Patents Examined by Particia A Duffy
  • Basic protein purification tags from thermophilic bacteria
    Patent number: 8426566
    Abstract: The invention is related to a method for purification of recombinant proteins using highly basic proteins from thermophilic bacteria as purification tags for use in a cation-exchange chromatography purification step. The basic proteins may be ribosomal proteins. The recombinant proteins are expressed in eukaryotic or prokaryotic host cells. The purification tag will typically have a pl above about 9 and comprise from about 15 to about 250 amino acid residues.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: April 23, 2013
    Assignee: Novo Nordisk HealthCare AG
    Inventors: Allan Christian Shaw, Susanne Bang, Jing Su