Abstract: A method for estimation of change in bone mineral density or a method for diagnosis of osteoporosis, comprising the step of measuring change in a concentration of soluble interleukin-6 receptor in a blood sample, by for example, sandwich assay or competition assay; and a kit for carrying out the methods, comprising: (1) an anti-sIL-6R antibody immobilized to a solid carrier, and (2) an anti-sIL-6R antibody bound to a detectable marker or capable of binding to a detectable marker.

Abstract: The invention describes the particles comprising an energy donor as a first component and a fluorescent dye as a second component positioned in said particles at an energy exchanging distance from one another, wherein the two components have a Stokes shift of greater than or equal to 50 nm, said particle having bound on its surface, a protein, polypeptide, nucleic acid, nucleotide or protein containing ligand analogue are disclosed and claimed. In addition, novel fluorescent dyes are described which exhibit intramolecular energy transfer for use to label various molecules, proteins, polypeptides, nucleotides and nucleic acids or to incorporate into particles.

Abstract: Utilization of albumin as a stable plasma transporter with a therapeutic function that is derived from a membrane receptor. The present invention is exemplified by the description of new therapeutic agents that can be used in the treatment of Acquired Immunodeficiency Syndrome: hybrid macromolecules composed of albumin derivatives coupled to derivatives of the CD4 receptor having a normal or a higher affinity for the HIV-1 virus.

Abstract: The device and methods herein disclosed were developed to allow a large number of small samples of organic tissue to be processed. The goal was to allow for the capture of these intracellular contents for study, use, and/or amplification. Though the device and specific protocols can be used to retrieve a variety of intracellular molecules one of the preferred embodiments particularly lends itself to the extraction of DNA. The electromagnetic device uses a set of terraced coils controlled in such a matter as to continually alternate polarity and thereby emulate the random motion of a manual mortal and pestle. This simulation of random motion is created through the arrangement of coils found in this invention. Methods were also developed to aid in the retrieval of DNA or other intracellular components using this device such that these components can be isolated and then used for study, amplification, or a variety of different purposes.

Abstract: The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on selected gram-positive organisms. BPI protein product also increases the susceptibility of gram-positive organisms to antibiotics and can even reverse resistance of gram-positive organisms to antibiotic.

Abstract: A mask (2) having a predetermined pattern formed on a work surface of amagnetic head slider substrate (1) containing aluminum oxide and titanium carbide as main constituents. The magnetic head slider substrate (1) with the mask (2) formed thereon as set on an electrode disposed inside an etching apparatus. While a reactive gas an insert gas are introduced into an excitation chamber (14) of the etching apparatus to cause plasma excitation of said gases to occur, a radio frequency power is applied to the electrode. Hereupon, reactive gas ions (4) and inert gas ions (5) that are generated by the plasma excitation are drawn to the magnetic head slider substrate (1), causing reactive etching by the reactive gas ions (4) and sputter-etching by the inert gas ions (5) to proceed concurrently.

Abstract: Fluorescent conjugates suitable for use in flow cytometry and other biological applications. The fluorescent conjugates comprise an antibody having a polymeric dye bound thereto. The polymeric dye is preferably enhanced by a hydrophobic and conformationally restrictive moiety either bound thereto or in close association therewith. The hydrophobic and conformationally restrictive moiety is preferably derived from a cyclodextrin. The polymeric dye comprises a polymeric entity having signal-generating groups, such as aminostyryl pyridinium dye residues attached thereto. The fluorescent conjugates exhibit exceptional stability characteristics and avoid many of the problems of energy transfer, bio-conjugability, and solubility.

Abstract: Microelectronics wafer substrate surfaces are cleaned to remove metal contamination while maintaining wafer substrate surface smoothness by contacting the wafer substrate surfaces with an aqueous cleaning solution of an alkaline, metal ion-free base and a polyhydroxy compound containing from two to ten --OH groups and having the formula: ##STR1## wherein or in which --R--, --R.sup.1 --, --R.sup.2 -- and --R.sup.3 -- are alkylene radicals containing two to ten carbon atoms, x is a whole integer of from 1 to 4 and y is a whole integer of from 1 to 8, with the proviso that the number of carbon atoms in the polyhydroxy compound does not exceed ten, and wherein the water present in the aqueous cleaning solution is at least about 40% by weight of the cleaning composition.

Abstract: The present invention discloses compositions containing a transfer agent and/or bactericidal compounds, and hydrophobic materials which form, upon application to dental surfaces, adhesive, protective and bacteria-inhibiting barriers.

Abstract: A floating magnetic head device in which a slider carrying a magnetic head is supported by a supporting member. An intermediate layer composed of elements of the groups III or IV of the Periodic Table and an upper layer composed of hard carbon are sequentially deposited at least on the surface of slide rails formed on the major surface of the slider operating as a floating surface. It is possible with the floating magnetic head device to reduce the abrasion and sticking between the slider and the magnetic disc for improving abrasion resistance and CSS durability of the slider and the magnetic disc as well as durability and operational reliability of the magnetic head and the magnetic disc as articles of commerce.

Abstract: A method of removing a resist layer formed on a substrate wherein the resist layer includes an ion-implanted upper region. The method includes hydrogenating the ion implanted upper region of the resist layer resulting in the hydrogenated ion-implanted upper region. The resist layer, including the hydrogenated ion-implanted upper region is then removed. A hydrogenation of the ion-implanted upper region may be performed by immersing the resist layer, including the ion-implanted upper region, into pressurized boiling water, and/or treating the ion-implanted upper region with pressurized water vapor.

Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.