Abstract: A dressing includes a barrier film layer, a wound contact layer coupled to the barrier film layer, and a plurality of felted foam strips positioned between the barrier film layer and the wound contact layer. Each strip provides a manifolding pathway. The barrier film layer and the wound contact layer include a central region and a plurality of peninsular projections extending therefrom in the shape of a hand.

Abstract: The invention relates to an apparatus for preparing a peritoneal dialysis solution at the point of use comprising a disposable having a solution bag and associated filling lines and patient lines; a storage unit for liquid connected to the filling line; a control unit; and actuators for regulating a flow from the storage unit to the disposable, wherein the apparatus furthermore comprises a scale at which the solution bag of the disposable is arranged, with the control unit being configured to initiate a filling of the solution bag with liquid from the storage unit using the actuators and to determine the quantity of the liquid that has flowed into the solution bag using the scale.

Abstract: A dressing or wound filler comprising a laminate structure of materials. In one example embodiment, a dressing may include a first layer comprising a first film, a second layer adjacent to the first layer and comprising a foam, and a third layer comprising a second film. The first layer and the second layer may further include a plurality of perforations or fenestrations. The third layer may include a plurality of raised features. The perforations or fenestrations of the first and second layers may be positioned or aligned with the raised features of the third layer so as to facilitate tearing of the dressing for sizing and application purposes. In some embodiments, the first layer may comprise a polyurethane film, the second layer may comprise a polyurethane foam, and the third layer may comprise an additional polyurethane film.

Abstract: The present disclosure provides devices and methods for the treatment of ophthalmological conditions such as dry eye. Among the devices provided are punctal plugs and devices for inserting punctal plugs. The punctal plugs may be shaped for insertion in the punctum and/or the canaliculus. They may also be coated with a bioadhesive. Methods for inserting the punctal plugs are provided, as well as methods for preparing bioadhesive-coated punctal plugs. A method is also provided to treat dry-eye using a bioadhesive without use of a punctal plug.

Abstract: An apparatus includes an enclosure containing a hermetically sealed region, the enclosure configured to be implanted on or within a recipient. The apparatus further includes circuitry within the hermetically sealed region and configured to generate signals. The apparatus further includes at least one heating element configured to receive the signals and to generate heat in response to the signals. The apparatus further includes at least one flow control element outside the hermetically sealed region and configured to respond to the heat by controlling a flow of liquid through at least one cannula to controllably administer the liquid internally to the recipient.

Abstract: Disclosed are powder spray dispensing devices for comminuted extracellular matrix powder materials, and terminally sterilized products for providing such devices, as well as related methods for manufacture and use. A powder spray dispensing device can include a squeeze pump bottle having a bottle body defining a bottle opening and an interior chamber. A dry collagenous extracellular matrix material powder is received in the interior chamber of the squeeze pump bottle, and a cap is fitted over the bottle opening. The cap has a dispensing spout fluidly communicating with the bottle opening and having a spout lumen, desirably of decreasing diameter in a direction extending away from the bottle opening.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, having an air leak channel separated from a suction channel.

Abstract: At least one system for storage of pharmaceutical compositions includes: a container including a neck and a crown that includes an upper crown surface; a stopper including a flange and a plug, the flange including a lower flange surface and a flange height; and a holding element configured to exert a force on the crown and the flange to form a horizontal contact area between the upper crown surface and the lower flange surface. The horizontal contact area has a size of 30 mm2 to 300 mm2 and the flange height is compressed at least partially in the horizontal contact area by 10% to 40%.

Abstract: Embodiments disclosed herein are directed to the treatment of wounds using negative pressure. Some embodiments disclosed herein provide for a foam pad, which may be suitable for use in abdominal wound sites, and which may be sized in a dimensionally-independent manner. Additional embodiments provide for a wound contact layer, as well as a system for the treatment of abdominal wounds.

Abstract: Embodiments of secure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, the apparatus includes a pressure source, a user interface, and a locking mechanism. The locking mechanism can be in one of at least two states, the at least two states including a first state in which the locking mechanism physically prevents user adjustment of one or more operational parameters with the user interface and a second state in which the locking mechanism does not physically prevent user adjustment of the one or more operational parameters with the user interface. The locking mechanism can include an authentication key and a receiver configured to receive an authentication input, which may be compared to the authentication key. Providing a sufficiently matching authentication input can transition the locking mechanism from the first state to the second state, permitting adjustments to the one or more operational parameters.

Abstract: A wearable article includes a front and back elastic belts, a crotch region, a waist opening, and leg openings. Each elastic belt is a laminate having an inner sheet, an outer sheet, and an elastic member. Elastic adhesive bonding continuously bonds the elastic member for at least about 10 mm in the direction of stretch adjacent the side edges of the belts. A discrete patterned adhesive bonding is applied to at least one of the inner and outer sheets to intermittently bond the inner and outer sheets. The discrete patterned adhesive bonding extends substantially along the transverse direction between the elastic adhesive bonding, and substantially along the longitudinal direction between the distal and proximal edges of the elastic belts. The same adhesive agent provides the elastic adhesive and discrete patterned adhesive bonding. Heat bonds form side seams, and the remainder of the laminate is free of heat bonds.

Abstract: The present disclosure provides devices and methods for the treatment of ophthalmological conditions such as dry eye. Among the devices provided are punctal plugs and devices for inserting punctal plugs. The punctal plugs may be shaped for insertion in the punctum and/or the canaliculus. They may also be coated with a bioadhesive. Methods for inserting the punctal plugs are provided, as well as methods for preparing bioadhesive-coated punctal plugs. A method is also provided to treat dry-eye using a bioadhesive without use of a punctal plug.

Abstract: An absorbent article includes a topsheet, a backsheet, and an absorbent core disposed between the topsheet and backsheet; and a fastening system. The fastening system has a fastening component disposed on an article component. A plurality of layers overlap at least a portion of the fastening component in an overlapping region. The fastening component includes a first plurality of fastening elements integrally formed from a first set of layers and a second plurality of fastening elements integrally formed from a second set of layers.

Abstract: An evaporative bridge dressing that may be used with negative-pressure treatment of tissue. The evaporative bridge dressing may have one or more fluid transfer layers comprised of high-density wicking material enclosed between layers of film having high moisture-vapor transfer rates to reduce liquid storage and minimize pressure drop.

Abstract: In some non-limiting examples, a system for stimulating tissue growth at a tissue site may include a porous foam and a moisture barrier. The porous foam may include an exterior-facing surface, a tissue contact surface, and a plurality of struts positioned at the tissue contact surface. The plurality of struts may be configured to contact the tissue site and to create tissue deformation at the tissue site without the application of a reduced pressure. The moisture barrier may be configured to cover the exterior-facing surface of the porous foam and to trap moisture at the tissue site. Also provided are other systems, apparatus, and methods suitable for stimulating tissue growth.

Abstract: The present invention is directed to wall box for hemodialysis interface having two isolated zones. The first zone is a clean interface zone having sources of purified water and dialysis fluids. The second zone is a waste interface zone comprising waste connectors and a waste drain.

Abstract: A wound dressing according to certain embodiments includes an adhesive layer for adhering the wound dressing adjacent to a wound, a wound contact layer for contacting the wound, a backing layer comprising a port, a tube having a first end connected with the port and an opposite second end, a first fitting connected to the second end of the tube, the first fitting configured for connection with a second fitting of the negative pressure wound therapy system to apply a negative pressure via the port, and a filter disposed within the first fitting. In certain embodiments, the filter is formed of polyethersulfone (PESU) and has an average pore size of at least 2 microns.

Abstract: A dressing for treating a tissue site with negative pressure may comprise a first polymer film having a plurality of fluid restrictions, and a second polymer film comprising a plurality of standoffs disposed adjacent to the first polymer film. The first polymer film and the second polymer film may be substantially transparent to allow observation of the tissue site. In some embodiments, at least some of the standoffs may be offset from the fluid restrictions. The second polymer film may comprise fluid passages adjacent to the standoffs in some examples.

Abstract: A wound dressing includes a hydrophilic foam layer, a drape layer, superabsorbent projections, and printed indicators. The hydrophilic foam layer is configured to engage a wound bed and has a first side and a second side, the second side configured to face the wound bed. The drape layer has a first side and a second side, the second side configured to face the first side of the hydrophilic foam layer. The plurality of non-contiguous superabsorbent projections are fixed to and extend from the first side of the hydrophilic foam layer towards the second side of the drape layer. The one or more non-contiguous printed indicators surround one or more of the plurality of superabsorbent projections.

Abstract: The invention provides an apparatus for the generation and administration of a micro-nanobubble solution to a tissue, a method for the treatment of a tissue with a solution of micro-nanobubbles, and a kit for the treatment of tissue with micro-nanobubbles.