Patents Examined by Patricia D Patten
  • Patent number: 6268119
    Abstract: A cell separation method comprising steps of introducing a cell-containing fluid containing cells to be recovered and cells to be removed, into a cell-capturing means capable of substantially capturing the cells to be recovered and substantially permitting passage therethrough of cells to be removed; taking out the resulting fluid containing the cells to be removed, from the cell-capturing means; and then introducing a liquid with a viscosity of not more than 500 mPa·s and not less than 5 mPa·s into the cell-capturing means to recover therefrom the cells to be recovered which have been captured by the cell-capturing means.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: July 31, 2001
    Assignee: Asahi Medical Co., Ltd.
    Inventors: Masaya Sumita, Shuji Terashima
  • Patent number: 6265181
    Abstract: The invention is based on the discovery that, for many drugs (e.g., antiviral or antimicrobial drugs such as antifungal or antibacterial drugs, including bacteriocidal or bacteriostatic drugs) and many pathogen strains (e.g., viral, fungal, or bacterial pathogens), a concentration of drug can be identified at which drug-resistant mutant pathogen strains are not selected. This concentration is herein referred to as the “mutant prevention concentration” (MPC). Maintaining serum concentrations of the drug above the MPC throughout a course of treatment should severely restrict selection of drug-resistant mutants. Additionally, it is discovered that drug-resistant mutant pathogens are selected exclusively within a drug concentration window, termed the “mutant selection window” (MSW). A quantitative expression of this window, which we call the “window index” (WI), is defined as the ratio of the MPC to the MIC.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: July 24, 2001
    Assignee: The Public Health Research Institute of the City of New York, Inc.
    Inventors: Yuzhi Dong, Karl Drlica, Xilin Zhao
  • Patent number: 6258588
    Abstract: Palmaria cultivars having a growth rate greater than wild type and known strains, particularly when cultured at temperatures greater than about 16° C., and specific embodiments of such cultivars, many of which had a rosette morphology, are described. Methods for isolating such cultivars and using the cultivars as a food source also are described. One embodiment of the method for isolating such cultivars comprised providing at least one sample of Palmaria and cultivating such sample in a container under environmental conditions to produce at least one Palmaria cultivar having a growth rate greater than wild type when cultured at temperatures greater than about 16° C. A particular embodiment of the method resulted in the isolation of Palmaria cultivars having a rosette morphology. Isolated Palmaria cultivars can be used as a food source for feeding organisms, such as humans.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: July 10, 2001
    Assignees: Oregon State University, Big Island Abalone Corporation
    Inventors: Carl L. Demetropoulos, Christopher J. Langdon
  • Patent number: 6235289
    Abstract: Methods for treating pain by intrathecal administration to a human patient of a therapeutically effective amount of a neurotoxin such as botulinum toxin type A are disclosed.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: May 22, 2001
    Assignee: Allergan Sales, Inc.
    Inventors: Kei Roger Aoki, Minglei Cui
  • Patent number: 6210681
    Abstract: Compounds isolated from plant materials, particularly plants of the genus Vaccinium, which have biological activity measurable as inhibition with adhesion of bacterial cells to surfaces, and an extract of such plant materials which is significantly enriched for the anti-adhesion activity. The specific compounds include procyanidins (also known as “condensed tannins”), leukocyanin and leucodelphinin, and flavonol glucosides including myricetin-3-pyranoside and proanthocyanidin extracts. These proanthocyanidin extracts are capable of inhibiting agglutination reactions of P-type E. coli. The extracts containing proanthocyanidins contain at least one A-type interflavanoid bond. Methods of making an extract having the properties.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: April 3, 2001
    Assignee: JLB, Inc.
    Inventors: Edward B. Walker, Richard A. Mickelsen, Jr., Jennifer N. Mickelsen
  • Patent number: 6194016
    Abstract: The present invention provides for optimal extraction conditions for extracting yellow mustard gum from yellow mustard bran to provide for high yield. The four variables examined were extraction temperature, pH, water:solid ratio and extraction time. Of these variables, temperature and pH had a much greater influence on the yield and rheological properties of the extracted gum compared to water/solid ratio and extraction time. Optimum extraction conditions were temperatures between 50-70° C., pH 7-10, water/solid ratio of 40:1-60:1 and extraction time of 2-2.5 hr. The yield of gum obtained under the optimum extraction conditions was 30% of bran weight. The extracted gum exhibited maximum shear thinning flow behaviours. It can be incorporated into cosmetic products and skin lotions.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: February 27, 2001
    Inventors: Wuwei (Steve) Cui, N. A. Michael Eskin, Nam Fong Han, Zhi Zhong Duan, Xiao Ying Zhang
  • Patent number: 6193977
    Abstract: The present invention is directed to a pharmaceutical composition comprising an extract of a mixture of Anemarrhena Rhizoma, a member of the family Liliaceae and, Phellodendron bark, a member of the family Rutaceae that produces analgesic and anti-inflammatory effects, and its preparing method. The present invention is applicable to act on inflammation and pain, for example, chronic gastritis, arthralgia, benign prostate hyperplasia, chronic and recurrent cystitis, cervical disc, degenerative joint arthritis, rheumatoid arthritis, tennis elbow, osteoportotic pain, migraine, diabetic neuropathy pain, right flank pain, etc. The present invention a crude extract suitable for long-period administration with less side effects. Also, the present invention does not lead to dependency or resistance.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: February 27, 2001
    Assignee: Medvill Co., Ltd.
    Inventors: Young-Bok Han, Eun-Kyung Hong, Young-Shin Chung, Sung-Jin Kim, Kyung-Yung Lee, Young-Lok Shin
  • Patent number: 6139857
    Abstract: A method of repelling rodents and vermin comprising the steps of providing an effective quantity of dry dusting sulfur and inserting said dusting sulfur into burrowing holes and other spaces traveled by rodents and vermin. The method is primarily directed to gardens and yards where animal burrows are evident, but will work in agricultural fields and living structures as well. In the latter application, the dusting sulfur may be applied, for example, in pipes, underneath floor boards, and inside wall and crawl spaces.
    Type: Grant
    Filed: December 3, 1999
    Date of Patent: October 31, 2000
    Inventor: Norman Gaddini