Patents Examined by Nyeemah Grazien
  • 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
    Patent number: 7232815
    Abstract: The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-? (TNF-?) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: June 19, 2007
    Assignee: GlaxoSmithKline
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Iva Benko