Patents Examined by P. O'Sullivan
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Patent number: 5352400Abstract: Processes are provided for making polycarbodiimides with high carbodiimide contents from isocyanates, and for selectively making mixed aryl-tertiary carbodiimides from isocyanates. Also provided are carbodiimides containing alpha-methylstyryl groups, and polymers made therefrom. All of these polymers and compounds are useful in coatings, and for other applications.Type: GrantFiled: April 29, 1992Date of Patent: October 4, 1994Assignee: E. I. Du Pont de Nemours and CompanyInventor: Michael W. J. West
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Patent number: 5328909Abstract: A novel cyclopropenone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent properties regarding oral absorbance, tissue transference and cell membrane permeability, and are clinically useful in the treatment of various diseases such as muscular dystrophy, amyotrophy. Also provided are a process for producing the compound (I) and a pharmaceutical composition containing the same.Type: GrantFiled: June 25, 1992Date of Patent: July 12, 1994Assignee: Mitsubishi Kasei CorporationInventors: Ryoichi Ando, Yasuhiro Morinaka, Chizuko Takahashi, Yoshikuni Tamao, Akihiro Tobe
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Patent number: 5310620Abstract: Novel nitrone compounds of the following formula are provided ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 may be the same or different and represent an alkyl group, an aryl group or a hydrogen atom, R.sup.4 to R.sup.8 may be the same or different and represent an alkyl group, a hydrogen atom or a carboxyl group provided that at least one of R.sup.4 to R.sup.8 is a carboxyl group, X represents an alkoxy group of the formula, R.sup.9 O--, wherein R.sup.9 represents an alkyl group, a dialkylamino group of the formula, R.sup.10 R.sup.11 N--, wherein R.sup.10 and R.sup.11 may be the same or different and represent an alkyl group, or a hydrogen atom, and n is a value of 0, 1 or 2. A contrast enhanced material comprising the nitrone compound is also provided, which is able to enhance a contrast when exposed to light having a wavelength of 300 to 450 nm.Type: GrantFiled: November 5, 1992Date of Patent: May 10, 1994Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Satoshi Watanabe, Toshinobu Ishihara, Ken'Ichi Itoh
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Patent number: 5302755Abstract: Thioalkylated aromatic amines are prepared by reacting a mixture of an aromatic amine, an organic disulfide and a Lewis acid or organometallic catalyst to form a product mixture and adding to said product mixture a poly(oxyalkylene)polymer or by reacting a mixture of an aromatic amine, an organic disulfide and a Lewis acid or organometallic catalyst in the presence of a poly(oxyalkylene)polymer for the purpose of easy handling of the catalyst residue for recycling.Type: GrantFiled: October 29, 1992Date of Patent: April 12, 1994Assignee: Ethyl CorporationInventors: Robert A. Schaerfl, Jr., Gordon G. Knapp, W. Dirk Klobucar
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Patent number: 5300640Abstract: A novel herbicidal pyrimidine derivative represented by the formula ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y.sup.1, Y.sup.2, Y.sup.3, X and Z are as defined herein.Type: GrantFiled: December 19, 1991Date of Patent: April 5, 1994Assignee: Sumitomo Chemical Company, LimitedInventors: Mitsumori Hiratsuka, Naonori Hirata, Kazuo Saito, Hideyuki Shibata
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Patent number: 5300689Abstract: An improved process for oximation of carbonyl compounds, such as ketones and aldehydes by oximation with hydroxylamine including oximation processes carried out in the presence of a catalytic amount of an acid phase transfer catalyst, such as 2-ethylhexanoic acid, and/or the presence of an alkali metal or alkaline earth metal catalyst. The resulting oximes are useful as metal extractants.Type: GrantFiled: March 20, 1992Date of Patent: April 5, 1994Assignee: Henkel CorporationInventors: Leroy O. Krbechek, Mary I. Casey
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Patent number: 5300690Abstract: A polyoxime can be formed by reacting hydroxylamine with a copolymer of carbon monoxide and propylene. When the relative amount of oxime units in the polyoxime is high the polyoxime is soluble in water. Conversely, solubility in organic solvent is conferred when the oxime content is relatively low.Type: GrantFiled: October 14, 1992Date of Patent: April 5, 1994Assignee: Akzo N.V.Inventor: Gurudas D. Sinai-Zingde
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Patent number: 5290814Abstract: The present invention is concerned with compounds of formula (I) ##STR1## wherein m is 0 or 1;W is hydrogen, a C.sub.1-16 straight, branched, or cyclic alkyl group, or a C.sub.2-16 straight, branched, or cyclic alkenyl or alkynyl group, or Ph(CH.sub.2).sub.n -- where Ph is phenyl and n is an integer of from 0 to 2, the phenyl group being optionally substituted by one or more atoms or groups independently selected from halogen, hydroxy, nitro, C.sub.1-4 alkoxy and C.sub.1-4 alkyl wherein one or more of the hydrogen atoms in said alkyl group is optionally replaced by halogen, or R.sup.1 NHCO-- where R.sup.1 is hydrogen or a C.sub.1-6 alkyl group, or R.sup.2 CONH-- where R.sup.2 is hydrogen or a C.sub.1-6 alkyl group; X is ##STR2## where A is halogen; Y is --(CH.sub.2).sub.q, where q is an integer of from 1 to 3, or --CH.dbd.CH-- (E or Z);Z is a C.sub.Type: GrantFiled: November 5, 1992Date of Patent: March 1, 1994Assignee: Burroughs Wellcome Co.Inventors: William P. Jackson, Clifford J. Harris, Richard J. Arrowsmith, John G. Dann, Kevin J. O'Connor, Robert F. G. Booth
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Patent number: 5288909Abstract: A process of reforming an alkyleneamine feedstock or a mixture of such feedstocks to an alkyleneamine or a mixture of alkyleneamines which is different from the feedstock or feedstock mixture. The process is catalyzed by one of the following: Group VB metal oxides, Group VB metal phosphates, Group IIA metal silicates, and tungsten oxides. For example, ethylenediamine is contacted with a catalyst of niobic acid or magnesium silicate to yield predominantly diethylenetriamine and non-cyclic triethylenetetramines; whereas high molecular weight polyethylenepolyamines are cracked by the same catalysts to mixtures of lower molecular weight linear and cyclic materials.Type: GrantFiled: August 19, 1992Date of Patent: February 22, 1994Assignee: The Dow Chemical CompanyInventors: George E. Hartwell, Robert G. Bowman, David C. Molzahn
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Patent number: 5286905Abstract: The present invention relates to a process for the production of a biguanide derivative useful as an intermediate for triazine-type herbicides, in which the biguanide derivative can be produced at high yields by reacting a phenoxyalkylamine salt with dicyandiamide in a solvent containing a paraffinic hydrocarbon having 8 to 15 carbon atoms, or by reacting a free phenoxylakylamine with a hydrogen halide in a solvent containing a paraffinic hydrocarbon having 8 to 15 carbon atoms and reacting the resultant a phenoxyalkylamine salt with dicyandiamide in the same solvent without isolating the phenoxyalkylamine salt.Type: GrantFiled: December 23, 1991Date of Patent: February 15, 1994Assignee: Idemitsu Kosan Company LimitedInventors: Kazufumi Nakamura, Masahiro Nishii, Ryoichi Adachi, Masatoshi Uemura, Ichiro Nasuno, Izumi Terada, Takashi Mitsuyama, Hidetoshi Koga
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Patent number: 5286752Abstract: Novel diarylamidines, and compositions and methods for treating cardiac arrhythmias in mammals utilizing the novel and related known diarylamidines of formula I, II, III and IV ##STR1##Type: GrantFiled: September 10, 1991Date of Patent: February 15, 1994Assignee: Sterling Winthrop Inc.Inventors: Robert E. Johnson, Thomas E. D'Ambra
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Patent number: 5284974Abstract: An improved process for the reaction of acetonitrile and hydrogen sulfide to produce thioacetamide, wherein a polymer-supported amine catalyst is used. Examples of the polymer-supported amine catalyst are polymeric dimethylaminopyridine resins, poly(4-vinylpyridine) cross-linked with divinylbenzene, and cross-linked polymer-supported 4-(N-benzyl-N-methylamino)pyridine.Type: GrantFiled: August 11, 1992Date of Patent: February 8, 1994Assignee: Monsanto CompanyInventor: Eric L. Williams
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Patent number: 5276191Abstract: According to the invention, there is provided a process for the preparation of an aminoalkyl p-hydroxyphenyl ketone comprising reacting phenol with a nitrile, in the presence of a Lewis acid catalyst, to cause condensation thereof, the process being characterised in that the reaction is carried out in a medium comprising a nitroalkane solvent for the reactants.Type: GrantFiled: October 29, 1991Date of Patent: January 4, 1994Assignee: Fine Organics LimitedInventors: James I. Grayson, Graham Heyes
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Patent number: 5276187Abstract: This invention relates to novel ketoxime carbonates and a process for the synthesis of ketoxime carbonates generally. Ketoxime carbonates are useful in a variety of applications. They may be used for example as pesticides, pharmaceuticals, weed control agents and dye stuff intermediates.Type: GrantFiled: August 23, 1991Date of Patent: January 4, 1994Assignee: AlliedSignal Inc.Inventors: Halasya Ramanathan, Chempolil T. Mathew
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Patent number: 5276186Abstract: A process for the production of phenylguanidine carbonate and hydrogencarbonate by reacting aqueous cyanamide with aniline hydrochloride within a specified pH range, combining the reaction mixture with an alkali metal carbonate or hydrogencarbonate, and separating the crystalline product.Type: GrantFiled: November 25, 1992Date of Patent: January 4, 1994Assignee: Ciba-Geigy CorporationInventor: Rudolf Waditschatka
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Patent number: 5276195Abstract: A process for preparing a dimethylorganoborane represented by the formula R*BMe.sub.2 wherein R* is a chiral organyl group attached to the boron, B is boron and Me is methyl comprising treating a chiral boronic ester R*B(OR').sub.2 with a methyl magnesium salt or trimethylaluminum wherein R* is the same chiral organyl group and R' is alkyl.Type: GrantFiled: July 14, 1993Date of Patent: January 4, 1994Assignee: Aldrich Chemical Company, Inc.Inventor: Herbert C. Brown
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Patent number: 5276053Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.Type: GrantFiled: October 6, 1992Date of Patent: January 4, 1994Assignee: Warner-Lambert CompanyInventor: Graham Johnson
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Patent number: 5268508Abstract: A method of manufacturing 3-amino-2-cyclohexene-1-one by hydrogenating m-phenylenediamene to produce a novel intermediate salt of 3-amino-2-cyclohexene-1-imine followed by hydrolysis to produce 3-amino-2-cyclohexene-1-one. The novel intermediate 3-amino-2-cyclohexene-1-imine has also be isolated.Type: GrantFiled: August 17, 1992Date of Patent: December 7, 1993Assignee: E. I. Du Pont de Nemours and CompanyInventor: Stephen E. Jacobson
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Patent number: 5262440Abstract: This invention provides the use of certain indenesulfonamide derivatives in the treatment of susceptible neoplasms in mammals. Also provided are certain novel indenesulfonamide derivatives and their pharmaceutical formulations.Type: GrantFiled: December 10, 1991Date of Patent: November 16, 1993Assignee: Eli Lilly and CompanyInventors: William J. Ehlhardt, James E. Ray, John E. Toth
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Patent number: 5262569Abstract: Disclosed are salts of N-nitrosophenylhydroxylamine and their use as polymerization inhbitors.Type: GrantFiled: July 17, 1991Date of Patent: November 16, 1993Assignee: Rohm and Haas CompanyInventors: Rita K. Upmacis, William Bauer, Jr., Samuel F. Reed, Jr.