Abstract: The present invention relates to an economic process for preparing surface-reacted calcium carbonate. The present invention further relates to a surface-reacted calcium carbonate having an increased specific BET surface area, and the use of a process for adjusting the specific BET surface area.
Type:
Grant
Filed:
June 26, 2014
Date of Patent:
August 2, 2016
Assignee:
Omya International AG
Inventors:
Patrick A.C. Gane, Daniel E. Gerard, Joachim Schölkopf
Abstract: The present invention relates to processes for preparing 3-methylsulfonylpropionitrile. The processes provide a good yield and a good purity of the final product and provide a controllable reaction. The present invention also relates to a crystalline form of 3-methylsulfonylpropionitrile having X-ray diffraction peaks at 13.9±0.1, 19.2±0.1, 20.0±0.1, 22.5±0.1, 23.2±0.1, 25.7±0.1, 28.1±0.1, 29.9±0.1, and 30.6±0.1 degrees 2?, and wherein the most intense peak is the peak at 13.9±0.1 degrees 2?.
Type:
Grant
Filed:
April 29, 2015
Date of Patent:
July 26, 2016
Assignee:
OLATEC THERAPEUTICS LLC
Inventors:
Joseph P. St. Laurent, Gerald S. Jones, David M. Bresse
Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Type:
Grant
Filed:
October 16, 2013
Date of Patent:
July 19, 2016
Assignee:
Tolero Pharmaceuticals, Inc.
Inventors:
Koc-Kan Ho, Yong Xu, Michael David Saunders, Xiaohui Liu, Scott Albert Pearce, Kevin Bret Wright, Jason Marc Foulks, Kenneth Mark Parnell, Steven Brian Kanner, David Lee Vollmer, Jihua Liu
Abstract: Disclosed is a method for preparing a dinitrile compound. The method includes reacting an alcohol compound with a nitrile compound having a terminal carbon-carbon unsaturated bond under anhydrous conditions. A potassium alkoxide having 1 to 5 carbon atoms is used as a catalyst in the course of the reaction. According to the method, a high-purity dinitrile compound can be prepared in a simple manner within a short reaction time indicating high productivity.
Type:
Grant
Filed:
September 13, 2013
Date of Patent:
July 19, 2016
Assignee:
LG CHEM, LTD.
Inventors:
Byoung-Bae Lee, Jae-Seung Oh, You-Jin Shim, Yeon-Suk Hong
Abstract: To provide a plant disease control composition having excellent control effect against plant diseases. A plant disease control composition comprising an amide compound represented by formula (I): wherein each symbol is as defined in the description, and captan has excellent control effect against plant diseases.
Abstract: Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds are described that correspond to general formula (I). Also described, are pharmaceutical compositions that include these compounds and methods of using these compounds and compositions for the treatment of chemokine-mediated diseases.
Abstract: Disclosed are pharmaceutical compositions comprising a compound having the formula: or a pharmaceutically acceptable salt thereof, or a hydrate of thereof, and at least one pharmaceutically acceptable polymer. The pharmaceutically acceptable salt of the compound of Formula I, or a hydrate thereof, can be a mesylate salt, including, for example, a mono-mesylate or a bis-mesylate salt, or a hydrate thereof. Also disclosed are methods of use for the pharmaceutical composition.
Type:
Grant
Filed:
July 29, 2014
Date of Patent:
July 5, 2016
Assignee:
Gilead Connecticut, Inc.
Inventors:
Melissa Jean Casteel, Bei Li, Rowchanak Pakdaman, Diana Sperger, Dimitrios Stefanidis
Abstract: The invention is directed to the use of a compound of formula I as defined herein, a pharmaceutically acceptable salt thereof; or a pharmaceutical composition containing a compound of formula I, in treating a mammal, including a human, for a psychiatric disorder or condition selected from the group consisting of stroke, Huntington's disease and amyotrophic lateral sclerosis (ALS).
Type:
Grant
Filed:
July 28, 2015
Date of Patent:
July 5, 2016
Assignee:
MediSynergics, LLC
Inventors:
Dennis Michael Godek, Harry Ralph Howard
Abstract: The present invention relates to a series of quinoline and cinnoline derivatives of general formula I, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof. And the compounds of general formula I show potent inhibitory activity gainst c-Met kinase. The present invention further relates to the uses of the compounds, pharmaceutically acceptable salts and hydrates for the preparation of medicaments for the treatment and/or prevention of diseases caused by abnormal expression of c-Met kinase, especially for treatment and/or prevention of cancer.
Type:
Grant
Filed:
December 7, 2012
Date of Patent:
July 5, 2016
Assignees:
Shenyang Pharmaceutical University, Shenyang Pharmaceutical University (Benxi) Pharmaceutical Science and Technology Co., Ltd.
Abstract: Isolated stereoisomeric forms of the compound (S)2-N(3-O-(propan 2-ol) -1-propyl-4-hydroxybenzene)-3-phenylpropylamide and uses in the treatment of pain.
Abstract: The present invention relates to a process for preparing a crystalline solid from glycine-N,N-diacetic acid derivatives (e.g., MGDA) of sufficiently low hygroscopicity, which is characterized in that at least one crystalline compound of the formula I is introduced as seed, and a spray granulation is carried out with at least one compound of the formula I, preferably followed by a heat treatment.
Abstract: The present invention is directed to pharmaceutical compositions comprising: (a) a cyclopolysaccharide and (b) a compound of Formula (I) or its pharmaceutical acceptable salt: wherein X1, X2, Q, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compositions.
Type:
Grant
Filed:
September 14, 2012
Date of Patent:
June 28, 2016
Assignee:
Purdue Pharmaceuticals Products L.P.
Inventors:
Yu Chen, Lan Yang, Feiyu Feng, Qiufu Ge, Dianwu Guo, Yi Chen
Abstract: A photoelectric conversion element is provided. The photoelectric conversion element includes a first electrode and a second electrode. The first electrode is covered with an electron transport layer. The electron transport layer is covered with a material represented by the following formula (1): wherein each of R1 and R2 independently represents a straight-chain or branched-chain alkyl group, Ar represents a substituted or unsubstituted aryl group, each of X1 and X2 independently represents a substituted or unsubstituted aryl group or a substituted or unsubstituted saturated hydrocarbon group, n represents an integer of from 1 to 3, and Ar may share bond connectivity with X1 or X2 to form a ring. The second electrode is facing the electron transport layer.
Abstract: Disclosed are as represented by Formula (I) a quinazoline derivative and a pharmaceutical acceptable salt thereof, or, an enantiomer, a non-enantiomer, a tautomer, a racemate, a solvate, a metabolic precursor, or a prodrug of both. Also disclosed are a preparation method therefor, an intermediate, a pharmaceutical composition having the quinazoline derivative, and an application thereof. The quinazoline derivative of the present invention is provided with improved anti-tumor activity.
Type:
Grant
Filed:
July 27, 2012
Date of Patent:
June 21, 2016
Assignees:
SHANGHAI PHARMACEUTICALS HOLDINGS CO., LTD., ZHEJIANG UNIVERSITY
Abstract: The present disclosure provides compositions, pharmaceutical preparations and methods for the diagnosis and treatment of cancers expressing a GLI polypeptide. The disclosed compositions and pharmaceutical preparations may comprise one or more pyrazolyl-containing compounds, or an analog or derivative thereof.
Type:
Grant
Filed:
July 20, 2012
Date of Patent:
June 21, 2016
Assignee:
The Regents of the University of California
Inventors:
Biao He, Michael Mann, David M. Jablons
Abstract: An object of the present invention is to provide an oxide catalyst that prevents the reduction degradation of the catalyst even during industrial operation for a long time and less reduces unsaturated aldehyde yields, diolefin yields, or unsaturated nitrile yields, and a method for producing the same, and methods for producing unsaturated aldehyde, diolefin, and unsaturated nitrile using the oxide catalyst. The present invention provides an oxide catalyst for use in the production of unsaturated aldehyde, diolefin, or unsaturated nitrile from olefin and/or alcohol, the oxide catalyst satisfying the following (1) to (3): (1) the oxide catalyst comprises molybdenum, bismuth, iron, cobalt, and an element A having an ion radius larger than 0.96 ? (except for potassium, cesium, and rubidium); (2) an atomic ratio a of the bismuth to 12 atoms of the molybdenum is 1?a?5, an atomic ratio b of the iron to 12 atoms of the molybdenum is 1.
Abstract: The invention is directed to compounds that are specific inhibitors of PKC delta, and methods and compositions for the treatment and prevention of cancers and other disorders. Compositions comprising compounds of the invention are used to treat cancers such as, for example, carcinoid and neuroendocrine tumors, malignant melanomas, pancreatic, gastrointestinal and lung cancers. Neuroendocrine tumor cell lines of pulmonary and gastrointestinal origin are surprisingly sensitive to PKC delta inhibition by the compounds of the invention. The invention is further directed to methods, compositions and kits containing compounds of the formulas (Ia), (IIa), (IIIa), (IVa), and (V) as disclosed and described in FIGS. 11 and 12.
Abstract: The present invention relates to a process for preparing dithiinetetracarboximides by reaction of succinic monoamides with thionyl chloride, with continuous performance of at least one of the process steps.
Abstract: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
Type:
Grant
Filed:
May 22, 2013
Date of Patent:
June 14, 2016
Assignee:
Novartis AG
Inventors:
Simona Cotesta, Pascal Furet, Vito Guagnano, Philipp Holzer, Joerg Kallen, Robert Mah, Keiichi Masuya, Achim Schlapbach, Stefan Stutz, Andrea Vaupel
Abstract: The present invention provides a method for producing alkyl nitrate. The centrifugal extraction equipment acts as the esterification separator; a mixed acid solution containing sulfuric acid and nitric acid enters from the heavy phase inlet of the centrifugal extraction equipment; alkyl alcohol enters from the light phase inlet of the centrifugal extraction equipment; the feeding molar ratio of alkyl alcohol and nitric acid equals to 1:1.0-3.0; esterification reaction occurs with the mixed acid and alkyl alcohol at a temperature of 10˜60° C.