Abstract: An autoinjector for dispensing a liquid product includes a housing; a product container arranged in the housing, particularly, a syringe comprising a displaceable piston; a drive member; a first spring which acts on the drive member and the piston to dispense the product from the container; a signal element releasably axially coupled with the drive member so that the signal element is transported in the dispensing direction as the drive member is displaced; and a second spring, which exerts a spring force on the signal element against the dispensing direction and is tensioned as the signal element is transported in the dispensing direction. When the signal element is released or detached from the axial coupling, the second spring causes the signal element to accelerate opposite the dispensing direction and strike against a signal stop and generate an acoustic and/or tactile signal.

Abstract: A percutaneous connection device to be fixed in an osseous structure of a patient to connect an internal entity located inside the body of the patient to an entity external to said body, the device comprising a percutaneous socket having a first end comprising a percutaneous abutment and a second end opposite to the first end, an elongated extension member designed to be inserted within a hole created into the osseous structure, said extension member having a first end to be removably coupled to the second end of the socket and a second end opposite to the first end, an anchoring mechanism for anchoring the device to the osseous structure by osseointegration and a separate connection running through the device from the first end of the percutaneous socket to the second end of the extension member, and comprising at least a first connector arranged within the percutaneous abutment.

Abstract: There is provided a computer-implemented method for controlling dispensing of at least one biologically active agent in intermittent doses over discrete predefined time periods, comprising the steps of: (i) initiating the dispensing of the biologically active agent in intermittent doses at a first background dosage rate; and (ii) adjusting to a background dosage rate according to the number of input signals received over each predefined time period from a signalling device.

Abstract: Provided is a liquid delivering pump which can determine whether the pump is suitable for use, while in a standby state, and thus, the pump can be efficiently managed and utilized. A liquid delivering pump which delivers a drug to the inside of a living body includes a storage unit that stores a drug library, a starting state switching unit that switches a starting state of the liquid delivering pump between a liquid deliverable state and a standby state, and a display unit that displays various types of information related to the liquid delivering pump. The display unit displays specification information which specifies the drug library stored in the storage unit, while in the standby state.

Abstract: A syringe containing a high water content product and for use in a drug infusion system is provided. The syringe includes a plunger carrying front and rear o-rings made of a diene rubber compound such as chlorobutyl rubber or bromobutyl rubber to impart very low gas permeability characteristics to the o-rings. The plunger may be molded as a single part or in two parts. If molded as one part with radially-engaging mold portions, the seal glands in the plunger may include parting lines from the mold. If molded as two parts with axially-engaging mold portions, the front seal gland may include a sealing surface and under cut that has no parting line. The o-rings may be surface treated with a lubricant to improve sealing where the molding process gives rise to parting lines in the seal glands.

Abstract: A method for delivering multiple substances in a delay fashion to a bone of a patient is provided. The method includes providing a cannulated bone screw, creating an aperture in the skin of a patient, and inserting the bone screw into a bone of the patient through the aperture. The method further includes delivering a first substance into the bone through the bone screw, wherein the first substance changes over time into a solid hardened material, and then delivering a second substance into the bone through the bone screw after the first substance changed into a solid hardened material. The solid hardened material of the first substance may be a permeable material that allows the second substance to transport through, or the second substance may transport through the first substance by diffusion, or may reach a desired location in the bone through pores or cracks in the hardened solid material.

Abstract: A medicinal xiding vial, and a dispensing apparatus and an injection apparatus thereof, comprise a reversely pressed medicinal xiding vial, a reversely pressed dispensing apparatus and a reversely pressed injection apparatus thereof, a general medicinal xiding vial, and a general injection apparatus. The reversely pressed medicinal xiding vial comprises a vial body whose inner wall is a straight cylinder. A first piston is disposed on a position close to the vial opening of the vial body. A blind hole is disposed at the center of an outer bottom surface of the first piston. The vial opening is provided with an outer edge, and a seal cap is fixed on the out edge to prevent the first piston from falling off. In combination with the dispensing apparatus and the injection apparatus thereof, the medicinal xiding vial can solve the problem of secondary pollution during medicine dispensing and injection.

Abstract: Constriction valves for catheters and method of using constriction valves are presented. The catheter valve has a conduit defining a lumen. The catheter also has a spring that is configured to bias the lumen from an open position to a closed position by altering an effective length of the conduit or altering the circumference of the conduit. The spring is further configured to change its configuration by changes of intraluminal pressure of the valve. A user can insert a tool into a catheter having a valve by manipulating the valve to expand a substantially closed lumen by compressing the spring, twisting the spring, or pulling on a cord coupled with the valve.

Abstract: An infusion adapter for connection with an infusion fluid container includes a connection portion including an anchor component for connecting to an injection port of the infusion fluid container, and a first port adapted for connection with a syringe assembly containing a medication fluid. The first port is in fluid communication with the connection portion. The anchor component is configured to securely connect the infusion adapter to the infusion fluid container to substantially prevent disconnection of the infusion adapter from the infusion fluid container once the infusion adapter is connected to the infusion fluid container.

Abstract: A method for treating a subject diagnosed with a cancer or other disorder comprising a hyperproliferative tissue is described herein. The method includes localized delivery of a material which contains a therapeutically effective agent and/or moiety. The localized delivery of the agent is achieved using a catheter-based delivery system and an implant. An implant can include a support component, a cover component, and a valve component. The valve component can be operable to permit flow through the implant. The implant can be delivered on a catheter, with one of the ends of the implant being selectively expanded to permit temporary occlusion of a vessel while delivering a material through the valve component to a downstream target region. The other end of the implant can thereafter be released such that the implant occludes the vessel, or the implant can be removed from the vessel entirely.

Abstract: This disclosure relates to medical fluid pumping systems and related devices and methods. In some aspects, a medical fluid pumping system includes a medical fluid pumping machine including a piston head that can be linearly displaced and a medical fluid cassette that can be secured to the medical fluid pumping machine. The medical fluid cassette includes a fastening member attached to a region of a flexible membrane overlying a fluid pump chamber, and the piston head is configured to be mechanically connected to the fastening member of the cassette.

Abstract: A catheter management system comprises several layers where a top layer has one or more channels to receive one or more elongated medical devices or members and a bottom layer comprises adhesive to secure the catheter management system to a patient or other secure site in the operating field. A firm upper surface causes the elongated medical devices or members to stay in the channels, whereas a firm inner layer facilitates maintaining the shape of the catheter management system and providing resistance for an operator to easily release an elongated medical device or member.

Abstract: A drug delivery device is provided. In an embodiment, the device includes a device body having an elongated drug reservoir lumen, a drug positioned in the drug reservoir lumen, and at least one end plug positioned at an end of the device body, for example inserted in an end of the drug reservoir lumen. The end plug may include an aperture therethough, and the drug delivery device may be configured to release the drug from the drug reservoir lumen through the aperture.

Abstract: A pressure activated valve for controlling the flow of fluid through a medical device, the pressure activated valve comprises a housing including a lumen extending therethrough and a flow control membrane extending across the lumen of the housing to control the flow of fluid through the lumen by opening when a pressure threshold has been reached.

Abstract: A catheter is disclosed which has at least a two-layered structure and can suppress decrease in function thereof by suppressing the disorder at an interface between layers during use, and a method for manufacturing the same. The catheter has an inner layer as a tube shaped body made of a thermoplastic resin and an outer layer, as a tube shaped body made of a thermoplastic resin, coming into contact with the outer surface of the inner layer, and has a reinforcement member which is at least partially embedded in the inner layer and includes a gap leading the inner layer toward the radial outside of the catheter. The inner layer has a protrusion which extends in an axial direction of the catheter while protruding from the gap to the radial outside, is positioned on the radial outside of the reinforcement member, and ingrows into the outer layer.

Abstract: The various embodiments herein relate to a boosting catheter for positioning through a conventional guiding catheter into the vasculature of a patient, the boosting catheter having a distal tubular member and a proximal elongated shaft coupled to the distal tubular member.

Abstract: A needle tip assembly for a pre-loaded syringe or a pen needle injection device. The needle tip assembly includes a body comprising a double-ended needle and being installable and removable from the pre-loaded syringe or pen needle injection device. A needle cap is configured to cover a skin puncturing end of the double-ended needle and is removable to exposed the skin puncturing end. An outer cover is structured and arranged to at least install the body onto the pre-loaded syringe or pen needle injection device and remove the body from the pre-loaded syringe or pen needle injection device after the outer cover is re-installed. The body is lockable to the outer cover upon one of re-installation of the outer cover and prior to the body being removed from the pre-loaded syringe or pen needle injection device.

Abstract: A cartridge, which may be suitable for use as a portion of a transdermal drug delivery apparatus, may include a body at least partially defining an interior for containing fluid for being delivered by the transdermal drug delivery apparatus. The body may also at least partially define first and second openings to the interior of the body, wherein the first and second openings are respectively proximate opposite first and second ends of the body. The cartridge may also include a self-sealing member at least partially closing the first opening, and a movable member at least partially closing the second opening, wherein at least a portion of the movable member is for being urged into the interior of the body for increasing pressure within the interior of the body.

Abstract: Provided is a syringe pressure generating and pressure displaying device applied to a syringe configured such that an auxiliary device is detachably attached to the cylinder flange while the rod bar is installed in the auxiliary device so as to pass therethrough, and a grip of the hand on a lever that is hinge-connected to the auxiliary device so as to be disposed horizontally in line with the syringe creates a rotational motion due to leverage, whereupon the rotational motion is converted into a linear motion via a motion-converting means, and the rod bar and the piston are moved with increased force.

Abstract: A method and apparatus for injecting saline into an open cavity of a patient's body, and, alternatively, vacuuming fluids from said cavity, during laparoscopic surgery that provides constant feed and amplified pressure to provide a steady fluid output, in a disposable, single use handheld surgical device. The apparatus has a pump portion that includes a vacuum powered pump motor with a spring-biased valve.