Patents Examined by Patricia Ann Bucci
  • Aryl substituted pyrido[1,4]benzodiazepines and their use as antidepressives
    Patent number: 4556667
    Abstract: Novel [2-[(aminopyridinyl)amino]phenyl]arylmethanones and their thioxomethyl, ketal or thioketal analogs of the formula: ##STR1## wherein; R is selected from the group consisting of hydrogen, loweralkyl, --alk.sup.1 --halo, --alk.sup.1 --NR.sup.1 --NR.sup.1 R.sup.2 or --alk.sup.1 --N.dbd.CH--OC.sub.2 H.sub.5 ;R.sup.1 and R.sup.2 are selected from the group consisting of hydrogen, loweralkyl, --C(O)O-loweralkyl or R.sup.1 and R.sup.2 taken together with the adjacent nitrogen atom may form a heterocyclic residue selected from the group consisting of 1-piperidinyl, 1-phthalimido, 1-pyrrolidinyl, 4-morpholinyl, 1-piperazinyl and 4-substituted-1-piperazinyl;B is selected from carbonyl, thioxomethyl, ketal or thioketal;Ar is selected from the group consisting of 2, 3 and 4-pyridinyl, 2 or 3-thienyl, phenyl or phenyl substituted by 1 to 3 radicals selected from halo, loweralkyl, loweralkoxy, trifluoromethyl or nitro and may be the same of different;alk.sup.
    Type: Grant
    Filed: December 9, 1983
    Date of Patent: December 3, 1985
    Assignee: A. H. Robins Company, Incorporated
    Inventor: Chandler R. Taylor, Jr.
  • 1,5-Methano-1H-4-benzazonine dicarboxylates, process for preparing and use as calcium blockers
    Patent number: 4548941
    Abstract: There are disclosed novel substituted and bridged pyridines which are useful as calcium channel blockers.
    Type: Grant
    Filed: July 30, 1984
    Date of Patent: October 22, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Wasyl Halczenko, George D. Hartman
  • 2-Arylbenzothiazoline derivatives and their use in treating angina cordis
    Patent number: 4547513
    Abstract: This invention relates to novel benzothiazoline derivatives of the formula [I] and salts thereof, ##STR1## wherein R.sup.1 is formyl or lower alkanoyl;R.sup.2 is hydrogen, lower alkyl, lower alkoxy or nitro;R.sup.3 is hydrogen, lower alkyl, lower alkoxy or halogen;A is lower alkylene;B is --CO--(CH.sub.2).sub.m -- or --CH(OH)--;m is 0 or 1; andwhen m is 0, R.sup.3 is not hydrogen.The compounds of this invention are useful for treatment of cardiovascular diseases.
    Type: Grant
    Filed: December 7, 1984
    Date of Patent: October 15, 1985
    Assignee: Santen Pharmaceutical Co., Ltd.
    Inventors: Jun-ichi Iwao, Tadashi Iso, Masayuki Oya