Patents Examined by Noble Jarrell
  • Patent number: 10005731
    Abstract: The present invention relates to novel retinoid-related orphan receptor gamma (ROR?) modulators and their use in the treatment of diseases mediated by ROR?.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: June 26, 2018
    Assignee: Glaxo Group Limited
    Inventors: Fangbin Han, Hui Lei, Xichen Lin, Qinghua Meng, Yonghui Wang
  • Patent number: 10000491
    Abstract: A process for producing a diazabicyclooctane derivative represented by Formula (IV) and intermediates thereof by carrying out the following steps: wherein P is an NH protecting group capable of being removed with acid; R1 is 2,5-dioxopyrrolidin-1-yl, 1,3-dioxo-3a,4,7,7a-tetrahydro-1H-isoindol-2(3H)-yl, 1,3-dioxohexahydro-1H-isoindol-2(3H)-yl, or 3,5-dioxo-4-azatricyclo[5.2.1.02.6]dec-8-en-4-yl; R2 is hydrogen, ClCO— or Cl3COCO—; R3 is C1-6 alkyl or heterocyclyl, or forms a 3- to 7-membered heterocyclic ring together with the —O—NH— to which it is attached; and OBn is benzyloxy.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: June 19, 2018
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao Abe, Takeshi Furuuchi, Yoshiaki Sakamaki, Nakako Mitsuhashi
  • Patent number: 9896425
    Abstract: An acid composition comprising 2-formyl-furan-5-carboxylic acid and 2,5-furandicarboxylic acid is purified in a process which comprises; contacting the acid composition with an alcohol to obtain an esterified composition; and separating the ester of 2-formyl-furan-5-carboxylic acid from the esterified composition to obtain a purified esterified product; and contacting the purified esterified composition with water for saponification or hydrolysis, to obtain a product composition, comprising 2,5-furandicarboxylic acid and a reduced amount of 2-formyl-furan-5-carboxylic acid.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: February 20, 2018
    Assignee: SYNVINA C.V.
    Inventors: Jagdeep Singh, Benjamin McKay, Bing Wang, Matheus Adrianus Dam, Gerardus Johannes Maria Gruter, Ana Sofia Vagueiro De Sousa Dias
  • Patent number: 9895404
    Abstract: A method for extracting cannabinoids from plant material containing one or more cannabinoids including: (1) shredding the plant material into an appropriate size; (2) soaking the shredded plant material in a polar solvent to dissolve the one or more cannabinoids into the alcohol to form a polar solvent/cannabinoid mixture; (3) separating the polar solvent/cannabinoid mixture from residual solid plant material; (4) treating the polar solvent/cannabinoid mixture to a non-polar solvent to remove the one or more cannabinoids into the non-polar solvent to form a non-polar solvent/cannabinoid mixture; (5) distilling the non-polar solvent/cannabinoid mixture to separate the non-polar solvent from the one or more cannabinoids; and (6) subjecting the cannabinoid mixture to a supercritical fluid to isolate and purify the cannabinoid mixture into individual cannabinoids of the one or more cannabinoids.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: February 20, 2018
    Inventor: Paul T. Baskis
  • Patent number: 9890151
    Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: February 13, 2018
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Gabriele Amari, Elisabetta Armani, Mauro Riccaboni, Charles Baker-Glenn
  • Patent number: 9884061
    Abstract: Provided are an injection preparation which include: an aqueous composition containing pemetrexed or a salt thereof, at least one antioxidant agent which is selected from the group consisting of ascorbic acid, an ascorbic acid derivative, and salts thereof, and the content of which is 0.0001 mass % to 0.5 mass % with respect to the total mass of the aqueous composition in terms of ascorbic acid, and an aqueous solvent of greater than or equal to 50 mass % with respect to the total mass of the aqueous composition; and a container which encloses the aqueous composition, in which the concentration of oxygen in gas within the container which encloses the aqueous composition is less than or equal to 0.2 volume %, and a method for producing the injection preparation.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: February 6, 2018
    Assignee: FUJIFILM CORPORATION
    Inventors: Shinichi Hashimoto, Shigetomo Tsujihata, Yasuyuki Izumi
  • Patent number: 9868713
    Abstract: The present invention relates to a catalyst system for oxidation of o-xylene and/or naphthalene to phthalic anhydride (PA), comprising a plurality of catalyst zones arranged in succession in the reaction tube, which have been produced using antimony trioxide comprising a noticeable proportion of senarmontite wherein some of the primary crystallites have a size of less than 200 nm. The present invention further relates to a process for gas phase oxidation, in which a gas stream comprising at least one hydrocarbon and molecular oxygen is passed through a catalyst system which comprises a plurality of catalyst zones arranged in succession in the reaction tube and which has been produced using an antimony trioxide comprising a noticeable proportion of senarmontite wherein some of the primary crystallites have a size of less than 200 nm.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: January 16, 2018
    Assignee: BASF SE
    Inventors: Nico F. Fischer, Diana C. Galeano Nunez, Michael Krämer, Markus Schubert, Jürgen Zühlke, Hans-Martin Allmann
  • Patent number: 9862686
    Abstract: This present disclosure is related to the field of N1-sulfonyl-5-fluoropyrimidinones and their derivatives and to the use of these compounds as fungicides.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: January 9, 2018
    Assignee: ADAMA MAKHTESHIM LTD.
    Inventors: Timothy Boebel, Kristy Bryan, Beth Lorsbach, W. John Owen, Jeffery D. Webster, Chenglin Yao, Mark A. Pobanz, Scott Thornburgh, Timothy P. Martin
  • Patent number: 9862666
    Abstract: A method for obtaining polyphenols from a vegetable raw material containing same, includes at least the following steps: optionally drying the raw material containing the polyphenols; crushing the raw material; defibrating the crushed raw material in an extruder in the presence of a solvent; separating the soluble phase from the fibers; and recovering the soluble phase, crude extract, containing the polyphenols.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: January 9, 2018
    Assignee: VALAGRO CARBONE RENOUVELABLE POITOU-CHARENTES
    Inventors: Stephane Soum, Antoine Piccirilli, Frederic Bataille
  • Patent number: 9862696
    Abstract: This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogs thereof and novel compounds prepared thereby.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: January 9, 2018
    Assignee: California Institute of Technology
    Inventors: Sarah Reisman, Kangway V. Chuang, Chen Xu
  • Patent number: 9856229
    Abstract: Provided is a method for producing a cyclic carbonate obtained by reacting epoxide and carbon dioxide in the presence of a quaternary onium salt as a counter ion or a quaternary phosphonium salt having a halogenated anion as a counter ion, or in the presence of a solid catalyst obtained by immobilizing the quaternary onium salt onto a carrier, wherein an organohalogen compound containing at least one halogen atom in one molecule is added to the reaction system.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: January 2, 2018
    Assignees: National Institute of Advanced Industrial Science and Technology, MARUZEN PETROCHEMICAL CO., LTD.
    Inventors: Toshikazu Takahashi, Hiroyuki Yasuda, Shouji Yamamoto, Takashi Naniki, Yasunori Hayashi, Takeshi Haruna, Takuro Furukawa
  • Patent number: 9855245
    Abstract: The present disclosure is directed to methods for reducing cardiovascular risk in a human subject by administering atrasentan, or a pharmaceutically acceptable salt thereof, in an amount sufficient to effect a reduction of about 5% or more in one or both of (a) total serum cholesterol, relative to the subject's baseline total serum cholesterol, and (b) serum LDL cholesterol, relative to the subject's baseline serum LDL cholesterol.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: January 2, 2018
    Assignee: AbbVie Inc.
    Inventors: Blas Coll Crespo, Dennis Andress, John J. Brennan, James C. Stolzenbach
  • Patent number: 9845303
    Abstract: Dapagliflozin compounds and process for dapagliflozin preparation are described. Pharmaceutical compositions comprising dapagliflozin or solvates of dapagliflozin, for the treatment of diabetes are also described.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: December 19, 2017
    Assignee: Cadila Healthcare Limited
    Inventors: Sanjay Jagdish Desai, Jayprakash Ajitsingh Parihar, Mahesh Laljibhai Rupapara
  • Patent number: 9839622
    Abstract: The invention generally relates to methods of treating a patient suffering from hypothalamic obesity using effective of amounts of a MetAP-2 inhibitor.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: December 12, 2017
    Assignee: Zafgen, Inc.
    Inventor: James E. Vath
  • Patent number: 9840488
    Abstract: The present disclosure relates to carbon monoxide releasing molecules (“CORMs”), and methods of synthesizing and applying the molecules. More specifically, this disclosure relates to structurally tunable CORMS, compounds containing CORMS (and salts thereof).
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: December 12, 2017
    Assignee: Utah State University
    Inventors: Lisa M Berreau, Stacey N. Anderson
  • Patent number: 9832997
    Abstract: A method for extracting the compound 3-methyl-2H-furo[2,3-c]pyran-2-one from smoke, the method comprising pyrolysis of cellulose or any biomass within a combustion chamber, directing the smoke into a scrubbing apparatus incorporating a spiral condenser tube extending along the chamber and having a number of mist spray units spaced along the entire spiral condenser tube, collecting smoke water thus formed and passing it to a cooling chamber and then to preparation for storage or despatch.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: December 5, 2017
    Inventor: Shane Gordon Sparg
  • Patent number: 9822368
    Abstract: Modulators of intracellular chloride concentration for treating down syndrome The present invention relates to a modulator of a chloride transporter for use in the treatment of Down syndrome.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: November 21, 2017
    Assignees: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, B&A THERAPEUTICS
    Inventors: Laura Cancedda, Yehezkel Ben-Ari, Andrea Constestabile
  • Patent number: 9815837
    Abstract: The invention relates to polymorphous crystal modifications of a DPP-IV inhibitor, the preparation thereof and the use thereof for preparing a medicament.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: November 14, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Peter Sieger, Dirk Kemmer, Peter Kohlbauer, Thomas Nicola, Martin Renz
  • Patent number: 9809546
    Abstract: The present invention provides a low-toxic and high-recovery industrial process for synthesizing an optically active diamine derivative represented by formula (D), the process comprising the steps of: (a) mixing a compound represented by formula (A) and a compound represented by formula (C) in organic solvents and secondary amine; (b) reaction under heating; (c) cooling and adding water to the mixed solution, allowing it to crystallize to obtain the compound represented by formula (D).
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: November 7, 2017
    Assignee: Chungwha Chemical Synthesis & Biotech Co., Ltd.
    Inventors: Tzu-Chiang Lu, Chien-Yi Chen, Ching-Shuen Cheng, Chin-Cheng Mai
  • Patent number: 9809543
    Abstract: The present invention relates to a novel process for producing of 2,3-dichloro-5-(trichloromethyl)pyridine by using PCl as chlorinating agent at elevated temperature and pressure.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: November 7, 2017
    Assignee: CHEMINOVA A/S
    Inventor: Casper Stoubaek Andersen