Abstract: A magnetic resonance imaging apparatus includes a collection unit which applies a uniform static magnetic field to a subject and also applies a radio-frequency magnetic field and a gradient magnetic field to the subject in accordance with a predetermined pulse sequence to collect a magnetic resonance signal from the subject, a imaging unit which images the subject based on the magnetic resonance signal collected by the collection unit, a detection unit which detects a respiratory level of the subject, an informing unit which informs the subject of whether the detected respiratory level falls within an allowable range, and a unit which controls the collection unit and the imaging unit in such a manner that the magnetic resonance signal for imaging is collected and the subject is imaged based on the thus collected magnetic resonance signal for imaging when the detected respiratory level falls within the allowable range.

Abstract: An ultrasonic probe that can be relatively easily manufactured and has a desired ultrasonic radiation surface. The ultrasonic probe includes: plural supporting materials, each having a principal surface on which plural signal wires are formed, the plural supporting materials arranged such that the principal surfaces are oriented in different directions from one another; plural groups of ultrasonic transducers, plural ultrasonic transducers in each group having plural electrodes formed on side surfaces, the plural electrodes respectively joined to the plural signal wires formed on the principal surface of the respective one of the plural supporting materials.

Abstract: An apparatus for accessing the lumen of a vessel. The apparatus includes a main body and a disposable cartridge. The main body includes a imaging device attachment, wherein the imaging device attachment is utilized to secure an image capturing instrument to the main body; a cartridge carrier coupled to the imaging device attachment, wherein the cartridge carrier is adjustable to achieve a target insertion depth; and a first motor coupled to the cartridge carrier, wherein the first motor adjust the cartridge carrier to achieve the target insertion depth. The disposable cartridge is attached to the cartridge carrier and houses a sheath, needle, or guidewire to be inserted into the vessel to the target insertion depth.

Abstract: An external ultrasound probe assembly capable of scanning a three-dimensional volume is provided. The ultrasound probe assembly contains a plurality of ultrasonic transducers disposed along a longitudinal axis of the probe assembly. The plurality of ultrasonic transducers is disposed on a mechanism operable to reciprocally pivot the plurality of ultrasonic transducers enabling the plurality of ultrasonic transducers to scan the entire three-dimensional volume. A helically disposed electrical interconnection member may be disposed about a pivot axis of the plurality of ultrasonic transducers and may electrically interconnect the plurality of ultrasonic transducers to an ultrasound imaging system. The ultrasound probe assembly may be fluid filled and contain bubble position control and fluid expansion compensation features.

Abstract: An apparatus for accessing the lumen of a vessel. The apparatus includes a reusable handheld device and a disposable cartridge. The reusable handheld device includes a imaging device attachment utilized to secure an image capturing instrument, an arm coupled to the imaging device attachment, and a depth scale coupled to the arm, wherein the depth scale provides a scale indicating an insertion depth. The disposable cartridge attaches to the reusable handheld device. The disposable cartridge includes a sheath, needle or guidewire coupled to the disposable cartridge. The sheath or needle extends to the insertion depth when fully advanced, thereby allowing the sheath, needle, or guidewire to access the lumen of a vessel.

Abstract: In general, in one aspect, the invention features a method that includes using an optical coherence tomography system to acquire a plurality of frames of a sample where each frame includes optical information about the composition of the sample through a section of the sample. The method further includes averaging over two or more of the frames to provide an image of the section of the sample where successive frames of the two or more frames are acquired with a time lapse of 0.05-0.7 seconds. Embodiments of the method may have unique advantages for endoscopic subcellular imaging. For example, they can enable subcellular imaging with low-NA optics (e.g., NA=0.25 or less) while providing morphological imaging of the underlying tissue up to 0.6 mm without focal tracking.

Abstract: Methods for imaging or optical sensing of a material are provided. A first fluorescent image or optical signal of a material can be recorded, the material can be perturbed, and then a second fluorescent image or optical signal of the material can be recorded. The two fluorescent images or signals can be subtracted to give a differential image or optical signal.

Abstract: A diagnostic imaging arrangement comprises a magnetic resonance examination (1) system to acquire magnetic resonance signals and an emission tomography system (2) to acquire nuclear decay signals. An analysis module (4) is provided to derive motion correction(s) from the magnetic resonance signals. A reconstruction module (5) reconstructs a motion corrected emission tomographic image from the nuclear decay signals on the basis of the motion correction. Also a therapeutic arrangement is disclosed with a diagnostic imaging arrangement and a therapy module, with a system controller is further coupled to the therapy module and has the function to control the therapy module on the basis of image information generated by the diagnostic imaging system.

Abstract: An ultrasound treatment includes applying ultrasound at a first energy level to a region of interest in a subject for activating a cavitation nucleation agent during a first portion of a treatment cycle. Ultrasound at a second energy level is applied to the region of interest during a second portion of the treatment cycle for implementing a desired thermal therapy in the presence of the cavitation nucleation agent activated during the first portion of the treatment cycle. The second energy level is at an energy level different from the first energy level.

Abstract: A method and apparatus for continuously measuring the absolute intracranial pressure in a non-invasive manner is described by using an ultrasonic Doppler device which detects the pulsatility indexes of the blood flow inside the eye artery for both intracranial and extracranial eye artery portions. The eye in which the blood flow is monitored is subjected to a small pressure, sufficient to equalize the pulsatility index measurements of the internal and external portions of the eye artery. The pressure at which such equalization occurs is used as a reference for autocalibration of the apparatus so that continuous absolute intracranial pressure measurements may be taken over a particular sampling period.

Abstract: Generally, a photoacoustic signal has a wavelength longer than a general ultrasonic signal. That is, it does not matter even if at the time of acquisition of the photoacoustic signal, an element pitch of a probe is several times as large as at the time of acquisition of the ultrasonic signal. Thus, at the time of acquisition of the photoacoustic signal, a plurality of neighboring elements in a receiving element array are collectively considered as one element, and a phasing process is performed. As a result, the same effect as a plurality of phasing addition circuits are disposed in parallel is obtained, and not only a phasing addition process of the photoacoustic signal but also image reconstruction can be performed in real time at a high speed.

Abstract: A radiopaque marker for inclusion within an implantable medical device (IMD) may comprise one or more radiopaque articles selected from a predetermined set of radiopaque articles. The one or more radiopaque articles may be carried by an object formed of or including, a desiccant. The predetermined set of radiopaque articles may undergo a single qualification process that approves the use of any combination of one or more of the articles as a radiopaque marker within an IMD. This allows a potentially-limitless number of markers to be made available based on a single qualification process. The radiopaque marker may serve to provide information such as the make, model, and feature set of the device.

Abstract: A system for examining a colon includes a catheter, such as a rectal catheter, having a proximal end, a distal end, and a central lumen extending from the proximal end to the distal end of the catheter, and a flexible tube coupled with the catheter. The system includes a first balloon located adjacent a distal end of the flexible tube, and a second balloon extending around the catheter and being located between the distal and proximal ends of the catheter, whereby the distance between the first and second balloons is adjustable by sliding the flexible tube through the central lumen of the catheter. The first and second balloons are inflatable for isolating a section of a colon, and a gas or contrast agent may be introduced into the isolated colon section for conducting the examination.

Abstract: A substrate configured for placement on an internal organ or internal tissue is provided. In certain embodiments, the substrate conforms to and moves with the internal organ or internal tissue. Three or more sensor elements are integrated on the substrate. In one implementation, the substrate and associated sensor elements provide dynamic referencing of the internal organ or internal tissue after registration of the sensor data with images and/or volumetric representations of the internal organ or internal tissue.

Abstract: A system includes an in vivo imaging device for imaging a blood vessel with a resolution level of at least fifty micrometers. The in vivo imaging device is capable of detecting a microcalcification in a fibrous cap of an atheroma. The system also includes a processor for receiving an image of the blood vessel from the in vivo imaging device. The processor uses the image to determine whether the blood vessel contains at least one microcalcification within the fibrous cap. In some embodiments, the processor is configured and arranged to predict a risk of rupture of the fibrous cap based, at least in part, on the presence of the at least one microcalcification. In some embodiments, treatment of a patient is based on the determination from the imaging whether the blood vessel includes at least one microcalcification within the fibrous cap of the atheroma.

Abstract: A procedure and kit are provided for performing an ultrasound-guided transversus abdominis plane (TAP) procedure. The patient's abdomen is scanned with an ultrasound probe to identify and mark the external oblique, internal oblique, and TAP. An introducer sheath is placed over a fluid delivery needle such that the distal end of the needle extends beyond the distal end of the sheath, the needle having echogenic properties for ultrasound imaging. The needle and sheath are ultrasonically guided into the TAP. A local anesthetic or saline/anesthetic combination is injected through the needle to create a liquid pool in the TAP. The needle is removed from the sheath while maintaining the sheath within the TAP and a catheter is subsequently advanced through the sheath and into the pooled liquid in the TAP. The sheath is withdrawn while maintaining the catheter located within the TAP.

Abstract: Beam enhancement through sidelobe reduction and/or mainlobe sharpening is shown. Embodiments utilize dynamic resolution, improved dynamic resolution, and/or enhanced dynamic resolution techniques to synthesize beams, such as ultrasonic beams used in ultrasonic imaging, having desired attributes. Embodiments simultaneously form a first sample beam and a second or auxiliary sample beam for every sample to synthesize enhanced scan beams. According to a dynamic resolution techniques herein a new beam may be formed from the sum of the two sample beams. A synthesized dynamic resolution beam of embodiments has reduced sidelobes with relatively little or no spread of the mainlobe. An enhanced dynamic resolution beam sharpening function can be applied to provide a further enhanced beam, such as to further narrow the mainlobe.

Abstract: An optical analyzer performing analysis excellent in spatial resolution and in invasion depth is provided.

Abstract: A method and system for ultrasound treatment are provided. Acoustic energy, including ultrasound, can serve as input energy to a mask with apertures, such apertures acting as secondary acoustic sources to create a modulated output acoustic energy in a treatment region and treatment effects. Under proper control output energy can be precisely placed and controlled in tissue. In some embodiments, methods and systems are configured for ultrasound treatment based on creating an output energy distribution in tissue. In some embodiments, methods and systems are configured based on creating an output temperature distribution in tissue.

Abstract: Surface selective photoacoustic (PA) medical imaging is introduced. Surface selective PA imaging is responsive to surface features and does not image sub-surface features, in contrast to conventional PA imaging. The surface PA signal can be considerably larger than the bulk PA signal, for an air-coupled (or gas-coupled) acoustic transducer. Distinguishing these two signals based on time of arrival at the transducer can further distinguish the two signals. This approach provides numerous advantages. Non-contact imaging simplifies and expedites imaging, and can serve as a replacement for visual inspection by physicians. Applications include skin screening and endoscopy.