Patents Examined by Nizal S. Chandrakumar
  • N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
    Patent number: 10829488
    Abstract: The present disclosure provides compounds having Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein A, X1, X2, X3 R1a, R1b E, and = are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a disease, disorder, or condition responsive to Bcl-2 protein inhibition such as cancer.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: November 10, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Jianyong Chen
  • Niacin and berberine compositions and methods of use thereof
    Patent number: 10828286
    Abstract: In some embodiments, the present disclosure pertains to a composition including niacin up to about 1000 mg and berberine up to about 800 mg. In some embodiments, the niacin is in an amount of about 500 mg and the berberine is in an amount of about 100 mg. In some embodiments, the present disclosure pertains to a method that includes administering a composition to a subject in need thereof, where the composition includes niacin up to about 1000 mg and berberine up to about 800 mg. In some embodiments, the niacin is in an amount of about 500 mg and the berberine is in an amount of about 100 mg.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: November 10, 2020
    Assignee: GM Pharmaceuticals, Inc.
    Inventor: Odes W. Mitchell
  • Processes and intermediates for the preparations of isomer free prostaglandins
    Patent number: 10822321
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: November 3, 2020
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • Hydrogen sulphide compounds
    Patent number: 10821122
    Abstract: The application describes Hydrogen Sulphide (H2S), or a (H2S) generating compound or compound capable of stimulating H2S production in a pregnant subject, for use in the treatment of pre-eclampsia (PE) or fetal growth restriction.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: November 3, 2020
    Assignee: ASTON UNIVERSITY
    Inventors: Asif Ahmed, Keqing Wang
  • Use of trans-[tetrachlorobis(1H-indazole)ruthenate(III)] for the treatment of cancer
    Patent number: 10821095
    Abstract: IT-139, sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)], is an intravenously administered small molecule compound. In preclinical anti-tumor and mechanism of action studies, IT-139 showed activity against a broad range of tumor types, including those which are resistant to standard anti-cancer agents (e.g., platinums, vinca alkaloids, taxanes, anthracyclines). This activity is believed to arise from IT-139's novel mechanism of action that targets the GRP78 pathway. It was found that up-regulation of GRP78 is a key cancer cell survival pathway. Downregulation of GRP78 using IT-139 removes this resistance pathway allowing for chemotherapy and immuno-oncology agents to be more effective in treating cancer.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: November 3, 2020
    Assignee: Bold Therapeutics, Inc.
    Inventors: Suzanne Bakewell, Jyothi Sethuraman
  • Printable cannabinoid and terpene compositions
    Patent number: 10821147
    Abstract: This disclosure relates to new printable cannabinoid and terpene compositions, and method for making and using the same. Inkjet printer technology is used to dose precise amounts of purified cannabinoids such that a user may select the type of effect desired and in the amount they want. Various methods include inhaling and ingesting through the use of different substrates.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: November 3, 2020
    Assignee: Canopy Growth Corporation
    Inventors: Jonathan Michael Cooper, Kurt Aron Levy
  • [1,2,4] triazolo [1,5-a] pyridine derivative and crystalline form thereof
    Patent number: 10815231
    Abstract: The present invention discloses [1,2,4]triazolo[1,5-a]pyridine derivatives, as well as the crystalline form thereof. Compounds provided in the present invention have significant inhibitory effects on tumor cells, can be used for the prevention and/or treatment of tumor-related diseases, especially lung cancer, and have wide application prospects.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: October 27, 2020
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: Weimin Li, Yang He, Li Zhang, Bojiang Chen, Zhixin Qiu
  • Heterocyclic compounds as kinase inhibitors
    Patent number: 10807966
    Abstract: The present invention is directed to certain amides and heterocyclic compounds. The present invention also relates to uses of these compounds to treat several diseases including autoimmune disorders, cardiovascular disorders, inflammation, central nervous system disorders, arterial thrombotic disorders, fibrotic disorders, glaucoma, and neoplastic disorders.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: October 20, 2020
    Assignee: Translational Drug Development, LLC
    Inventors: Tong Wang, Stephen Gately
  • 1,4-bis(3-aminopropyl)piperazine derivative and its use
    Patent number: 10807958
    Abstract: The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or preventing a Tauopathy.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: October 20, 2020
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), UNIVERSITE DE LILLE 2 DROIT ET SANTE
    Inventors: Nicolas Sergeant, Luc Buee, Patricia Melnyk, Marion Gay, Nicolas Le Fur
  • Electrospun cationic nanofibers and methods of making and using the same
    Patent number: 10808335
    Abstract: Methods of making polycationic nanofibers by grafting cationic polymers onto electrospun neutral nanofibers and polycationic nanofibers produced by the methods are provided herein. In addition, methods of using the polycationic nanofibers to reduce inflammation, to adsorb anionic compounds such as heparin or nucleic acids, to inhibit the growth of microbes or inhibit the formation of a biofilm are also provided. The polycationic nanofibers may be in a mesh and may be included in a medical device, wound dressing, bandage, or as part of a graft.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: October 20, 2020
    Assignee: Duke University
    Inventors: Bruce A. Sullenger, Hemraj A. Juwarker, Kam W. Leong, Jennifer Gamboa Jackman
  • Method for preparing triacetone amine
    Patent number: 10807954
    Abstract: An improved method is used for preparing triacetone amine while recycling the by-products. This involves treating the crude product from triacetone amine preparation, which leads to an increase in the content of compounds which react readily with ammonia. This method enables efficient recycling of the by-products formed in the synthesis of triacetone amine.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: October 20, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Katharina Minke, Julia Rieb, Manfred Neumann
  • Method for producing fluorine-containing cyclopropane carboxylic acid compound
    Patent number: 10793540
    Abstract: The present invention provides an industrially applicable method for production of a fluorine-containing cyclopropane carboxylic acid compound useful as an intermediate for pharmaceutical and agrichemical products. A fluorine-containing cyclopropane monoester is obtained by: forming a fluorine-containing cyclic sulfate with the use of a fluorine-containing diol compound and sulfuryl fluoride (as a cyclic sulfuric esterification step); reacting the fluorine-containing cyclic sulfate with a malonic diester, thereby forming a fluorine-containing cyclopropane diester (as a cyclopropanation step); and hydrolyzing the fluorine-containing cyclopropane diester (as a hydrolysis step).
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: October 6, 2020
    Assignee: Central Glass Company, Limited
    Inventors: Takashi Kashiwaba, Takako Yamazaki, Shoko Ishii, Shunsuke Mimura, Masanori Fushimi, Ryuichi Okamoto, Haruki Kobayashi, Manabu Yasumoto
  • Modulator of the cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
    Patent number: 10793547
    Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: October 6, 2020
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alexander Russell Abela, Timothy Alcacio, Corey Anderson, Paul Timothy Angell, Minson Baek, Jeremy J. Clemens, Thomas Cleveland, Lori Ann Ferris, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Robert M. Hughes, Pramod Virupax Joshi, Ping Kang, Ali Keshavarz-Shokri, Haripada Khatuya, Paul John Krenitsky, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Jean Denis Pierre, Yi Shi, Muna Shrestha, David Andrew Siesel, Kathy Stavropoulos, Andreas P. Termin, Fredrick F. Van Goor, Johnny Uy, Timothy John Young, Jinglan Zhou
  • Hydrazinyl and aminooxy compounds and their methods of use
    Patent number: 10793518
    Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: October 6, 2020
    Assignee: Life Technologies Corporation
    Inventors: Wenjun Zhou, Kyle Gee, Yolanda Tennico, Peter Slade, Hee Chol Kang, Shaheer Khan, Brian Evans, James Stray
  • Amino acid compounds and methods of use
    Patent number: 10793564
    Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: October 6, 2020
    Assignee: PLIANT THERAPEUTICS, INC.
    Inventors: Jacob Cha, Chengguo Dong, Timothy Hom, Lan Jiang, Katerina Leftheris, Hui Li, David J. Morgans, Jr., Manuel Munoz, Maureen Reilly, Yajun Zheng
  • Block co-poly(metal organic nanostructures) (BCPMONs) and uses thereof
    Patent number: 10793683
    Abstract: The present disclosure provides (block co-polymer)-(metal organic framework) conjugates (BCPMOFs), such as (block co-polymer)-(metal organic nanostructure) conjugates (BCPMONs), and thermoplastic elastomers, gels, and compositions thereof. Exemplary BCPMONs include (block co-polymer)-(metal organic cage) conjugates (BCPMOCs), (block co-polymer)-(metal organic paddlewheel) conjugates, and (block co-polymer)-(metal organic square) conjugates, such as BCPMONs of Formula (A), (B), or (C). Also described herein are macromonomers for preparing the BCPMONs; thermoplastic elastomers, gels, and compositions involving the BCPMONs; methods of preparing the BCPMONs, thermoplastic elastomers, gels, and compositions; and methods of using the BCPMONs, thermoplastic elastomers, gels, and compositions.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: October 6, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Jeremiah A. Johnson, Yufeng Wang, Michelle MacLeod
  • Process for the preparation of tocols and squalene
    Patent number: 10793539
    Abstract: The invention relates to a process for the preparation of tocols [tocopherols (T) and tocotrienols (T3)] and squalene from vegetable oil refining by-products like fatty acid distillates. It particularly relates to the process of preparation of tocopherols, tocotrienols and squalene without any degradation from the fatty acid distillates obtained during processing of oils from the palm.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: October 6, 2020
    Assignee: PRAJ INDUSTRIES LIMITED
    Inventors: Pallavi Vinitkumar Pathak, Prajakt Subhash Charhate, Mangesh Ganesh Kurkarni
  • Administration of NEDD8-activating enzyme inhibitor and chemotherapeutic agents
    Patent number: 10786505
    Abstract: Disclosed are methods for the treatment of various solid tumors in patients in need of such treatment. The methods comprise administering to such a patient an NEDD8-activating enzyme (NAE) inhibitor such as ((1S,2S,4R)-4-(4-((1S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]-pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate (MLN4924) or a pharmaceutically acceptable salt in combination with one or more chemotherapeutic agents. Also disclosed are medicaments for use in the treatment of various solid tumors.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: September 29, 2020
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Allison Berger, Eric S. Lightcap
  • Aqueous solution containing n-long-chain acyl acidic amino acid and/or salt thereof, and method for producing same
    Patent number: 10780167
    Abstract: The present invention provides a method of producing an aqueous solution containing an N—C8-22 acyl acidic amino acid and/or a salt thereof and having pH 8.4-9.5, including the first step for reacting an acidic amino acid and/or a salt thereof with a C8-22 fatty acid chloride in a water solvent at pH 10-13 to form an N—C8-22 acyl acidic amino acid salt, and the second step for adjusting the pH of the aqueous solution after the first step to 8.4-9.5.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: September 22, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Gaku Hattori, Hiroji Ishii, Masahiro Ino
  • 5,6-dihydro-11H-indolo[2,3-B]quinolin-11-ones as alk inhibitors
    Patent number: 10781208
    Abstract: The present disclosure provides compounds represented by Formula (I), and the pharmaceutically acceptable salts and solvates thereof wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, R7, E and (B) are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat a condition or disorder responsive to inhibition of ALK such as cancer.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: September 22, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jianyong Chen, Liu Liu, Xuyuan Dong, Chao-Yie Yang, Donna McEachern, Shaomeng Wang