Patents Examined by Nissa M Westerberg
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Patent number: 11007183Abstract: The present invention provides, inter alia, methods, kits, and compositions for treating or ameliorating the effects of a cancer in a subject in need thereof. This method includes administering to the subject an effective amount of (i) a first anti-cancer agent, which is BVD-523 or a pharmaceutically acceptable salt thereof and (ii) a second anti-cancer agent, which is an inhibitor of the PI3K/Akt pathway or a pharmaceutically acceptable salt thereof. Also provided are methods of treating or ameliorating the effects of a subject with cancer in which the subject has a somatic KRAS and a somatic PIK3CA mutation or in which the cancer is refractory to a therapy selected from RAF inhibitor therapy, MEK inhibitor therapy, and RAF and MEK inhibitor therapy.Type: GrantFiled: December 19, 2014Date of Patent: May 18, 2021Assignee: BIOMED VALLEY DISCOVERIES, INC.Inventors: Saurabh Saha, Dean Welsch, Gary DeCrescenzo, Jeffrey James Roix
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Patent number: 11007184Abstract: The present invention provides, inter alia, methods, kits, and pharmaceutical compositions for treating or ameliorating the effects of a cancer in a subject in need thereof. The method includes administering to the subject an effective amount of (i) a first anti-cancer agent, which is BVD 523 or a pharmaceutically acceptable salt thereof and (ii) a second anti-cancer agent, which is a type 2 MEK inhibitor, or other MEK inhibitors, or pharmaceutically acceptable salts thereof, to treat or ameliorate the effects of the cancer. Additional methods for effecting cancer cell death are also provided.Type: GrantFiled: December 19, 2014Date of Patent: May 18, 2021Assignee: BIOMED VALLEY DISCOVERIES, INC.Inventors: Saurabh Saha, Dean Welsch, Gary DeCrescenzo, Jeffrey James Roix
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Patent number: 11000461Abstract: A method of combatting colour loss from a dyed material, the method comprising contacting the material with a composition comprising an alpha-substituted aldehyde.Type: GrantFiled: April 21, 2017Date of Patent: May 11, 2021Assignee: Innospec LimitedInventors: Nicholas John Dixon, Matthew Robert Giles, Kimberley Elizabeth Griffiths, Tony Gough, Ian Malcolm McRobbie
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Patent number: 10994998Abstract: The invention relates to hardenable ceramic bone substitute compositions having improved setting, powders for such compositions and methods for their manufacture and use in medical treatment. More specifically the invention relates to hardenable bone substitute powder and hardenable bone substitute paste with improved setting properties, comprising calcium sulfate and heat-treated hydroxyapatite (passivated HA), which bone substitute is suitable for treatment of disorders of supportive tissue such as bone loss, bone fracture, bone trauma and osteomyelitis.Type: GrantFiled: May 16, 2018Date of Patent: May 4, 2021Assignee: BONE SUPPORT ABInventors: Kristina Caroline Victoria Ehrenborg, Veronica Rebecca Sandell, Eva Christina Lidén
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Patent number: 10967062Abstract: Certain embodiments of the present invention provide functionalized nanoparticles and methods of use thereof. Certain embodiments provide nanoparticles functionalized with streptokinase. Certain embodiments of the present invention provide methods for treating a pathological fibrin associated disorder (e.g., cancer) in an animal.Type: GrantFiled: December 13, 2017Date of Patent: April 6, 2021Assignee: Regents of the University of MinnesotaInventors: Jayanth Panyam, Tanmoy Sadhukha, Ameya Kirtane
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Patent number: 10952434Abstract: Disclosed are compositions for attracting insects (e.g., harmful or troublesome insects such as blood-sucking and biting insects, ticks and mites) to an object (e.g., insect trap) or area (e.g., field, orchard). Also disclosed are methods for attracting insects involving treating (or exposing) the object or area with a composition containing compounds described herein (e.g., a pro-fragrance compound selected from the group consisting of an acetal, a ketal, hemiacetal and mixtures thereof, wherein at least one of a parent aldehyde, ketone, or alcohol of the pro-fragrance acetal or ketal is a fragrance compound), and optionally a carrier or carrier material.Type: GrantFiled: December 28, 2017Date of Patent: March 23, 2021Assignee: The United States of America, as represented by the Secretary of AgricultureInventor: Kamlesh R. Chauhan
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Patent number: 10905775Abstract: Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.Type: GrantFiled: May 29, 2013Date of Patent: February 2, 2021Assignees: Celator Pharmaceuticals, Inc., The Trustees of Princeton UniversityInventors: Lawrence D. Mayer, Robert K. Prud'homme, Christine J. Allen, Walid S. Saad
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Patent number: 10881656Abstract: The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.Type: GrantFiled: February 14, 2017Date of Patent: January 5, 2021Assignee: THE GENERAL HOSPITAL CORPORATIONInventors: Othon Iliopoulos, Michael Albert Zimmer
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Patent number: 10864170Abstract: Pharmaceutical composition containing poly(bile) acid (PBA) polymers for oral delivery of agent(s) show enhanced uptake by the pancreas, liver, and colon. These nanoparticles show significant retention in the pancreas and colon and are therefore useful for selective delivery. The examples demonstrate efficacy of oral administration of insulin to treat diabetes, and oral induction of tolerance by administration of insulin or ovalbumin in combination with rapamycin. Diabetic animals treated with the insulin or insulin with rapamycin showed normalization of blood glucose levels.Type: GrantFiled: September 2, 2016Date of Patent: December 15, 2020Assignee: YALE UNIVERSITYInventors: Tarek M. Fahmy, Jung Seok Lee, Dongin Kim
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Patent number: 10814022Abstract: The present invention relates to a nanogel comprising a polyamine-based polymer cross-linked by oxamide bonds, a preparation method of the nanogel, a contrast agent for ultrasound imaging comprising the nanogel, a composition for ultrasound diagnosis of inflammatory diseases comprising the contrast agent, a preparation method of the contrast agent, and a method for providing information for diagnosis of inflammatory diseases using the composition for ultrasound diagnosis.Type: GrantFiled: April 28, 2017Date of Patent: October 27, 2020Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Sehoon Kim, Chang-Keun Lim, Jeong yun Heo, Keunsoo Jeong
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Patent number: 10792301Abstract: Described herein are materials and methods useful for the treatment of neurodegenerative disorders as well as bone disorders in a subject. Materials described herein include polysaccharide digestive products resulting from the enzymatic hydrolysis of low acyl gellan gum. Also describe herein are pharmaceutical compositions comprising one or more of such materials, and methods for their preparation and use.Type: GrantFiled: February 12, 2016Date of Patent: October 6, 2020Assignee: The University of ToledoInventors: Joshua J. Park, Dong-Shik Kim, Kenneth Hensley, Kevin Christopher, Vishruti Makani
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Patent number: 10729157Abstract: The invention provides methods and compositions for regulating weight and size in animals.Type: GrantFiled: November 2, 2005Date of Patent: August 4, 2020Assignee: Oragenics, Inc.Inventors: Jeffrey Daniel Hillman, Eric W. T. Chojnicki, Ravi Shankar Orugunty
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Patent number: 10722443Abstract: Embodiments herein are directed to moisturizing compositions comprising interpenetrating polymer networks, methods of making moisturizing compositions and methods of using moisturizing compositions.Type: GrantFiled: February 13, 2017Date of Patent: July 28, 2020Assignee: RODAN & FIELDS, LLCInventors: Kathy Ann Fields, Kathryn Pregerson Rodan, George Paul Majewski, Timothy John Falla, Dzung Q. Le
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Patent number: 10722525Abstract: The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.Type: GrantFiled: January 19, 2017Date of Patent: July 28, 2020Assignee: MADRIGAL PHARMACEUTICALS, INC.Inventors: Dinesh U. Chimmanamada, Weiwen Ying
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Patent number: 10668055Abstract: The present invention provides, inter alia, methods of treating or ameliorating the effects of a cancer in a subject. The methods include administering to the subject an effective amount of (i) a first anti-cancer agent, which is BVD-523 or a pharmaceutically acceptable salt thereof and (ii) a second anti-cancer agent, which is a type 1 RAF inhibitor (such as dabrafenib) or another RAF inhibitor (such as regorafenib) or a pharmaceutically acceptable salt thereof, to treat or ameliorate the effects of the cancer. Also provided are pharmaceutical compositions and kits for treating or ameliorating the effects of a cancer in a subject.Type: GrantFiled: December 19, 2014Date of Patent: June 2, 2020Assignee: BIOMED VALLEY DISCOVERIES, INC.Inventors: Saurabh Saha, Dean Welsch, Gary DeCrescenzo, Jeffrey James Roix
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Patent number: 10662295Abstract: Trehalose-based hydrogels and methods of making such hydrogels are disclosed. Specifically, a method of creating a trehalose-based hydrogel, comprising the steps of: a) forming a trehalose homopolymer or co-polymer; b) preparing a cross-linker; and c) reacting the trehalose homopolymer or co-polymer with the cross-linker to form the trehalose-based hydrogel.Type: GrantFiled: August 12, 2015Date of Patent: May 26, 2020Assignee: The Regents of the University of CaliforniaInventor: Heather D. Maynard
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Patent number: 10596100Abstract: The present invention relates to composition for styling hair comprising: (a) a first phase comprising: at least one alkoxysilane having at least one solubilizing functional group and at least one amino substituent; at least one water-soluble metal salt; at least one acidifying agent; and at least one cosmetically acceptable carrier comprising water; and (b) a second phase comprising: at least one silsesquioxane resin and at least one volatile solvent. The present invention also relates to methods of styling hair.Type: GrantFiled: December 19, 2012Date of Patent: March 24, 2020Assignee: L'OREALInventors: Michell Chen, Bayle Augustin, Xiang Zhu
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Patent number: 10583178Abstract: The present disclosure relates to the synergistic combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, a cofactor of the enzyme, and a glucan. The present disclosure also relates to the synergistic combination of sulforaphane or a derivative thereof and a glucan. The present disclosure also relates to the synergistic combination of a broccoli extract or powder and a glucan. The glucan may be a ?-glucan. The glucan may be provided in a mushroom extract or powder selected from one or more of a maitake, a shiitake, or a reishi mushroom. Compositions and methods relating to these combinations are described.Type: GrantFiled: August 23, 2016Date of Patent: March 10, 2020Assignee: NUTRAMAX LABORATORIES, INC.Inventors: Brian Cornblatt, Grace Cornblatt, Anton Bzhelyansky, Robert Henderson
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Patent number: 10561663Abstract: A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148-clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.Type: GrantFiled: August 22, 2018Date of Patent: February 18, 2020Assignee: University of Southern CaliforniaInventors: Jean C. Shih, Florence M. Hofman, Thomas C. Chen
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Patent number: 10561629Abstract: The present invention provides a food of the type based on unit of intake per serving, which contains glycine or a substance that can be hydrolyzed to give glycine in an amount of not less than 0.5 g based on glycine per serving. The food of the present invention can be applied as a food flavoring, a deep sleep disorder improving food, or a bowel movement improving food.Type: GrantFiled: June 24, 2005Date of Patent: February 18, 2020Assignee: AJINOMOTO CO., INC.Inventors: Tohru Kouda, Chika Morishima, Kentaro Inagawa, Shinobu Seki