Patents Examined by Nina Archie
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Patent number: 7851605Abstract: Disclosed is a recombinant vaccine for porcine atrophic rhinitis. A vaccine is provided which uses a Pasteurella multocida (D:4) outer membrane protein H. The vaccine uses a small size of peptides, so that it exhibits a remarkable activity. In addition, it is possible to provide a vaccine that can be applied in the body through a variety of routes.Type: GrantFiled: October 24, 2007Date of Patent: December 14, 2010Assignee: Sungkyunkwan University Foundation for Corporate CollaborationInventors: Moo Sik Kwon, Woo Seok Shin, Bo Ram Han
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Patent number: 7851170Abstract: Hybridoma cell lines which produce and secrete monoclonal antibodies which selectively bind to Mycobacterium avium subspecies paratuberculosis have been produced. Cells of M. avium subspecies paratuberculosis in biological samples may be detected and quantified by contacting the sample with the antibodies to form a M. avium subspecies paratuberculosis/antibody immunocomplex when M. avium subspecies paratuberculosis is present, which immunocomplex may then be detected. The monoclonal antibodies also may be incorporated into kits for the detection and quantification of M. avium subspecies paratuberculosis.Type: GrantFiled: December 17, 2008Date of Patent: December 14, 2010Assignee: The United States of America as represented by the Secretary of AgricultureInventor: John P. Bannantine
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Patent number: 7851198Abstract: Disclosed is a novel L-lysine-inducible promoter nucleic acid molecule. Also disclosed are a vector containing the nucleic acid molecule, a host cell transformed with the vector, and a method of inducing expression of a target gene using the L-lysine-inducible promoter nucleic acid molecule.Type: GrantFiled: December 30, 2005Date of Patent: December 14, 2010Assignee: CJ Cheiljedang CorporationInventors: Young Hoon Park, Hyun Min Koo, Jun Ok Moon, Seong Jun Kim, Hyo Jin Kim, Jung Kee Lee
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Patent number: 7807803Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.Type: GrantFiled: July 3, 2003Date of Patent: October 5, 2010Assignee: Coley Pharmaceutical Group, Inc.Inventor: Arthur M. Krieg
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Patent number: 7794736Abstract: The present invention provides vectors that contain and express in vivo Leishmania KMP11 or an epitope thereof that elicits an immune response in a dog against Leishmania, compositions comprising said vectors, methods of vaccination against Leishmania, and kits for use with such methods and compositions.Type: GrantFiled: November 19, 2007Date of Patent: September 14, 2010Assignee: Merial LimitedInventor: Laurent Bernard Fischer
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Patent number: 7790184Abstract: The invention provides methods for identifying a compound that inhibits cytochrome c synthesis. This invention further provides a method for the high throughput screening of compounds that inhibit cytochrome c synthesis.Type: GrantFiled: July 31, 2007Date of Patent: September 7, 2010Assignee: Washington University in St. LouisInventor: Robert Kranz
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Patent number: 7745598Abstract: The present invention provides an adjuvant, which includes at least one single strand deoxynucleotide containing a CpG dinucleotide. The single strand deoxynucleotide comprises one or more CpG dinucleotides. When used in combination with rabies vaccine, HBV vaccine or other vaccines, the adjuvant can significantly improve the immune effect of the vaccine.Type: GrantFiled: December 5, 2008Date of Patent: June 29, 2010Assignee: Changchun Huapu Biotechnology Co., Ltd.Inventors: Liying Wang, Musheng Bao, Yongli Yu
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Patent number: 7741437Abstract: Substantially purified salivary P. ariasi and P. perniciosus polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the P. ariasi and P. perniciosus polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating or preventing Leishmaniasis are disclosed.Type: GrantFiled: September 18, 2003Date of Patent: June 22, 2010Assignees: The United States of America as represented by the Department of Health and Human Services, Merial LimitedInventors: Jesus G. Valenzuela, Jose M. C. Ribiero, Shaden Kamhawi, Yasmine Belkaid, Laurent Fischer, Jean-Christophe Audonnet, Francis Milward
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Patent number: 7741098Abstract: Plasmid vectors for expression in Caenorhabditis elegans harbouring a heat inducible promoter nucleotide sequence, a synthetic intron nucleotide sequence optionally containing a Shine-Dalgarno sequence for efficient shuttling between C. elegans and E. coli, optionally a nucleotide sequence coding for a nuclear localisation signal or secretion signal, a nucleotide sequence coding for a recognizable tag, optionally a nucleotide sequence coding for a fluorescent protein, a nucleotide sequence coding for a protease cleavage site, a multiple cloning site containing a nucleotide sequence coding for an eukaryotic, such as human, protein or a nucleic acid molecule and a nucleotide sequence coding for termination of translation, are described. Methods of particularly large scale production of eukaryotic, such as human, proteins and nucleic acid molecules in nematodes are also described.Type: GrantFiled: November 26, 2002Date of Patent: June 22, 2010Assignee: neXyte ABInventors: Uwe H Sauer, Simon Tuck
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Patent number: 7727734Abstract: This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the ectoparasite itself or may have been introduced into the ectoparasite because of its blood feeding activity. The method of the present invention comprises collecting from the enclosure or area, a sample comprising environmental dust or materials and subjecting the sample to tests for detecting the presence of hematophagous ectoparasitic markers, host markers or both.Type: GrantFiled: July 27, 2006Date of Patent: June 1, 2010Assignee: CytoSignet, Inc.Inventor: Nathan L. Smith
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Patent number: 7722890Abstract: The present invention provides methods of making and using immunogenic oligosaccharide compositions comprising native O-linked and S-linked oligosaccharides coupled to a protein carrier, wherein the resultant conjugate elicits a protectively immunogenic response. These compositions may be useful in vaccines against pathogenic Candida species.Type: GrantFiled: April 25, 2003Date of Patent: May 25, 2010Assignee: Theracarb, Inc.Inventors: David R. Bundle, Mark Nitz, Jim E. Cutler
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Patent number: 7722879Abstract: The invention relates to Babesia proteins of a 28kDa protein family and to immunogenic fragments of such proteins, to nucleic acids encoding such proteins or fragments, to cDNA fragments, recombinant DNA molecules, live recombinant carriers, or host cells comprising such nucleic acids, to vaccines, to methods for the preparation of such vaccines, to the use of such proteins or fragments for the prophylactic or therapeutic treatment of an infection or its clinical signs caused by an organism of the family Babesiidae, and to diagnostic tests for detection of nucleic acids, antibodies or antigens of an organism of the family Babesiidae.Type: GrantFiled: July 12, 2004Date of Patent: May 25, 2010Assignee: Intervet International B.V.Inventors: Bernard Piere Dominique Carcy, Andre Francois Gorenflot, Theodorus Petrus Maria Schetters, Prisca Laetitia Cibrelus, Karina Moubri, Delphine Depoix
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Patent number: 7709001Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 3 polysaccharide covalently linked to a carrier protein, the method including periodic acid oxidation of the polysaccharide in the presence of bivalent cations.Type: GrantFiled: December 22, 2006Date of Patent: May 4, 2010Assignee: Wyeth LLCInventors: William P. Hausdorff, George Rainer Siber, Peter R. Paradiso, A. Krishna Prasad
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Patent number: 7691971Abstract: Use of a novel vaccine antigen applied in a preventive or therapeutic way against diseases in general, being such disease of bacterial, viral, cancer related, or other origin. The technical objective that this invention pursues is the development of formulations with the ability to increase the protective spectrum of existing vaccines and hence expanding it against different pathogens. In order to achieve this goal the NMB1125 protein was isolated and identified as a component of outer membrane preparations of Neisseria meningitidis capable of inducing bactericidal activity. Additionally, the gene codifying for NMB1125 protein was cloned and expressed, and the said polypeptide was purified and its immunogenicity evaluated in animal models. The sequence data from homologous genes showed, due to the high degree of conservation, its high value as a target antigen of a cross-reactive response when it is presented by different routes.Type: GrantFiled: December 2, 2004Date of Patent: April 6, 2010Assignee: Centro Ingenieria Genetica Y BiotecnologiaInventors: Rolando Pajon Feyt, Enrique Guillen Nieto Gerardo, Gretel Sardinas Garcia, Nunez Lazaro Hiram Betancourt, Serra Lila Rosa Castellanos, Negrin Yasser Perera, Diaz Darien Garcia, Perez Olivia Niebla, Menendez Evelin Caballero, Blanco Sonia Gonzalez
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Patent number: 7659059Abstract: The present invention relates to a method for detecting and/or identifying bacteria of the genus Staphylococcus, comprising the following steps: A. the nucleic acid material of the bacteria of the genus Staphylococcus is extracted, B. at least one target sequence of the nucleic acid material of the bacteria of the genus Staphylococcus is amplified using at least one amplification primer comprising at least 10 nucleotide motifs of SEQ ID No. 1 and/or at least one amplification primer comprising at least 10 nucleotide motifs of SEQ ID No. 2, in order to obtain amplicons of the target sequence, C. the presence of bacteria of the genus Staphylococcus is determined by detecting said amplicons.Type: GrantFiled: July 8, 2004Date of Patent: February 9, 2010Assignee: BiomerieuxInventors: Alain Troesch, Bruno Lacroix, Corinne Jay
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Patent number: 7655413Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.Type: GrantFiled: June 28, 2004Date of Patent: February 2, 2010Assignee: Lifesensors, Inc.Inventors: Tauseef R. Butt, Oxana A. Malakhova, Michael P. Malakhov
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Patent number: 7625707Abstract: A method of identifying a molecule capable of inducing death of a bacterial cell which includes exposing toxin and antitoxin polypeptides of a toxin-antitoxin pair produced by the bacterial cell to a plurality of molecules, and identifying a molecule of the plurality of molecules capable of preventing or disrupting binding between the antitoxin and said toxin polypeptides, thereby identifying the molecule capable of inducing death of the bacterial cell.Type: GrantFiled: September 27, 2004Date of Patent: December 1, 2009Assignee: Ramot At Tel Aviv University Ltd.Inventors: Ehud Gazit, Izhack Cherny
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Patent number: 7622121Abstract: The present invention is directed to heat shock proteins from Mycobacterium leprae as well as their encoding polynucleotides and vectors and host cells containing these polynucleotides. These heat shock proteins and their encoding polynucleotides are useful in detection of Mycobacterium leprae. In addition, the heat shock protein can be used as an adjuvant in a pharmaceutical composition containing an antigen to induce or enhance the immune response against the antigen. Further, the heat shock protein may be used to treat atopic conditions or as a vaccine against Mycobacterium leprae. Alternatively, the heat shock protein can be used to form a fusion protein with an antigen to induce or enhance the immune response against the antigen.Type: GrantFiled: September 19, 2006Date of Patent: November 24, 2009Assignee: New York UniversityInventors: William R. Levis, Frank T. Martiniuk
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Patent number: 7585936Abstract: The invention provides a peptide having at least about 75% amino acid homology with the sequence shown in SEQ ID No: 2. The peptide of the invention also can include an amino acid homology with the sequence shown in SEQ ID No: 2 corresponding to at least about 80%, at least about 85%, at least about 90% or can include the amino acid sequence shown in SEQ ID No: 2. The peptide of the invention can further include an amino acid sequence selected from the sequences shown in SEQ ID Nos: 1, 3 or 4-6.Type: GrantFiled: October 22, 2004Date of Patent: September 8, 2009Assignees: Queensland University of Technology, Dairy Australia LimitedInventors: Mark S. Turner, Philip M. Giffard
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Patent number: 7582459Abstract: A method for producing a polysaccharide and a conjugate vaccine including the polysaccharide produced according to the method. A characteristic step in the method is that the pH of the culture medium is kept at a constant value with base or acid until adjustment with respectively base or acid is not possible anymore. Using the method, capsular polysaccharide may be obtained in a high yield in a relatively short time. The method is straightforward, reproducible and cost-effective.Type: GrantFiled: September 10, 2004Date of Patent: September 1, 2009Assignee: De Staat der Nederlanden, vert. door de minister van VWSInventors: Ahd Hamidi, Michel Francois Beurret