Abstract: A system for controlled neuromodulation procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Systems and methods for imaging, monitoring, stimulating, and/or ablating neurological structures coupled to one or more organs of the lower urinary tract (LUT) are disclosed. Such processes may be used to alter the hormonal secretions from one or more organs, to modulate the growth of an organ, alter the growth rate or rate of perineural invasion of a tumor, or the like. In particular such processes may be used to slow, halt and/or reverse the growth of a prostate gland or a prostate tumor.

Abstract: Devices, systems and methods provide forms of asymptomatic diaphragmatic stimulation (ADS) therapy that affect pressures within the intrathoracic cavity, including: 1) dual-pulse ADS therapy, during which a first ADS pulse is delivered during a diastolic phase of a cardiac cycle and a second ADS pulse is delivered during a systolic phase, 2) paired-pulse ADS therapy, during which a first ADS pulse is delivered, closely followed by a second ADS pulse, with the second ADS pulse functioning to extend or enhance a phase of a transient, partial contraction of the diaphragm, and 3) multiple-pulse ADS therapy, during which a stream of ADS pulses is delivered, wherein the time between pulses is based on heart rate. Devices, systems and methods also monitor electromyography (EMG) activity of the diaphragm relative to baseline activity to assess the health of a diaphragm subject to ADS therapy and to adjust ADS therapy parameters or sensing parameters.

Abstract: In some embodiments, the instant invention includes a laser device that includes: a laser generating module that produces a plurality of laser pulses having a time-stricture pulse format that includes at least: a plurality of micropulses, a macropulse time envelope, where the plurality of micropulses are within the macropulse time envelope; where the time-stricture pulse format is configured so that the laser device is capable of treating human tissue by selectively targeting or affecting at least one first tissue or at least one first disease organisms while not substantially affecting at least one first surrounding or adjacent tissue.

Abstract: Systems and methods for generating a personalized cognitive treatment recommendation for an individual. The system includes one or more processors; and a memory to store processor-executable instructions. Upon execution of the instructions, the one or more processors receive parameters for at least one cognitive treatment tool; receive physiological data indicative of a condition of the individual, and/or clinical data associated with the individual; and generate the personalized cognitive treatment recommendation based on the physiological data and/or the clinical data. The recommendation includes a specification of (i) at least one first cognitive treatment tool, (ii) at least one second cognitive treatment tool different from the at least one first cognitive treatment tool, or (iii) both (i) and (ii). Optionally, the one or more processors receive performance data indicative of the individual's performance of at least one task associated with the at least one cognitive treatment tool of the recommendation.

Abstract: A system may include one implantable pulse generator and at least one implantable lead. The pulse generator may include a processor, a driving system for driving electrodes, a communication circuit, and a housing configured to be subcutaneously implanted. The lead may be configured to extend from the pulse generator to at least one neural target on a left side of a head and a neural target on a right side of the head. The lead may include at least two electrode sets, each including at least two electrodes. The lead be configured to be used to subcutaneously place the at least two electrode sets near the at least two neural targets, respectively, and electrically connect the pulse generator to each of the at least two electrodes sets to enable the driving system to drive the at least two electrode sets to stimulate the at least two neural targets.

Abstract: Systems, devices, and methods for using vagus nerve stimulation to treat demyelination disorders and/or disorder of the blood brain barrier are described. The vagus nerve stimulation therapy described herein is configured to reduce or prevent demyelination and/or promote remyelination to treat various disorders related to demyelination, such as multiple sclerosis. A low duty cycle stimulation protocol with a relatively short on-time and a relatively long off-time can be used.

Abstract: An implanted neurostimulator has a processor which controls stimulation parameter values to create stimulation signals which are applied to a patient's body to maintain relative proportional amplitudes of a set of linked stimulation signals during stimulation in accordance with a stimulation protocol. An external programmer receives user input data and can adjust the stimulation protocol. A set of independently operable electrode contacts are electrically coupled to the neurostimulator and the set of independently operated electrode contacts have at least two subset electrode contacts which are linked together to receive the set of linked stimulation signals. An information transmission system has telemetry circuitry to transmit to the neurostimulator the set of stimulation signal values in accordance with the stimulation protocol.

Abstract: A strap for a wearable physiological monitor can be adjusted to a desired tension. The strap may include a buckle that retains a length of the strap as the strap is removed from and replaced to the wearable physiological monitor. In this manner, one or more straps may be removed and replaced without requiring readjustment of strap length for a particular user.

Abstract: The present invention provides a microelectrode, comprising a flexible layer, an electrically conductive layer and a plurality of platinum dendrite structures, wherein the electrically conductive layer is arranged in the flexible layer, and wherein on the surface of the flexible layer are a plurality of grooves within which the electrically conductive layer is revealed partially, and wherein each of the groove is provided with one platinum dendrite structure therein. The plurality of grooves serve as focal electrodes distributed uniformly, with smaller electrode sites and more recording points. The modified platinum dendrite structures increase the surface area, electrical performance, biocompatibility and service life of the microelectrode. Besides, creating virtual electrodes by current steering technique increases the number of stimuli received by microelectrode during use, and improves its resolution in applications.

Abstract: A system and method for determining the proper dynamic strain profile of an elastomeric construct. The strain characteristics of a deficient heart are determined and compared to the normal strain characteristics of a healthy heart. A construct having elastomeric elements is provided that can expand along multiple axes. In an unloaded condition remote from the deficient heart, the elastomeric elements are pressurized to determine the pressure differential being experienced. Furthermore, optimal strain characteristics are calculated along a first axis and a second axis as a function of the pressure differential. The first optimal strain characteristic and the second optimal strain characteristic are used to estimate the dynamic strain characteristics that will be applied to the heart. The dynamic strain characteristics are compared to the optimal strain characteristics required by the heart to determine if the construct is proper using an automated drive.

Abstract: Provided herein are methods, devices and compositions for assessing neuromodulation efficacy based on changes in the level of one or more biomarkers in plasma or urine collected from a human subject following a renal neuromodulation procedure.

Abstract: A wireless power transfer system is provided. The system includes an external transmit resonator and an implantable receive resonator. The transmit resonator is configured to transmit wireless power, wherein the external transmit resonator includes one of i) one or more loops of Litz wire and ii) a plurality of stacked plates. The implantable receive resonator is configured to receive the transmitted wireless power from the external transmit resonator, wherein the implantable receive resonator is configured to power a ventricular assist device (VAD) implanted in a subject using the received wireless power. The implantable receive resonator includes the other of i) the one or more loops of Litz wire and ii) the plurality of stacked plates.

Abstract: An extravascular nerve cuff that is configured to hold a leadless, integral, implantable microstimulator. The nerve cuff may include a cuff body having a pocket or pouch for removably receiving the implantable device within. The nerve cuff can be secured around the nerve such that the electrodes of the device are stably positioned relative to the nerve. Furthermore, the nerve cuff drives the majority of the current from the stimulation device into the nerve, while shielding surrounding tissues from unwanted stimulation.

Abstract: One aspect relates to a medical electrode, having a conductor, an insulation, which surrounds the conductor at least in some sections over its entire circumference, protrusions in the insulation, electrode segments arranged between the protrusions, and insulating areas arranged between the electrode segments, wherein the electrode segments have steps, wherein the steps engage with the insulating areas.

Abstract: An electrical stimulation device is provided. The electrical stimulation device includes a boost circuit, a voltage selecting circuit and a control circuit. The boost circuit generates a plurality of voltages, wherein the voltages have different voltage values. The voltage selecting circuit is coupled to the boost circuit and selects one voltage according to a reference voltage on a tissue impedance to generate an output voltage. The control circuit is coupled to the boost circuit and in response to electrical stimulation; it transmits a control signal to enable the boost circuit.

Abstract: A lead system and method of use for treating breathing disorders by the transvenous stimulation of the phrenic nerve.

Abstract: A method to guide a targeted neurostimulation to the brain of a patient. Neuroimaging data is sensed from the brain of the patient. A processor is used to evaluate the neuroimaging data in order to calculate result data for a modeled functional measure of a particular brain network which defines a first brain region and a second brain region. A target location is determined in the first brain region based upon the result data and a functional connection measure between first and second brain region. A transcranial magnetic stimulator is adjusted to provide a magnetic stimulation signal for stimulation of the target location.

Abstract: A method of implanting includes inserting a stimulation element into a head-and-neck region and positioning an electrode array of the stimulation element relative to a target portion of a nerve.

Abstract: There is provided an output control device, an output control method, and a program to provide technologies for enabling users to control their internal states more easily. The output control device including: an output control unit configured to control output of output information in accordance with a change in a state point in a physiological index space corresponding to a physiological index value based on biosensors. The output control unit controls the output of the output information in accordance with distribution density of previous state points for which a current state point serves as a standard in the physiological index space.

Abstract: An irrigated ablation catheter adapted for direct tissue contact has micro-elements that provide more accurate sensing of tissue, including thermal and electrical properties for temperature and impedance measurements. The micro-elements extend through a hollow chamber of an irrigated ablation electrode, and distal ends thereof can protrude outside of electrode or be flush with the electrode. The micro-elements have a protective guide tube in which components enabling temperature sensing or electrical sensing are encased.