Abstract: An advanced polymeric, surgical clip is provided for clamping a blood vessel between two legs. A hook section of the clip comprises two sharpened forward edges for penetrating connective tissue adjacent a vessel before closing the surgical about a blood vessel. The upper leg of the surgical clip may comprise an oblique flank for disposing over the one or more edge of the hook section, the lower surface of the oblique flank defining a channel in which a tip of the hook section travels.

Abstract: Medical devices and methods of using medical devices are disclosed. An example tissue engagement device includes a first actuation member including a body coupled to a first jaw and a second jaw at a pivot point, wherein the body is designed to shift between a first configuration and a first compressed configuration and a second actuation member coupled to the first actuation member at the pivot point and at a fixation point, wherein the second actuation member is designed to shift between a second configuration and a second compressed configuration. Further, shifting the first actuation member from the first configuration to the first compressed configuration, shifting the second actuation member from the second configuration to the second compressed configuration, or both, shifts the first jaw and the second jaw between a closed configuration and an open configuration.

Abstract: A handle assembly for use with a surgical tack applier includes an actuation assembly and an articulation lever assembly configured to articulate an articulation portion of the surgical tack applier. The actuation assembly includes a motor, an actuation rod, and an actuation switch configured to actuate the motor. The actuation rod has a first end operatively coupled to an output shaft of the motor for concomitant rotation therewith, and a second end operatively coupled to a loading unit of the surgical tack applier such that rotation of the actuation rod ejects a surgical tack from the loading unit. The articulation lever assembly includes an articulation rod operatively coupled with an articulation portion of the surgical tack applier such that axial displacement of the articulation rod causes articulation of the articulation portion, and an articulation lever operatively coupled with the articulation rod.

Abstract: A clot retrieval device for removing occlusive clot from a blood vessel. The device comprises an inner elongate body having a collapsed delivery configuration and an expanded deployed configuration. An outer elongate body is at least partially overlying the inner elongate body. The outer elongate body is expandable to a radial extent which is greater than the radial extent of the inner body in the deployed configuration to define a clot reception space. The outer elongate body has a plurality of clot receiving openings and a plurality of clot engaging regions. The clot engaging regions are adapted, on engagement with clot, to urge clot towards the clot receiving openings and into the reception space between the outer elongate body and the inner elongate body, wherein the radial force profile of the device varies along the length of the device.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: Disclosed herein are methods and devices for treating pancreatitis. In the methods described herein, the distal portion of a catheter is routed into the pancreatic duct. The catheter delivers to the pancreatic duct an effective amount of a composition at an effective infusion pressure, wherein the amount and infusion pressure of the composition are effective to decrease the secretion of digestive enzymes from one or more exocrine tissues of the pancreas. The reduction of digestive enzymes may reduce damage to the islet cells typically seen in chronic pancreatitis. Backflow of the composition out of the pancreatic duct is limited, for example, by an occluding system, and aspiration system, or both.