Abstract: Compounds having the formula ##EQU1## wherein R is 2-picolyl, 3-picolyl or 4-picolyl. The compounds are prepared by reacting dipropylacetic acid, or the corresponding chloride or anhydride, with 2-picolylamine, 3-picolylamine or 4-picolylamine. The compounds possess anti-convulsant and barbiturate potentiation properties.

Abstract: Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 5-Methylthio-7-isopropoxyxanthone-2-carboxylic acid and 5,7-di-(methylthio)xanthone-2-carboxylic acid are illustrated as representative compounds.

Abstract: Compositions containing and methods employing, as the essential ingredient, novel substituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. 6-Acetylxanthone-2-carboxylic acid is illustrated as a representative compound.

Abstract: New stabilizers for carotene, which retard its oxidation and protect it against destruction, and which are 3,5-di-carbonyl derivatives of 2,6-dimethyl-1,4-dihydropyridine, conforming to the general formula ##SPC1##Where R is a lower alkyl, such as methyl, or an alkoxy, such as an ethoxy group.The introducing of said stabilizers into fodder products for animals such as, for instance, into grass four, makes it possible to preserve valuable nutritive properties of such products during a long period of time, of at least 6 months.

Abstract: A novel spray-drying technique process, and the resulting composition, for preparing a high density, agglomerated vitamin-containing composition having improved tableting characteristics.

Abstract: Addiction to opiate drugs, e.g., heroin, is treated by administering a beta-adrenergic-receptor-blocking drug, e.g. propranolol, which is found to block the rewarding and euphoric effects of the narcotic and to prevent the recurrence of hunger for the narcotic after withdrawal with methadone.

Abstract: An ophthalmic solution is provided for treatment of "dry eye", providing lubricating and cushioning effects for traumatized eyes, including trauma caused by the wearing of hard or gel-type contact lenses, and as a carrier for ophthalmic medicaments. The solution is an aqueous solution of polyethylene oxide, optionally polyethylene glycol, and other optional ingredients.

Abstract: 2,4,7-Substituted 5-hydroxy benzopyrans and dihydrobenzopyrans and their esters represented by the formulae ##SPC1##Wherein each R.sub.1 is loweralkyl, and R.sub.2 is hydrogen, loweralkanoyl or ##SPC2##With Y being a straight or branched chain alkylene group having from 1-8 carbon atoms; a is an integer from 1-4; b is an integer from 1-4; X is CH.sub.2, O, S, or NR.sub.5 with R.sub.5 being hydrogen or loweralkyl, with the limitation that when X is O, S, or NR.sub.5, the sum of a and b is 3 or 4 and R.sub.4 is hydrogen or loweralkyl; and R.sub.3 is ##SPC3##With Y' being a straight or branched chain alkylene group having from 1-10 carbon atoms; and each R.sub.7, R.sub.8 and R.sub.9 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl and the pharmaceutically acceptable salts thereof.

Abstract: Indolyl alkyl amines of the following formula: ##SPC1##And their salts with organic or inorganic acids. In this formula I, A and A.sup.1 denote identical or different alkyl radicals which both together have a total of 3-8 C-atoms. R.sup.1 denotes hydrogen, a lower alkyl radical having up to 4 C-atoms or a possibly substituted benzyl or benzoyl radical. R.sup.2 and R.sup.3 may be the same or different and denote hydrogen, a halogen (more particularly chlorine, bromine or fluorine) or (possibly halogenated) lower alkyl radicals or (possibly etherified) hydroxy radicals. R.sup.4 denotes hydrogen, a lower alkyl radical, an acyl group or a (possibly substituted) benzyl radical or the cyano-ethyl group. The compounds are useful as anoretics (appetite inhibitors) and can be made by various disclosed methods.

Abstract: .alpha.-Aminomethyl-4-hydroxy-3-sulfamylbenzyl alcohols and 4-hydroxy-3-sulfamylphenethylamines are disclosed. These compounds have .beta.-adrenergic antagonist activity.

Abstract: Certain fluorenone and anthraquinone compounds, each of which is 2-substituted by a carboxyl group or a salt, ester or optionally substituted amide thereof and each of which is optionally substituted in the 5,6-,7- or 8- position, by a second carboxyl group, salt, ester or optionally substituted amide thereof, the substitutent in the 5,6-7- or 8- position of the fluorenone compounds, also being selected from cyano, halogen, nitro, alkyl, alkoxy and acyl, are useful for the relief or prophylaxis of allergic conditions.

Abstract: Novel pyrano[3,2-c][1,2]benzothiazine 6,6-dioxides are disclosed, substituted on the 3 position by a lower alkyl, carboxaldehyde, or hydroxymethyl group and, optionally substituted on the 5 position by a lower alkyl group. The corresponding aldehyde thiosemicarbazone derivatives of these compounds are also disclosed. Pharmaceutical compositions containing the substituted pyrano[3,2-c][1,2]benzothiazine 6,6-dioxides of this invention are useful in the treatment of hyperacidity; certain of these compounds also demonstrate anti-allergy activity.

Abstract: The invention provides novel aminoethyl esters of 2,2-diphenylcyclopropane carboxylic acids which are anti-tussive agents.

Abstract: Novel compounds are disclosed having useful activity as bronchodilators of improved longevity of action and reduced incidence of side effects. These compounds are described by the formula: ##EQU1## wherein R.sub.1 is a member of the class consisting of tertiary butyl and cyclobutyl, and R.sub.2 is a hydrogen or 2 to 5 carbon atom acyl radical, and pharmaceutically acceptable salts thereof. The activity of these compounds is compared to previously known bronchodilators such as 1-(3', 5'-dihydroxyphenyl)-2-(isopropylamino)-ethanol, having the common name orciprenaline, and 1-(3', 4'-dihydroxyphenyl-2-isoproplyamino-ethanol, having the common name isoprenaline.

Abstract: A process for antagonizing the pharmacologic effects of a narcotic agent in warm-blooded animals, and compositions for effecting this process are disclosed.

Abstract: Novel (hydroxymethylene) chromone derivatives of the general formula I: ##SPC1##wherein n represents 1 or 2, are prepared by reacting a cycloalkanone II with a boron trifluoride compound and acetic anhydride to obtain novel boron complex intermediates of the formula III: ##SPC2##wherein n represents 1 or 2, and reacting III with a Vilsmeier reagent prepared from phosphorus oxychloride and dimethylformamide. The final product I and pharmaceutical compositions containing I are useful in the treatment of allergic conditions and in the treatment of hyperacidity.

Abstract: Treatment of dogs and cats to overcome mouth odors by feeding tablets rich in methionine.

Abstract: Apparatus and process are provided for the conservation of living organs by using a cooled perfusing means enriched with a respiratory gas in a thermally insulated receptacle with a pumping device driven by a gas and which regulates the perfusing medium according the flow-resistance in the organ.

Abstract: Halo-fusaric acid amides having the formula ##SPC1##Wherein X represents halogen or hydrogen, Y represents halogen and R.sub.1 and R.sub.2 are same or different and represent hydrogen or a lower alkyl group (C.sub.1-4) which are characterized by significant activity in the treatment of hypertension.

Abstract: A class of substituted 2-cycloalkylaminoalkylphenols, preferably D,L-6-(N-.alpha.-pipecolinomethyl)-5-hydroxyindane, enantiomers thereof and acid addition salts thereof have been found to exhibit oral antifertility activity in male aves and mammals. These compounds may therefore be utilized to induce temporary or non-reversible sterility in treated subjects.