Abstract: The present invention describes methods and compositions for non-invasively assessing the molecular structure of biocompatible hydrogels using MRI analysis. It is shown that biocompatible hydrogels prepared from polymerizing macromolecules that are attached to a paramagnetic, superparamagnetic or ferromagnetic contrast agents form reporter gels wherein monitoring of the changes in the structure of the hydrogels by MRI is facilitated by the presence of such paramagnetic, superparamagnetic or ferromagnetic agents in the biocompatible hydrogel.
Abstract: The subject of the present invention is yarns, fibers or filaments and also a textile article and a medical device obtained from said yarns, for improving skin cicatrization, in particular by activating collagen synthesis at the surface of the injured skin. The yarns, fibers or filaments of the invention comprise a polymeric matrix and inorganic fillers, uniformly dispersed in the polymeric matrix, having properties of absorption and/or of emission in the 2-20 ?m far-infrared region.
Type:
Grant
Filed:
May 16, 2012
Date of Patent:
November 14, 2017
Assignee:
Rhodia Poliamida E Especialidades LTDA
Inventors:
Tarcis Cordeiro Bastos, Gabriel Gorescu, Thomas Canova
Abstract: This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.
Type:
Grant
Filed:
October 20, 2016
Date of Patent:
November 7, 2017
Assignee:
PSIVIDA US, INC.
Inventors:
Paul Ashton, Leigh T. Canham, Christian Barnett
Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
Type:
Grant
Filed:
May 2, 2016
Date of Patent:
November 7, 2017
Assignee:
Nektar Therapeutics
Inventors:
Xuan Zhao, Michael David Bentley, Zhongxu Ren, Tacey X. Viegas
Abstract: The present invention relates to a structure having a nanoantenna, a method for manufacturing same, a drug delivery body having the same, a thermotherapy complex, a drug therapy device, and a thermotherapy device. The structure of the present invention has a nanoantenna pattern formed on the outer surface of a porous micro-container, thereby enabling wireless control from the outside, and when the structure is used as a drug delivery system and a thermotherapy complex, drug therapy and thermotherapy can be carried out at a desired application region inside a living body at a desired time. Also, the structure of the present invention enables transmission and reception of a wireless signal with an external controller through the nanoantenna, thereby enabling the detection of a signal inside the living body and the transmission of the signal to the external controller, and the discharge of a drug or nanowires according to a response signal transmitted from the external controller.
Type:
Grant
Filed:
January 31, 2012
Date of Patent:
October 31, 2017
Assignee:
KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Inventors:
Sung Hoi Choi, Jung Rae Park, Young Keun Kim
Abstract: A nanophosphor in accordance with one exemplary embodiment of the present disclosure includes a fluoride-based nanoparticle co-doped with Ce3+ and one selected from a group consisting of Tb3+, Eu3+ and a combination thereof. The nanophosphor may be excited by a single wavelength of ultraviolet rays to emit various colors of green, yellow, orange, red and the like, and exhibit high photostability without photoblinking. The nanophosphor may be utilized as a bio imaging contrast agent, a transparent display device, an anti-counterfeit code and the like.
Type:
Grant
Filed:
April 11, 2014
Date of Patent:
October 24, 2017
Assignee:
Korea Institute of Science and Technology
Inventors:
Ho Seong Jang, Kyoungja Woo, Su Yeon Kim
Abstract: The invention relates to a nanostructured delivery system comprising at least one polymer and/or at least one lipid and at least one polymethine dye, wherein the at least one polymethine dye acting as a targeting unit brings about the targeted transport of the nanostructured delivery system into a target issue. The invention also relates to a pharmaceutical composition and the uses of the nanostructured delivery system for transporting said system and, optionally, a pharmaceutical active ingredient into the target tissue, as well for treating liver and/or kidney diseases.
Type:
Grant
Filed:
September 11, 2014
Date of Patent:
October 24, 2017
Assignee:
SMARTDYELIVERY GMBH
Inventors:
Michael Bauer, Ulrich Schubert, Michael Gottschaldt, Anja Trager, Christian Pietsch, Falk Gonnert, Peter Recknagel, Adrian Press
Abstract: The invention provides methods of hair loss or inducing new hair growth, as well as methods of preventing hair loss, comprising applying an effective amount of a dihydromyricetin compound to the scalp. The invention also provides methods of delaying or reversing signs of aging skin comprising applying an effective amount of a dihydromyricetin compound to the skin. Also provided are cosmetic products (e.g., skin and hair products) comprising a dihydromyricetin compound and methods of making the same.
Abstract: This invention provides block copolymer (BCP) encapsulated nanoparticles. The BCP-encapsulated nanoparticles are used in methods for targeting a tumor, in methods of imaging a tumor and in methods of treating cancer including hyperthermia of tumors. This invention further provides processes for preparation of BCP-encapsulated nanoparticles.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
October 10, 2017
Assignee:
Purdue Research Foundation
Inventors:
You-Yeon Won, Ronald P. Andres, Dae Hwan Kim
Abstract: A ceramic or polycrystalline scintillator composition is represented by the formula (LuyGd3-y)(GaxAl5-x)O12:Ce; wherein y=1±0.5; wherein x=3±0.25; and wherein Ce is in the range 0.01 mol % to 0.7 mol %. The scintillator composition finds application in the sensitive detection of ionizing radiation and may for example be used in the detection of gamma photons in the field of PET imaging.
Type:
Grant
Filed:
December 16, 2014
Date of Patent:
October 3, 2017
Assignee:
KONINKLIJKE PHILIPS N.V.
Inventors:
Herfried Karl Wieczorek, Cornelis Reinder Ronda, Jacobus Gerardus Boerekamp, Anne-Marie Andree Van Dongen, Sandra Johanna Maria Paula Spoor, Daniela Buettner, Wilhelmus Cornelis Keur
Abstract: In the early detection of cancer, in particular bladder cancer, a photodynamic diagnosis uses, as a photosensitizer, a formulation that contains sodium hypericinate that is bonded to polyvinylpyrrolidone or complexed with polyvinylpyrrolidone.
Type:
Grant
Filed:
March 27, 2017
Date of Patent:
October 3, 2017
Assignee:
SANOCHEMIA PHARMAZEUTIKA AG
Inventors:
Stefan Welzig, Beate Kälz, József Gungl, Klaus Gerdes, Werner Frantsits, Christina Abrahamsberg
Abstract: The present invention provides among other things a composition of a polymeric reagent and an antioxidant, such as butylated hydroxyl toluene.
Type:
Grant
Filed:
June 1, 2016
Date of Patent:
October 3, 2017
Assignee:
Nektar Therapeutics
Inventors:
Michael D. Bentley, Sean M. Culbertson, Samuel P. McManus
Abstract: The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
Type:
Grant
Filed:
March 16, 2015
Date of Patent:
October 3, 2017
Assignee:
Rhode Island Hospital
Inventors:
Qian Chen, Yupeng Chen, Hongchuan Yu, Michael G. Ehrlich
Abstract: The invention generally relates to synthetic mimics of cell penetrating peptides. More particularly, the invention relates to certain novel monomers, oligomers and polymers (e.g., co-polymers) that are useful for the preparation of synthetic mimics of cell penetrating peptides, their compositions, preparations and use.
Type:
Grant
Filed:
June 7, 2016
Date of Patent:
September 26, 2017
Assignee:
University of Massachusetts
Inventors:
Gregory N. Tew, Gregory J. Gabriel, Abhigyan Som, Arife Ozgul Tezgel
Abstract: A hydrogel plug is placed under stress during its curing stage, in one embodiment, by application of an externally applied force. The stress may also be induced during or after the dehydration process. The direction of the externally applied force increases the length, width, depth, or radial extent of the plug. The elastic limit of the plug is exceeded when the external force is applied so that the plug substantially retains its stressed size and shape when the externally applied force is removed. When the stretched or otherwise deformed dehydrated plug is hydrated, it substantially returns to the configuration it had prior to its dehydration and prior to the application of the externally applied force.
Abstract: The present invention relates to a solid precursor in the form of an organic salt, the solid precursor having a solid support, a method for manufacturing same, and an application thereof. The solid precursor of the present invention enables omission of the [18F]fluoride refining process using additional cartridge, and the use of excessive phase-transfer catalyst, and can easily remove remaining substance after reaction through the solid support inside the precursor. The solid precursor of the present invention is very appropriate for an automated synthesis device as an all-in-one system that can carry out overall process of [18F]fluorosis reaction, when used by charging in a cartridge.
Abstract: A hydrogel plug is placed under stress during its curing stage, in one embodiment, by application of an externally applied force. The stress may also be induced during or after the dehydration process. The direction of the externally applied force increases the length, width, depth, or radial extent of the plug. The elastic limit of the plug is exceeded when the external force is applied so that the plug substantially retains its stressed size and shape when the externally applied force is removed. When the stretched or otherwise deformed dehydrated plug is hydrated, it substantially returns to the configuration it had prior to its dehydration and prior to the application of the externally applied force.
Abstract: A hyaluronic acid conjugates including hyaluronic acid, a disulfide bond-containing crosslinking agent, and a cationic, amphiphilic polymer; a hyaluronic acid-nucleic acid complex in which a nucleic acid is bound to the hyaluronic acid conjugate; a composition in which the hyaluronic acid-nucleic acid complexes are crosslinked with each other; a nucleic acid delivery composition including the hyaluronic acid-nucleic acid complex; and a method of nucleic acid delivery using the hyaluronic acid-nucleic acid complex.
Type:
Grant
Filed:
April 1, 2014
Date of Patent:
August 29, 2017
Assignees:
SAMSUNG ELECTRONICS CO., LTD., RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
Inventors:
Hyun-Ryoung Kim, Jae Hyung Park, Hong Yeol Yoon
Abstract: Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid-polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-? plaque deposits characteristic of Alzheimer's Disease.
Type:
Grant
Filed:
October 8, 2015
Date of Patent:
August 29, 2017
Inventors:
Ananth V. Annapragada, Eric A. Tanifum, Mayank Srivastava