Patents Examined by Nitta Minnifield
  • Use of IL-12 and IL-12 antagonists in the treatment of autoimmune diseases
    Patent number: 7138115
    Abstract: Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-? or TNF-?. Suitable conditions for treatment include multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes melitis and autoimmune inflammatory eye disease.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: November 21, 2006
    Assignee: Genetics Institute, LLC
    Inventors: John P. Leonard, Samuel Goldman, Richard O'Hara, Jr.