Patents Examined by Nizal Chandrakumar
  • Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase
    Patent number: 9724354
    Abstract: Disclosed are methods for the treatment of proliferative disorders. Disclosed in particular, are methods for treatment of proliferative disorders such as cancer, by administering an mTORC1/2 inhibitor in combination with a selective inhibitor of Aurora A kinase. Preferred MTORC1/2 inhibitors include MLN0128 and the preferred Aurora A kinase inhibitor of the combination is MLN8237.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: August 8, 2017
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Rachael L. Brake, Huifeng Niu
  • Methods of treating cancer through the inhibition of USP7 and immune system modulation
    Patent number: 9717717
    Abstract: Methods and compounds for treating cancer by, for example, modulating immune system activity, are provided.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: August 1, 2017
    Assignees: Progenra, Inc., The Children's Hospital of Philadelphia
    Inventors: Joseph Weinstock, Jian Wu, Suresh Kumar Kizhakkethil-George, Feng Wang, Matthew P. Kodrasov, Saket Agarwal, Wayne W. Hancock
  • Vacuolin-1 as an inhibitor of autophagy and endosomal trafficking and the use thereof for inhibiting tumor progression
    Patent number: 9717737
    Abstract: Methods of treating autophagy related diseases, e.g. cancer and malaria, using novel autophagy inhibiting agents are described.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: August 1, 2017
    Assignee: THE UNIVERSITY OF HONG KONG
    Inventors: Jianbo Yue, Yingying Lu
  • Methods and agents for treating tyrosinase-positive albinism
    Patent number: 9717722
    Abstract: Methods for treating a subject with tyrosinase-positive albinism; agents and compositions thereof for use in treating tyrosinase-positive albinism; and medicaments for treating tyrosinase-positive albinism are described herein. Such methods; agents and compositions thereof; and medicaments relate to chloroquine or rapamycin or compositions thereof and may further relate to nitisinone used in conjunction with the chloroquine or rapamycin or a composition of either of which.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: August 1, 2017
    Assignee: New York University
    Inventors: Seth J. Orlow, Prashiela Manga
  • Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists
    Patent number: 9714242
    Abstract: The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: July 25, 2017
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Timo Fleβner, Frank-Gerhard Böβ, Christina Erb, Frank-Thorsten Hafner, Katrin Schnizler, Dieter Lang, Joachim Luithle, Marja Van Kampen, Franz-Josef Van Der Staay
  • Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) for use in the treatment of endometriosis
    Patent number: 9713603
    Abstract: Method of treating endometriosis and related indications, comprising the administration of Pro-EGCG, a synthetic and derivative product of epigallocatechin-3-gallate [(?)-EGCG]. Use of Pro-EGCG in the manufacture of a medicament for treating endometriosis and related indications. Pro-EGCG for use in the treatment of endometriosis and related indications.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: July 25, 2017
    Assignees: The Hong Kong Polytechnic University, The Chinese University of Hong Kong
    Inventors: Tak-Hang Chan, Chi-Chiu Wang
  • Oxidation catalyst for furfural compounds and applying method thereof
    Patent number: 9707547
    Abstract: An oxidation catalyst includes a nickel-containing material, a manganese-containing material and a bromine-containing material, wherein the molar number of the element bromine (Br) in the oxidation catalyst to the total molar number of the element nickel (Ni) and the element manganese (Mn) in the oxidation catalyst substantially ranges from 0.01 to 7.5.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: July 18, 2017
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Ying-Ting Huang, Jinn-Jong Wong, Jau-Hong Chen
  • Losmapimod for use in treating glomerular disease
    Patent number: 9707219
    Abstract: The present invention relates to a method of treating a glomerular disease with 6-(5-cyclopropylcarbamoyl-3-fluoro-2-methyl-phenyl)-N-(2,2-dimethylpropyl)-nicotinamide or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: July 18, 2017
    Assignee: GlaxoSmithKline Intellectual Property (No.2) Limited
    Inventors: Dennis Sprecher, Robert Nicholas Willette
  • Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
    Patent number: 9707223
    Abstract: The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: July 18, 2017
    Assignee: CORCEPT THERAPEUTICS, INC.
    Inventors: Hazel Hunt, Tony Johnson, Nicholas Ray, Iain Walters
  • Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
    Patent number: 9700554
    Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, Y1, Y2, or L are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: July 11, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Mingzhe Ji, Scott E. Lazerwith, Hyung-jung Pyun
  • Decreasing expression level of apoptosis-related genes by treating a human subject with a nitroxide
    Patent number: 9700550
    Abstract: Disclosed herein are methods for treating a human subject having a disease associated with an increased level of apoptosis using a nitroxide. Further disclosed are methods for treating a human subject in need of a reduced expression level of a gene associated with the apoptosis pathway using a nitroxide.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: July 11, 2017
    Inventor: Louis Habash
  • Methods useful in the synthesis of halichondrin B analogs
    Patent number: 9695188
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: July 4, 2017
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Yongbo Hu, Huiming Zhang, Hiroyuki Chiba, Yuki Komatsu, Bryan M. Lewis
  • Hydrogenation of catmint oil
    Patent number: 9688652
    Abstract: Disclosed are methods for treating catmint oil. The process allows the separation of sulfur-containing compounds from the catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: June 27, 2017
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Scott Christopher Jackson, Leo Ernest Manzer, Henry Max Schleinitz, Mark A Scialdone, Keith W Hutchenson
  • Solid agroformulations for preparing near micro-emulsion aqueous pesticides
    Patent number: 9686980
    Abstract: Disclosed are extruded pesticide granules that when mixed with water form a near micro-emulsion that is highly stable. The extruded pesticide granules include at least one pesticide active ingredient, a non-ionic surfactant, and a carrier, which is desirably urea powder or urea pearl. Processes for making the extruded pesticide granules are also disclosed.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: June 27, 2017
    Assignee: BASF CORPORATION
    Inventor: Ronald O. Richardson
  • Multisubstituted aromatic compounds as serine protease inhibitors
    Patent number: 9687479
    Abstract: There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of kallikrein.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: June 27, 2017
    Assignee: VERSEON CORPORATION
    Inventors: Kevin Michael Short, Son Minh Pham, David Charles Williams, David Ben Kita
  • Treatment of potatoes and root vegetables during storage
    Patent number: 9686982
    Abstract: The turgidity of potato tubers and other root vegetables is improved, maintained, or restored and/or the greening of potato tubers is delayed, prevented or inhibited and/or internal diseases caused by fungi and bacteria are prevented or treated by the application of one or more ?,?-unsaturated aliphatic aldehydes and ketones, C3 to C14 aliphatic aldehydes and ketones, and/or C3 to C7 saturated or unsaturated primary and secondary aliphatic alcohols.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: June 27, 2017
    Assignee: AMVAC Chemical Corporation
    Inventors: John A. Immaraju, Anthony A. Zatylny
  • Opioid agonists and uses thereof
    Patent number: 9688638
    Abstract: Provided are compounds, including those of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.
    Type: Grant
    Filed: November 27, 2014
    Date of Patent: June 27, 2017
    Assignee: Nektar Therapeutics
    Inventors: Franco J. Duarte, Neel K. Anand, Pankaj Sharma, Devendrapratap Singh
  • Compounds for the treatment of mycobacterial infections
    Patent number: 9682064
    Abstract: The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: June 20, 2017
    Assignees: The Broad Institute, Inc., Massachusetts General Hospital
    Inventors: Deborah Hung, Sarah Stanley, Tomohiko Kawate, Noriakie Iwase, Motohisa Shimizu
  • Method for preventing or treating neurodegenerative diseases
    Patent number: 9682111
    Abstract: Provided herein is a method for preventing or treating neurodegenerative disease in a subject, comprising administrating to the subject an effective amount of a composition which comprises a semen biotae extract. The neurodegenerative disease is associated with ?-synuclein, such as Alzheimer's disease, Parkinson's disease, Huntington disease, or Amyotrophic lateral sclerosis.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: June 20, 2017
    Inventors: Weiwei Su, Yonggang Wang, Fengyin Liang, Ning Wang, Zhong Pei, Haibin Liu
  • Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
    Patent number: 9676750
    Abstract: The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: June 13, 2017
    Assignees: Incyte Corporation, Incyte Holdings Corporation
    Inventors: Yun-Long Li, David M. Burns, Hao Feng, Chu-Biao Xue, Anlai Wang, Jun Pan