Abstract: An ultrasound imaging system may use a capacitive membrane or electrostrictive ultrasound transducer to realize isotropic volumetric imaging with bias-line element selection and a variety of aperture synthesis techniques. Two dimensional beam formation may be performed by using a beamformer to focus along one dimension, and then perform a second round of “off-line” or “retrospective” beam formation along the other direction.

Abstract: The invention provides a device for percutaneously implanting an imaging marker for identifying a location within a tissue mass. The subcutaneous imaging marker comprises at least a first element and a second element, each of which have a primary imaging mode. The primary imaging mode of the first element is different from that of the second element.

Abstract: A method of imaging, comprising: (a) providing an isotope at a low dosage in a body of a patient; (b) receiving radiation generated by said isotope from said body using a radiation camera; and (c) reconstructing a 3D distribution of said isotope from said received radiation, wherein the dosage is less than ? of a standard dose set forth in Table 5.

Abstract: A tissue marking system for use in marking a tissue sample comprises an ink-based applicator device and at least one tissue marking clip. The ink-based applicator device includes a container, a first number of ink reservoirs at least partially defined by the container, wherein each reservoir contains ink of a different color, a second number of applicators, wherein each applicator is configured to absorb a quantity of ink for application to the tissue sample, and a cover coupled to and cooperating with the container to fully enclose each of the first number of ink reservoirs. The at least one tissue marking clip includes an actuator portion movable between an actuated position and a non-actuated position, and a jaw portion coupled to the actuator portion and movable between an open position and a closed position in response to movement of the actuator portion between the actuated and non-actuated positions.

Abstract: A method for position sensing includes inserting a probe having a first probe-electrode and a second probe-electrode into a body of a subject, and coupling body-surface electrodes to a surface of the body. Currents passing between the first probe-electrode and the body-surface electrodes are measured, using first circuitry coupled to at least the first probe-electrode and having a first electrical ground, and position coordinates of the probe are determined responsively to the measured currents. Second circuitry, having a second electrical ground, is coupled to at least the second probe-electrode, and the first electrical ground is isolated from the second electrical ground.

Abstract: An elongated optical guidewire assembly, such as for optically imaging a patient from within another catheter, can have a lead portion and a probe portion. A connector between the lead and probe portions can include a bore including first and second bore ends. The first bore end can include a substantially circular cross-sectional profile. The second bore end can include a substantially non-circular cross-sectional profile. The bore can be configured to receive the optical guidewire assembly at the first bore end and configured to deform the optical guidewire assembly at the second bore end such that probe and lead ends of the optical guidewire assembly are deformed into a substantially non-circular profile and located between the first and second bore ends.

Abstract: A device and a method for handling and withstanding electromagnetic fields, specifically such fields as occur in magnetic resonance tomography examinations (i.e., MRT or MRI). This refers in particular to an IMD that can transmit data and/or parameters to an MRT device.

Abstract: Apparatus for generating high intensity acoustic beams, the apparatus comprising: a piezoelectric transducer characterized by a plurality of harmonic resonant frequencies of vibration; and at least one driving circuit connected to the transducer that is controllable to excite at least two vibrations of the transducer at different harmonic vibration frequencies of the vibrator, which vibrations generate a high intensity acoustic beam for each of the harmonic frequencies.

Abstract: A radioactive emission probe in communication with a position tracking system and the use thereof in a variety of systems and methods of medical imaging and procedures, are provided. Specifically, wide aperture collimation—deconvolution algorithms are provided, for obtaining a high-efficiency, high resolution image of a radioactivity emitting source, by scanning the radioactivity emitting source with a probe of a wide-aperture collimator, and at the same time, monitoring the position of the radioactive emission probe, at very fine time intervals, to obtain the equivalence of fine-aperture collimation. The blurring effect of the wide aperture is then corrected mathematically. Furthermore, an imaging method by depth calculations is provided, based on the attenuation of photons of different energies, which are emitted from the same source, coupled with position monitoring.

Abstract: Non-invasive methods for determining the cardiovascular status of an individual comprising measuring the thickness of the artery intima layer and/or the artery media layer and determining the cardiovascular status of the individual based on the thickness of the intima layer and/or the intima to media (I/M) thickness ratio are provided.

Abstract: Embodiments of the present invention describe methods of determining the occlusion of body lumens and apparatuses for doing so. In one particular embodiment, the occlusion of the fallopian tubes by an intrafallopian contraceptive device may be confirmed by contrast enhanced ultrasonography (also known as stimulated acoustic emission hysterosalpingo-contrast sonography). In these embodiments a contrast agent containing microbubbles is used.

Abstract: Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.

Abstract: Embodiments of endfire aperture-based traveling-wave antennas are described. For example, an embodiment, including a Vivaldi antenna, may have a director incorporated into the aperture region of the antenna to provide enhanced radiation directivity. The director may be a shaped dielectric that interacts with an electromagnetic field to reduce the divergence of the resultant beam as it exits the antenna. Additional dielectric substrate layers may be stacked on both sides of the antenna in order to balance the dielectric loading between the different conductors. The dielectric substrates may also eliminate contact between the antenna metallization and the lossy environment. Certain disclosed Vivaldi antennas may be used in tissue screening applications.

Abstract: Systems, methods and articles of manufacture are disclosed for capturing motion information in a magnetic resonance imaging (MRI) environment. A light sink in the MRI environment may detect light emitted from a plurality of light sources. Each of the plurality of light sources may emit light of a different frequency. Further, each of the plurality of light sources may be located at a different spatial position in the MRI environment. The detected light may be analyzed. A change in spatial position of the light sink may be computed based on the analysis.

Abstract: A high-speed laser perfusion imaging instrument including a laser source, a detector, a signal-processing unit, data memory, and a screen to display results. A section of a sample surface is illuminated with laser light; reemitted light from the irradiated surface is collected by focusing optics on a 2D array of integrating photodetectors having elements that can be accessed individually or in a pre-defined selection of pixels at high speed. This 2D array measures intensity variations at each individual pixel. Average amplitude and mean frequency of the measured signal contain information about concentration and speed of moving blood cells. For real-time imaging, exposure time is used as a parameter to measure relative perfusion changes. These data are stored and processed with the signal-processing unit to deliver 2D flow maps of the illuminated sample section, and allow a simple overlay between a conventional image and processed flow maps.

Abstract: A diagnostic imaging system is provided that includes an image acquisition component, a transmitter operatively coupled to the image acquisition component to transmit a signal therefrom, and a beamformer operatively coupled to the image acquisition component to receive image data therefrom. Also included is a processor configured to assemble images from the acquired image data and a display configured to display the images. The image acquisition component includes a multi-headed probe that has a plurality of transducers configured to permit a change of active transducers during an imaging session without a change of the image acquisition component.

Abstract: HIFU therapy to a desired tissue site is controlled based on detected changes in one or more characteristics of a received backscatter signal resulting from exposure of the tissue to HIFU or other interrogation signals. In one embodiment, the bloom of backscatter signals outward from a treatment region (e.g., towards the HIFU transducer) is detected and monitored. Once the bloom reaches a predetermined location, treatment is stopped. Other signal characteristics such as angular distribution of frequency components in the backscatter signal, changes in reflection, power required to saturate a tissue characteristic, changes in attenuation and changes in a cumulative energy distribution function of the backscatter signal that change as a result of the application of HIFU power are also used to control the delivery of HIFU signals in accordance with other embodiments of the disclosed technology.

Abstract: A method for reconstructing images of structures undergoing physiological motion comprises acquiring a first volume of data over a first motion cycle. The first volume comprises a first overlap volume. A second volume of data is acquired over a second motion cycle and comprises a second overlap volume. The first and second overlap volumes comprise like anatomical regions with respect to each other. A reconstructed volume of data is formed based on temporal data within the first and second overlap volumes.

Abstract: To improve patient comfort and reduce claustrophobia experienced by patients in a medical diagnosis or therapy apparatus, in particular a CT apparatus or an MR apparatus, with an examination region demarcated by said inner wall, in which examination region a patient can be positioned, a display is arranged in a region forming at least a portion of the inner wall.

Abstract: A method, including: receiving an input indicative of respective apparent locations of a plurality of points disposed along a length of a probe inside a body of a subject, and applying a model of known mechanical properties of the probe to the respective apparent locations so as to minimize a first cost function with respect to shapes that can be assumed by the probe in the body. The method further includes choosing a shape responsively to the minimized first cost function and determining preliminary coordinates of the apparent locations responsively to the shape, minimizing a second cost function with respect to differences between the apparent locations and the preliminary coordinates, and generating corrected coordinates of the points along the length of the probe based on the minimized second cost function.