Abstract: The present invention describes a new functional biomarker of vascular inflammation and its use in predicting all-cause or cardiac mortality. The invention also provides a method for stratifying patients according to their risk of all-cause or cardiac mortality using data gathered from a computer tomography scans of a blood vessel to determine a specific combination of structural and functional biomarkers of vascular inflammation and disease.

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

Abstract: The present invention relates to a device (100), systems (500, 500?, 500?) and a method for providing imaging of one or more aspects of blood perfusion induced by cardiac induced blood motion in a skin region (12) of a subject. Current perfusion imaging systems use either photoplethysmography (PPG) or speckle contrast (SC), but a problem of both techniques is that considerable ambiguity exists because the source of the signal (volume pulsatility in PPG or blood flow in SC) is unknown. The present invention is based on the idea of combining two different types of measurement, namely widefield imaging and radial imaging, in order to estimate the source depth (20) of the signal to provide more accurate PPG imaging and SC imaging.

Abstract: The present invention provides a closed loop generation and/or infusion system comprising a radionuclide generator, an activity detector, a controller, a dose calibrator, a pump, eluant source and an automated elution system controlled by software and hardware for generation and infusion of a radionuclide for administering a dose of generated radionuclide into a subject for diagnosing a peripheral arterial disease in a subject suffering from or suspected of suffering from peripheral arterial disease and/or metabolic disease via Positron Emitting Tomography (PET) or Single-photon emission computed tomography (SPECT) imaging technologies.

Abstract: Systems and methods are provided for determining surgical trajectories (including target points and entry points) for delivering therapy to a patient's brain using a three-dimensional (3D) representation of the patient's brain (including the patient's scalp, skull, and brain) adapted from imaging data (e.g., MRI data, CT data, etc.) of the patient's brain.

Abstract: Disclosed herein are tissue marking devices and methods that enables marking a target tissue more than 24 hours prior to surgery. The tissue marking device includes a hook assembly having a compressed configuration and a deployed configuration and a handle assembly for positioning the hook assembly in a targeted tissue. The hook assembly may include a hook body comprising at least two hooks and a thread connected to the hook body. The handle assembly may include a handle body, a needle having a lumen, and a stylet having a lumen.

Abstract: A method of removing microvessels includes applying a burst of acoustic energy at a target location, applying a pulse of optical energy at the target location, and promoting cavitation at the target location by synchronizing an arrival of the burst of acoustic energy and the optical energy at the target location. The burst of acoustic energy has a pressure below 5.0 MPa. The pulse of optical energy at the target location has a fluence less than 100 mJ/cm2. At least a portion of the pulse is concurrent with the burst and the optical energy has an optical area that is overlapping with an acoustic area of the acoustic energy at the target location.

Abstract: Marking device (100) for implantation into a tissue (260), having a support structure (102) which is formed by at least one elastic metal wire, is compressible and is self-expanding and which, in an expanded state, encompasses an interior space (104), characterized in that the marking device (100) is designed to transform itself on its own from a compressed state into an expanded state, even against a tissue pressure prevailing at a tissue site to be marked, and the marking device (100) in the expanded state has a hollow, approximately spherical shape.

Abstract: A streaming content delivery system is provided for processing and broadcasting digital video content obtained from a distributed wearable camera device having eye tracking and movement sensing circuitry, or combination of devices or components, worn by an athlete, sports participant, or first responder. The system which may include eye sensors, accelerometers, as well as other sensors and specific wearable devices are disclosed which provide sensor data-enhanced video content from the point of view of an athlete during competition including for the sports of football, baseball, golf, skiing, and snowboarding.

Abstract: A method for generating a transducer layout for delivering tumor treating fields includes storing medical images of a subject, identifying one of the medical images as an anchor medical image, and registering computed tomography medical images with magnetic resonance imaging medical images. The method further includes segmenting abnormal tissue in the medical images from other tissue types and defining a region of interest (ROI) in the medical images. The method further includes creating a 3D model of the subject. The method further includes generating a plurality of transducer layouts for application of tumor treating fields to the subject, selecting at least two of the transducer layouts as recommended transducer layouts, presenting the recommended transducer layouts, receiving a user selection of at least one recommended transducer layout, and providing a report for the selected recommended transducer layout(s).

Abstract: A method for detecting inflammatory activity, including: providing a catheter including a near-infrared fluorescence (NIRF) imaging system configured to perform NIRF imaging and an optical coherence tomography (OCT) imaging system configured to perform structural imaging; introducing a near-infrared fluorescent cathepsin-activatable imaging agent into a blood vessel; placing a distal end of the catheter within the blood vessel; obtaining, using the OCT imaging system, structural images of an atherosclerotic plaque within the blood vessel; obtaining, using the NIRF imaging system. NIRF images of the atherosclerotic plaque within the blood vessel; detecting the near-infrared fluorescent cathepsin-activatable imaging agent in the NIRF images; and identifying inflammation within the atherosclerotic plaque based on detecting the near-infrared fluorescent cathepsin-activatable imaging agent in the NIRF images.

Abstract: Systems, methods, and computer software are disclosed that allow the automatic recalling of imaging parameters from computer memory for controlling an MRI system to perform treatment-day scans of a patient on a treatment couch in a radiotherapy system, prior to treatment. The treatment-day scans can be automatically initialized and the MRI system can then be controlled to perform the treatment-day scans according to the recalled imaging parameters. Reoptimized radiation treatment plan(s) can be automatically generated and predicted doses to anatomical structures of the patient based on the plan(s) can be displayed. Clinicians can be enabled to perform numerous reoptimization tasks simultaneously through parallel workflow interfaces and then a radiation therapy device can be controlled to deliver radiation according to a selected radiation treatment plan.

Abstract: A method for identifying brain-state dependent functional areas of unitary pooled activity (FAUPAs) using a statistical model that does not require a priori knowledge of the activity-induced ideal response signal time course is provided. A system for identifying a functional network in a brain of a living object includes a FAUPA identifier configured to identify FAUPAs by analyzing a plurality of images of the brain over a predetermined period. The plurality of images include a plurality of voxels, and the FAUPA identifier analyzes each voxel of the plurality of voxels in relation to one or more surrounding voxels of each voxel until each voxel of the plurality of voxels is evaluated. A brain network identification module configured to construct the functional network based on the identified FAUPAs that are functionally connected. A display module configured to display images of the brain depicting the FAUPAs included in the functional network.

Abstract: A PET apparatus according to one embodiment includes processing circuitry. The processing circuitry acquires list mode data. The processing circuitry reconstructs a PET image based on the list mode data. The processing circuitry identifies first coincidence data that is obtained by coincidence counting by a first detector and a second detector that is different from the first detector from among a plurality of pieces of coincidence data included in the list mode data. The processing circuitry estimates a time lag amount between the first detector and the second detector based on TOF information included in the first coincidence data and the PET image.

Abstract: The present invention relates to multispectral imaging. In order to improve an identification of relevant multispectral material transitions (in particular caused by injected contrast agent), an apparatus is proposed to use the local maxima of the variances and/or covariances of the intensities of the multi-channel images to locate material transitions. In comparison to gradient vectors, the local variance is not directed and not prone to noise. An alternative apparatus is proposed to use the local covariance deficits of the intensities of the multi-channel images to locate material transitions. The proposed alternative approach is independent of spatial drifts across the image volume.

Abstract: An endoscopic imaging device (e.g., a catheter) comprises a light-transmitting tubing, at least one optical fiber disposed in the light-transmitting tubing, and at least one metalens. The metalens is optically coupled to the optical fiber and is configured to focus light from the optical fiber, through the light-transmitting tubing, and to a target point located outside of the light-transmitting tubing. The metalens includes a plurality of nanostructures. The nanostructures define a phase profile that corrects astigmatism caused by the light-transmitting tubing.

Abstract: The present disclosure provides a vital sign measuring device and method that may measure a heart rate signal of a living body in a motion state. The method comprises detecting two different signals, using an adaptive noise removal algorithm for removing noise from the two signals, and obtaining a more accurate heat rate signal after a certain operation.

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

Abstract: A method is provided to model a 3D structure comprising: producing a surface mesh representation of the 3D structure; producing a volume mesh representation of the 3D structure based upon the surface mesh; sorting vertices of the volume mesh into a first sub-list that includes only surface vertices and a second sub-list that includes only internal vertices; applying shading to the surface mesh by accessing only surface vertices in the first sub-list; determining deformation of the volume mesh by accessing both surface vertices in the first sub-list and internal vertices in the second sub-list.