 27, 2018
    Assignee: Fluidigm Corporation
    Inventor: Antoine Daridon
  • Patent number: 9927421
    Abstract: The invention relates to a sample chamber for testing samples, comprising a bottom plate and a cover plate connected thereto, a sample reservoir for receiving a liquid and/or a sample to be tested, and a contact electrode which is arranged entirely in the bottom plate, in the cover plate or between the bottom plate and the cover plate and which is electrically conductively connected to a conductor element or semiconductor element disposed in and/or on the sample chamber, wherein the bottom plate and/or the cover plate are designed in such a way that an electrical contact with the contact electrode can be established from the outside in such a way that an electrically conductive connection to the conductor element or to the semiconductor element can be established from the outside through the bottom plate or through the cover plate via the contact electrode.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: March 27, 2018
    Assignee: IBIDI GMBH
    Inventors: Roman Zantl, Valentin Kahl
  • Patent number: 9920290
    Abstract: The present disclosure relates to a continuous fermentation apparatus and a multi-step continuous fermentation process using the same.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: March 20, 2018
    Assignees: Biol Systems Co., Ltd., Daewoo Shipbuilding & Marine Engineering Co., Ltd.
    Inventors: Myung Kyo Shin, Jin Hyuk Shin, In Sik Kim, Dongjoong Im
  • Patent number: 9918464
    Abstract: The straw comprises a tube (11) having a swelling plug (15) provided with a fibrous support agent and a swelling agent combined with the support agent and configured, at least close to a second end (18) of the swelling plug, after a liquid-based substance has come up against its second end, to be in a state of swelling constrained by said tube such that if a first part (26) of the swelling plug of length comprised between 2 mm and 3 mm starting from its second end has come out of the tube via a second end (14) of the tube, whereas a second part of the swelling plug remains in the tube, the first part of the swelling plug becomes decompacted and expands with the second end of the swelling plug which assumes a diameter (d) at least equal to one and a half times the inner diameter of the tube.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: March 20, 2018
    Inventors: Eric Schmitt, Jean-Charles Gorges