Abstract: Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis.
Type:
Grant
Filed:
June 18, 2013
Date of Patent:
April 29, 2014
Assignee:
Supernus Pharmaceuticals, Inc.
Inventors:
Rong-Kun Chang, Arash Raoufinia, Niraj Shah