Patents Examined by Nathan Bowers
  • Automatic microfluidic system for rapid personalized drug screening and testing method for personalized antibiotic susceptibility
    Patent number: 11007524
    Abstract: The present disclosure provides an automatic microfluidic system for rapid personalized drug screening including a microfluidic chip. The microfluidic chip includes a fluid storage unit, a fluid driving unit, a reaction unit and a plurality of valve units. The fluid driving unit includes two mixing pumps. Each of the mixing pumps includes two pneumatic micro-pumps, a mixing chamber and a blocking structure. The blocking structure is disposed in the mixing chamber and is connected between the two pneumatic micro-pumps. When the two pneumatic micro-pumps are started alternately, the blocking structure is deflected alone with the operation of the two pneumatic micro-pumps.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: May 18, 2021
    Assignees: National Tsing Hua University, Kaohsiung Chang Gung Medical University
    Inventors: Gwo-Bin Lee, Shiuann-Sheng Lee, Wen-Bin Lee, Huey-Ling You
  • Manufacturing facility for the production of biopharmaceuticals
    Patent number: 11008540
    Abstract: A manufacturing facility for the continuous production of biopharmaceuticals integrated with single-use disposable technology.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: May 18, 2021
    Assignee: Lonza Ltd.
    Inventor: Atul Mohindra
  • Medical sample transportation container
    Patent number: 10995311
    Abstract: A portable apparatus for transport and incubation of a medical sample in a blood culture flask includes a sealable container having a thermally insulated compartment for receiving the blood culture flask and a heater for heating the medical sample to a temperature suitable for pre-culturing of the sample. An agitator is provided for agitating the sample in the blood culture flask.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: May 4, 2021
    Assignee: Q-linea AB
    Inventors: Jonas Jarvius, Anders Lind, Henrik Soderstrom, Jan Grawe, Ian Fitzpatrick, Jurg Bartholdi
  • Methods, compositions, and devices for supplying dietary fatty acid needs
    Patent number: 10987280
    Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: April 27, 2021
    Assignee: Alcresta Therapeutics, Inc.
    Inventors: Alexey L. Margolin, Robert Gallotto, Bhami Shenoy
  • Apparatus for detecting pH and dissolved oxygen
    Patent number: 10983056
    Abstract: Embodiments of a cell culture monitoring system are disclosed that may include a device having collimating and filtering components to elicit and detect fluorescence from a substrate located within a reaction vessel. The device may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells. Excitation light beams can be generated and collimated by a beam combiner and directed into the reaction vessel so as to be incident upon the substrate to cause the substrate to fluoresce. Some embodiments include use of expected wavelength offsets and shifted filters/mirrors to improve functionality and reduce space of device components.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: April 20, 2021
    Assignee: Scientific Industries, Inc.
    Inventors: Michael Tolosa, William Chandler, Douglas J. Koebler, Joseph G. Cremonese, Brookman P. March
  • Carbon dioxide conversion reactor, series reactor for converting and capturing carbon dioxide including the same, and process of converting and capturing carbon dioxide using the same
    Patent number: 10981111
    Abstract: The present invention relates to a carbon dioxide conversion reactor and more particularly, to a carbon dioxide conversion reactor capable of converting carbon dioxide contained in flue gas into an aqueous bicarbonate solution that may be used in many applications; and at the same time, preventing back pressure from increasing due to supplied flue gas by allowing a conversion process to rapidly proceed, thereby significantly reducing the level of carbon dioxide contained in flue gas with high efficiency and high conversion speed, a series reactor for converting and capturing carbon dioxide including the carbon dioxide conversion reactor, and a process of converting and capturing carbon dioxide using the carbon dioxide conversion reactor.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: April 20, 2021
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Jungbae Kim, Han Sol Kim, Sung Gil Hong
  • Devices for cell culture and methods of making and using the same
    Patent number: 10982181
    Abstract: Devices and systems for cell culture that include one or more hollow fibers or channels integrated into a chamber are provided. The hollow fibers or channels and/or the chamber are seeded with one or more cell types. Methods of co-culturing two or more cell types in the devices are also provided.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: April 20, 2021
    Assignee: Triad National Security, LLC
    Inventors: Pulak Nath, Jen-Huang Huang
  • Device for treating at least one biological cell, notably with a view to intracellular delivery
    Patent number: 10968422
    Abstract: A device for treating at least one biological cell includes at least one treatment support comprising a receiving surface enabling the adhesion of the at least one biological cell, at least one actuator capable of deforming said support in order to apply a stress to said at least one cell, and means of controlling said at least one actuator such that the actuator deforms the treatment support according to a given amplitude of deformation and for a given duration so as to generate at least one transitory pore in a membrane of the biological cell.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: April 6, 2021
    Assignees: Commissariat A L'Energie Atomique et aux Energies Alternatives, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Fabrice Casset, Arnaud Millet
  • Nanoscale topography system for use in DNA sequencing and method for fabrication thereof
    Patent number: 10961563
    Abstract: A method of fabricating a nanoscale topography system for inducing unfolding of a DNA molecule for sequencing includes providing a substrate and creating trench walls on the substrate which define a trench therebetween. The method further includes depositing a layer of a block copolymer (BCP) in the trench and forming cylindrical domains by self-assembly of the BCP between the trench walls, removing a first portion of the cylindrical domains to create a vacant region in the trench, and depositing a subsequent layer of the BCP in the vacant region and forming spherical domains by self-assembly of the BCP between the trench walls adjacent a second portion of the cylindrical domains. The spherical domains form staggered post structures for unfolding the DNA molecule and the cylindrical domains form parallel channel structures for entry of the DNA molecule for sequencing.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: March 30, 2021
    Assignee: Robert Bosch GmbH
    Inventors: Karim Gadelrab, Giovanna Bucci, Nathan Craig, Christopher Johnson, Nadezda Fomina, Young Shik Shin
  • Systems and methods for preparing protein enhanced serums
    Patent number: 10960026
    Abstract: A system for preparing a serum includes a containment device, a cage positioned inside the containment device, a cap attachable to the containment device and configured to cover the cage, an inlet port configured to introduce an autologous fluid into the containment device, and an outlet port configured to remove a serum from the containment device.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: March 30, 2021
    Assignee: ARTHREX, INC.
    Inventors: Christopher Bare, Abigail Nabors, Melissa Tucker, Robert Harrison
  • System, method, and device for high-throughput, automated culturing of genetically modified organisms
    Patent number: 10954483
    Abstract: A fluid transfer system includes a transfer carousel capable of rotational and/or translational movement; at least one holding vessel (e.g. syringe) having a plunger, wherein the syringe is connected to the transfer carousel such that the movement of the transfer carousel results in movement of the syringe and wherein the syringe is capable of translational movement relative to the transfer carousel; a drive motor connected to the syringe that is capable of controlling the position of the plunger; and a peripheral module comprising at least one vessel that is capable of containing a fluid, wherein the vessel has an opening that can be mated with the syringe to allow fluid transfer between the vessel and the syringe. Methods for transferring a fluid are also disclosed.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: March 23, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Michael Hogan, Orkan M. Telhan, Karen Hogan
  • Automated cell processing methods, modules, instruments, and systems
    Patent number: 10954512
    Abstract: In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: March 23, 2021
    Assignee: Inscripta, Inc.
    Inventors: Jorge Bernate, Kevin Ness, Phillip Belgrader, Don Masquelier, Ryan Gill
  • Integrated circuits for analyzing biological systems
    Patent number: 10955404
    Abstract: Integrated circuits for sensing biological molecules are disclosed. The integrated circuits can be used to measure the impedance of a biological sample under test. The integrated circuits can be used to sequence polynucleotides using a cell array.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: March 23, 2021
    Assignee: AXBIO INC.
    Inventors: Stephen F. Dreyer, Priyanka Agrawal, Hui Tian
  • Automated cell processing methods, modules, instruments, and systems
    Patent number: 10947532
    Abstract: In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: March 16, 2021
    Assignee: Inscripta, Inc.
    Inventors: Don Masquelier, Phillip Belgrader, Jorge Bernate, Ryan Gill, Kevin Ness
  • Device for high-throughput multi-parameter functional profiling of the same cells in multicellular settings and in isolation
    Patent number: 10940476
    Abstract: A device for high-throughput multi-parameter functional profiling of the same cells in multicellular settings and in isolation is provided. In certain aspects, an integrated microfluidic device for multi-parameter metabolic and other phenotypic profiling of live biological cells is useable with: 1) multicellular clusters or small biopsy tissue samples, 2) cultures of the constituent cells obtained after cluster/tissue dissociation, and 3) the same constituent single cells in isolation. The approach enables study of the effects of multicellular complexity, such as in response to treatment, pathogens, stress, or other factors concerning disease origination and progression. Measurements may be performed on single cells or multicellular populations or tissues in the same assay at the same time.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: March 9, 2021
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Laimonas Kelbauskas, Honor Glenn, Jeff Houkal, Clifford Anderson, Yanqing Tian, Fengyu Su, Deirdre Meldrum
  • Fully automated continuous cell culture system
    Patent number: 10934513
    Abstract: The invention provides a full-automatic cell culture system, at least comprising: a control module, a control platform, a dark field microscope for on-line observation of cell culture, a cell incubator shaker and a cell culture bag. The control platform is connected to the dark field microscope for on-line observation of cell culture and the cell incubator shaker respectively, and the control module is connected to the control platform. The invention also provides a culture bag support frame for a continuous cell incubator shaker, the continuous cell incubator shaker, a non-contact sensor connector, the cell culture bag and the dark field microscope for on-line observation of cell culture which are related to the full-automatic cell culture system, thereby realizing continuous culture and observation of cells.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 2, 2021
    Assignee: SHANGHAI GENBASE BIOTECHNOLOGY CO., LTD.
    Inventor: Xuejun Yu
  • Vessels and spinner flasks with reduced impeller wobble for culturing cells
    Patent number: 10920185
    Abstract: A vessel for culturing cells is provided that includes a vessel body having a top portion, a bottom portion comprising a bottom interior surface, and a cylindrical sidewall. The vessel additionally has an impeller assembly inside the vessel body having a top portion rotatably coupled to the top portion of the vessel body, the impeller assembly having a plurality of planar blades, a central axis, a flexible shaft extending down from the top portion of the impeller assembly, a magnet receptacle molded within the plurality of planar blades, a magnet within the magnet receptacle, and an impeller o-ring coupled to a bottom surface of the planar blades. The vessel also includes a plurality of positioning nubs coupled to the bottom interior surface of the vessel body, spaced from an inside edge of the impeller o-ring.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: February 16, 2021
    Assignee: Corning Incorporated
    Inventors: Jeffery Joseph Scibek, James Clark Walck, Jr.
  • Modular platform for tissue integrated cell culture
    Patent number: 10913925
    Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: February 9, 2021
    Assignees: The Charles Stark Draper Laboratory, Inc., The Massachusetts Institute of Technology
    Inventors: Joseph Cuiffi, Jeffrey T. Borenstein, Anilkumar Harapanahalli Achyuta, Mark J. Mescher, Linda Griffith, Samuel Walker Inman
  • Systems and methods for allergen detection
    Patent number: 10908139
    Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: February 2, 2021
    Assignee: DOTS TECHNOLOGY CORP.
    Inventors: Adi Gilboa-Geffen, Renuka Babu Brown, Sarah Stidham, Valerie Villareal, Adam J. Young, Joshua Glenn Anthony, Patrick Murphy, John H. Kepler, Adam Jacobs
  • Composting device sliding lid with a seal assembly
    Patent number: 10906847
    Abstract: The disclosure relates to a composting device including a housing defining an interior with an access opening providing access to the interior, a composter bin located within the interior and in communication with the access opening, and a cover slidably mounted to the housing and slidable along a sliding path between opened and closed conditions to selectively open and close the access opening. An angled seal assembly is provided on the cover and housing. Both a sealing surface and a seal are angled relative to a sliding path such that the space between the seal and the sealing surface decreases as the cover is slid from the opened to the closed condition.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: February 2, 2021
    Assignee: Whirlpool Corporation
    Inventors: Abhishek Buzruk, Christopher C. Wilcox, Brian Clark