Abstract: Provided is a pharmaceutical composition comprising suplatast tosilate or pharmaceutically acceptable derivatives thereof that provides for a constant exposure of the compound.

Abstract: An intensity adapting optical aiming system that automatically adjusts the intensity of the reticle to adapt to the light condition of the external light. The aiming system may be mounted to a weapon and the external light may be a weapon mounted light. The aiming system may include an illuminateable reticle and a light connector for transmitting light from the external light to the reticle.

Abstract: The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers.

Abstract: The present invention relates to an innovative thermal design concept of tailoring the absorptance and emittance of a coating—namely silicon oxide (SiOx) coated aluminized Kapton—as a radiator coating for small, nano-satellite (i.e., CubeSat) thermal management. The present invention improves on the thermal design of existing satellites, by: a) thermally coupling all components to the baseplate to eliminate the need for heater power for the battery; b) using all six sides of the CubeSat as radiators by changing the wall material from fiberglass to aluminum; c) using a different ratio of absorptance to emittance for each side by tailoring the SiOx thickness; d) having a high emittance for the wall interior and components; and e) eliminating the need for MLIs. The elimination of the MLIs reduces the volume and increases the clearance to minimize the risk for solar array deployment and cost of the thermal control subsystem.

Abstract: Avalanches often trap people under the snow. Although nearly all avalanche victims survive the initial avalanche, asphyxiation will occur after about fifteen minutes if rescuers do not know where to dig to uncover avalanche victims. Drones can include unique hardware and software that enables them to search for avalanche victims and mark the locations of avalanche victims to quickly and accurately notify rescuers where to dig through the snow to save avalanche victims from asphyxiation.

Abstract: The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VI): wherein: R1 is H, Cl, F, —CF3, —OCF3, —OMe, or methyl; R8 is selected from the group consisting of: —NH2, —N(H)Alk, —N(Alk)2, R7 is H or alkyl; m is 3 to 6; p is 1 to 4; q is 1 to 4; p+g is 3 to 6; and each Alk is independently an aliphatic carbon group consisting of 1 to 6 carbon atoms, and methods of making and using same.

Abstract: An unmanned aerial vehicle (UAV) includes one or more processors individually or collectively configured to assess a location of the UAV, calculate a distance between the UAV and a flight-restricted region using the location of the UAV, assess whether the distance falls within a first distance threshold, and instruct the UAV to take a flight response measure selected from (1) a first flight response measure when the distance falls within the first distance threshold, and (2) a second flight response measure different from the first flight response measure when the distance falls outside the first distance threshold. The first flight response measure at least includes causing the UAV to descend or hover over a location. A rate at which the UAV descends is determined based on the location of the UAV.

Abstract: Preparations and formulations capable of crossing and incorporating into a membrane of a cell or an organelle or an exosome are described. Methods of treatments utilizing the preparations and formulations are also described.

Abstract: Systems and methods for measuring air gaps between opposing surfaces of two structural components. In one application, such measurements are used to fabricate a shim that fills the air gap between two structural members, such as parts of an aircraft. The resonant inductive coupling-based sensing system has the capability to remotely measure an air gap using an on-board transmit system. Furthermore, the system has the capability to switch between multiple inductor-capacitor sets such as to simultaneously measure air gaps across an area so that a better profile of the air gap can be determined. The resonant inductive coupling-based gap sensor is configured as signal generating and signal sensing electronics printed or mounted on respective flexible substrates to provide a flexible and portable measurement solution.

Abstract: The invention provides an animal feed composition comprising microbial ?-amylase, for example, an animal feed composition comprising transgenic plant material comprising a microbial ?-amylase (e.g., a thermostable microbial ?-amylase). The invention further provides methods of increasing animal performance and/or the efficiency of feed utilization by an animal (e.g., for milk or meat production), comprising feeding to the animal an animal feed composition of the present invention.

Abstract: The invention relates to polymorphic forms of the calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester. The calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester is useful in the treatment of various conditions and disorders responsive to the inhibition of neutral endopeptidases.

Abstract: A system and method for management of propulsors for an electric aircraft, where the electric aircraft is configured to transition between a hover state and a fixed-wing flight state. The electric aircraft may include at least one set of a plurality of propulsors coupled to the electric aircraft. A flight controller may be coupled to the electric aircraft and configured to detect a state transition of the electric aircraft from the hover state to the fixed-wing flight state and send a parking command to the at least one set of a plurality of propulsors.

Abstract: Aspects of the disclosure relate to manufacturing a balloon envelope for use in a stratospheric balloon system. For instance, a stream of polyethylene mixture us extruded through an extruder in order to orient molecules of polymer chains of polyethylene and to provide an oriented film. The oriented film is passed through an electron beam and thereby crosslinking the polymer chains to provide a cross-linked film. The cross-linked film is heat sealed to form the balloon envelope.

Abstract: The present invention relates to compound of Formula (I) containing carbon-carbon linker, a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, a polymorph, N-oxide, S-oxide, or a carboxylic acid isostere thereof; processes for their preparation; pharmaceutical compositions comprising said compounds; and their use for the treatment of the diseases or disorders mediated by GPR120 receptor.

Abstract: Provided is a drone with an airbag with which it is possible to prevent the danger of injuring a person when a crashed drone collides with the person. A first airbag 11 is provided in a state surrounding a drone 9 within the horizontal plane. The first airbag 11 is held by a first holding part 10 provided on a central mounting part 2. The first airbag 11 is installed in the first holding part 10 in a folded state, the first airbag 11 being inflatable so as to project outward by gas being supplied. The first airbag 11 is capable of expanding before impacting another object such as a person and surrounding the drone 9 in the horizontal plane.

Abstract: An aircraft is configured for thrust-borne lift in a vertical takeoff and landing flight mode and wing-borne lift in a forward flight mode. The aircraft includes an airframe having a first wing and a first payload station. A distributed propulsion system that is coupled to the airframe includes a plurality of propulsion assemblies configured to provide vertical thrust in the vertical takeoff and landing flight mode and forward thrust in the forward flight mode. A control system is operably associated with the distributed propulsion system and is operable to independently control each of the propulsion assemblies. A payload module is configured to be transported by the airframe from a pickup location to a delivery location. The payload module is magnetically coupled to the first payload station during transportation and, responsive to a command from the control system, is magnetically decoupled from the first payload station at the delivery location.

Abstract: A transport device for transporting an unmanned aerial vehicle and methods for using the transport device are described herein. An example embodiment of the transport device includes: a carriage configured to engage the unmanned aerial vehicle; a plurality of engagement arms movably attached to the carriage and movable between a first locking position and a second locking position, each of the plurality of engagement arms, and configured to maintain engagement of the unmanned aerial vehicle by the carriage when in the first locking position; and a handle adapter having a first end configured for attachment to the carriage and a second end configured to receive an extension member.

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: A remotely controlled unmanned aerial device for use in proximity or in contact with high voltage powerlines, includes an unmanned aerial vehicle and an electrically conductive shield forming part of or operatively coupled to so as to encapsulate the unmanned aerial vehicle. When in the presence of a high voltage powerline, the unmanned aerial vehicle either when bonded-on or within the corresponding magnetic fields of the powerline, so as to transfer the powerline potential in whole or in part to the unmanned aerial vehicle, electrically energizes the conductive shield around the unmanned aerial vehicle while leaving components of the unmanned aerial vehicle within the shield substantially electrically unaffected by the voltage potential.

Abstract: An aircraft humidification system includes a first duct configured to guide a first air stream, and a second duct configured to guide a second air stream, the second duct including a humidifier for humidifying the air stream in the second duct. A first conduit directs part of the second air stream to the first duct. The first conduit includes a first conduit inlet leading into the first duct and a first conduit outlet extending from the second duct. A second conduit directs part of the first air stream to the second duct, the second conduit including a second conduit inlet leading into the second duct and a second conduit outlet extending from the first duct. The first conduit outlet is arranged downstream of the humidifier, the second conduit inlet is arranged downstream of the first conduit outlet and the first conduit inlet is arranged downstream of the second conduit outlet.