Patents Examined by Neil N Turk
  • Patent number: 10408790
    Abstract: A multiple capillary florescent detection system employing optical fiber bundles that each fiber bundle has more than one fiber illuminating each sample vessel.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: September 10, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Ho-ming Pang, Wei Wei
  • Patent number: 10408745
    Abstract: A method of referencing in optical absorption spectroscopy using broadband light sources for determining the concentration of substances in gaseous or fluid media through and to a device for measuring the concentration of substances in gaseous or fluid media within the measurement path of a measurement cell using absorption spectroscopy of light emitted from broadband light sources via light guiding optics.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: September 10, 2019
    Inventors: Martin Degner, Hartmut Ewald, Nils Damaschke, Elfred Lewis
  • Patent number: 10401295
    Abstract: A method of detecting a condition in a subject comprises the steps of contacting cells of the subject with single-walled carbon nanotubes (SWCNTs), monitoring photoluminescence emitted by SWCNTs internalized into the cells and generating an SWCNT emission profile, comparing the SWCNT emission profile to a control emission profile for the SWCNTs to produce a result, and determining a likelihood of having the condition in the subject based on the result from the comparing step. Also disclosed is a method for screening agents capable of changing endocytic environment using SWCNTs.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: September 3, 2019
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Prakrit Jena, Daniel A. Heller, Daniel Roxbury
  • Patent number: 10393665
    Abstract: One aspect of the present disclosure relates to an analyte sensor device. The analyte sensor device can include an optode layer that undergoes an optical change in the presence of an analyte. The analyte sensor device can also include a selectively-permeable membrane encapsulating the optode layer to form a stable membrane that that minimizes fouling of the analyte sensor device. The analyte sensor device can also include a plurality of microparticles that suppress a background physical interference on a detection of the optical change of the optode layer.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: August 27, 2019
    Inventors: Punkaj Ahuja, Maria A. Peshkova, Brian D. Hemphill, Miklós Gratzl
  • Patent number: 10393659
    Abstract: The present disclosure provides an instrument and methods for detecting an analyte, comprising a light source capable of generating excitation light for exciting a plurality of luminescence labels, an excitation beam path extending between said light source and said analyte, a detector capable of detecting light emitted from said luminescence label, an emission beam path extending between said analyte and said detector, a filter carrier carrying two or more pairs of filter portions, each pair being related to one luminescence label and comprising a first filter portion for transmitting excitation light and a second filter portion for transmitting emitted light, wherein said first filter portion of one pair is said second filter portion of another pair, and wherein said filter portions are arranged in a manner that a respective one of said pairs can be brought in an operative condition in which said first filter portion is in said excitation beam path and said second filter portion is in said emission beam pat
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: August 27, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Alan Furlan
  • Patent number: 10345240
    Abstract: The invention combines recent advances in barcode technology with portable wireless communication devices to engineer a simple and low-cost chip-based multiplex wireless detection system. The system can analyze multiple targets of interest simultaneously in minutes and is applicable to detection of pathogens or contaminants in a wide range of fields including medicine, agriculture and the environment.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: July 9, 2019
    Inventors: Warren Che Wor Chan, Kevin Ming
  • Patent number: 10338000
    Abstract: There is provided a sensor fiber including an electrically insulating material having a fiber length. At least one transduction element is disposed along at least a portion of the fiber length and is arranged for exposure to an intake species. A photoconducting element is in optical communication with the transduction element. At least one pair of electrically conducting electrodes are in electrical connection with the photoconducting element. The pair of electrodes extend the fiber length.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: July 2, 2019
    Assignees: Massachusetts Institute of Technology, FLIR Systems, Incorporated
    Inventors: Alexander Gumennik, Alexander Mark Stolyarov, Brent Richard Schell, Chong Hou, Guillaume Romain Lestoquoy, Fabien Sorin, William Richard McDaniel, II, Yoel Fink, Aimee Rose, John Dimitris Joannopoulos
  • Patent number: 10324020
    Abstract: Embodiments are directed to an apparatus that includes a fluidic structure and optical components. The fluidic structure includes a transparent channel through which objects in an analyte fluid can travel along respective paths during operation of the apparatus. The optical components are configured to provide measurement light to the objects traveling through the transparent channel. The fluidic structure is configured to reversibly engage with a host structure. The host structure includes a source of the measurement light and electronics to receive and process output light emanating from the objects traveling in the channel. The fluidic structure makes an air-tight seal when engaged with the host structure.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: June 18, 2019
    Assignee: Palo Alto Research Center Incorporated
    Inventors: David M. Johnson, Noble M. Johnson, Michael I. Recht, Joerg Martini, Tim Curley, Peter Kiesel, Martin Sheridan
  • Patent number: 10302649
    Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: May 28, 2019
    Assignee: Meso Scale Technologies, LLC
    Inventors: Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Sandor L. Kovacs, Sudeep M. Kumar, George Sigal, Carl Stevens, Michael Vock
  • Patent number: 10266463
    Abstract: Apparatuses, systems and methods for extracting isoprene using minimum capital investment, operating cost, and relatively corrosion free environment are disclosed herein. Embodiments of the invention are directed to producing pure isoprene and gasoline quality raffinate (free or sulfur and acetylenes) which are of value in manufacturing rubbers and other polymers.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: April 23, 2019
    Assignee: GTC Technology US LLC
    Inventors: Venkata K. Ramanujam, Michael McCaulley, Joseph C. Gentry
  • Patent number: 10265700
    Abstract: A diabetes test system for measuring blood glucose levels is provided, which includes a glucose meter, at least one diabetic test strip, and a container or pouch for storing the diabetes test strips and protecting them during transport. Methods of packaging diabetes test strips are also provided. The glucose meter includes software for detecting the validity of the at least one diabetic test strip, and a communication device that transmits data relating to the blood glucose level of the user to an external device. A secure packaging system for diabetes test strips which eliminates gray market sales of such test strips is also provided.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: April 23, 2019
    Inventor: Samuel Messinger
  • Patent number: 10254225
    Abstract: Biosensor including a device base having a sensor array of light sensors and a guide array of light guides. The light guides have input regions that are configured to receive excitation light and light emissions generated by biological or chemical substances. The light guides extend into the device base toward corresponding light sensors and have a filter material. The device base includes device circuitry electrically coupled to the light sensors and configured to transmit data signals. The biosensor also includes a shield layer having apertures that are positioned relative to the input regions of corresponding light guides such that the light emissions propagate through the apertures into the corresponding input regions. The shield layer extends between adjacent apertures and is configured to block the excitation light and the light emissions incident on the shield layer between the adjacent apertures.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: April 9, 2019
    Assignee: ILLUMINA, INC.
    Inventors: Cheng Frank Zhong, Hod Finkelstein, Boyan Boyanov, Dietrich Dehlinger, Darren Segale
  • Patent number: 10247699
    Abstract: The invention describes a detection system (1) for analytical separation processes, particularly for electrophoresis, characterized by an optoelectronic sensor layer (5) made from organic semiconductor materials extending along the carrier layer (2) for the sample to be tested, for detecting the separated sample.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: April 2, 2019
    Assignee: ASMAG-Holding GmbH
    Inventor: Max Sonnleitner
  • Patent number: 10241233
    Abstract: A method for characterizing an interaction between a first particle and a second particle is provided. The method includes the steps of: (i) providing an optical trap system including a photonics-based trap, a light source, and a camera; (ii) optically trapping, using the photonics-based trap, the first particle; (iii) obtaining a first measurement of a trap stiffness of the photonics-based trap; (iv) introducing the second particle to the optically trapped particle; (v) incubating the first and second particles under conditions suitable for an interaction between the first and second particles; (vi) obtaining a second measurement of the trap stiffness of the photonics-based trap after the incubation; and (vii) determining, using the first measurement of trap stiffness and the second measurement of trap stiffness, a property of the interaction between the first particle and the second particle.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: March 26, 2019
    Inventors: David Erickson, Pilgyu Kang
  • Patent number: 10201331
    Abstract: A biopsy tissue sample transport device and method of using thereof including a tissue storage assembly having a sample container, having a holding structure to hold a tissue sample, the holding structure having a sample access opening formed in a sidewall; a housing that receives the tissue storage assembly, the housing comprising an assembly insertion opening through which the tissue storage assembly is inserted into the housing; a sealing member configured to engage and substantially seal the sample access opening of the holding structure of the sample container of the tissue storage assembly; and a lid to engage and substantially seal the assembly insertion opening of the housing.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: February 12, 2019
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Jo Fleming, Charles E. Clemens, David Berardelli
  • Patent number: 10184891
    Abstract: A biochip device comprising a substrate constituted by at least one plate of material forming a multimode planar waveguide and carrying chromophore elements suitable for emitting fluorescence in response to excitation by guided waves having an evanescent portion, the device being characterized in that it includes coupling means for coupling excitation light with the waveguide in the form of guided waves, the coupling means being substantially non-directional.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: January 22, 2019
    Assignee: GENEWAVE
    Inventors: Claude Weisbuch, Lucio Martinelli, Henri Benisty, Christof Schafauer, Gabriel Sagarzazu, Thierry Gacoin, Mélanie Bedu
  • Patent number: 10180441
    Abstract: The invention relates to a microplate reader and a respective method, wherein the microplate reader comprises at least one measuring device and a holding device for accommodating at least one microplate and for positioning the samples-containing wells of this(these) microplate(s) in relation to the at least one measuring device. The at least one measuring device is used for detecting light which is emitted by samples in wells of a microplate inserted in this microplate reader and/or which is influenced by samples transilluminated by light in wells of a microplate inserted in this microplate reader. The microplate reader comprises a control unit for controlling the temperature of a gas atmosphere surrounding the wells containing the samples of microplates used in this microplate reader.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: January 15, 2019
    Assignee: TECAN TRADING AG
    Inventors: Florian Reiner, Harald Gebethsroither, Josef Grassl
  • Patent number: 10156524
    Abstract: A device for use in the detection of binding affinities, the device comprising a planar waveguide (2) arranged on a substrate (3), and further comprising an optical coupler (41) having a predetermined length for coupling coherent light (1) of a predetermined wavelength into the planar waveguide (2) such that a parallel beam of coherent light propagates through the planar waveguide (2) with an evanescent field (11) of the coherent light propagating along an outer surface (21) of the planar waveguide (2). The outer surface (21) of the planar waveguide (2) comprises binding sites thereon capable of binding target samples to the binding sites such that light of the evanescent field (11) is diffracted by target samples bound to the binding sites. The binding sites are arranged along a plurality of predetermined straight lines (7) running parallel to one another with a constant distance between adjacent straight lines.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: December 18, 2018
    Assignee: Hoffmann-La-Roche Inc.
    Inventor: Christof Fattinger
  • Patent number: 10132821
    Abstract: The present invention provides a processing station for automatically processing a biological sample, a system for automated real-time inventory control of consumables within a biological sample handling or assay instrument, a high throughput random access automated instrument for processing biological samples, an automated instrument for processing or analysis of a sample, and processes for automated mucoid detection and elimination. Methods of using the disclosed instruments, mucoid detection processes, and systems to process and/or analyze samples are also disclosed.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: November 20, 2018
    Inventors: Rolf Silbert, David Opalsky, David Aaron Buse, Robert J. Rosati, Olev Tammer, Richard Capella, Matthias Merten
  • Patent number: 10011481
    Abstract: The present invention provides an electronic nose device based on chemically sensitive field effect transistors. In particular, the sensors of the electronic nose device are composed of non-oxidized, functionalized silicon nanowires which can detect volatile organic compounds with very high sensitivity. Methods of use in diagnosing diseases including various types of cancer are disclosed.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: July 3, 2018
    Assignee: Technion Research and Development Foundation Ltd.
    Inventor: Hossam Haick