Abstract: The present disclosure relates to a system for generating a predefined electrical signal in an MR scanner for use in electrical stimulation of a subject during MRI or functional MRI of said subject, wherein said MR scanner is located inside a shielded MRI room. The system comprises a control unit to be located outside the MRI room for generating an electrical signal and an electrical to optical converter to be located outside the MRI room for converting said electrical signal to a corresponding optical signal. An optical transmitting element, such as an optical fiber, is used for transmitting the optical signal into the MRI room, and an optical to electrical converter is used for converting the optical signal to said predefined electrical signal for electrical stimulation of the subject during magnetic resonance imaging. The optical to electrical converter is configured for being located inside the MRI room and for operation during magnetic resonance imaging.

Abstract: A medical device with closed-loop responsive stimulation may include techniques to mitigate the impact on the therapy output of noise coupled into the medical device. A medical device according to this disclosure may determine the presence of noise and alter the closed loop policy to provide the necessary therapy to the patient and avoid prolonged under stimulation caused by the noise. The medical device may continue therapy, while testing for noise. When the device determines the noise level no longer affects the output therapy, the device may return the closed loop policy to a no-noise mode of operation. The medical device may also include techniques to mitigate the impact of manual adjustment while the medical device is subject to noise or is responding to changes in the patient's physiological signals.

Abstract: An electronic apparatus according to various embodiments of the present disclosure may comprise: a sensor unit for sensing the movement of the electronic apparatus; a communication unit for communicating with an external apparatus; an input unit for receiving a user input; an output unit for providing information to a user; and a control unit for outputting a message inducing a particular action to the user through the output unit on the basis of medical information of the user and the movement of the electronic apparatus, or controlling the communication unit to transmit information related to the electronic apparatus to an external apparatus.

Abstract: Techniques, systems, and devices are disclosed for delivering stimulation therapy to a patient. In one example, a medical device determines a first set of stimulation parameters that define entrainment stimulation pulses configured to entrain electrical activity in a patient. The medical device may control a stimulation generator to generate the entrainment stimulation pulses according to the first set of stimulation parameters. The medical device may further determine a second set of stimulation parameters that define at least one desynchronization stimulation pulse configured to disrupt at least a portion of the electrical activity entrained by the entrainment stimulation pulses. The medical device may subsequently control the stimulation generator to generate the desynchronization stimulation pulse(s) according to the second set of stimulation parameters.

Abstract: Implantable medical devices including interconnections having strain-relief structure. The interconnections can take the form of flexible circuits. Strain relief gaps and shapes are integrated in the interconnections to relieve forces in each of three dimensions. In some examples, the region of an interconnection which couples with a component of the implantable medical device is separated by a strain relief gap from a connection to a second component and/or a location where the flex bends around a corner.

Abstract: Disclosed herein are implantable medical devices (IMDs) including a receiver and a battery, and methods for use therewith. The receiver includes first and second differential amplifiers, each of which monitors for a predetermined signal within a frequency range and drains power from the battery while enabled, and while not enabled drains substantially no power from the battery. To remove undesirable input offset voltages, each of the differential amplifiers, while enabled, is selectively put into an offset correction phase during which time the predetermined signal is not detectable by the differential amplifier. At any given time at least one of the first and second differential amplifiers is enabled without being in the offset correction phase so that at least one of the differential amplifiers is always monitoring for the predetermined signal. In this manner, the receiver is never blind to signals, including the predetermined signals, sent by another IMD.

Abstract: A medical system for sensing a physiological state requiring defibrillation in a patient. The system comprising: a low power sensor, a physiological parameter measuring device, and a processor. The low power sensor generating a baseline signal relating to a physiological status of said patient. The physiological parameter measuring device comprising at least one higher power sensor configured to output at least one physiological parameter signal indicative of at least one physiological parameter of said patient. The processor assessing the baseline signal and determining if the physiological status is outside predetermined threshold boundaries.

Abstract: An ophthalmic phototherapy device and associated treatment methods to expose an eye to selected multi-wavelengths of light to promote the healing of damaged or diseased eye tissue. The device includes a housing having an interior; an eyepiece disposed on the housing and configured and arranged for placement of an eye of the patient adjacent the eyepiece; a first light source producing a first light beam having a first therapeutic wavelength and disposed within the housing; a second light source producing a second light beam having a second therapeutic wavelength and disposed within the housing, where the second therapeutic wavelength differs from the first therapeutic wavelength by at least 25 nm.

Abstract: Embodiments of the present disclosure provide techniques and configurations for an apparatus for opportunistic measurements and processing of user's context. In one instance, the apparatus may include a sensor module with sensors disposed on a work surface to maintain direct or indirect contact with portions of user's limbs for a time period when the portions of user's limbs are disposed on the work surface, to obtain readings of first and second parameters of user's context over the time period of the direct or indirect contact; and a processing module to process the readings of the first and second parameters, including to identify a first feature of the first parameter and a second feature of the second parameter that is temporally correlated with the first feature, and determine a third parameter of the user's context based on the identified first and second features. Other embodiments may be described and/or claimed.

Abstract: Physiological monitoring can be provided through a wearable monitor that includes two components, a flexible extended wear electrode patch and a removable reusable monitor recorder. The wearable monitor sits centrally on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline (or immediately to either side of the sternum) benefits extended wear by removing the requirement that ECG electrodes be continually placed in the same spots on the skin throughout the monitoring period. The wearable monitor can interoperate wirelessly with other physiology and activity sensors and mobile devices. An application executed by the sensor or device can trigger the dispatch of a wearable monitor to the patient upon detecting potentially medically-significant events. The dispatched wearable monitor would then be capable of providing precise medically-actionable data, not merely an alert that some abnormality may be present.

Abstract: Visual or photic stimuli generating methods, devices and control systems for inducing steady-state visual evoked potential (SSVEP) from human viewers without causing discomfort to the viewers or distorting the embedding images are disclosed. The control system includes a stimuli-generating device and an electroencephalography (EEG) sensing device. The stimuli-generating device includes a first and a second light source. The first light source generates a flickering light with a first wavelength while a second light source generates another flickering light with one or more wavelength(s) differ from that of the first one. Together, the light sources generate visual/photic stimuli flickering above their critical flicker fusion threshold while maintaining the colorfulness and hue of the embedding images. At least one electrode of the EEG sensing device is connected to each viewer, configured to receive and analyze his/her EEG signals in order to detect and determine his/her responses to the stimuli.

Abstract: A system and method for monitoring the health of an animal using multiple sensors is described. The wearable device may include one or more sensors whose resultant signal levels may be analyzed in the wearable device or uploaded to a data management server for additional analysis.

Abstract: A biological body state estimation device configured such that a homeostatic function level is sorted and acquired in plural stages by using a biological signal obtained from an upper body of a person and each stage of the homeostatic function level is plotted in time series in accordance with a time axis indicated on the lateral axis and displayed as a graph by a display. A highest part on the vertical axis of the graph can be displayed as a highly active state and a lowest part as a function decline state. Therefore, a state of fluctuation due to autonomous nerves as an attempt to maintain homeostasis, progress of a feeling of fatigue, and a state stimulated by activation of the brain can be captured as a periodic function. Moreover, a sleep prediction phenomenon can be captured.

Abstract: A system for detecting valvular malfunction includes a monitoring device and a processor. The monitoring device includes a heart sound sensor configured to detect heart sounds of the patient, and a signal processor. The processor is configured to receive a signal representative of the detected heart sounds from the signal processor, wherein the processor is configured to compare the signal to a baseline signal stored in memory. The processor may be part of the monitoring device or may be part of an external device, or both.

Abstract: A handheld device measures all vital signs and some hemodynamic parameters from the human body and transmits measured information wirelessly to a web-based system, where the information can be analyzed by a clinician to help diagnose a patient. The system utilizes our discovery that bio-impedance signals used to determine vital signs and hemodynamic parameters can be measured over a conduction pathway extending from the patient's wrist to a location on their thoracic cavity, e.g. their chest or navel. The device's form factor can include re-usable electrode materials to reduce costs. Measurements made by the handheld device, which use the belly button as a ‘fiducial’ marker, facilitate consistent, daily measurements, thereby reducing positioning errors that reduce accuracy of standard impedance measurements. In this and other ways, the handheld device provides an effective tool for characterizing patients with chronic diseases, such as heart failure, renal disease, and hypertension.

Abstract: This disclosure describes a remote patient monitoring system configured to monitor one or more patient parameters via one or more monitoring apparatuses for transmitting patient data to a remote, central data-processing facility via a network. The system further includes an interactive voice recognition (“IVR”) system and mobile interfaces for health data collection and transmission via direction communication with the patient. According to embodiments, with the information received from the patient monitoring system, one or more scored indicative of a patient's health status is calculated. The scores are compared to threshold values and, based on the comparisons, further action is taken. For example, a medical caregiver can evaluate the patient's condition, including the effectiveness of the drug therapy, patient compliance, whether the patient's condition is improving, whether the patient requires hospitalization or an office consultation to prevent the condition from getting worse, etc.

Abstract: A method and system for determining a signal quality metric of a cardiovascular time series utilizing a wireless sensor device are disclosed. In a first aspect, the method comprises determining subsequent values of the cardiovascular time series and comparing the determined subsequent values to a threshold value. In a second aspect, a wireless sensor device comprises a processor and a memory device coupled to the processor, wherein the memory device includes an application that, when executed by the processor, causes the processor to determine subsequent values of the cardiovascular time series and compare the determined subsequent values to a threshold value.

Abstract: A system includes an input to receive at least one electrophysiological signal representing cardiac electrical activity measured from a body surface of a patient. The system also includes a signal processor to analyze the at least one electrophysiological signal and compute a score having a value to indicate a likelihood of arrhythmogenic activity, the score being computed as a function of at least two of cycle length, amplitude and polarity of the at least one signal.

Abstract: This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond at the full-width-half-maximum. This treatment may prevent at least growth of the lesion.

Abstract: A method for managing bradycardia through vagus nerve stimulation is provided. An implantable neurostimulator configured to deliver electrical therapeutic stimulation in both afferent and efferent directions of a patient's cervical vagus nerve is provided. An operating mode is stored, which includes parametrically defining a maintenance dose of the electrical therapeutic stimulation tuned to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. The maintenance dose is delivered via a pulse generator through a pair of helical electrodes via an electrically coupled nerve stimulation therapy lead independent of cardiac cycle. The patient's physiology is monitored, and upon sensing a condition indicative of bradycardia, the delivery of the maintenance dose is suspended.