Abstract: This invention relates to heteropolyacids characterized by their comprising phosphorus as the heteroatom and molybdenum and/or tungsten at octahedral sites, some of the molybdenum and/or tungsten having been replaced with vanadium and at least one transition metal or main group cation, the vanadium and cation occupying the octahedral sites surrounding the phosphorus heteroatom in the heteropolyacid structure. This invention also concerns the use of these heteropolyacids as catalysts in the oxidation of n-butane to maleic anhydride.
Abstract: The present invention relates to novel oxazine ether derivatives of Formula I, to compositions containing them, to methods of using the compounds or compositions to control the growth of undesired vegetation and novel intermediates for their preparation. ##STR1## wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and Q are defined in the text.
Abstract: Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R is a C-17 side chain, R.sup.1 is --OH, .dbd.O, or the like, and X and Y are N, N.fwdarw.O, CH, C--OH, C--OCH.sub.3 or C--Z. Methods of using the compound of formula (I) or other novel oxysterol analogs to treat hypercholesterolemia are provided, as are pharmaceutical compositions containing the compounds.
Type:
Grant
Filed:
June 12, 1992
Date of Patent:
April 23, 1996
Assignee:
SRI International
Inventors:
Wesley K. M. Chong, Wan-Ru Chao, Dennis M. Yasuda, John G. Johansson, Mitchell A. Avery, Masato Tanabe
Abstract: A method of treating depression or stroke in a patient suffering therefrom by administering a substituted aminomethylchroman of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## and R.sup.1, E and F can be hydrogen or other radicals, or salts thereof.
Type:
Grant
Filed:
December 21, 1993
Date of Patent:
April 9, 1996
Assignee:
Bayer Aktiengesellschaft
Inventors:
Bodo Junge, Rudolf Schohe, Peter-Rudolf Seidel, Thomas Glaser, Jorg Traber, Ulrich Benz, Teunis Schuurman, Jean-Marie V. De Vry
Abstract: Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a physiological-hydrolyzable, ester-forming group. The physiologically hydrolyzable, ester-forming group useful in the penem compound of the present invention means a group which can be removed easily by in vivo hydrolysis, such as an acetyloxymethyl, 1-(acetyloxy)ethyl, pivaloyloxymethyl, 1-(ethoxycarbonyloxy)ethyl, 1-(isopropyloxycarbonyloxy)ethyl, 1-(cyclohexyloxycarbonyloxy)ethyl or 3-phthalidyl group. Antibiotic compositions for oral administration are also described.
Abstract: Phthalocyanine of formula (I), wherein M is a metal or is 2H, bonded at 29 and 31 positions shown, R.sub.1 to R.sub.8 are the same or different and are independently selected from C.sub.1 to C.sub.20 alkyl, C.sub.1 -C.sub.20 alkenyl, --X--COO--X.sup.1, --X--O--Y, a, and --X--COZ where X is independently selected from a chemical bond, (CH.sub.2).sub.n where n-0-20 or (CH.sub.2).sub.a CH--CH (CH.sub.2).sub.b where a and b are independently selected from 0-20 and a+b is in the range 0-20, X.sup.1 is independently selected from C.sub.1 -C.sub.20 alkyl or C.sub.2 -C.sub.20 alkenyl, Y is independently selected from C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.20 alkenyl or H and Z is selected from OH or NR.sup.1 R.sup.11 are independently selected from H, C.sub.1 -C.sub.20 alkyl and C.sub.2 -C.sub.20 alkenyl. These phthalocyanines may exhibit discotic liquid crystal phases, absorb infra-red radiation and make good Langmuir-Blodgett films.
Type:
Grant
Filed:
July 17, 1989
Date of Patent:
April 9, 1996
Assignee:
The Secretary of State for Defence in Her Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
Inventors:
Kenneth J. Harrison, Michael J. Cook, Andrew J. Thomson, Neil B. McKeown, Mervyn F. Daniel, Adrian J. Dunn
Abstract: A compound of the formula ##STR1## wherein R is=0 or ##STR2## and the rings A and B are selected from the group consisting of ##STR3## K is oxo or a protector group of oxo of the formula ##STR4## n is 2 or 3 and R.sub.1 is an ether or ester remainder, K' is oxo or a protector oxime, hydrazone or semicarbazone group and the wavy lines symbolize an isomer mixture, a process for their preparation and their use as intermediates.
Type:
Grant
Filed:
March 9, 1995
Date of Patent:
April 2, 1996
Assignee:
Roussel Uclaf
Inventors:
Jean Buendia, Remi Chauvin, Michel Vivat
Abstract: 7.beta.- 2-(aminothiazolyl and thiadiazolyl)-2-oxyiminoacetamido!cephalosporin derivatives having a 3- N-(optionally substituted) aminopyridiniumthiomethyl! substituent have antibacterial activity and are of use in antibacterial therapy. Processes for the preparation of such cephalosporins plus intermediates for use in the preparation thereof, including N-(optionally substituted)amino-thiopyridones, are also described.
Type:
Grant
Filed:
December 19, 1994
Date of Patent:
April 2, 1996
Assignee:
Pfizer Inc.
Inventors:
Clive L. Branch, Angela W. Guest, Richard G. Adams
Abstract: A compound selected from those of formula (I): ##STR1## in which A represents ##STR2## X represents N--R.sub.4 or oxygen, and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, n and m are as defined in the description,useful in improving glucose tolerance in the treatment of non-insulin-dependent diabetes.
Type:
Grant
Filed:
April 19, 1995
Date of Patent:
March 19, 1996
Assignee:
Adir et Compagnie
Inventors:
Jean-Jacques Godfroid, Aazdine Lamouri, Estera Touboul, Xuan Wang, Pierre Renard, Bruno Pfeiffer, Beatrice Guardiola
Abstract: A method for preparing cephalosporm derivatives by reacting cephalosporin alkaline metal salts with organic halide in the presence of quaternary ammonium salts catalyst is disclosed. .DELTA..sup.3 .fwdarw..DELTA..sup.2 isomerization, a side reaction commonly reported in preparation of cephalosporin derivatives was successfully eliminated. The desired .DELTA..sup.3 was obtained as a sole product in the reaction.
Type:
Grant
Filed:
April 20, 1994
Date of Patent:
March 12, 1996
Assignee:
Standard Chemical & Pharmaceutical Co., Ltd.
Abstract: New griseolic acid derivatives have various groups attached to the sugar part in place of the adenine group of griseolic acid itself. These groups are all purine derivatives or ring-opened purine analogs. The compounds are useful as inhibitors of phosphodiesterases.
Abstract: Cephalosporin compounds of the formula I ##STR1## are disclosed. The compounds are useful against MRSA/MRCNS. Compositions and methods of use are also included.
Type:
Grant
Filed:
July 20, 1994
Date of Patent:
March 12, 1996
Assignee:
Merck & Co., Inc.
Inventors:
Lovji D. Cama, Mary F. Sasor, Milton L. Hammond
Abstract: Compounds of the formula ##STR1## where Z, A, and R are as disclosed herein and pharmaceutically compatible, readily hydrolyzable esters and salts of these compounds are disclosed.The compounds have .beta.-lactamase inhibiting properties and are useful in the control of .beta.-lactamase-forming pathogens in combination with .beta.-lactam antibiotics. They also exhibit antibacterial activity of their own and can accordingly be used themselves in the control or treatment of infectious diseases.
Type:
Grant
Filed:
June 9, 1995
Date of Patent:
February 27, 1996
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Markus Bohringer, Christian Hubschwerlen, Philippe Pflieger, Jean-Luc Specklin
Abstract: A process for preparing hydroxygallium phthalocyanine comprising reacting a gallium trialkoxide and phthalonitrile or diiminoisoindoline in an alcohol solvent, preferably an alcohol having a boiling point of not lower than 150.degree. C., such as ethylene glycol, and hydrolyzing the resulting gallium phthalocyanine, preferably in an aqueous solution of an acid, such as sulfuric acid. The resulting hydroxygallium phthalocyanine exhibits stable electrophotographic characteristics, particularly photosensitivity, charging properties, and a dark decay rate.
Abstract: Crystalline acetoxymethyl and pivaloyloxymethyl esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo-[3.2.0] hept-2-ene-carboxylic acid can be obtained by adding a poor solvent to a solution of acetoxymethyl or pivaloyloxymethyl ester of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo-[3.2.0] hept-2-ene-carboxylic acid in a good solvent. The crystalline penem compounds obtained show improved stability and are useful antibacterial agents.
Abstract: Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked, by a non-ester linking moiety, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula: ##STR1## wherein (1) R.sup.3, R.sup.4, and R.sup.5, together with bonds "a" and "b", form any of a variety of lactam-containing moieties similar to those known in the art to have antimicrobial activity;(2) A, R.sup.6, R.sup.7, and R.sup.8 form any of a variety of quinolone or naphthyridine structures similar to those known in the art to have antimicrobial activity; and(3) Y, together with R.sup.5, form a variety of non-ester linking moieties between the lactam-containing moiety and the quinolone moiety.
Abstract: This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of the formula ##STR1## wherein R, R.sub.1 and A are as defined in claim 1. These compounds are useful to treat central nervous system disorders.
Abstract: 14-Deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and pharmaceutical compositions comprising same for treating cardiovascular disorders, such as heart failure and hypertension, are disclosed.
Abstract: The invention provides a novel class of 6-(isoxazolinyl)methyl penicillanic acid 1,1-dioxide compounds having the formula: ##STR1## wherein M, X, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are described in the specification;which exhibit activity as a .beta.-lactamase inhibitor.
Type:
Grant
Filed:
February 7, 1994
Date of Patent:
January 30, 1996
Assignee:
American Cyanamid Company
Inventors:
Carl Ziegler, Paul Fabio, Karen Bush, Deborah Steinberg
Abstract: This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of the formula I: ##STR1## wherein X is --(CH.sub.2).sub.n -- or --C(R.sub.1)(H)--; R is C.sub.1 -C.sub.8 alkyl; and R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8) alkynyl, aryl and benzyl.These compounds are useful to treat central nervous system disorders and are unexpectedly resistant to metabolism by the liver and have superior oral plasma bioavailability.
Type:
Grant
Filed:
October 28, 1993
Date of Patent:
January 23, 1996
Assignee:
The Upjohn Company
Inventors:
Chiu-Hong Lin, Susanne R. Haadsma-Svensson, Robert B. McCall, Arthur G. Romero, William H. Darlington, Michael D. Ennis