Patents Examined by Patrick Lewis
  • Process for the purification of heparan sulfate and use thereof in cosmetological and dermatological preparations
    Patent number: 9440099
    Abstract: The present invention relates to cosmetological and dermatological compositions comprising heparan sulfate. The invention further discloses a process for the purification of heparan sulfate for dermatological and cosmetological applications, which process comprises the following steps: solubilization of heparan sulfate in water, adsorption on an anion exchange resin, desorption from the resin by using conditions which result in selective desorption of hepar an sulfate. The cosmetological and dermatological compositions according to the invention show, inter alia, anti-age, lenitive, and whitening effect.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: September 13, 2016
    Assignee: LABORATORI DERIVATI ORGANICI SPA
    Inventor: Luigi De Ambrosi
  • Method and apparatus for isolating nucleic acids
    Patent number: 9441220
    Abstract: A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: September 13, 2016
    Assignee: General Electric Company
    Inventors: Lin Chen, Bing Shang, Klaus Hochleitner, Rong Hou, Yanju Wang
  • Method and a system for manufacturing cellulosic material
    Patent number: 9441052
    Abstract: A method for manufacturing cellulosic material includes: introducing cellulose fibers as cellulosic raw material to a system, conveying the cellulose fibers to an extruder comprising a mixing part and/or a refining part, dosing at least one chemical to the system before the extruder and/or in the extruder and performing a reaction between the cellulose fibers and the chemical(s) at least partly in the extruder, wherein the reaction is performed at a consistency of at least 40%, and/or dosing at least one chemical to the system before the extruder and/or in the extruder and mixing the cellulose fibers and the chemical(s) in the mixing part of the extruder, wherein the mixing step is performed at a consistency of at least 40%, and/or refining the introduced cellulose fibers at least partly in the refining part of the extruder, wherein the refining step is performed at a consistency of at least 5%.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: September 13, 2016
    Assignee: UPM-KYMMENE CORPORATION
    Inventors: Juha Tamper, Markus Nuopponen, Harri Kosonen
  • Method of preparation of an oxidized derivative of hyaluronic acid and a method of modification thereof
    Patent number: 9434791
    Abstract: The invention relates to a new method of preparation of a hyaluronan derivative with an aldehydic group in the position (6) of the polysaccharide glucosamine part. The hyaluronic acid oxidation can be performed by means of TEMPO/NaCIO or TEMPO/TCC systems in a protic environment with or without the presence of anorganic salts. Thus prepared aldehyde can be used for binding amines, diamines, amino acids, peptides and other compounds containing an amino group, e.g. by means of the reductive amination with NaBH3CN in water or in a water-organic solvent system. When a diamine or compounds containing three or more amino groups are used, cross-linked hyaluronan derivatives can be prepared. Cross-linked derivatives can be also prepared by a reaction of the aldehyde with a hyaluronan substituted by an amino-alkyl group HA-alkyl-NH2.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: September 6, 2016
    Assignee: Contipro Pharma a.s.
    Inventors: Radovan Buffa, Sofiane Kettou, Lucie Pospisilova, Gloria Huerta-Angeles, Drahomira Chladkova, Vladimir Velebny
  • Process for the extraction of wood
    Patent number: 9434790
    Abstract: The invention relates to a process for the extraction of wood, comprising the following steps: providing wood particles, at least a first class and a second class, stacking a fine layer consisting of the first class wood particles over a further layer consisting of the second class wood particles, and extracting the wood particles using a liquid extractant, in which the extractant flows from the top downwards, first through the fine layer and then through the further layer, in which the wood particles of the first class are finer than the wood particles of the second class, and thus the fine layer has a lower permeability than the further layer.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: September 6, 2016
    Assignee: LDA AG
    Inventor: Franz Wiesbeck
  • Binding of galectin-3 by low molecular weight pectin
    Patent number: 9427449
    Abstract: Administration of low molecular weight (10,000-20,000 Daltons, or lower) pectins, particularly modified citrus pectins (MCP), like PectaSol-C reduces galectins-3 levels in vivo. Reduction of galectin-3 levels by MCP inhibits inflammation, inhibits fibrosis formation in organs and tissues, and inhibits cancer formation, progression, transformation and metastases. The reduction in circulating, serum and cellular galectin-3, inherently resulting from the administration of MCP, provides benefit over a spectrum of biological conditions, as evidenced by in vivo trials.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: August 30, 2016
    Assignee: ECONUGENICS, INC.
    Inventor: Isaac Eliaz
  • Oligomeric compounds comprising tricyclic nucleosides and methods for their use
    Patent number: 9428750
    Abstract: The present disclosure provides tricyclic nucleosides, oligomeric compounds comprising at least one of the tricyclic nucleosides and methods of using the oligomeric compounds. The methods provided herein include contacting a cell or administering to an animal at least one of the oligomeric compounds. In certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: August 30, 2016
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventors: Eric E. Swayze, Andrew M. Siwkowski, Punit P. Seth, Thazha P. Prakash
  • Anti-viral pyrimidine nucleoside derivatives
    Patent number: 9427447
    Abstract: A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH2, Y is O, S or NH, Z is O, S or CH2, R1 is C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of R2 and R3 is OH, and the other of R3 and R2 is a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety R2 or R3 may be (IV): in which R4, R5, R6 and R7 are each independently H or C1-2 alkyl. In preferred embodiments, one of R2 or R3 is valine, leucine, isoleucine or alanine, particularly valine.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: August 30, 2016
    Assignees: University College Cardiff Consultants Limited, K.U. Leuven Research and Development
    Inventors: Christopher McGuigan, Jan Balzarini, Marco Migliore
  • Method for dehydrating hydrous low-substituted hydroxypropyl cellulose and method for producing low-substituted hydroxypropyl cellulose by using same
    Patent number: 9428590
    Abstract: Reduction of the energy burden in a step of drying hydrous low-substituted hydroxypropyl cellulose (L-HPC), reduction of water content of a cake obtained by dehydration, and others are targeted. More specifically, provided is a method for dehydrating hydrous L-HPC with a compression type dehydrator by feeding the hydrous L-HPC to a screw conveyer connected to the inlet of the dehydrator, including steps of: starting the operation of the conveyer to fill the conveyer and the dehydrator with the hydrous L-HPC, starting the operation of the filled dehydrator, and feeding the hydrous L-HPC to the conveyer, while discharging dehydrated L-HPC from an outlet of the dehydrator, wherein a feed rate of feeding the hydrous L-HPC to the conveyer is equal to a discharge rate of discharging the dehydrated L-HPC in terms of net weight of cellulose ether, and a method for producing L-HPC by using the above method.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: August 30, 2016
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Junichi Matsubara, Atsuhiko Yonemochi, Mitsuo Narita
  • Methods and columns for nucleic acid purification
    Patent number: 9422596
    Abstract: Provided are methods and columns employing a solid support comprising silica and silicon carbide for the isolation and purification of nucleic acids, and in particular, the isolation and purification of both high and low molecular weight RNA.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: August 23, 2016
    Assignee: Norgen Biotek Corp.
    Inventor: Yousef Haj-Ahmad
  • Substituted nucleosides, nucleotides and analogs thereof
    Patent number: 9422322
    Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: August 23, 2016
    Assignee: Alios BioPharma, Inc.
    Inventors: Natalia Dyatkina, Guangyi Wang, Leonid Beigelman, Vivek Kumar Rajwanshi
  • Compositions and methods for borocarbohydrate complexes
    Patent number: 9421216
    Abstract: Borocarbohydrate complex containing compositions are presented that have an improved di-complex to boric acid ratio. In some embodiments, compositions are characterized by a di-complex to boric acid ratio of at least 5:1 and more typically at least 10:1 in liquid form, and at least 20:1 in dried form. In other embodiments, compositions are characterized by a minimum content of 80 wt % di-complex and a boric acid content of less than 15 wt %, and more typically less than 5 wt %. Contemplated compositions are thought to have improved biological activity and reduced content of undesired components.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: August 23, 2016
    Assignee: VDF Futureceuticals, Inc.
    Inventor: John M. Hunter
  • Saponin nano micelle, preparing method, application and pharmaceutical composition thereof
    Patent number: 9421269
    Abstract: A saponin nano micelle, preparing method, application and pharmaceutical composition thereof is disclosed in the present invention. The saponin nano micelle comprises one or more of saponins represented by formula 1, in which, R1 and R2 are independently —H or a hydrophilic group, R3 is —H or —OH, R4 is a lipophilic group. The preparing method of the saponin nano micelle is that mixing the saponin with an organic solvent which can dissolve saponin, and then removing the organic solvent. The saponin micelle acts as a convey medium of the drug ingredients, and can replace conventional drug carriers such as pharmaceutical solubilizers or polymeric micelle, which has high safety and great significance. The pharmaceutical ingredients can prolong circulation time and biological half-life of drug in the blood, and increase the accumulation of drug in lesions, and reduce adverse reactions.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: August 23, 2016
    Assignee: FUJIAN SOUTH PHARMACEUTICAL CO., LTD.
    Inventors: Huaxing Zhan, Zhihong Jiang, Dan Wang, Xin Shen, Jidong Yang, Jianping Luo, Hongsheng Zhang, Min Du, Pengfei Miao
  • Compounds and methods for preventing, treating and/or protecting against sensory hair cell death
    Patent number: 9416141
    Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair cell death. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: August 16, 2016
    Assignees: University of Washington through its Center for Commercialization, Fred Hutchinson Cancer Research Center
    Inventors: Julian Simon, Graham Johnson, Edwin Rubel, Sarwat Chowdhury, R. Jason Herr, Qin Jiang, Xinchao Chen, Kelly N Owens, David Raible
  • Method for purification of nucleic acids, particularly from fixed tissue
    Patent number: 9416399
    Abstract: The invention relates to a method for purification of nucleic acids, to a kit for performing the method according to the invention and to a new application of magnetic particles for purification of a biological sample. The method according to the invention comprises the following steps: a) accommodating of the sample in a first sample vessel in an aqueous solution and lysing of the sample under non-chaotropic conditions; suspending of first magnetic particles in the solution and inserting of the first sample vessel in a sample vessel holder, wherein the sample vessel is inserted in the annular interior space of a ring magnet associated with the sample vessel holder; separating of the solution from the magnetic particles; and isolating of the nucleic acids from the solution.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: August 16, 2016
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Heike Euting, Guido Hennig, Alexandre Izmailov
  • Method and device for producing and/or purifying polynucleotides and products obtainable thereof
    Patent number: 9416400
    Abstract: An apparatus and a method for obtaining a (poly)nucleotide sequence of interest include steps of cultivating hosts cells to produce a nucleotide sequence of interest and harvesting these cells, introducing these cells in a passageway and disintegrating them in a continuous process. In the continuous process, performing in the passageway a precipitation of contaminants by a mixing of the disintegrated cells with a solution containing one or more salt(s) and obtaining a mixture and allowing a precipitate to separate from the solution of this mixture, preferably to float and/or to sediment from the solution of this mixture for 1-48 hours and pumping out a soluble material from this solution, while excluding recovering the precipitate.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: August 16, 2016
    Assignee: EUROGENTEC S.A.
    Inventor: Philippe Ledent
  • Method and apparatus for processing fibril cellulose and fibril cellulose product
    Patent number: 9409998
    Abstract: A method for processing fibril cellulose which is in the form of aqueous fibril cellulose gel includes lowering the pH of the aqueous fibril cellulose gel to provide aqueous fibril cellulose gel of reduced water retention capacity, and dewatering the aqueous fibril cellulose gel of reduced water retention capacity to provide dewatered fibril cellulose. The dewatering is performed by pressure filtration.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: August 9, 2016
    Assignee: UPM-KYMMENE CORPORATION
    Inventors: Antti Laukkanen, Markus Nuopponen
  • Pentaerythritol core, phosphonic acid terminated dendrimer and its preparation method
    Patent number: 9403707
    Abstract: A pentaerythritol core, phosphonic acid terminated dendrimer, its preparation method and application are provided. A preparation method of the pentaerythritol core, phosphonic acid terminated dendrimer (PETA-ADA-12PO3H2) comprises steps of processing Michael addition reaction on pentaerythritol tetraacrylate (C(CH2OCOCH2=CH2)4) and alkylidene diamine (NH2CH2(CH2)nNH2), wherein n is an integer from 1 to 5, so as to obtain pentaerythritol core, amino group terminated dendrimer, and modifying the amino group by methylene phosphonic acid to obtain the PETA-ADA-12PO3H2 having a chemical formula of C[CH2OCOCH2CH2N(CH2PO3H2)CH2(CH2)nN(CH2PO3H2)2]4, wherein n is an integer from 1 to 5.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: August 2, 2016
    Assignee: Tongji University
    Inventors: Bingru Zhang, Fengting Li, Hongmei You
  • Method of preparing oligomeric compounds using modified capping protocols
    Patent number: 9403865
    Abstract: Provided herein are methods for the solid phase synthesis of oligomeric compounds wherein at least one of the capping steps has been modified. More particularly, methods are provided wherein one or more of the capping steps is omitted or performed using reduced equivalents of acetic anhydride. In certain embodiments, the methods provide an enhanced purity profile. In certain embodiments, the methods provide an increased yield. The methods provided herein also provide at least an economic advantage over currently used methods in that reduced amounts of the mixture of capping reagents are required.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: August 2, 2016
    Assignees: Ionis Pharmaceuticals, Inc., Genzyme Corporation
    Inventors: Isaiah E. Cedillo, Darren Janczak, Phillip Michael Weaver
  • Oxidized derivative of hyaluronic acid, a method of preparation thereof and a method of modification thereof
    Patent number: 9403918
    Abstract: The invention relates to a hyaluronic acid derivative and methods of preparation and modification of a hyaluronan derivative with an aldehydic group in the position (6) of the polysaccharide glucosamine part. The oxidation of the hyaluronic acid can be performed by means of Dess-Martin periodinane (DMP) agent. The prepared aldehyde can be used for binding amine, diamine, amino acid, peptide and other compounds containing an amino group, e.g. by means of the reductive amination with NaBH3CN in water or in a water-organic solvent system. When a diamine or compounds containing three or more amino groups are used, cross-linked hyaluronan derivatives can be prepared. Cross-linked derivatives can also be prepared by the reaction of the aldehyde with a hyaluronan substituted by an amino-alkyl group HA-alkyl-NH2.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: August 2, 2016
    Assignee: Contipro Pharma a.s.
    Inventors: Radovan Buffa, Sofiane Kettou, Lucie Pospisilova, Miroslava Berkova, Vladimir Velebny