Patents Examined by Pancham Bakshi
  • Patent number: 11142508
    Abstract: Compounds having a structure of Formula I or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: October 12, 2021
    Assignees: The University of British Columbia, Provincial Health Services Authority
    Inventors: Raymond J. Andersen, Marianne Dorothy Sadar, Kunzhong Jian, Nasrin R. Mawji, Jun Wang, Carmen Adriana Banuelos, Yu-Chi Yang
  • Patent number: 11135182
    Abstract: In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The medicant moiety can be a toxin including an acylfulvene or a drug moiety. The affinity moiety can be an antibody, a binding protein, a steroid, a lipid, a growth factor, a protein, a peptide or non peptidic. The affinity moiety can be covalently bound to the medicant via a linker. Novel linkers that can be directed to cysteine, arginine or lysine residues based on solution pH allow greater flexibility in preserving and/or generating specific epitopes in the AMC.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: October 5, 2021
    Assignee: AF CHEMICALS, LLC
    Inventor: Michael Kelner
  • Patent number: 11139162
    Abstract: Described herein are precursors and methods for forming silicon-containing films. In one aspect, the precursor comprises a compound represented by one of following Formulae A through E below: In one particular embodiment, the organoaminosilane precursors are effective for a low temperature (e.g., 350° C. or less), atomic layer deposition (ALD) or plasma enhanced atomic layer deposition (PEALD) of a silicon-containing film. In addition, described herein is a composition comprising an organoaminosilane described herein wherein the organoaminosilane is substantially free of at least one selected from the amines, halides (e.g., Cl, F, I, Br), higher molecular weight species, and trace metals.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: October 5, 2021
    Assignee: Versum Materials US, LLC
    Inventors: Mark Leonard O'Neill, Manchao Xiao, Xinjian Lei, Richard Ho, Haripin Chandra, Matthew R. MacDonald, Meiliang Wang
  • Patent number: 11118017
    Abstract: A process for the production of ethoxylated and hydroxylated lignin fractions, cellulose, lignocellulosic sugars, and ethanol in high yields is provided. The process comprises steaming, pretreatment, chemical recovery, saccharification, and optionally fermentation. A combination of pretreatment conditions is provided resulting in simultaneously high yields of ethoxylated or hydroxylated lignin and cellulose or cellulosic sugars and hernicellulosic sugars. High yield production of ethanol through fermentation can be obtained using this process.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: September 14, 2021
    Assignee: American Process International LLC
    Inventors: Mikhail Iakovlev, Theodora Retsina, Adriaan van Heiningen, Myrto Papaioannou, Eleni Natsi
  • Patent number: 11110113
    Abstract: Disclosed is a therapeutic regimen which includes S-adenosyl methionine, or a salt thereof; folic acid, or a metabolite therof, or a salt thereof; and a compound of Formula (I), or salt thereof, useful in the treatment of a variety of conditions, e.g., neuropsychiatric conditions such as depression. The therapeutic regimen may be used in combination with therapeutic agents as described here.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: September 7, 2021
    Assignee: Gentelon, Inc.
    Inventor: Alexander Vuckovic
  • Patent number: 11110174
    Abstract: The present invention provides a phosphorothioate-modified oligonucleotide comprising a structure shown below: The present invention also provides a phosphorothioate-modified oligonucleotide comprising a structure having formula (CIII):
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: September 7, 2021
    Assignee: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Jayaprakash Nair, Martin Maier
  • Patent number: 11110111
    Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: September 7, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Michio Hirano, Caterina Garone, Ramon Marti
  • Patent number: 11104654
    Abstract: Ester derivatives of sobetirome with enhanced CNS distribution are disclosed.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: August 31, 2021
    Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Thomas S. Scanlan, Andrew Placzek, Tapasree Banerji, Sky Ferrara, James Matthew Meinig
  • Patent number: 11096410
    Abstract: The invention discloses a composition comprising oligosaccharide, for use in the prevention and/or treatment of skin conditions and/or skin diseases by increasing SCFA, in particular colonic propionate and butyrate. Said skin disease is in particular atopic dermatitis.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: August 24, 2021
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Carine Blanchard, Chiara Nembrini
  • Patent number: 11096953
    Abstract: Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: August 24, 2021
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Joseph Desimone, Yogen Saunthararajah
  • Patent number: 11083742
    Abstract: The present invention relates to a nutritional composition comprising at least one fucosylated oligosaccharide for use in an infant or young child for preventing a later in life health disorder by preventing premature adiposity rebound. The invention also relates to nutritional composition for use to promote healthy growth.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: August 10, 2021
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Aristea Binia, Norbert Sprenger
  • Patent number: 11077127
    Abstract: The invention relates to a nutritional adjuvant, comprising baicalin and/or baicalein diluted on a medium, and to a feed comprising such an adjuvant, for improving production performance in farm animals in stressful situations.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: August 3, 2021
    Assignee: DELTAVIT
    Inventor: Fabrice Robert
  • Patent number: 11071789
    Abstract: The disclosure provides compounds of Formula (I), wherein X, Y, and Z are defined herein. The disclosure also provides particles comprising one or more compounds described herein, compositions comprising one or more compounds or particles described herein and a pharmaceutically acceptable carrier, and methods of treating a subject in need thereof comprising administering one or more compounds, particles, or compositions described herein to the subject. X—Y—Z??(I).
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: July 27, 2021
    Assignee: Cephalon, Inc.
    Inventors: Anthony S. Drager, Paritosh Wattamwar
  • Patent number: 11072668
    Abstract: Large molecular weight alginates which are covalently modified to store and release nitric oxide, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates may be tailored to release nitric oxide in a controlled manner and are useful for eradication of both planktonic and biofilm-based bacteria.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: July 27, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Mona Jasmine R. Ahonen, Dakota J. Suchyta, Kaitlyn Rose Rouillard
  • Patent number: 11066485
    Abstract: Described herein is an octenyl succinic acid modified starch (OSA modified starch) degraded by at least one enzyme capable of cleaving 1,4-linkages of a starch molecule from the non-reducing ends to produce short chain saccharides, wherein the content of non-covalently bound, free octenyl succinic acid in the OSA modified starch is less than about 0.50% by weight, based on total weight of the modified starch, and wherein content of alpha-1,6-glycosidic linkages is higher than 12%, a method of preparing same, and an encapsulation agent comprising same as well as a method of encapsulating an active agent with said encapsulation agent.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: July 20, 2021
    Assignee: Corn Products Development, Inc.
    Inventors: Friedrich Heinze, Justus Hierneis
  • Patent number: 11066484
    Abstract: Provided is cellulose acetate with which a hollow fiber membrane having excellent salt rejection and water permeability can be produced. The cellulose acetate, in which a total content of calcium and magnesium is 2.8 to 3.5 ?mol/g; a 6 percent viscosity is 40 to 80 mPa·s; a degree of filtration Kw is 35 g?1 or less; a molecular weight distribution Mw/Mn is 3.00 or less; and a degree of acetylation is 61.3 to 62.3%.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: July 20, 2021
    Assignee: DAICEL CORPORATION
    Inventors: Naohiro Oyamada, Akihiro Higuchi
  • Patent number: 11066415
    Abstract: The present invention encompasses the use of compounds for a novel approach to treat and prevent diseases, conditions, and disorders such as diabetes and ischemic reperfusion injury. Compounds of the invention, including but not limited to BAM15 ((2-fluorophenyl){6-[(2-fluorophenyl)amino](1,2,5-oxadiazolo[3,4-e]pyrazin-5-yl)}amine), a mitochondrial uncoupler, can improve glucose tolerance, increases cellular oxygen consumption, treat or prevent kidney ischemia reperfusion injury reverse insulin resistance, reverse or treat hyperinsulinemia, and reverse or treat hyperlipidemia. The present invention further provides novel compounds as well as methods for identifying compounds with the same or similar properties as BAM15.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: July 20, 2021
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Kyle Hoehn, Brandon Kenwood
  • Patent number: 11052098
    Abstract: The present invention relates to a composition comprising an araloside-based compound and, more particularly, to a composition for external application to skin, the composition comprising, as an active component, an araloside-based compound, including araloside X, araloside V and araloside VII. Thus, the composition restores skin markers damaged by external environmental stress, such as harmful substances or fine dusts, and reduces the expression of skin inflammatory factors to help the recovery of damaged skin, thereby providing effects, such as anti-oxidation, skin trouble suppression, anti-inflammation, or skin barrier improvement.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: July 6, 2021
    Assignee: Amorepacific Corporation
    Inventors: Jin Sup Shim, Jae Young Ko, Mi Suk Yang, Se Jin Yoo, Ho Hyun Song, Yong Jin Kim, Jon Hwan Lee
  • Patent number: 11052060
    Abstract: Compounds and compositions useful in methods of treating, ameliorating, or inhibiting the development of autoimmune diseases or Celiac disease by modulating the binding of DQ8 MHC class II molecules to antigenic peptides or fragments of antigenic peptides.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: July 6, 2021
    Assignees: The Regents of the University of Colorado, a body corporate, ImmunoMolecular Therapeutics, Inc.
    Inventors: Steve Orndorff, Aaron Michels
  • Patent number: 11045786
    Abstract: Provided are superabsorbent materials composed of agar, and one or more water-soluble natural polysaccharides, and dietary compositions containing such superabsorbent materials. The disclosed superabsorbent materials have various food and therapeutic applications and can be used as loading vehicles for nutrients and therapeutic agents. Also provided are methods for preparing such superabsorbent materials.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: June 29, 2021
    Assignee: Healthall Laboratory, Inc.
    Inventor: Lijun Sun