Patents Examined by Pablo Whaley
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Patent number: 8321135Abstract: The present invention relates to a method and apparatus for predicting the resistance of soybean seed samples to infection by soybean cyst nematode parasites using near-infrared spectroscopy and discriminant analysis.Type: GrantFiled: February 19, 2002Date of Patent: November 27, 2012Assignee: The Curators of the University of MissouriInventors: Christopher M. Fender, David A. Sleper
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Patent number: 8321136Abstract: The present invention relates to a method and system for classifying biological specimen. A number of objects of interest are identified in a biological specimen. The nuclear area and nuclear integrated optical density for each object of interest in the specimen are measured and used for generating a scatter plot. The specimen is classified as normal or suspicious based on the distribution of points within the scatter plot.Type: GrantFiled: March 5, 2004Date of Patent: November 27, 2012Assignee: CYTYC CorporationInventors: Kam Lin Wong, Louise Isenstein, David Zahniser
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Patent number: 8321138Abstract: Methods, systems, and computer readable media for determining the quality of a CGH array, including calculating a spread of the derivative of log ratio value differences between consecutive probes representing consecutive positions along a chromosome, wherein ratio values are calculated from probe signals from a CGH array.Type: GrantFiled: July 29, 2005Date of Patent: November 27, 2012Assignee: Agilent Technologies, Inc.Inventors: Bo U. Curry, Jayati Ghosh
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Patent number: 8296071Abstract: Methods, devices and device components are presented for uniformly treating fluids undergoing mixing with electromagnetic radiation. In one aspect, the present invention provides methods of treating a fluid undergoing continuous fluid mixing wherein net radiant energies necessary to provide uniform treatment of the fluid samples with electromagnetic radiation are calculate on the basis of the volume, mass or mixing rate of the fluid or any combination of these variables. In another aspect, the present invention provides algorithms for determining net radiation energies, radiant powers, and/or illumination times necessary for providing uniform treatment of fluid samples. The present invention provides methods for uniformly reducing pathogens in biological fluids, including blood and blood components.Type: GrantFiled: March 14, 2005Date of Patent: October 23, 2012Assignee: Terumo BCT Biotechnologies, LLCInventors: Richard Alan Edrich, Laura Goodrich, Glen Delbert Antwiler
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Patent number: 8234099Abstract: Selecting the nutrition for an animal or animal group comprises performing a diagnostic test to obtain first data. A data base that comprises first data relating a genomic analysis of a bodily fluid or tissue sample from an animal to a physiological condition and optionally the genotype of the animal is accessed. A data base that comprises second data relating to effects of nutrition on genomic analysis is accessed. The first and second data are processed with input data defining the physiological condition and optionally the genotype of the animal or animal group to derive the nutrition for an animal or animal group.Type: GrantFiled: November 30, 2010Date of Patent: July 31, 2012Assignee: HEMOPETInventor: W. Jean Dodds
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Patent number: 8224587Abstract: Determining a nutritional diet for a canine or feline companion animal comprises employing a computer; at least one electronic database coupled to the computer; and at least one software routine executing on the computer. First data comprises a relationship between expression data from the genomic map and a physiological condition of the animal, and second data comprises an effect of nutrition on the expression data from the genomic map. Based on said first and second data, a nutritional diet for the canine or feline companion animal is determined.Type: GrantFiled: March 12, 2012Date of Patent: July 17, 2012Assignee: HemopetInventor: W. Jean Dodds
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Patent number: 8185317Abstract: Methods, systems, and computer software for determining the stain quality of a plurality of biological specimens. A number of objects of interest are identified in a biological specimen. A first feature of each object of interest (e.g., nuclear area) and a second feature of each object of interest (e.g., nuclear integrated optical density) are measured, and a scatter plot of the first and second features is generated. The stain quality of the specimens are determined based on the distribution of points within the scatter plot.Type: GrantFiled: March 5, 2004Date of Patent: May 22, 2012Assignee: Cytyc CorporationInventors: Kam Lin Wong, Louise Isenstein, David Zahniser
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Patent number: 8060354Abstract: Selecting the nutrition for an animal or animal group comprises performing a diagnostic test to obtain first data. A data base that comprises first data relating a genomic analysis of a bodily fluid or tissue sample from an animal to a physiological condition and optionally the genotype of the animal is accessed. A data base that comprises second data relating to effects of nutrition on genomic analysis is accessed. The first and second data are processed with input data defining the physiological condition and optionally the genotype of the animal or animal group to derive the nutrition for an animal or animal group.Type: GrantFiled: November 30, 2010Date of Patent: November 15, 2011Assignee: HEMOPETInventor: W. Jean Dodds
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Patent number: 8024132Abstract: The present invention concerns a method for the quantification of a target nucleic acid in a sample comprising the following steps: (i) determination of the amplification efficiency of the target nucleic acid under defined amplification conditions, (ii) amplification of the target nucleic acid contained in the sample under the same defined reaction conditions, (iii) measuring the amplification in real-time, (iv) quantification of the original amount of target nucleic acid in the sample by correction of the original amount derived from step (iii) with the aid of the determined amplification efficiency. The efficiency correction of PCR reactions according to the invention for the quantification of nucleic acids can be used for absolute quantification with the aid of an external or internal standard as well as for relative quantification compared to the expression of housekeeping genes.Type: GrantFiled: August 27, 2009Date of Patent: September 20, 2011Assignee: Roche Molecular SystemsInventors: Gregor Sagner, Karim Tabiti, Martin Gutekunst, Richie Soong
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Patent number: 8005624Abstract: A method and system of supplying rodents, such as mice, to medical researchers pre-installs and/or embeds physiologic sensors onto or within the rodents prior to selling the modified rodents to the researchers. The specialty skills, such as small animal surgical and anesthesia skills and sensor placement and testing, are centralized in one organization rather than being spread about a collection of researchers. The subjects with preinstalled, pre-tested hardware, are sold to the researcher as needed. Communication hardware and software will be supplied for the user to convert their desktop computer into a wireless monitoring station. Additionally an external pulse oximeter for small rodents, such as mice, provides measurements on a hand or foot of the rodent with a sensor configured to avoid shunting around the rodent appendage, and configured for high heart rates (200-900 beats per minutes) of the subjects.Type: GrantFiled: April 26, 2005Date of Patent: August 23, 2011Assignee: STARR Life Sciences Corp.Inventor: Eric William Starr
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Patent number: 7865343Abstract: Selecting the nutrition for an animal or animal group comprises performing a diagnostic test to obtain first data. A data base that comprises first data relating a genomic analysis of a bodily fluid or tissue sample from an animal to a physiological condition and optionally the genotype of the animal is accessed. A data base that comprises second data relating to effects of nutrition on genomic analysis is accessed. The first and second data are processed with input data defining the physiological condition and optionally the genotype of the animal or animal group to derive the nutrition for an animal or animal group.Type: GrantFiled: January 16, 2009Date of Patent: January 4, 2011Inventor: W. Jean Dodds
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Patent number: 7837622Abstract: A recording medium includes a sensor circuit unit generating a current in accordance with a blood glucose level in blood, and a control unit calculating blood glucose level data from the data obtained by digital conversion of the generated current at signal processing unit, writing the calculated data to an EEPROM as a memory unit, reading the blood glucose level data from EEPROM and transmitting the same to a portable terminal on which recording medium is mounted, through a communication control unit. The recording medium further includes a power supply control unit receiving power from the portable terminal on which the recording medium is mounted, and supplying power to various portions in the recording medium.Type: GrantFiled: August 6, 2002Date of Patent: November 23, 2010Assignee: Nipro CorporationInventors: Takehito Itoh, Hideyuki Tomita
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Patent number: 7797145Abstract: A physical blood sample of animal is sent to a satellite laboratory facility. The blood sample is pre-processed into sub-samples of the sample and the sub-samples are coded. The coded blood sub-samples are physically carried to the main laboratory for analysis. The satellite facility electronically inputs a request for a laboratory analysis by a main laboratory. The request is electronically transmitted to the main laboratory, and the main laboratory coordinates the electronically received input from the satellite facility with the physical blood sub-samples. A computer report of the analysis from the laboratory is obtained for the satellite facility. A clinical pathologist with data of physical characteristics of the animal makes a diagnosis. A menu on a computer permits the generation of a supplemental report to support the diagnosis. An integrated computer report having the laboratory analysis, supplemental report, and a pathologist-enhanced report is electronically communicated to the client.Type: GrantFiled: April 17, 2009Date of Patent: September 14, 2010Inventor: W. Jean Dodds
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Patent number: 7767788Abstract: The present invention is a two-domain, bi-functional fusion protein that functions as a molecular switch wherein the free energy released by the folding of a first domain of the fusion protein drives an unfolding of a second domain of the fusion protein, and vice versa. The molecular structure of the fusion protein is engineered so that, at any time, the folding of the first domain necessarily unfolds the other domain, and vice versa, thereby making the folded and unfolded states of the first and second domains mutually exclusive. This is accomplished by the insertion of ubiquitin insert protein into a surface loop of barnase target protein subject to the structural design criterion that the N-C terminal length of the ubiquitin insert protein is at least two-times greater than the C?-C? alpha-carbon-alpha-carbon length of the surface loop of the barnase target protein.Type: GrantFiled: March 17, 2004Date of Patent: August 3, 2010Assignee: The Research Foundation of State University of New YorkInventors: Stewart Loh, Mark C. Butler, Jeung-Hoi Ha, Tracy L. Radley
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Patent number: 7739091Abstract: The present invention is directed to a method of predicting the binding affinity between a first molecular entity and a second molecular entity. The method includes (1) calculating the free energy of binding ?Gbind between the first molecular entity and the second molecular entity according to the equation (17): ?Gbind=?0.82?X+/?+0.064?Xc/s?0.6Xsb?0.93Xhb?0.0007Xgap?0.06?Xtor?0.36??(17) where X+/? is the total number of exposed charged groups; Xc/s is the total number of exposed hydrophobic groups; Xsb is the total number of salt bridges; Xhb is the total number of hydrogen bonds; Xgap is the gap volume at the interface of the first molecular entity and the second molecular entity; Xtor is the total number of exposed side chain torsions; and where ? refers to the difference between the bound and unbound states; and (2) evaluating the free energy of binding to predict the binding affinity between the first and second molecular entities.Type: GrantFiled: March 21, 2007Date of Patent: June 15, 2010Assignee: The Research Foundation of State University of New YorkInventor: Joseph Audie
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Patent number: 7603240Abstract: The present invention provides a peptide identification method along with related peptide databases, method of generating the databases, computer usable media, and computer program products. The peptide identification method involves the use of qualitative amino acid composition or partial qualitative amino acid composition information of a query peptide obtained by mass spectrometry to correlate the query peptide to one or more peptides with defined amino acid sequences in a peptide database generated according to the present invention.Type: GrantFiled: January 19, 2005Date of Patent: October 13, 2009Assignee: MCW Research Foundation, Inc.Inventors: Brian D. Halligan, Edward A. Dratz
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Patent number: 7552039Abstract: A physical blood sample of animal is sent to a satellite laboratory facility. The blood sample is pre-processed into sub-samples of the sample and the sub-samples are coded. The coded blood sub-samples are physically carried to the main laboratory for analysis. The satellite facility electronically inputs a request for a laboratory analysis by a main laboratory. The request is electronically transmitted to the main laboratory, and the main laboratory coordinates the electronically received input from the satellite facility with the physical blood sub-samples. A computer report of the analysis from the laboratory is obtained for the satellite facility. A clinical pathologist with data of physical characteristics of the animal makes a diagnosis. A menu on a computer permits the generation of a supplemental report to support the diagnosis. An integrated computer report having the laboratory analysis, supplemental report, and a pathologist-enhanced report is electronically communicated to the client.Type: GrantFiled: September 1, 2004Date of Patent: June 23, 2009Assignee: HemopetInventor: W. Jean Dodds
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Patent number: 7548839Abstract: A diagnosis of the health of an animal is obtained through a combination of computerized data and human interpretation. Data relates to the physical characteristics of the animal, and includes data obtained from a physical inspection of the animal. A blood or other fluid sample is used to obtain a computer generated laboratory analysis. This is reported through an internet network to the clinical pathologist. The clinical pathologist has the data relating to the physical characteristics, and thereby makes a diagnosis of the animal health. A drop-down menu on a computer screen provides supplemental reports to support the diagnosis. This can be enhanced by further input from the pathologist through keyboard entry into the computer to obtain an integrated computer report having the laboratory analysis, supplemental report, and selectively an enhanced report. The integrated report is electronically communicated to a client.Type: GrantFiled: August 5, 2003Date of Patent: June 16, 2009Assignee: HemopetInventor: W. Jean Dodds
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Patent number: 7167802Abstract: This invention is directed to the crystal structures of MK2, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of MK2 proteins. Such agents may be useful as therapeutic agents.Type: GrantFiled: November 13, 2002Date of Patent: January 23, 2007Assignee: WyethInventors: Kevin D. Parris, Kathryn W. Underwood, Mark L. Stahl, Lidia Mosyak, Kristine Svenson, Tania Shane, Meggin L. Taylor
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Patent number: 7022476Abstract: The present invention provides methods for predicting the likelihood of development of systemic lupus erythematosus (SLE) in an individual, which comprise determining the sequence at one or more polymorphic positions within the human genes encoding Fc?RIIB. The invention also provides isolated nucleic acids encoding Fc?RIIB polymorphisms, nucleic acid probes that hybridize to polymorphic positions and kits for the prediction of SLE status.Type: GrantFiled: February 26, 2002Date of Patent: April 4, 2006Assignee: New York Society for Ruptured and Crippled Maintaining the Hospital for Special SurgeryInventor: Luminita Pricop