Patents Examined by Pancham Bakshi
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Patent number: 12291544Abstract: A process for preparing trimethylchlorosilane (M3) and methyltrichlorosilane (M1) by disproportionation of dimethyldichlorosilane (M2) in the presence of an Al2O3 catalyst is described herein. The dimethyldichlorosilane used is in the form of a silane mixture that includes 80-100% by weight of dimethyldichlorosilane (M2). The difference in content from 100% by weight includes M1 and M3.Type: GrantFiled: December 4, 2019Date of Patent: May 6, 2025Assignee: Wacker Chemie AGInventors: Jan Tillmann, Richard Weidner
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Patent number: 12285738Abstract: A treatment for reducing glucose bioaccessibility can include providing a superabsorbent material that includes a porous network structure formed from a mixture of a plurality of water soluble polysaccharides that are not chemically crosslinked together. The superabsorbent material can be administered to a subject in an effective amount to reduce glucose bioaccessibility in the subject. In some aspects, the treatment for reducing glucose bioaccessibility with the superabsorbent material retains a substantially unaltered fatty acid bioaccessibility and/or retains a substantially unaltered protein bioaccessibility.Type: GrantFiled: August 12, 2021Date of Patent: April 29, 2025Inventor: Lijun Sun
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Patent number: 12281059Abstract: Provided is a method for producing a halogenated hydrocarbon magnesium compound, the method including bringing a halogenated hydrocarbon compound into contact with magnesium having a specific surface area of 1×10?5 to 2×10?4 m2/g. Also provided are methods for producing a tertiary alcohol compound and an organosilicon compound, wherein said production method is utilized.Type: GrantFiled: January 21, 2021Date of Patent: April 22, 2025Assignee: TOKUYAMA CORPORATIONInventors: Hiroyuki Oda, Ryosuke Nishimoto, Daisuke Abiko, Takenori Isomura
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Patent number: 12280021Abstract: In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The medicant moiety can be a toxin including an acylfulvene or a drug moiety. The affinity moiety can be an antibody, a binding protein, a steroid, a lipid, a growth factor, a protein, a peptide or non peptidic. The affinity moiety can be covalently bound to the medicant via a linker. Novel linkers that can be directed to cysteine, arginine or lysine residues based on solution pH allow greater flexibility in preserving and/or generating specific epitopes in the AMC.Type: GrantFiled: August 4, 2023Date of Patent: April 22, 2025Assignee: AF CHEMICALS, LLCInventor: Michael Kelner
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Patent number: 12280072Abstract: A purified oligosaccharide compound having antithrombotic activity or a mixture of a homologous compound thereof and a pharmaceutically acceptable salt thereof, a preparation method for the mixture, a pharmaceutical composition containing the mixture, and uses thereof serving as an intrinsic factor X-enzyme (Xase) inhibitor in the preparation of drugs for preventing and/or treating thrombotic diseases.Type: GrantFiled: September 28, 2023Date of Patent: April 22, 2025Assignees: Jiuzhitang Co., Ltd., Mudanjiang YouBo Pharmaceutical Co., LtdInventors: Jinhua Zhao, Zhenguo Li, Na Gao, Mingyi Wu, Yanming Chen, Longyan Zhao, Yongsheng Wu, Zi Li, Chuang Xiao, Shunliang Zheng, Zhiyuan Nan, Jianbo Zhou, Jianping Xu, Lutan Zhou, Yafang Guo, Hongbo Qin, Jikai Liu
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Patent number: 12274709Abstract: The present invention discloses a dual-drug co-delivery system, a preparation method therefor and use thereof, the dual-drug co-delivery system being prepared from raw materials comprising a block copolymer, Homoharringtonine and Doxorubicin hydrochloride. The dual-drug co-delivery system provided by the present invention has a stronger killing effect on various hematologic tumors and solid tumor cells, can provide a feasible drug delivery system for inhibiting tumor growth and leukemia treatment, and has broad prospects.Type: GrantFiled: February 27, 2020Date of Patent: April 15, 2025Assignee: INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCESInventors: Haiyan Xu, Doudou Yan, Jie Meng, Jian Liu, Tao Wen, Yangyang Ge
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Patent number: 12268778Abstract: A bifunctional nucleoside hydrogel is formed by dissolving isoguanosine, guanosine and a borate in water or an aqueous solution and then crosslinking same. The bifunctional nucleoside hydrogel integrates a carrier and a drug effect and has a significant inhibitory effect on the activity of tumor cells, and in particular has a significant inhibitory effect on the activity of cells related to lung cancer, glioma, osteoma, colon cancer, breast cancer, oral squamous cell carcinoma and tongue squamous cell carcinoma, of which the inhibitory effect on the activity of cells related to oral squamous cell carcinoma is the best. Therefore, the bifunctional nucleoside hydrogel has potential application prospects in preparing anti-tumor drugs, and particularly, same can provide a new approach for treating oral squamous cell carcinoma.Type: GrantFiled: May 31, 2019Date of Patent: April 8, 2025Assignee: SICHUAN UNIVERSITYInventors: Hang Zhao, Xin Zeng, Ning Ji, Hui Feng, Jiang Liu, Qianming Chen
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Patent number: 12269834Abstract: A method of preparing an organosilicon compound via selective silylation of ethylene is disclosed. The method comrises prises reacting via silylation (A) a hydridochlorosilane compound and (B) ethylene in the presence of (C) a catalyst, thereby preparing the organosilicon compound. The silylation may be selectively conducted as a dehydrogenative coupling to prepare the organosilicon ompound as a vinylchlorosilane compound, or as a hydrosilylation to prepare the organosilicon compound as an ethylchlorosilane compound. The catalyst (C) comprises a Ru(0) complex, and may be recycled for use in subsequent silylation reactions without purification. The organosilicon compound prepared according to the method is also disclosed.Type: GrantFiled: December 17, 2020Date of Patent: April 8, 2025Assignee: DOW SILICONES CORPORATIONInventors: David Lawrence Witker, Juan Mauricio Venegas, Ronen Weingarten, Dimitris E. Katsoulis
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Patent number: 12251392Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.Type: GrantFiled: April 24, 2023Date of Patent: March 18, 2025Assignee: The Trustees of Columbia University in the City of New YorkInventors: Michio Hirano, Caterina Garone, Ramon Marti
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Patent number: 12252464Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.Type: GrantFiled: May 10, 2023Date of Patent: March 18, 2025Assignee: The Board of Regents of The University of Texas SystemInventors: Daniel J. Siegwart, Jason B. Miller
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Patent number: 12239650Abstract: The present invention relates to compounds with high chemical stability and methods for inhibiting the pathological activity of NETs in a subject. In particular, the invention relates to compounds with high chemical stability, uses thereof and methods for inhibiting or ameliorating NET mediated ailments (such as, for example, sepsis, systemic immune response syndrome (SIRS) and ischemia reperfusion injury (IRI)). More particularly, the invention relates to methods and uses of a polyanionic sulfated cellobioside modified with a small uncharged glycosidically linked substituent at its reducing terminus, wherein the presence of the substituent results in a molecule with high chemical stability without affecting the ability of the molecule to be effective in the therapy of NET mediated ailments. For example, the present invention relates to methods and uses of ?-O-methyl cellobioside sulfate (mCBS) or a pharmaceutically acceptable salt thereof (e.g., mCBS.Type: GrantFiled: February 25, 2019Date of Patent: March 4, 2025Assignees: The Australian National University, Griffith UniversityInventors: Christopher Parish, Connor O'Meara, Lucy Coupland, Benjamin Ju Chye Quah, Farzaneh Kordbacheh, Anna Orlov, Anna Browne, Ross Stephens, Gregory David Tredwell, Lee Andrew Philip, Karen Knox, Laurence Mark von Itzstein, Chih-Wei Chang, Anne Bruestle, David Anak Simon Davis
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Patent number: 12227531Abstract: There is provided herein a silylated organo-modified compound which comprises: at least one moiety having the formula (A): wherein the subscript a is 1 or 2, each D is independently NH or O, each of X, Y and Z are independently an unsubstituted or substituted C or N, the dashed lines between X, Y, and Z indicate an optional double bond between either X and Y or Y and Z, with the proviso that when any of X, Y, or Z is a substituted N atom, such substituted N atom does not participate in a double bond, and each Q is independently O or S; and, at least two moieties having the formula (B):Type: GrantFiled: November 17, 2022Date of Patent: February 18, 2025Assignee: Momentive Performance Materials Inc.Inventors: Cheng Diao, Monjit Phukan, Neal Patel
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Patent number: 12227529Abstract: This disclosure provides a method of preparing a silanol-functional organosilicon compound with a cytochrome P450 variant that facilitates the oxidization of a silyl hydride group to a silanol group in the presence of oxygen. The method includes combining the cytochrome P450 variant and an organosilicon compound having at least one silicon-bonded hydrogen atom to give a reaction mixture and exposing the reaction mixture to oxygen to oxidize the organosilicon compound, thereby preparing the silanol-functional organosilicon compound. Cytochrome P450 variants suitable for use in the method are also disclosed, along with methods for engineering and optimizing the same. Nucleic acids encoding the cytochrome P450 variants and compositions, expression vectors, and host cells including the same are also disclosed.Type: GrantFiled: February 19, 2021Date of Patent: February 18, 2025Assignees: DOW SILICONES CORPORATION, CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: John Roberts, Dimitris Elias Katsoulis, Susanne Baehr, Sabine Brinkmann-Chen, S. B. Jennifer Kan, Frances H. Arnold
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Patent number: 12230496Abstract: Described herein are precursors and methods for forming silicon-containing films. In one aspect, the precursor comprises a compound represented by one of following Formulae A through E below: In one particular embodiment, the organoaminosilane precursors are effective for a low temperature (e.g., 350° C. or less), atomic layer deposition (ALD) or plasma enhanced atomic layer deposition (PEALD) of a silicon-containing film. In addition, described herein is a composition comprising an organoaminosilane described herein wherein the organoaminosilane is substantially free of at least one selected from the amines, halides (e.g., Cl, F, I, Br), higher molecular weight species, and trace metals.Type: GrantFiled: September 8, 2021Date of Patent: February 18, 2025Assignee: VERSUM MATERIALS US, LLCInventors: Mark Leonard O'Neill, Manchao Xiao, Xinjian Lei, Richard Ho, Haripin Chandra, Matthew R. MacDonald, Meiliang Wang
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Patent number: 12221605Abstract: The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).Type: GrantFiled: October 23, 2023Date of Patent: February 11, 2025Assignee: CureVac Manufacturing GmbHInventors: Andreas Funkner, Stefanie Dorner, Stefanie Sewing, Johannes Kamm, Norbert Broghammer, Thomas Ketterer, Thorsten Mutzke
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Patent number: 12213990Abstract: Provided is an A3 adenosine receptor (A3AR) ligand for use in achieving at least one fat loss effect selected from: reducing weight of the subject; reducing body fat mass in the subject; treating obesity in the subject and inhibiting adipocytes proliferation in a subject. The disclosure also concerns pharmaceutical compositions, methods of treatment and kits comprising the A3AR ligand.Type: GrantFiled: January 5, 2020Date of Patent: February 4, 2025Assignee: CAN-FITE BIOPHARMA LTD.Inventors: Motti Farbstein, Inbal Itzhak, Shira Cohen, Pnina Fishman
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Patent number: 12202847Abstract: A process for dehydrogenating and methylating silanes. The process includes providing methyl chloride that is reacted with a silane selected from the group consisting of SiH4, H2SiMe2, H2SiMeCl, H3SiMe, H3SiCl and HSiMe2Cl, in the presence of at least one ammonium and/or phosphonium salt at a temperature in the range of 70-350° C.Type: GrantFiled: April 23, 2020Date of Patent: January 21, 2025Assignee: Wacker Chemie AGInventors: Jan Tillmann, Richard Weidner
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Patent number: 12195484Abstract: A molecular complex including a cationic lanthanide metal, two anionic ligands bonded to the cationic lanthanide metal, and a non-coordinating anion. The two anionic ligands bonded to the cationic lanthanide metal selected from the group consisting of an anionic carbon ring ligand, an anionic monodentate ligand, an anionic polydentate ligand, and combinations thereof.Type: GrantFiled: October 9, 2020Date of Patent: January 14, 2025Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Benjamin G. Harvey, Kenneth R. McClain
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Patent number: 12195488Abstract: According to the organometallic compound of the present invention and the thin film manufactured using the same, requirements of high volatility and excellent chemical/thermal stability are satisfied, and significantly improved thin-film deposition rates are exhibited even at low temperatures. In addition, property degradation due to by-products can be improved, excellent step coverage can be realized, and a thin film which, due to having a high dielectric constant, electrically satisfies the equivalent oxide thickness (EOT) requirement while having a thickness at which tunneling does not physically occur can be implemented.Type: GrantFiled: January 25, 2019Date of Patent: January 14, 2025Assignee: Merck Patent GMBHInventors: Seung Won Ha, Young Hun Byun, Jeum Jong Kim, Ho Hoon Kim, Seong Hak Cheon
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Patent number: 12180238Abstract: Described herein are methods for making alkenyl disiloxanes, comprising combining an alkenyl halosilane with a bis-hydrido terminated alkyl disiloxane and adding the mixture to water, an acidic aqueous solution, or a basic aqueous solution. The ratio of the alkenyl halosilane to the bis-hydrido terminated alkyl disiloxane is about 1:10 to about 10:1. The alkenyl halosilane and bis-hydrido terminated alkyl disiloxane are mixed at about 20° C. to about 45° C. In an example, no organic solvent is present. The reaction product is separated and washed with saturated NaHCO3 solution (e.g., sodium bicarbonate).Type: GrantFiled: December 11, 2020Date of Patent: December 31, 2024Assignee: Dow Silicones CorporationInventors: Xiaoyuan Zhou, Zhanjie Li, Eric Joffre