Abstract: 5,6,7,8,9,10-Hexahydro-7,10-iminocyclohept[b]indole, 6,7,8,9,10,11-hexahydro-7,11-imino-5H-cyclooct[b]indole and substituted derivatives are effective in the treatment of psychoses with limited liability to produce concomitant adverse extrapyramidal symptoms. These compounds are also useful for treating other central nervous system and cardiovascular disorders.
Type:
Grant
Filed:
March 13, 1992
Date of Patent:
October 5, 1993
Assignee:
Scios Nova Inc.
Inventors:
Richard E. Mewshaw, Carl Kaiser, Mary E. Abreu
Abstract: Phenoxyalkyl-substituted heteroaromatics of the general formulae Ia and Ib ##STR1## where A is an unsubstituted or substituted heteroaromatic radical having 6 ring members and 1, 2 or 3 nitrogen atoms in the ring, R.sup.1 is hydrogen, halogen or C.sub.1 -C.sub.3 -alkyl, R.sup.2 is hydrogen or C.sub.1 -C.sub.4 -alkyl, Q.sub.a is an unsubstituted or substituted azole radical and Q.sub.b is a substituted or unsubstituted heteroaromatic radical which has a five-membered ring,and their use for combating pests.
Type:
Grant
Filed:
August 4, 1989
Date of Patent:
February 26, 1991
Assignee:
BASF Aktiengesellschaft
Inventors:
Joachim Leyendecker, Hans-Juergen Neubauer, Uwe Kardorff, Christoph Kuenast, Peter Hofmeister, Wolfgang Krieg
Abstract: The invention concerns a new stable crystal form of anhydrous, crystalline 1,4-dihydro-2-(imidazol-1-ylmethyl)-6-methyl-4-(3-nitrophenyl)pyridine)-3, 5-dicarboxylic acid 3-ethyl 5-methyl diester hydrochloride, "having a melting point greater than about 215.degree. C., an infra red spectrum (nujolmull) having sharp peaks at 3195 cm.sup.-1, 3100 cm.sup.-1, 2735 cm.sup.-1 and 2625 cm.sup.-1 and an x-ray powder diffraction pattern with specific peaks occurring at 2.theta.=12.3.degree. and 44.5.degree..
Type:
Grant
Filed:
December 12, 1988
Date of Patent:
January 8, 1991
Assignee:
John Wyeth and Brothers Limited
Inventors:
Gerald Bradley, Geoffrey P. R. Carr, Albert Opalko, Richard J. Yarwood