Abstract: A prefilled syringe of a before-use mixing type not requiring a bypass portion defined by a recessed inner surface portion of an outer cylinder, including first and second gaskets (4,5) fitted in the outer cylinder (2), and non-rotatively and complementarily shaped engagement portions (12, 13) respectively at a front end of the first gasket (4) and a rear end of the second gasket (5) to reduce the period for transferring a liquid between two chambers separated by the gaskets. During storage, the engagement portions abut each other to be kept out of engagement with each other, whereby a drug containing space is defined between the gaskets. When a liquid is transferred from a space defined on a rear side of the first gasket (4) to the drug containing space, the internal pressure of the drug containing space is prevented from being excessively increased.

Abstract: The invention relates to an auto-injector for administering a dose of a liquid medicament (M), comprising of an elongate housing arranged to contain a syringe with a hollow needle and a bung for sealing the syringe and displacing the medicament (M), the elongate housing having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the housing; spring means capable of, upon activation, pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P) as well as operating the syringe to supply the dose of medicament (M); and activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.

Abstract: A thermal ablation system comprises a fluid handling unit receiving fluid from a fluid source at a first pressure, the fluid handling unit including a heater heating the fluid to a desired temperature and a pump and an introducer including a sheath which, when in an operative position, is received within a hollow organ, the sheath including a delivery lumen introducing fluid heated by the heater to the hollow organ and a return lumen withdrawing fluid from the hollow organ and returning the withdrawn fluid to the console via a return lumen, wherein the pump increases a pressure of the fluid between the fluid source and the delivery lumen of the introducer.

Abstract: A vascular introducer sheath includes a sheath body having an interior lumen for accommodating a dilator. The vascular introducer further includes a guidewire positioning means operatively associated with the interior lumen of the sheath body for directing a guidewire in either a vascular direction or an arterial direction within a venous system.

Abstract: A catheter having an internal advancing mechanism that can advance stiffening wires or other devices, has a catheter with a catheter body, a tip section distal the catheter body, a device extending through at least the catheter body, and a control handle proximal the catheter body, where the control handle has an advancing mechanism with a threaded member, an adjustment member, and a guided member to which the device is connected, and the advancing mechanism is configured to advance and retract the device along the catheter body as controlled by a user. Each of the threaded member and the adjustment member has a generally cylindrical configuration. The threaded member has an outer surface configured with a helical guide channel. The adjustment member is configured to guide the guided member to move within the helical guide channel to advance and retract the device. The adjustment member can be rotatable over the threaded member by the user to control advancement and retraction of the device.

Abstract: Balloon catheter includes an elongate tubular shaft having an outer tubular member having proximal and distal portions, and an inner tubular member having a distal length extending distally from the distal portion of the outer tubular member. The elongate tubular shaft has an inflation lumen and a guidewire lumen defined therein. The guidewire lumen extends along at least the distal length of inner tubular member. The balloon catheter also includes a distal end section coupled to a distal end of the inner tubular member and having a proximal end and a distal end. The balloon catheter also includes a balloon having a proximal portion sealingly coupled to the distal portion of the outer tubular member, a distal portion sealingly coupled to the distal end section, and a working length therebetween. The balloon defines an inner chamber. The proximal end of the distal end section is disposed within the inner chamber.

Abstract: A catheter includes a sheath insertable inside a body lumen and provided with a window portion permeable to inspection waves, a detection unit movable in the axial direction of the sheath inside the sheath and which detects the inspection waves, and a reinforcement tube positionable to cover the inner surface or the outer surface of the window portion and movable in the axial direction of the sheath.

Abstract: The present disclosure relates to a self-venting cannula assembly. The self-venting cannula assembly including an outer tube that defines a throughbore, an inner tube, a vent aperture, and a filter element. The inner tube is positioned within the outer tube, which defines a vent channel therebetween. The vent aperture is formed in the outer tube to provide fluid communication between the vent channel and an external environment. The filter element is positioned over the vent aperture and prevents particles having a dimension greater than about 0.2 microns from passing therethrough.

Abstract: An applicator comprising a transmission member, a housing guiding a reciprocation of the transmission member, and a cap covering the housing. The transmission member is provided with a stopper extending in a direction orthogonal to an axial direction thereof. An upper end of the housing is formed with a projection sliding the stopper. The inside of the cap is formed with a lead part. The stopper is slid by the lead part to an end part of the projection when the cap is pushed and thereafter disengages from the projection when the cap is further pushed, so that the transmission member transmits the biasing force of an elastic member to a microneedle. This enables the microneedle to be applied to skin.

Abstract: A projectile syringe has a barrel, a spring loaded power assembly with an attached plunger, a notched plunger shaft terminating in a knob and a breach plug secured to the barrel. The spring loaded power assembly has a cylindrical sleeve with four dissected fingers, two projections on the sleeve's outer cylindrical surface securing a compressed compression spring. A cylindrical weight is captured within the sleeve by four fingers. The user attaches a needle and draws a desired amount medicament. The plunger shaft is broken flush against the breech plug. The user attaches a stabilizing tail to the breech plug end and the projectile syringe is aimed at a target animal. Stopping the syringe displaces the cylindrical weight, allowing the four fingers to displace. The proximal projections move inward, allowing the compressed compression spring to expand to the fixed breech plug, pushing the piston to deliver medicament to the animal.

Abstract: A pumping unit for use in a device for expressing human breast milk comprises a breast shield for resting against a mother's breast and a dimensionally stable or approximately dimensionally stable milk collection container for receiving the expressed mother's milk. The breast shield comprises a first longitudinal center axis, and the milk collection container comprises a second longitudinal center axis, wherein the milk collection container is detachably attachable to the breast shield, and wherein in the attached state of the milk collection container the first longitudinal center axis is arranged at an angle to the second longitudinal center axis. In the attached state the milk collection container is movable relative to the breast shield, and consequently the angle between the first and second longitudinal center axes is variable. The pumping unit according to the invention can be designed in a compact and space-saving manner and is particularly suited to a hands-free arrangement.

Abstract: A treatment device is disclosed for treating an area within a biological pathway or space. The treatment device includes a catheter that has a first pair of dilation balloons and a second pair of dilation balloons configured to create a sealed treatment area within a vessel. Treatment fluids may be provided to the treatment area via a fluid lumen and fluid may be removed from the treatment area via the same fluid lumen or separate aspiration lumen.

Abstract: Drug delivery connectors are provided for permitting and blocking fluid flow between a container and a catheter connector or other drug delivery site. Embodiments of the drug delivery connectors include a ball valve for forming a releasable seal within the drug delivery connectors. In one or more embodiments, the ball valve prevents fluid flow between an open proximal end and an open distal end of the drug delivery connector and is movable in a proximal direction to release the releasable seal to permit fluid flow from the open proximal direction to the open distal direction. Methods of delivering medication to a catheter connector that includes an actuator are also provided.

Abstract: Embodiments directed to a degassing device for removing gas bubbles from a liquid drug stream and an ambulatory infusion system are disclosed. The degassing device may comprise an inlet chamber with an inlet opening, an outlet chamber with an outlet opening, and a degassing opening. A hydrophilic membrane and a hydrophobic membrane, wherein the hydrophilic membrane fluidically couples the inlet chamber with the outlet chamber, enabling a transfer of liquid from the inlet chamber to the outlet chamber. The hydrophobic membrane fluidically couples the inlet chamber with the degassing opening, enabling a transfer of gas from the inlet chamber to the degassing opening. The hydrophilic and hydrophobic membranes being joined along a joint to establish a joined membrane, such that a contact line of a liquid-gas phase separation on the joined membrane does not coincide with the joint independent of an orientation of the degassing device with respect to gravity.

Abstract: A device for use with an endotracheal tube. The device includes a shaft having a wall with a flexible region proximate a tip of the shaft. The shaft both distally and proximally of the flexible region is of a higher durometer than the durometer of the flexible region.

Abstract: A medical device control handle has with a distal component which is adjustable by an actuator assembly by means of a puller member or wire. The actuator assembly includes a user interface rotational dial, a detent tab washer and a spool, where the dial is rotationally coupled to the detent tab washer which transmits rotational movement of the dial to the spool. The spool has a shaft body and a drum end onto which an proximal end portion of the puller member can be wound to manipulate or adjust the distal component. Rotational movement of the detent washer is limited to prevent overrotation and breakage of the puller member. At least one washer is mounted on the shaft body of the spool to help apply compression load on the actuator assembly in friction-inducing contact with one or more components of the actuator assembly.

Abstract: A hub for a sheath, catheter, or other tubular device includes a first hub portion including a first hub lumen sized for receiving a medical device therethrough, and a second hub portion including a second hub lumen, the second hub portion coupled to the first hub portion such that the first and second hub lumens are aligned with one another and the first and second hub portions are spaced apart from one another to define a gap. A valve is secured within the gap between the first and second hub portions that includes a valve passage therethrough, e.g., for accommodating receiving a medical device through the first and second hub lumens into the tubular device, while providing a substantially fluid tight seal. For example, the valve passage may include a bore extending partially from a first end of the valve towards a second end of the valve, and a slit that extends from the end of the bore to the second end of the valve.

Abstract: According to the invention, a safety device for a pre-filled syringe comprises a hollow support body having a releasable mounting means adapted to mount a pre-filled syringe within the support body, a hollow outer body sildably arranged with respect to the support body and adapted to receive the support body and a release collar non-rotatably arranged within the support body. The release collar is movable relative to the support body and adapted to release the mounting means. A guide track is formed into at least one substantially planar side wall of the support body. The release collar comprises at least one flexible arm with a guide pin that extends from the flexible arm and protrudes through the guide track. The guide pin is movable within and along the guide track in a plane defined by the substantially planar side wall. A guide rail is formed into at least one substantially planar inner surface of the outer body.

Abstract: A liquid injector comprises a contact member comprising a tube body including an opening located at a distal end of the contact member; an inner structure body comprising: a cylindrical main body; and a hollow needle, wherein the inner structure body is movable to (i) a first position at which a needle tip is located proximal of the opening, and (ii) a second position at which the needle tip is located distal of the opening; and a regulating member detachably mounted on the inner structure body, including a fixing portion to be fixed to the contact member at the second position. When the inner structure body moves to the second position from the first position and returns to the first position again, the regulating member is fixed to the contact member with the fixing portion at the second position, separated from the inner structure body, and stays at a position at which the regulating member covers at least part of an area of the opening.

Abstract: A device for suctioning nasal secretions, including a nasal tip having an opening through which the nasal secretions are suctioned, a first pipe, a first end of which is connected to the nasal tip and the other end of which communicates via a first opening, and a second pipe, one end of which communicates via a second opening, and these two pipes form an angle no more than 90°, and the opening connected to the nasal tip is aligned with the second pipe and arranged with the air stream exiting the opening of the second pipe.