Abstract: Systems, devices, and related methods for phototherapeutic treatment of skin, and more particularly phototherapeutic treatments for skin conditioning and/or the treatment of skin wrinkles are disclosed. Certain aspects relate to impinging light having a first peak wavelength on skin tissue at a first radiant flux, a second peak wavelength on the skin tissue at a second radiant flux, and, optionally, a third peak wavelength on skin tissue at a third radiant flux. The first wavelength may be selected to produce nitric oxide in the skin and/or to release endogenous stores of nitric oxide; the second wavelength may be selected to promote collagen production. Certain methods involve impinging light having a third peak wavelength that may be selected to reduce inflammation. Devices are disclosed that include combinations of housings, light-transmissive elements, and flexible substrates that are configured to deliver such light to one or more targeted areas.

Abstract: Devices, systems and methods for the treatment of chronic inflammatory disorders that include an implantable microstimulator and an external charger/controller wherein the microstimulator is configured to operate using closed-loop feedback. The feedback for the microstimulator can be electrical activity of the vagus nerve and/or heart sensed by the microstimulator. The feedback can be used to modulate the stimulation duration, intensity, frequency, on-time and off-time.

Abstract: A system for electrical stimulation of the salivary glands for the treatment of dry mouth is disclosed. In one embodiment, the system includes a headset with an electronic control module, placed on the back head, and a stimulating module, placed on the area to be stimulated. Both modules are connected by an elastic arm. The stimulating module provides one or more pairs of electrodes in contact with neuro-sensitive areas of a patient, and is anchored in the ear canal. The position of the electrodes is adjustable for optimized stimulation. The system may be operated by control bottoms that are part of the electronic control module or by a mobile device, such as a wireless remote control, a smartphone, or a tablet. A mobile device camera may be used for correcting the placement of the electrodes.

Abstract: The present disclosure relates to a positioning device for positioning an object in a positioning plane. To minimize the position error (contouring error) in a continuous orbital travel in contrast to two linear adjusters (X and Y) arranged at a right angle to each other, the positioning device includes two rotation drives having different diameters and an object receiver for receiving the object. The object receiver is coupled to a first of the two rotation drives, which in turn is coupled to the second of the two rotating drives so that the object receiver is rotatable about the axes of rotation (A2, A3) of both rotation drives that are offset in parallel, and is thereby adjustable in the positioning plane. A light processor having such a positioning device, and a method for laser eye surgery using such a light processor are also disclosed.

Abstract: An accessory for use with a portable container includes a jacket configured to extend around at least a portion of the sidewall of the container, the jacket including a plurality of modular sections formed separately and connected together around the at least a portion of the sidewall of the container. The modular sections include a first modular section having extending around a first portion of the sidewall of the container, a second modular section connected to the first modular section and extending around a second portion of the sidewall of the container, and at least one additional modular section extending around a third portion of the sidewall of the container. The first and second modular sections have different structural configurations. The accessory also includes a first connection member connected to the jacket and configured to support the jacket in connection with the container.

Abstract: A chamber providing controlled amounts of IR and visible light within an internal space sized to seat at least one human being. The chamber includes at least one heater configured to emit FIR energy, at least one heater configured to emit NIR energy, and at least one heater configured to emit at least MIR energy. The chamber includes at least one light emitting source configured to emit a selected wavelength of visible light, and a control panel configured to control the amount and duration of FIR, MIR, NIR and visible light within the chamber.

Abstract: Embodiments generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for lenticular laser incisions to form a top lenticular incision, a bottom lenticular incision of a lens in the subject's eye, an added shape between the top and bottom incisions where the added shape has no corrective power and a transition ring bisecting both the top and bottom lenticular incisions.

Abstract: Embodiments in accordance with the present disclosure are directed to methods and apparatuses used for slow wave activity (SWA) optimization. An example method includes receiving one or more bio-signals from a user and classifying sleep stages by processing the bio-signals. The method further include determining dominant peripheral nervous system (PNS) oscillations based on the bio-signals and as a function of time and stage of sleep, and characterizing at least one property of the dominant PNS oscillations, including a phase, a phase shift, an amplitude, and/or frequency. The method further include providing an indication of an optimal window for maximizing SWA generation based on the phase, the phase shift, the amplitude, or the frequency. The indication is provided to stimulation circuitry that delivers stimulation to the user within the optimal window. Feedback is provided responsive to the stimulation based on an EEG signal of the user.

Abstract: Certain embodiments describe an endoilluminator having a tube that includes an interior compartment between a proximal end and a distal end of the tube, wherein the distal end of the tube is configured to be inserted into an eye. The endoilluminator also includes a handpiece coupled to a light source and the proximal end of the tube, wherein the endoilluminator is configured to filter an incident component of light transmitted by the light source and emit a polarized component of the transmitted light through the distal end of the tube.

Abstract: Systems and methods are described herein for use in predicting impedance values or responses in a three-dimensional space. Broadly, an impedance potential field and its measurement characteristics is modeled in an impedance model such that an impedance measurement may be estimated for any location within the impedance potential field. The impedance model may evolve over time based on actual impedance measurements of electrodes located in the three-dimensional space. Initially a plurality of patch electrodes to provide an impedance field to a three-dimensional space while electrodes disposed in the impedance field measure impedances. While each patch is driven, a number of independent impedance fields exist between the non-driven patches. These independent impedance potential fields may be estimated and mapped to impedance measurements of the electrode(s) at locations(s) within the impedance field to model the impedance field.

Abstract: A diagnostic system includes one or more blood flow sensors adapted to contact but not penetrate the skin of the pedal arch and aligned with blood vessels of the pedal arch. Readings from the blood flow sensors are transformed into blood flow acceleration times, and the blood flow acceleration times are used to identify a blood flow pathology.

Abstract: Method for controlling an eye surgical laser of a treatment device for the separation of a volume body with a predefined posterior interface and a predefined anterior interface from a human or animal cornea. The method includes controlling the laser by means of a control device of the treatment device such that it emits pulsed laser pulses in a shot sequence in a predefined pattern into the cornea. The interfaces of the volume body are defined by the predefined pattern and are generated by means of an interaction of the individual laser pulses with the cornea by the generation of a plurality of cavitation bubbles by photodisruption along at least one cavitation bubble path. At least a partial area of an outer cavitation bubble path of the volume body is generated with a higher cavitation bubble density than an inner cavitation bubble path.

Abstract: In some examples, a laser-based ophthalmological surgical system includes a therapeutic radiation source, one or more optical elements, and a detector system. The therapeutic radiation source may be configured to emit therapeutic radiation. The one or more optical elements may be configured to direct the therapeutic radiation to a targeted area of an eye of a patient. A temperature of the targeted area may depend on a dosage of the therapeutic radiation. The detector system may be configured to measure thermal radiation emitted by the targeted area responsive to exposure to the therapeutic radiation. The one or more optical elements may be configured to optically couple the detector system to the targeted area.

Abstract: A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function value and the primary current signal; determining a connection function based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection function value.

Abstract: A method of filtering a signal in a continuous analyte monitoring (CAM) system includes applying time-varying filtering to the signal using a time-varying filter to generate a filtered continuous analyte monitoring signal during an analyte monitoring period. Other methods, apparatus, continuous analyte monitoring devices, and continuous glucose monitoring devices are also disclosed.

Abstract: Novel tools and techniques are provided for assessing, predicting and/or estimating a probability that a patent is bleeding, in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid detection of bleeding before, during, and after fluid resuscitation, in some instances, in real-time.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a medical device for measuring blood pressure. The medical device may include an elongated shaft having a proximal region and a distal region and a lumen extending therethrough and an optical pressure sensing block disposed within the lumen, the optical pressure sensing block including a distal portion bearing a pressure sensing membrane and a proximal portion forming an optical fiber connector extending proximally from the proximal portion. The optical fiber connector may be configured to be coupled to an optical fiber extending through the lumen.

Abstract: A blood sample collection system, may include a housing, the housing including a blood collection port; and a baffle chamber; a needle formed through the housing and into the blood collection port; and a baffle formed within the baffle chamber to counteract a vacuum within a blood collection tube when pierced by the needle.

Abstract: Two biomarkers are provided for obstructive apnea. A first biomarker determines amplitude and timing of inspiratory efforts from a bioelectric signal. The respiratory rate is compared with a normal pre-detection rate, and the amplitude of the effort is compared with a normal amplitude. The obstructive apnea is likely present if a series of inspiratory efforts are above a normal amplitude and with increasing amplitude, but at a normal rate. A second biomarker determines heart rate and respiratory rate. A normal lower threshold for heartbeat interval is established, and if subthreshold events occur (short RR intervals), a commencement time for each sequence of subthreshold events is compared for a respiratory rate-normalized window. If the number of subthreshold events exceeds a minimum for the window, obstructive apnea is likely present.

Abstract: Methods and systems for providing depth-resolved real-time visual feedback to a physician during cosmetic dermal filler injections with micrometer spatial resolution utilizing a noninvasive optical coherence tomography/elastography, 2D-3D virtual and real time system. This system can be automated to direct proper volumes and viscosity of the necessary injection substances. The methods and systems allow for assessment of the elasticity of the tissue before and after the injection to evaluate the efficacy of the injection, with predetermined virtual results before and matched post injection images. The elasticity assessment method preferably utilizes a focused air-pulse to induce a micrometer scale displacement in the skin and the optical coherence tomography system to image this displacement. By utilizing a model-based reconstruction method, the viscoelasticity of the tissue at a specific measurement position can be obtained and virtual and post injection real time projections can be imaged.