Patents Examined by Nathan G Esperon
  • Patent number: 11946027
    Abstract: Systems and methods for monitoring and tracking the behavior of cells and tissues in a culturing medium, for example, in a cell culture medium or an in vivo tissue environment, using a tissue scaffold system having one or more sensor arrays. Such monitoring systems include a tissue scaffold system and one or more sensor arrays on the tissue scaffold system in vertically stackable configurations. The sensor array(s) are configured to monitor electrical impedance and/or electrophysiological activities of cells or tissues which may be provided to an external data acquisition system for production of a three-dimensional (3D) map.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: April 2, 2024
    Assignee: Purdue Research Foundation
    Inventor: Chi-Hwan Lee
  • Patent number: 11898128
    Abstract: A culture apparatus includes a culture vessel including an internal space containing a culture solution in which a culture target is suspended, a gas supply apparatus supplying a single gas or a mixed gas to the internal space of the culture vessel, and an agitation apparatus agitating the culture solution by changing position and posture of the culture vessel. The agitation apparatus changes the position and posture of the culture vessel to circulate the culture solution in the internal space of the culture vessel so that a bottom surface of the internal space of the culture vessel is partially revealed and that the revealed portion transitions in a circulating direction R.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: February 13, 2024
    Assignee: Canon Kabushiki Kaisha
    Inventors: Akira Higuchi, Hiroyuki Naito, Itsuro Motegi
  • Patent number: 11879117
    Abstract: A gel tray for a bacteria transformation lab exercise has a transparent plastic body with four parallel gel channels and four filling ports, one for each channel into which unmodified bacteria and heat-shocked bacteria can be injected by students along with appropriate reaction constituents to demonstrate transformation of the bacteria under visualization.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: January 23, 2024
    Assignee: C.C. Imex
    Inventors: Callen Elizabeth Hyland, Christopher Karl Schroeder, Rita Mei Yi Wong, Richard Tat Lee Chan
  • Patent number: 11668697
    Abstract: A device for analysis of cells comprises: an integrated circuit arrangement on a substrate; a dielectric layer formed above the integrated circuit arrangement; a microelectrode array layer formed above the dielectric layer, said microelectrode array layer comprising a plurality of individual electrodes, wherein each electrode is connected to the integrated circuit arrangement through a via in the dielectric layer; and wherein a plurality of longitudinal trenches in the dielectric layer and the microelectrode array layer are for stimulating cell growth on a surface of the device
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: June 6, 2023
    Assignees: IMEC VZW, KATHOLIEKE UNIVERSITEIT LEUVEN, KU LEUVEN R&D
    Inventors: Dries Braeken, Veerle Reumers, Alexandru Andrei, Andrea Firrincieli, Thomas Pauwelyn
  • Patent number: 11643627
    Abstract: A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: May 9, 2023
    Assignee: CYTIVA SWEDEN AB
    Inventors: Klaus Gebauer, Nagaraj Raghavendra Rao, Anindya Kanti De, Anindya Sengupta, Mats Olsson, Colin R. Tuohey, Jonathan A. Kenney, Richard Lee Damren, Ralph Stankowski, Nirmal Kumar Thanikachalam
  • Patent number: 11629326
    Abstract: A storage assembly for storing a plurality of specimens includes a frame, a plurality of modular storage units for perfusion and/or incubation of one or more specimens removably coupled to the frame, a sample transfer apparatus configured to retrieve a specimen holder from a chosen modular storage unit of the plurality of modular storage units, and a control unit communicatively coupled to the sample transfer apparatus. The control unit is configured to cause the sample transfer apparatus to retrieve a specimen from a modular storage unit of the plurality of modular storage units and deliver the specimen to a delivery position.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: April 18, 2023
    Assignee: Advanced Solutions Life Sciences, LLC
    Inventors: Michael W. Golway, Scott Douglas Cambron
  • Patent number: 11565268
    Abstract: The present invention discloses a convective PCR apparatus by using a transparent conductive thin film to replace the traditional metal heater. The PCR reaction is activated when the container with reagents contacted the heated transparent conductive thin film and the temperature inside the container raised to initiate the convective circulation. Also, the present invention could apply for a quantitative PCR reaction by adding a specific probe, a fluorescent dye, a light source, or a photon receiver.
    Type: Grant
    Filed: December 16, 2018
    Date of Patent: January 31, 2023
    Assignee: Credo Diagnostics Biomedical Pte. Ltd.
    Inventors: Ying-Ta Lai, Yu-Cheng Ou, Ming-Lung Hung, Cheng-Yueh Chung, Han-Yi Chen
  • Patent number: 11530377
    Abstract: The bioenvironmental simulation device according to an embodiment of the present invention includes at least one mounting unit on which cells to be measured are placed, a rotational force application unit configured to rotate the mounting unit so as to apply a rotational force to the cells to be measured placed on the mounting unit, and a culture liquid flow device through which a culture liquid flows across the mounting unit, wherein the culture liquid flows by the culture liquid flow device so as to apply a shear force to the cells to be measured.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: December 20, 2022
    Assignees: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, SEOUL NATIONAL UNIVERSITY HOSPITAL
    Inventors: Seung Hee Yang, Yon Su Kim, Dong Ki Kim, Sa Ram Lee, Yong Chul Kim, Mi Yeon Yu, Ji Eun Kim
  • Patent number: 11446659
    Abstract: The present invention discloses a nucleic acid extraction apparatus and a method using the apparatus for extracting nucleic acids and amplifying target nucleic acids. The nucleic acid extraction apparatus comprising: a nucleic acid extraction element, a waste storage chamber, and a reaction chamber, wherein the reaction chamber is selectively in communication with the nucleic acid extraction element and the waste storage chamber, and the apparatus realizes fluid exchange through the pressure between the waste storage chamber and the reaction chamber. In the present invention, by using an integrated control system, the conventional manual process of nucleic acid extraction and purification is integrated into a fully automatic closed process, making the operation more conveniently and quickly and improving the efficiency of experimental work.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: September 20, 2022
    Assignee: HANGZHOU BIGFISH BIO-TECH CO., LTD.
    Inventor: Lianyi Xie
  • Patent number: 11434461
    Abstract: An airlift bioreactor for perfusion cell culture comprises a single- or multi-tiered riser for working volume scale-up, an internal inclined gravity settler for cell retention, an outlet port for cell-free spent culture medium removal, and an inlet port for fresh medium addition.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: September 6, 2022
    Assignee: KECK GRADUATE INSTITUTE OF APPLIED LIFE SCIENCES
    Inventor: Corinna Eleni Doris
  • Patent number: 11406101
    Abstract: A device for preserving a predetermined dose of liquid-based substance, notably animal semen or a preservation medium containing embryos or tissue samples, comprises a tube (11) made of a weldable plastics material. The tube allows a service state in which a receiving portion (21) intended to contain the said predetermined dose has a circular cross-section whereas a sealing portion (22) comprises a welded pinch (19) and a transition zone (23). Over at least part of the sealing portion a differentiating edge region (28) gives the external surface of the tube a visual appearance different from the visual appearance of the external surface of the tube outside of the differentiating edge region. A range comprises such a device and a similar device but without the differentiating edge region.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: August 9, 2022
    Assignee: IMV TECHNOLOGIES
    Inventors: Eric Schmitt, Jean-Charles Gorges, Olivier Couture