Abstract: Disclosed is a method for measuring or detecting inorganic phosphate ion in a sample. In the method, a sample is reacted with a phosphate-binding protein containing (i) an inorganic phosphate ion binding site and (ii) a detectable label that produces a signal whose amplitude changes detectably upon the binding of inorganic phosphate ion to the binding site, under conditions effective to allow binding of phosphate in the sample to the binding site. From a change in signal, the level of inorganic phosphate ion is measured or detected. Also disclosed are phosphate binding proteins for use in the method.

Abstract: The present invention provides a method for eliciting an opioidal analgesia in a living subject using two classes of chemical compositions previously thought to have directly contradictory and physiologically antagonistic roles in the spinal analgesic process. The present methodology relies upon a concurrent administration of an opioid in marginal concentrations in combination with marginal doses of substance P or its related entities which function in a synergistic relationship and mechanism of action. The methodology relies upon a powerful potentiation and enhancement of an opioid-mediated response by the enhancing action of substance P to modulate or eliminate pain and other nociceptive responses, as well as inducing anesthesia.

Abstract: Nucleotide sequences encoding a maize 5C9 polypeptide, the 5C9 polypeptide and structural and functional equivalents, and methods for controlling insect infestation in plants are provided.

Abstract: The present invention relates to compositions based on elastomeric polymers of vinylidene fluoride, hexafluoropropene and optionally tetrafluoroethylene suitable for providing microcellular foamed vulcanized articles by extrusion or compression molding. In the case of the production of extruded articles based on vinylidene fluoride and hexafluoropropene copolymers, the compositions comprise: the copolymer, bisphenol AF, a quaternary phosphonium or aminophosphonium salt, azodicarbonamide, MgO, Ca(OH).sub.2, zinc stearate and a plasticizer, each of the components being contained in an exactly defined proportion.

Abstract: Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.

Abstract: The present invention is a thermoplastic panel or piece having a resilient injection molded portion. The panel or piece of the present invention may be used in a variety of applications such as to provide sealing ends on thermoplastic panels or to create resiliently closable passages in thermoplastic panels through which wires and other objects may be passed while maintaining an even surface appearance of the baseboard panel. Other uses include attaching one or more thermoplastic pieces together. The invention also includes a method for making the subject thermoplastic panel or piece.

Abstract: The present invention relates to rubber stocks containing a metal salt of hydroxy-aryl substituted maleamic acid. The rubber stocks compounded with the cobalt salts of hydroxy-aryl substituted maleamic acid exhibit improved aged rubber/wire adhesion. The rubber stocks compounded with sodium salts of hydroxy-aryl substituted maleamic acid exhibit improved peel adhesion.

Abstract: An acrylic rubber composition comprising 100 parts by weight of acrylic rubber containing cross-linkable groups and 2 to 40 parts by weight of tri(2-ethylhexyl) phosphate has quite an unexpected effect on prevention of fixation of its vulcanized rubber moldings to metallic materials or resin moldings when brought into direct contact with the latter due to the presence of tri(2-ethylhexyl) phosphate in the acrylic rubber containing cross-linkable groups.

Abstract: The invention is directed to a method of highly purifying a polypeptide or other biological compounds from a contaminant by crystallization comprising contacting a mixture containing uncrystallized polypeptides and a contaminant with an exogenous nucleating agent, crystallizing the polypeptides, thereby forming at least one crystal of the polypeptide attached to the nucleating agent, the attached crystal being of a high purity, and at least one polypeptide crystal unattached to the nucleating agent, the unattached crystal being of a lower purity than the attached crystal, and separating the crystal attached to the nucleating agent from the crystal unattached to the nucleating agent.

Abstract: Processes for polymerizing ethylene/.alpha.-olefin interpolymer compositions are disclosed. The interpolymer compositions have a controlled composition and a controlled molecular weight distribution. The processes utilize a highly-efficient homogeneous catalyst composition in at least one reactor to produce a first interpolymer having a narrow composition distribution and a narrow molecular weight distribution, and a highly-efficient heterogeneous Ziegler catalyst in at least one other reactor. The reactors can be operated sequentially or separately, depending upon the desired product. The novel compositions have good optical properties (e.g., clarity and haze) and good physical properties (e.g., modulus, yield strength, toughness and tear). Useful products which can be formed from these compositions include film, molded articles and fiber.

Abstract: An unsaturated acid-functional monomer having the structure: ##STR1## wherein R is hydrogen or methyl and polymers prepared using the monomer are disclosed.

Abstract: A coextruded label material is provided which comprises a styrenic unfoamed layer and a styrenic foam layer wherein the styrenic unfoamed layer is the predominant portion as contrasted to the styrenic foam layer. In accordance with another aspect of the invention, an additional clear or translucent unfoamed plastic layer is adhered to the unfoamed layer with printing interposed between the unfoamed layers. Printing is provided on the unfoamed layer of the coextruded material or other side of the additional clear or translucent unfoamed layer. A container package is provided wherein a label is cut from the label material and wrapped about a hollow container.

Abstract: Pharmaceutical compositions comprising as active ingredient a synthetic random copolymer of average molecular weight of about 4,000-12,000, preferably 6,000-8,000, said copolymer consisting of glutamic acid (Glu), lysine (Lys), alanine (Ala) and tyrosine (Tyr) residues in a relative molar ratio of 1.4-2.1 parts of Glu to 3.2-4.4 parts of Lys to 4.0-6.0 parts of Ala to 1.0 parts of Tyr (herein GLAT copolymers), can be used in a method for prevention and treatment of graft-versus-host disease in patients in the course of bone marrow and organ transplantation.

Abstract: Adhesive proteins isolated from mature plants selected from the group consisting of macroalgae and microalgae, said proteins being characterized by the presence of at least one RGD or RGD-like or other adhesive recognition sequence, the absence of DOPA and hydroxyproline units, and by the fact that the proteins may be used by the plants in their natural state, for the purpose of adhesion to substrates.

Abstract: Devices and materials containing certain stable, polycyclic aromatic compounds exhibit sensible, second order nonlinear optical effects. In general, useful polycyclic aromatic compounds possess electron-donating and electron-withdrawing chemical functionality but no center of inversion symmetry on either the molecular or crystalline unit cell level.

Abstract: The invention provides artificial collagen comprising a stabilized ordered triple helix of copolypeptide strands containing repeating amino acid triads. The collagen may be modified with groups which improve its physical or chemical properties for the intended use, such as adhesive and cross-linking groups. Artificial collagen according to the invention is particularly useful as a wound closer and healer.

Abstract: The present invention is directed to novel carba cyclohexapeptide compounds of the formula ##STR1## where all substituents are defined herein, which are useful as antifungal agents and for the treatment of Pneumocystis carinii infections. Compositions containing the compounds of the invention are also disclosed.

Abstract: A polymeric blend formed from recycled carpet scrap and selected compatibilizing agents and/or a poly(ethylene-co-omylacetate) and the products produced from such blend.

Abstract: The present invention provides bradykinin antagonists effective to inhibit cancer cell growth. Also provided are methods of inhibiting lung cancer cell growth by administering a therapeutically effective amount of a dimerized bradykinin antagonist.

Abstract: The present invention provides a thread wound golf ball having improved flight performances, which comprises a solid center, a thread layer and an outer cover. The solid center is formed from a rubber component with crosslinked structure which contains an oily substance. Impact resilience of the solid center is 90 cm or more.