Patents Examined by Pancham Bakshi
  • Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids
    Patent number: 11542229
    Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: January 3, 2023
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Daniel J. Siegwart, Jason B. Miller
  • Compounds, compositions, and methods for coloring edible materials
    Patent number: 11542291
    Abstract: The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange, or yellow. The invention also provides compositions and methods for coloring edible materials to a desired color such as red, orange, or yellow.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: January 3, 2023
    Assignee: The Penn State Research Foundation
    Inventors: Gregory Ray Ziegler, Joshua David Lambert, Emmanuel Hatzakis, Eugene P. Mazzola
  • (Meth)acrylic-modified siloxane compound
    Patent number: 11535716
    Abstract: The present, invention aims to provide an additive which has a reactive group with good active energy ray curability. When incorporated in a paint, the additive does not bleed over time and imparts an excellent leveling property and a defoaming property to the paint. There is provided a (meth)acrylic-modified siloxane compound of formula (a1) which has, as a branch and, optionally, at one or both of the terminals, of a linear polysiloxane backbone, a specific number of moieties having a (meth)acryloyl group at a terminal and a (poly)oxyalkylene structure of the formula —(CaH2aO)b—. Also provided is an additive for paints, comprising said (meth)acrylic-modified siloxane compound.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: December 27, 2022
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventor: Tomoyuki Goto
  • Use of canagliflozin in preparation of antitumor drug
    Patent number: 11534448
    Abstract: The present invention provides a use of canagliflozin in preparation of an antitumor drug, especially in preparation of a drug for treating solid tumors. It has been proven through researches that canagliflozin has a significant down-regulation effect on immune checkpoint protein PD-L1 in various tumor cells and can effectively enhance the killing effect of T cells on tumor cells in a co-incubation model of T cells and tumor cells, thereby broadening a clinical application scope of the chemical drug canagliflozin in tumor immunotherapy. The present invention provides a new medical use of canagliflozin, and also provides new approaches and potential targets for the development of small molecular drugs based on PD-L1.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: December 27, 2022
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Bo Yang, Qiaojun He, Ling Ding
  • CD73 inhibitors
    Patent number: 11530236
    Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: December 20, 2022
    Assignee: ORIC PHARMACEUTICALS, INC.
    Inventors: Xiaohui Du, John Eksterowicz, Valeria R. Fantin, Daqing Sun, Qiuping Ye, Jared Moore, Tatiana Zavorotinskaya, Brian R. Blank, Yosup Rew, Kejia Wu, Liusheng Zhu, Johnny Pham, Hiroyuki Kawai, Chien-Hung Yeh
  • Use of ginsenoside M1 for manufacturing medicament for treating oral cancer
    Patent number: 11524021
    Abstract: A use of ginsenoside M1 for manufacturing a medicament for treating oral cancer.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: December 13, 2022
    Inventor: Sheau-Long Lee
  • Hyaluronan conjugates and uses thereof
    Patent number: 11524079
    Abstract: Disclosed herein is a hyaluronan conjugate, which includes a hyaluronic acid (HA), a sex hormone, and a linker for coupling one of the disaccharide units of the HA and the sex hormone. Also disclosed herein are the uses of the hyaluronan conjugate in treating or preventing neurodegenerative diseases.
    Type: Grant
    Filed: June 2, 2020
    Date of Patent: December 13, 2022
    Assignee: AIHOL CORPORATION
    Inventors: Szu-Yuan Lee, Ping-Shan Lai, Chih-An Lin
  • Organosilicon on solid oxides, and related complexes, compositions, methods and systems
    Patent number: 11512102
    Abstract: Organosilicon Lewis acids supported on activated oxides and metal oxo complexes grafted on the organosilicon Lewis acids as heterogeneous catalysts and the related compositions, methods and systems are described. These organosilicon Lewis acids and the grafted metal oxo complexes catalyze industrially important chemical reactions including, respectively, C—F bond activation and olefin metathesis reactions such as homocoupling and polymerizations.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: November 29, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Matthew P. Conley, Damien B. Culver
  • Synthetic composition and method for modulating emotion and mood disorders
    Patent number: 11491171
    Abstract: A synthetic composition for use in treating or improving one or more emotion and/or mood disorders in a patient, characterised in that the composition contains an effective amount of one or more neutral human milk oligosaccharides, is disclosed.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: November 8, 2022
    Assignee: GLYCOM A/S
    Inventors: Bruce McConnell, Emma Elison, Louise Kristine Vigsnæs
  • Induction of synthetic lethality with epigenetic therapy
    Patent number: 11491174
    Abstract: The disclosure generally relates to compositions and methods for the treatment of cancer. In some aspects, disclosed herein are methods for the induction of synthetic lethality with epigenetic therapy (ISLET) using a combination of at least one epigenetic compound and at least one chemotherapeutic agent. Also disclosed herein are screening methods for identifying compounds that induce killing of cancer cells when combined with at least one epigenetic compound. Further disclosed herein are methods of potentiating a therapeutic effect of a chemotherapeutic agent against a cancer, comprising administering to a subject having the cancer an epigenetic compound in an amount effective to potentiate the therapeutic effect of the chemotherapeutic agent against the cancer.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: November 8, 2022
    Assignee: The Johns Hopkins University
    Inventors: Srinivasan Yegnasubramanian, William G. Nelson, Ajay Vaghasia, Philipp Nuhn
  • Treatments of prostate cancer
    Patent number: 11478496
    Abstract: The present invention provides compounds, compositions and methods for the treatment of prostate cancers, preferably, advanced prostate cancers. The subject invention also provides compounds, compositions and methods for preventing/slowing down/reducing the progress and proliferation of prostate cancer cells. The subject invention further provides compounds, compositions and methods for inhibiting DNA repair within cancer cells to slow tumor growth, preferably, by inhibiting BER capacity, including pol ? and LIG I.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: October 25, 2022
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Yuk-Ching Tse-Dinh, Yuan Liu, Irina Agoulnik
  • Hydrogen-bonded organic framework (HOF) for water uptake
    Patent number: 11479482
    Abstract: A method of water uptake is provided. The method includes contacting a hydrogen-bonded organic framework (HOF) with water to form a mixture where the HOF comprises hydrogen bonded units of trimesic acid and guanazole. The HOF has a sheet structure, where the sheets form an intercrossed macroporous network with pores on a surface. The HOF absorbs at least a portion of the water in the mixture.
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: October 25, 2022
    Assignee: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
    Inventors: Mohd Yusuf Khan, Abuzar Khan, Aasif Helal, Zain H. Yamani
  • Methods of making metal halide perovskites
    Patent number: 11466040
    Abstract: Methods of making metal halide perovskites, including methods of making micro crystals of metal halide perovskites. The metal halide perovskites, including the micro crystals, may have a 0D structure. The metal halide perovskites may be a light emitting material.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: October 11, 2022
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Biwu Ma, Chenkun Zhou, Zhao Yuan
  • Cyanobacterium extracellular polymer, compositions and uses thereof
    Patent number: 11458202
    Abstract: The polysaccharide released from the unicellular cyanobacterium Cyanothece sp. CCY 0110 exhibits low cytotoxicity and proves to be suitable for the delivery of macromolecules. The cyanobacterium extracellular polymer disclosed in the present subject-matter, namely a polysaccharide and more in particular an heteropolysaccharide, assembles with proteins into a new phase with gel-like behaviour and the release kinetics can be modulated (i.e., delayed) by adding divalent cations and/or also exhibits physical and chemical properties typical of a bioemulsifier or a bioflocculant.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: October 4, 2022
    Assignee: INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR—IBMC
    Inventors: Rita Gil Vasconcelos Mota, Paula Tamagnini, Luis Miguel Gales Pereira Pinto, José Pedro Santos Leite, Sara Isabel Macedo Bernardes Pereira
  • Method for improving substitution rate and/or substitution efficiency of hyaluronan-drug conjugates
    Patent number: 11458204
    Abstract: Disclosed herein is a method for preparing a hyaluronan-drug conjugate. The method uses the ethyl cyano(hydroxyimino)acetate/diisopropylcarbodiimide coupling system in a homogeneous reaction phase, which unexpectedly improves the substitution rate and substitution efficiency of hyaluronan-drug conjugates for various drugs.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: October 4, 2022
    Assignee: Aihol Corporation
    Inventors: Szu-Yuan Lee, Ping-Shan Lai, Chih-An Lin
  • BACE1 inhibitors
    Patent number: 11447478
    Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: September 20, 2022
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Hans Hilpert, Roland Humm, Thorsten Muser, Christian Schnider, Roger Wermuth, Thomas Woltering
  • Solid supports and phosphoramidite building blocks for oligonucleotide conjugates
    Patent number: 11447451
    Abstract: Novel non-nucleoside solid supports and phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one non-nucleosidic moiety conjugated to a ligand of practical interest and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared using said solid supports and phosphoramidite building blocks, preferably followed by removal of protecting groups to provide oligonucleotides conjugated to ligands of interest.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: September 20, 2022
    Assignee: AM Chemicals LLC
    Inventors: Andrei Pavel Guzaev, Vladimir Y. VVedenskiy, Khirud Gogoi
  • Methods for treatment of vascular endothelial dysfunction using nicotinamide mononucleotide
    Patent number: 11433088
    Abstract: Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: September 6, 2022
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Douglas R. Seals, Lindsey Gano, Natalie Poliektor
  • Hydridosilapyrroles, hydridosilaazapyrroles, method for preparation thereof, and reaction products therefrom
    Patent number: 11434252
    Abstract: Hydridosilapyrroles and hydridosilaazapyrrole are a new class of heterocyclic compounds having a silicon bound to carbon and nitrogen atoms within the ring system and one or two hydrogen atoms on the silicon atom. The compounds have formula (I): in which R is a substituted or unsubstituted organic group and R? is an alkyl group. These compounds react with a variety of organic and inorganic hydroxyl groups by a ring-opening reaction and may be used to produce silicon nitride or silicon carbonitride films.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: September 6, 2022
    Assignee: GELEST, INC.
    Inventors: Barry C. Arkles, Youlin Pan, Fernando Jove
  • Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
    Patent number: 11426420
    Abstract: A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: August 30, 2022
    Assignees: CASE WESTERN RESERVE UNIVERSITY, BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Sanford Markowitz, Won Jin Ho, Yiyuan Yuan, Mukesh Jain, Mohamed Sabeh, Joseph Ready, Noelle Williams