Patents Examined by Neil N Turk
  • Patent number: 12222277
    Abstract: Aspects of the present disclosure include flow cytometers configured to compensate for optical noise caused by operational change of a laser. Flow cytometers according to certain embodiments include a laser assessor configured to assess operational change of a laser. In embodiments, the laser assessor includes a reference detector and a mirror positioned between the reference detector and the flow cell that is configured to reflect forward scattered light to a forward scatter detector and allow non-scattered laser light to pass through to the reference detector. Methods for assessing laser functionality and, where desired, dynamically adjusting flow cytometer data, based on laser reference data from the laser assessor are also provided.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: February 11, 2025
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Ihor Berezhnyy, Svitlana Berezhna
  • Patent number: 12196743
    Abstract: Provided is a method by which the disaccharides derived from glycosaminoglycans can be analyzed in a stable and highly reproducible manner. A method for analyzing a glycosaminoglycan according to the present invention includes: a first process for producing a plurality of kinds of disaccharides derived from a glycosaminoglycan in a biological sample by adding a plurality of kinds of glycosaminoglycan-specific enzymes to the biological sample; and a second process for separating and analyzing the plurality of kinds of disaccharides by a liquid chromatography-mass spectrometry method, where a column used for liquid chromatography in the liquid chromatography-mass spectrometry method is a column packed with a stationary-phase support to which an amide group as a functional group is bound, or a column packed with a stationary-phase support to which an adamantyl group as a functional group is bound.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: January 14, 2025
    Assignees: SHIMADZU CORPORATION, NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITY
    Inventors: Takanari Hattori, Jun Watanabe, Tetsuo Iida, Misa Tanaka, Hironori Kobayashi, Shunji Tomatsu
  • Patent number: 12178411
    Abstract: A plurality of color sensing sections are attached to a toilet seat so as to test a health state or a fecal occult blood portion every time by capturing the feces surface color during defecation. Before feces which have been excreted from a body sink into a water-seal portion, the circumference of the feces is optically captured to detect the color of the surface of the feces. By monitoring changes in color, the health state of the defecator is monitored. In particular, by checking the presence/absence of an occult blood portion, the present invention assists in early detection of colorectal cancer and allows a fecal occult blood test to be performed in a hygienic manner without burdening the user.
    Type: Grant
    Filed: October 18, 2023
    Date of Patent: December 31, 2024
    Assignees: SETECH CO., LTD., TOTO LTD.
    Inventor: Hirokazu Sekine
  • Patent number: 12173270
    Abstract: Systems, including methods and apparatus, for growing viable monoclonal colonies, identifying them as monoclonal after their viability has been demonstrated, and picking and placing them into a target environment. The methods may include plating cells at low density in a well, capturing at a first time shortly after plating a series of vertically spaced-apart images of the well showing locations of the cells, capturing at a second, later time images of the same well showing locations of candidate cell colonies, determining a likelihood that the candidate colonies are monoclonal based on information in the first set of images, and, based on the likelihood, picking candidate colonies using a picking head for transfer to a target environment.
    Type: Grant
    Filed: January 24, 2024
    Date of Patent: December 24, 2024
    Assignee: Molecular Devices, LLC
    Inventors: Timothy A. Floto, Alison A. Glaser, Lee Von Landau, John Phillips, Kyle Corey, Padmavathi Bandhuvula, Anna Louise Forsyth
  • Patent number: 12163183
    Abstract: Biosensors and methods for localized surface plasmon resonance biosensing are disclosed. The biosensor can include a substrate having a substrate surface to which a plurality of localized surface plasmon resonance (LSPR) antennae are affixed. The LSPR antennae can be affixed via an affixation surface of the LSPR antenna. The LSPR antennae can have a functional surface opposite the affixation surface. Each functional surface can be functionalized by a plurality of single-stranded DNA.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: December 10, 2024
    Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventors: Rajesh Sardar, Thakshila Liyanage, Adrianna Masterson, Hristos Z. Kaimakliotis
  • Patent number: 12157118
    Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: December 3, 2024
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Mark Brian Dockrill, Anthony Favaloro, Kenneth He-Cho Ng, Martin Limon, Peter Toogood, Stephen John Bagnato
  • Patent number: 12158423
    Abstract: Disclosed is an apparatus, such as an acoustic for parallel profiling cell-matrix adhesion at single-cell level via the introduction of localized and uniform acoustic streaming into an open chamber microfluidic device. The adherent cells within the open chamber can be detached by the streaming-induced Stokes drag force, thereby allowing an accurate determination of the relevant forces and kinetics. The current device and method includes the digital regulation of acoustic streaming from a low level to high levels, and a large number of adherent cells can be ruptured from the substrate, and the particular adhesive forces and kinetics can be determined by the applied power. The acoustic device and the associated detachment technique can characterize the adhesion dynamics and kinetics of cells, such as mammalian cells and bacterial cells.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: December 3, 2024
    Inventors: Feng Guo, Zheng Ao, Hongwei Cai
  • Patent number: 12146890
    Abstract: An automated analyzer includes two or more types of photometers to obtain suitable output of the measurement results of the plurality of photometers and suitable data alarm output even if there is an abnormality, or the like, at the time of measurement. The automated analyzer includes, for example, two types of photometers having different quantitative ranges and an analysis control unit for controlling analysis that includes measurement of a given sample using the two types of photometers. If two types of data alarms corresponding to abnormalities, or the like, during measurement have been added to the two types of measurement results from the two types of photometers, the analysis control unit selects measurement result and data alarm output corresponding to the combination of the two types of data alarms and outputs the same to a user as analysis results.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: November 19, 2024
    Assignee: Hitachi High-Tech Corporation
    Inventors: Yuto Kazama, Masahiko Iijima, Chie Yabutani, Kenji Kogure
  • Patent number: 12140541
    Abstract: An integrated detection, flow cell and photonics (DFP) device is provided that comprises a substrate having an array of pixel elements that sense photons during active periods. The substrate and pixel elements form an IC photon detection layer. At least one wave guide is formed on the IC photo detection layer as a photonics layer. An optical isolation layer is formed over at least a portion of the wave guide. A collection of photo resist (PR) walls patterned to define at least one flow cell channel that is configured to direct fluid along a fluid flow path. The wave guides align to extend along the fluid flow path. The flow cell channel is configured to receive samples at sample sites that align with the array of pixel elements.
    Type: Grant
    Filed: November 2, 2023
    Date of Patent: November 12, 2024
    Assignee: Illumina, Inc.
    Inventors: Hod Finkelstein, Cheng Frank Zhong, Eliane H. Trepagnier
  • Patent number: 12140543
    Abstract: Biosensor including a device base having a sensor array of light sensors and a guide array of light guides. The light guides have input regions that are configured to receive excitation light and light emissions generated by biological or chemical substances. The light guides extend into the device base toward corresponding light sensors and have a filter material. The device base includes device circuitry electrically coupled to the light sensors and configured to transmit data signals. A passivation layer extends over the device base and forms an array of reaction recesses above the light guides. The biosensor also includes peripheral crosstalk shields that at least partially surround corresponding light guides of the guide array to reduce optical crosstalk between adjacent light sensors.
    Type: Grant
    Filed: June 21, 2023
    Date of Patent: November 12, 2024
    Assignee: ILLUMINA, INC.
    Inventors: Cheng Frank Zhong, Hod Finkelstein, Boyan Boyanov, Dietrich Dehlinger, Darren Segale
  • Patent number: 12135287
    Abstract: A method, system and storage medium for providing an alarm for indicating that an abnormality is present in a sample analyzer are provided. The method includes: mixing a first aliquot of a blood sample with a diluent agent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample; detecting at least two types of optical signals of the second test sample; acquiring first platelet detection data based on the electrical impedance signals; acquiring second platelet detection data based on the at least two types of optical signals; acquiring an evaluation result based on a difference between the first platelet detection data and the second platelet detection data; determining whether the evaluation result meets a preset condition to provide an alarm.
    Type: Grant
    Filed: October 9, 2023
    Date of Patent: November 5, 2024
    Inventors: Huan Qi, Wenbo Zheng, Bo Ye, Zhaoyang Li, Yi Ye
  • Patent number: 12134756
    Abstract: A modular kit for integration and installation of one or more bioreactors for microalgae cultivation includes: —at least one bioreactor for microalgae cultivation, in the form of a vertically arranged transparent tubular column; —a supporting structure adapted to integrate and support the base of the at least one bioreactor, and also adapted to internally house a first connection to a system for loading and unloading a cultivation vector fluid into/from the at least one bioreactor, and a second connection to a system for supplying CO2-supplemented air into the at least one bioreactor; —multiple modules forming respective frames with internal empty spaces and adapted to be connected to one another to house, in the empty spaces, the at least one bioreactor; the multiple modules being also so shaped as to convey filtered light into the at least one bioreactor.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: November 5, 2024
    Assignee: Politecnico Di Milano
    Inventors: Saverio Pasquale Spadafora, Ingrid Paoletti
  • Patent number: 12117397
    Abstract: A biochip device includes a waveguide, chromophore elements, a diffusing structure, and a sloping surface. The chromophore elements are disposed on a portion of the waveguide and are configured to emit fluorescence in response to excitation by guided light waves transmitted by the waveguide. The diffusing structure is configured to generate guided light waves in the waveguide when illuminated. The sloping surface is sloped relative to a plane of the waveguide and is configured to direct excitation light into the waveguide, and the sloping surface and the waveguide are configured to deflect the excitation light to the diffusing structure to generate guided light waves within the waveguide. The sloping surface may be a face of a prism attached to or integrated with the waveguide, or the sloping surface may be a bevel formed at an edge of the waveguide.
    Type: Grant
    Filed: August 9, 2022
    Date of Patent: October 15, 2024
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Claude Weisbuch, Lucio Martinelli, Henri Benisty, Christof Schafauer, Gabriel Sagarzazu, Thierry Gacoin, Mélanie Bedu
  • Patent number: 12111263
    Abstract: A method of super-resolution microscopy is provided. The method includes mapping three-dimensional location of each single emission event in a plurality of single emission events from a series of optical images of a sample to create a point cloud. The point cloud is filtered or refined. Clusters within the point cloud are identified and characterized allowing for an assessment of molecular architecture.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: October 8, 2024
    Inventors: Ismail M. Khater, Ghassan Hamarneh, Ivan Robert Nabi, Fanrui Meng
  • Patent number: 12099011
    Abstract: The present invention relates to a fluorescent polymer cast on the surface of wells of a plate and a plate comprising the fluorescent polymer. The plate is used in a method for calibrating read-out values of plate readers. The method for calibrating the plate readers can effectively reduce the deviation of read-out values among different plate readers.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: September 24, 2024
    Assignee: PLEXBIO CO., LTD.
    Inventors: Cheng-Tse Lin, Yi-Ming Sun, Kuei-Shen Hsu, Liang-Han Chang, Yao-Kuang Chung, Chin-Yun Wu, Chin-Shiou Huang
  • Patent number: 12075987
    Abstract: A biological sample collection system includes (i) a sample collection vessel having an opening for receiving a biological sample, (ii) a selectively movable valve comprising a core and a collar disposed about the core, and (iii) a sealing cap coupled to the valve and including a reagent chamber for storing a sample preservation reagent. The valve is configured to retain the sample preservation reagent in the reagent chamber when the valve is in a closed configuration. The sealing cap is configured to associate and form a fluid tight connection with the sample collection vessel. Associating the sealing cap with the sample collection vessel causes the valve to be placed in an open configuration in which a fluid vent through the core is placed into fluid communication with the reagent chamber, thereby causing or allowing sample preservation reagent to pass from the regent chamber to the sample collection vessel.
    Type: Grant
    Filed: June 13, 2023
    Date of Patent: September 3, 2024
    Assignee: SPECTRUM SOLUTIONS, LLC
    Inventor: Neil Jeremy Johnson
  • Patent number: 12075986
    Abstract: A biological sample collection system includes (i) a sample collection vessel having an opening for receiving a biological sample, (ii) a selectively movable valve comprising a core and a collar disposed about the core, and (iii) a sealing cap coupled to the collar and including a reagent chamber for storing a measure of sample preservation reagent. The sealing cap is configured to associate and form a fluid tight connection with the sample collection vessel. Associating the sealing cap with the sample collection vessel causes a physical rearrangement of the core relative to the collar such that a fluid vent associated with the core is placed into fluid communication with the reagent chamber, thereby permitting sample preservation reagent to pass from the regent chamber to the sample collection vessel.
    Type: Grant
    Filed: June 13, 2023
    Date of Patent: September 3, 2024
    Assignee: SPECTRUM SOLUTIONS LLC
    Inventor: Neil Jeremy Johnson
  • Patent number: 12078581
    Abstract: A biological material measuring instrument is described. The biological material measuring instrument includes a rotating body and a main body. The rotating body includes one or more cartridge holders having cuvettes in which a reagent and an analyte in a sample react. The main body includes a pair of light-emitting parts and light-receiving parts to optically measure the analyte in the sample. The rotating body further includes a light-emitting optical waveguide for guiding the light of the light-emitting parts to the cuvette, and a light-receiving optical waveguide for guiding.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: September 3, 2024
    Assignee: TASCOM CO., LTD.
    Inventor: Sung Dong Lee
  • Patent number: 12070735
    Abstract: The present invention provides a process for preparing a functionalised polymeric chromatography medium, which process comprises (I) providing two or more non-woven sheets stacked one on top of the other, each said sheet comprising one or more polymer nanofibres, (II) simultaneously heating and pressing the stack of sheets to fuse points of contact between the nanofibres of adjacent sheets, and (III) contacting the pressed and heated product with a reagent which functionalises the product of step (II) as a chromatography medium.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: August 27, 2024
    Assignee: PURIDIFY LTD.
    Inventors: Oliver Hardick, Daniel Gilbert Bracewell, Stewart Dods
  • Patent number: 12053780
    Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: August 6, 2024
    Assignee: CUE HEALTH INC.
    Inventors: Ayub Khattak, Clinton Sever, Paul Nelson, Ryan Cooper, Thomas Congdon, Justin Demartino, Raphael Shapiro, Mark Duncan